WO2011130618A3 - Compositions et méthodes de production de protéine pdx-1 glycosylée humaine et leurs méthodes d'utilisation - Google Patents

Compositions et méthodes de production de protéine pdx-1 glycosylée humaine et leurs méthodes d'utilisation Download PDF

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Publication number
WO2011130618A3
WO2011130618A3 PCT/US2011/032671 US2011032671W WO2011130618A3 WO 2011130618 A3 WO2011130618 A3 WO 2011130618A3 US 2011032671 W US2011032671 W US 2011032671W WO 2011130618 A3 WO2011130618 A3 WO 2011130618A3
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WO
WIPO (PCT)
Prior art keywords
methods
protein
compositions
glycosylated human
producing glycosylated
Prior art date
Application number
PCT/US2011/032671
Other languages
English (en)
Other versions
WO2011130618A2 (fr
Inventor
Lijun Yang
Shi-Wu Li
Original Assignee
University Of Florida Research Foundation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by University Of Florida Research Foundation, Inc. filed Critical University Of Florida Research Foundation, Inc.
Publication of WO2011130618A2 publication Critical patent/WO2011130618A2/fr
Publication of WO2011130618A3 publication Critical patent/WO2011130618A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne de façon générale un système de culture de levures permettant la production de quantités importantes de polypeptides Pdxl glycosylés recombinants humains à activité biologique, ainsi que des méthodes thérapeutiques et prophylactiques impliquant de tels polypeptides.
PCT/US2011/032671 2010-04-16 2011-04-15 Compositions et méthodes de production de protéine pdx-1 glycosylée humaine et leurs méthodes d'utilisation WO2011130618A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32518310P 2010-04-16 2010-04-16
US61/325,183 2010-04-16

Publications (2)

Publication Number Publication Date
WO2011130618A2 WO2011130618A2 (fr) 2011-10-20
WO2011130618A3 true WO2011130618A3 (fr) 2012-04-19

Family

ID=44799336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/032671 WO2011130618A2 (fr) 2010-04-16 2011-04-15 Compositions et méthodes de production de protéine pdx-1 glycosylée humaine et leurs méthodes d'utilisation

Country Status (1)

Country Link
WO (1) WO2011130618A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6911324B2 (en) * 2001-10-18 2005-06-28 The Regents Of The University Of California Induction of beta cell differentiation in human cells
WO2008013737A2 (fr) * 2006-07-19 2008-01-31 University Of Florida Research Foundation, Inc. Compositions pour la reprogrammation d'une cellule et leurs utilisations
US20080267928A1 (en) * 2004-02-23 2008-10-30 Lijun Yang Compositions and Methods for Making Insulin-Producing Cells
WO2008151388A1 (fr) * 2007-06-15 2008-12-18 Cytomatrix Pty Ltd Procédés d'amorçage de la production d'insuline

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6911324B2 (en) * 2001-10-18 2005-06-28 The Regents Of The University Of California Induction of beta cell differentiation in human cells
US20080267928A1 (en) * 2004-02-23 2008-10-30 Lijun Yang Compositions and Methods for Making Insulin-Producing Cells
WO2008013737A2 (fr) * 2006-07-19 2008-01-31 University Of Florida Research Foundation, Inc. Compositions pour la reprogrammation d'une cellule et leurs utilisations
WO2008151388A1 (fr) * 2007-06-15 2008-12-18 Cytomatrix Pty Ltd Procédés d'amorçage de la production d'insuline

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARNOLD L. DEMAIN ET AL.: "Production of recombinant proteins by microbes and higher organisms", BIOTECHNOLOGY ADVANCES, vol. 27, 31 January 2009 (2009-01-31), pages 297 - 306 *
SHI-WU LI ET AL.: "Expression, purification, and characterization of recombinant human pancreatic duodenal homeobox-1 protein in Pichia pastoris", PROTEIN EXPRESSION AND PURIFICATION, vol. 72, 8 April 2010 (2010-04-08), pages 157 - 161 *

Also Published As

Publication number Publication date
WO2011130618A2 (fr) 2011-10-20

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