WO2011129607A8 - Method for increasing stem cell activity and stem cells produced thereby - Google Patents

Method for increasing stem cell activity and stem cells produced thereby Download PDF

Info

Publication number
WO2011129607A8
WO2011129607A8 PCT/KR2011/002622 KR2011002622W WO2011129607A8 WO 2011129607 A8 WO2011129607 A8 WO 2011129607A8 KR 2011002622 W KR2011002622 W KR 2011002622W WO 2011129607 A8 WO2011129607 A8 WO 2011129607A8
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
increasing
cell activity
cells produced
stem cell
Prior art date
Application number
PCT/KR2011/002622
Other languages
French (fr)
Other versions
WO2011129607A3 (en
WO2011129607A2 (en
Inventor
Hyo-Soo Kim
Eun-Ju Lee
Hyun-Jae Kang
Original Assignee
Seoul National University Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seoul National University Hospital filed Critical Seoul National University Hospital
Publication of WO2011129607A2 publication Critical patent/WO2011129607A2/en
Publication of WO2011129607A8 publication Critical patent/WO2011129607A8/en
Publication of WO2011129607A3 publication Critical patent/WO2011129607A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/365—Endothelin

Abstract

Disclosed is a method for increasing the activity of human stem cells. The method is characterized by treating a culture medium with endothelin-1. Also, the highly active human stem cells prepared by the method and cell therapeutics comprising the highly active human stem cells are provided. Human mesenchymal stem cells of various origins can be activated by the method, and thus resulting highly active human mesenchymal stem cells can be developed as effective cell therapeutics.
PCT/KR2011/002622 2010-04-16 2011-04-13 Method for increasing stem cell activity and stem cells produced thereby WO2011129607A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0035154 2010-04-16
KR1020100035145A KR101677293B1 (en) 2010-04-16 2010-04-16 Method for increasing stem cell activity and stem cells produced by thereof

Publications (3)

Publication Number Publication Date
WO2011129607A2 WO2011129607A2 (en) 2011-10-20
WO2011129607A8 true WO2011129607A8 (en) 2012-01-12
WO2011129607A3 WO2011129607A3 (en) 2012-03-08

Family

ID=45030238

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/002622 WO2011129607A2 (en) 2010-04-16 2011-04-13 Method for increasing stem cell activity and stem cells produced thereby

Country Status (2)

Country Link
KR (1) KR101677293B1 (en)
WO (1) WO2011129607A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101677293B1 (en) * 2010-04-16 2016-11-17 서울대학교병원 Method for increasing stem cell activity and stem cells produced by thereof
KR102048067B1 (en) * 2015-01-19 2019-11-22 서울대학교병원 Method for increasing stemness of human mesenchymal stem cell
KR102177349B1 (en) * 2018-02-13 2020-11-12 서울대학교병원 Composition for increasing efficiency of somatic cell nuclear transfer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080095749A1 (en) * 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
EP2267030A1 (en) * 2005-08-25 2010-12-29 Repair Technologies, Inc. Devices, compositions and methods for the protection and repair of cells and tissues
WO2007044418A2 (en) * 2005-10-06 2007-04-19 Moscatello David K Cell culture media, kits and methods of use
KR100908481B1 (en) * 2006-04-24 2009-07-21 코아스템(주) Mesenchymal stem cell culture medium and culture method of mesenchymal stem cells using the same
KR101175175B1 (en) * 2008-07-28 2012-08-20 서울대학교병원 Method for separating high activity stem cells form human stem cells and high activity stem cells separated by the method
KR101677293B1 (en) * 2010-04-16 2016-11-17 서울대학교병원 Method for increasing stem cell activity and stem cells produced by thereof

Also Published As

Publication number Publication date
WO2011129607A3 (en) 2012-03-08
WO2011129607A2 (en) 2011-10-20
KR101677293B1 (en) 2016-11-17
KR20110115688A (en) 2011-10-24

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