WO2011138795A3 - Process for preparing (s)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f] azepine-5-carboxamide - Google Patents

Process for preparing (s)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f] azepine-5-carboxamide Download PDF

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Publication number
WO2011138795A3
WO2011138795A3 PCT/IN2011/000303 IN2011000303W WO2011138795A3 WO 2011138795 A3 WO2011138795 A3 WO 2011138795A3 IN 2011000303 W IN2011000303 W IN 2011000303W WO 2011138795 A3 WO2011138795 A3 WO 2011138795A3
Authority
WO
WIPO (PCT)
Prior art keywords
dibenz
azepine
acetoxy
carboxamide
dihydro
Prior art date
Application number
PCT/IN2011/000303
Other languages
French (fr)
Other versions
WO2011138795A2 (en
Inventor
Manne Satyanarayana Reddy
Sajja Eswaraiah
Bairy Kondal Reddy
Mummadi Venkatesh
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2011138795A2 publication Critical patent/WO2011138795A2/en
Publication of WO2011138795A3 publication Critical patent/WO2011138795A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Processes for preparing (S)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide and its intermediates are provided.
PCT/IN2011/000303 2010-05-03 2011-05-02 Process for preparing (s)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f] azepine-5-carboxamide WO2011138795A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1229/CHE/2010 2010-05-03
IN1229CH2010 2010-05-03

Publications (2)

Publication Number Publication Date
WO2011138795A2 WO2011138795A2 (en) 2011-11-10
WO2011138795A3 true WO2011138795A3 (en) 2012-01-05

Family

ID=44904176

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000303 WO2011138795A2 (en) 2010-05-03 2011-05-02 Process for preparing (s)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f] azepine-5-carboxamide

Country Status (1)

Country Link
WO (1) WO2011138795A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012120356A2 (en) * 2011-03-08 2012-09-13 Jubilant Life Sciences Limited Process for the preparation of (s)-(+)-or (r)-(-)-10 hydroxy dihydrodibenz[b,f]azepines by enantioselective reduction of 10, 11-dihydro-10-oxo-5h-dibenz[b,f]azepines and polymorphs thereof
WO2013008194A2 (en) * 2011-07-13 2013-01-17 Ranbaxy Laboratories Limited Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
EP3064490A1 (en) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753646A (en) * 1995-06-30 1998-05-19 Portela & Ca., S.A. Substituted dihydrodibenzo/b,f/azepines, method of their preparation, their use in the treatment of some central nervous system disorders, and pharmaceutical compositions containing them
WO2002092572A1 (en) * 2001-05-11 2002-11-21 Portela & Ca Sa Method for preparation of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide
WO2007012793A1 (en) * 2005-07-29 2007-02-01 Portela & C.A., S.A. Asymmetric catalytic reduction of oxcarbazepine
WO2007117166A1 (en) * 2006-04-11 2007-10-18 Bial - Portela & C.A., S.A. Preparation of eslicarbazepine and related compounds by asymmetric hydrogenation
WO2011091131A2 (en) * 2010-01-23 2011-07-28 Dr. Reddy's Laboratories Ltd. Eslicarbazepine acetate and its polymorphs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753646A (en) * 1995-06-30 1998-05-19 Portela & Ca., S.A. Substituted dihydrodibenzo/b,f/azepines, method of their preparation, their use in the treatment of some central nervous system disorders, and pharmaceutical compositions containing them
WO2002092572A1 (en) * 2001-05-11 2002-11-21 Portela & Ca Sa Method for preparation of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide
WO2007012793A1 (en) * 2005-07-29 2007-02-01 Portela & C.A., S.A. Asymmetric catalytic reduction of oxcarbazepine
WO2007117166A1 (en) * 2006-04-11 2007-10-18 Bial - Portela & C.A., S.A. Preparation of eslicarbazepine and related compounds by asymmetric hydrogenation
WO2011091131A2 (en) * 2010-01-23 2011-07-28 Dr. Reddy's Laboratories Ltd. Eslicarbazepine acetate and its polymorphs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JAN, BENES ET AL.: "Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-SH-dibenz[b,fJazepine-5-carboxamide Derivatives.", J. MED. CHEM., vol. 42, no. 14, 17 June 1999 (1999-06-17), pages 2583 *

Also Published As

Publication number Publication date
WO2011138795A2 (en) 2011-11-10

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