WO2011128892A3 - Modified forms of pneumococcal surface immunogenic protein b (psipb) - Google Patents

Modified forms of pneumococcal surface immunogenic protein b (psipb) Download PDF

Info

Publication number
WO2011128892A3
WO2011128892A3 PCT/IL2011/000295 IL2011000295W WO2011128892A3 WO 2011128892 A3 WO2011128892 A3 WO 2011128892A3 IL 2011000295 W IL2011000295 W IL 2011000295W WO 2011128892 A3 WO2011128892 A3 WO 2011128892A3
Authority
WO
WIPO (PCT)
Prior art keywords
psipb
modified forms
pneumococcal surface
modified
immunogenic protein
Prior art date
Application number
PCT/IL2011/000295
Other languages
French (fr)
Other versions
WO2011128892A2 (en
Inventor
Michael Tal
Yaffa Mizrachi Nebenzahl
Maxim Portnoi
Ron Dagan
Original Assignee
Protea Vaccine Technologies Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protea Vaccine Technologies Ltd. filed Critical Protea Vaccine Technologies Ltd.
Publication of WO2011128892A2 publication Critical patent/WO2011128892A2/en
Publication of WO2011128892A3 publication Critical patent/WO2011128892A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants

Abstract

The present invention relates to modified forms of the protein Pneumococcal surface immunogenic protein B (PsipB) derived from Streptococcus pneumonia (S. pneumoniae). The modified PsipB polypeptides and fragments have enhanced immunogenicity, stability at physiological pH formulation and formulation properties as compared to wild type PsipB. The invention further provides immunogenic compositions and vaccines comprising the modified PsipB polypeptides and fragments, and use thereof in methods for eliciting protective immunity to S. pneumoniae.
PCT/IL2011/000295 2010-04-12 2011-04-10 Modified forms of pneumococcal surface immunogenic protein b (psipb) WO2011128892A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32292610P 2010-04-12 2010-04-12
US61/322,926 2010-04-12

Publications (2)

Publication Number Publication Date
WO2011128892A2 WO2011128892A2 (en) 2011-10-20
WO2011128892A3 true WO2011128892A3 (en) 2012-03-22

Family

ID=44799104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2011/000295 WO2011128892A2 (en) 2010-04-12 2011-04-10 Modified forms of pneumococcal surface immunogenic protein b (psipb)

Country Status (1)

Country Link
WO (1) WO2011128892A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10105412B2 (en) 2009-06-29 2018-10-23 Genocea Biosciences, Inc. Vaccines and compositions against Streptococcus pneumoniae
WO2012100234A1 (en) 2011-01-20 2012-07-26 Genocea Biosciences, Inc. Vaccines and compositions against streptococcus pneumoniae

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059438A1 (en) * 1995-09-15 2003-03-27 Nixon Peabody Llp Pneumococcal surface protein c (pspc), epitopic regions and strain selection thereof, and uses therefor
US20040115199A1 (en) * 1998-09-15 2004-06-17 M&E Biotech A/S Method for down-regulating osteoprotegerin ligand activity
US20040223976A1 (en) * 2003-03-07 2004-11-11 Elisabetta Bianchi Influenza virus vaccine
US20090148470A1 (en) * 2002-04-02 2009-06-11 Ben-Gurion University Of The Negev Research And Development Authority Protein-based streptococcus pneumoniae vaccines
US20100081151A1 (en) * 2004-07-14 2010-04-01 The Regents Of The University Of California Biomarkers for early detection of ovarian cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059438A1 (en) * 1995-09-15 2003-03-27 Nixon Peabody Llp Pneumococcal surface protein c (pspc), epitopic regions and strain selection thereof, and uses therefor
US20040115199A1 (en) * 1998-09-15 2004-06-17 M&E Biotech A/S Method for down-regulating osteoprotegerin ligand activity
US20090148470A1 (en) * 2002-04-02 2009-06-11 Ben-Gurion University Of The Negev Research And Development Authority Protein-based streptococcus pneumoniae vaccines
US20040223976A1 (en) * 2003-03-07 2004-11-11 Elisabetta Bianchi Influenza virus vaccine
US20100081151A1 (en) * 2004-07-14 2010-04-01 The Regents Of The University Of California Biomarkers for early detection of ovarian cancer

Also Published As

Publication number Publication date
WO2011128892A2 (en) 2011-10-20

Similar Documents

Publication Publication Date Title
DK2707393T3 (en) FUSION PROTEINS AND COMBINATION VACCINES COVERING HAEMOPH-ILUS INFLUENZAE PROTEIN E AND PILIN A
WO2008022302A3 (en) Immunogenic pcpa polypeptides and uses thereof
WO2009016639A3 (en) Multimeric multiepitope influenza vaccines
MX340830B (en) Pneumococcal vaccine and uses thereof.
WO2009039229A3 (en) Method of conferring a protective immune response to norovirus
WO2010149743A3 (en) Vaccine
WO2009156960A3 (en) Novel adjuvant compositions
WO2010149752A3 (en) Novel human papillomavirus (hpv) protein constructs and their use in the prevention of hpv disease
DK2566507T3 (en) Bioconjugate vaccines with capsular gram-positive bacteria
WO2010019262A3 (en) Polyvalent vaccine
WO2012025873A3 (en) STABLE FORMULATIONS OF NEISSERIA MENINGITIDIS rLP2086 ANTIGENS
EP2759307A3 (en) Vaccine against Streptococci
WO2015175355A8 (en) Compositions and methods of enhancing immunogenicity of polysaccharide-protein conjugates
WO2008148057A3 (en) Cationic lipids compositions and methods for enhancing immune responses to vaccines
WO2014009586A3 (en) Vectors for transforming mycoplasma hyopneumoniae, transformed m. hyopneumoniae strains, and use thereof
WO2010141312A3 (en) Flagellin fusion proteins and conjugates comprising pneumococcus antigens and methods of using the same
MY189495A (en) Hand, foot, and mouth vaccines and methods of manufacture and use thereof
WO2010150242A3 (en) Immunogenic streptococcus pneumoniae peptides and peptide-multimers
WO2009092113A3 (en) Methods and compositions for the delivery of vaccines to disrupted epithelium
BR112015008419A2 (en) immunogenic composition and vaccine
WO2012014073A3 (en) Vaccines against pregnancy-associated malaria
WO2011067758A3 (en) Immunogenic fragments and multimers from streptococcus pneumoniae proteins
WO2012118559A3 (en) Tetravalent and mixed head bivalent dengue vaccine
WO2009115509A3 (en) Antigenic protein fragments of streptococcus pneumoniae
WO2011128892A3 (en) Modified forms of pneumococcal surface immunogenic protein b (psipb)

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11768556

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 221822

Country of ref document: IL

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11768556

Country of ref document: EP

Kind code of ref document: A2