WO2011138032A3 - Universal influenza vaccines and methods for their generation - Google Patents

Universal influenza vaccines and methods for their generation Download PDF

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Publication number
WO2011138032A3
WO2011138032A3 PCT/EP2011/002237 EP2011002237W WO2011138032A3 WO 2011138032 A3 WO2011138032 A3 WO 2011138032A3 EP 2011002237 W EP2011002237 W EP 2011002237W WO 2011138032 A3 WO2011138032 A3 WO 2011138032A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
influenza vaccines
generation
universal influenza
vaccines based
Prior art date
Application number
PCT/EP2011/002237
Other languages
French (fr)
Other versions
WO2011138032A2 (en
Inventor
Amir Maksyutov
Denis Antonets
Anastasia Bakulina
Rinat Maksyutov
Original Assignee
Artemev, Timur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Artemev, Timur filed Critical Artemev, Timur
Publication of WO2011138032A2 publication Critical patent/WO2011138032A2/en
Publication of WO2011138032A3 publication Critical patent/WO2011138032A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

The invention relates to novel methods for creating universal broad-spectrum influenza vaccines based on influenza virus hemagglutinin protein (HA). Also disclosed herein are several specific examples of seasonal and pandemic influenza vaccines based on peptide libraries or representative peptide panels (RPPs) created using the methods of the invention.
PCT/EP2011/002237 2010-05-05 2011-05-05 Universal influenza vaccines and methods for their generation WO2011138032A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33166510P 2010-05-05 2010-05-05
US61/331,665 2010-05-05

Publications (2)

Publication Number Publication Date
WO2011138032A2 WO2011138032A2 (en) 2011-11-10
WO2011138032A3 true WO2011138032A3 (en) 2012-03-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/002237 WO2011138032A2 (en) 2010-05-05 2011-05-05 Universal influenza vaccines and methods for their generation

Country Status (1)

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WO (1) WO2011138032A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104151403B (en) * 2013-04-08 2020-11-03 中国医学科学院药物研究所 Polypeptide or derivative thereof and application thereof in influenza virus infection
GB202011652D0 (en) * 2020-07-28 2020-09-09 Univ Oxford Innovation Ltd Polypeptide panels and uses thereof
WO2023023523A1 (en) * 2021-08-16 2023-02-23 Duke University Next generation vaccines comprising antigenic libraries and methods of making and using same

Citations (6)

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WO2004031212A1 (en) * 2002-10-03 2004-04-15 State Research Center Of Virology And Biotechnology 'vector' Antigenic peptides
WO2007095318A2 (en) * 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Influenza antigens, vaccine compositions, and related methods
WO2008039267A2 (en) * 2006-07-21 2008-04-03 Pharmexa Inc. Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions
WO2008061939A1 (en) * 2006-11-20 2008-05-29 Paul-Ehrlich-Institut Bundesamt Für Sera Und Impfstoffe Recombinant modified vaccinia virus ankara (mva)-based vaccine for the avian flu
WO2008064488A1 (en) * 2006-11-30 2008-06-05 Variation Biotechnologies Inc. Influenza vaccine formulation
WO2009062348A1 (en) * 2007-11-14 2009-05-22 Institute Of Microbiology, Chinese Academy Of Sciences Methods for inhibiting influenza virus infection and their drugs

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US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US5811128A (en) 1986-10-24 1998-09-22 Southern Research Institute Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
US5690938A (en) 1989-07-07 1997-11-25 Oravax, Inc. Oral immunization with multiple particulate antigen delivery system
US5071743A (en) 1989-10-27 1991-12-10 Her Majesty The Queen In Right Of Canada, As Represented By The National Research Council Of Canada Process for conducting site-directed mutagenesis
AU646257B2 (en) 1990-04-24 1994-02-17 Flustat Pty Limited Oral vaccine comprising antigen surface-associated with red blood cells
JP3442774B2 (en) 1991-07-01 2003-09-02 バーレックス ラボラトリーズ，インコーポレイティド Novel mutagenesis methods and compositions
US5807722A (en) 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
US5789166A (en) 1995-12-08 1998-08-04 Stratagene Circular site-directed mutagenesis
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US5780270A (en) 1996-07-17 1998-07-14 Promega Corporation Site-specific mutagenesis and mutant selection utilizing antibiotic-resistant markers encoding gene products having altered substrate specificity

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031212A1 (en) * 2002-10-03 2004-04-15 State Research Center Of Virology And Biotechnology 'vector' Antigenic peptides
WO2007095318A2 (en) * 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Influenza antigens, vaccine compositions, and related methods
WO2008039267A2 (en) * 2006-07-21 2008-04-03 Pharmexa Inc. Inducing cellular immune responses to influenza virus using peptide and nucleic acid compositions
WO2008061939A1 (en) * 2006-11-20 2008-05-29 Paul-Ehrlich-Institut Bundesamt Für Sera Und Impfstoffe Recombinant modified vaccinia virus ankara (mva)-based vaccine for the avian flu
WO2008064488A1 (en) * 2006-11-30 2008-06-05 Variation Biotechnologies Inc. Influenza vaccine formulation
WO2009062348A1 (en) * 2007-11-14 2009-05-22 Institute Of Microbiology, Chinese Academy Of Sciences Methods for inhibiting influenza virus infection and their drugs
EP2223934A1 (en) * 2007-11-14 2010-09-01 Institute Of Microbiology, Chinese Academy Of Sciences Methods for inhibiting influenza virus infection and their drugs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANTONETS D V ET AL: "TEpredict: Software for T-Cell epitope prediction", MOLECULAR BIOLOGY (MOSCOW), vol. 44, no. 1, February 2010 (2010-02-01), pages 119 - 127, XP009151554 *

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Publication number Publication date
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