WO2011126842A3 - Targeting micrornas for the treatment of cardiac disorders - Google Patents

Targeting micrornas for the treatment of cardiac disorders Download PDF

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Publication number
WO2011126842A3
WO2011126842A3 PCT/US2011/030341 US2011030341W WO2011126842A3 WO 2011126842 A3 WO2011126842 A3 WO 2011126842A3 US 2011030341 W US2011030341 W US 2011030341W WO 2011126842 A3 WO2011126842 A3 WO 2011126842A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
cardiac disorders
targeting micrornas
micrornas
targeting
Prior art date
Application number
PCT/US2011/030341
Other languages
French (fr)
Other versions
WO2011126842A2 (en
Inventor
B. Nelson Chau
Peter Linsley
Original Assignee
Regulus Therapeutics Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regulus Therapeutics Inc. filed Critical Regulus Therapeutics Inc.
Publication of WO2011126842A2 publication Critical patent/WO2011126842A2/en
Publication of WO2011126842A3 publication Critical patent/WO2011126842A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Provided herein are methods and compositions for the treatment of cardiac disease using an inhibitor of miR-21.
PCT/US2011/030341 2010-03-30 2011-03-29 Targeting micrornas for the treatment of cardiac disorders WO2011126842A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31920010P 2010-03-30 2010-03-30
US61/319,200 2010-03-30

Publications (2)

Publication Number Publication Date
WO2011126842A2 WO2011126842A2 (en) 2011-10-13
WO2011126842A3 true WO2011126842A3 (en) 2011-12-01

Family

ID=44763489

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/030341 WO2011126842A2 (en) 2010-03-30 2011-03-29 Targeting micrornas for the treatment of cardiac disorders

Country Status (1)

Country Link
WO (1) WO2011126842A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012012716A2 (en) 2010-07-23 2012-01-26 Regulus Therapeutics, Inc. Targeting micrornas for the treatment of fibrosis
UA115652C2 (en) * 2011-04-25 2017-12-11 Реґюлус Терап'Ютікс Інк. Microrna compounds and methods for modulating mir-21 activity
EP2592145A1 (en) * 2011-11-11 2013-05-15 Medizinische Hochschule Hannover Medicament for the treatment of cardiac disease
AU2013251696B2 (en) 2012-04-25 2018-11-15 Sanofi MicroRNA compounds and methods for modulating miR-21 activity
UA116639C2 (en) 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Methods for treatment of alport syndrome
JP2019535839A (en) 2016-11-29 2019-12-12 ピュアテック ヘルス エルエルシー Exosomes for the delivery of therapeutic agents
EP3597197A4 (en) * 2017-03-17 2021-01-06 National University Corporation Chiba University Novel technique for treating cancer using structurally-reinforced s-tud
JP2021529202A (en) * 2018-06-28 2021-10-28 ユナイテッド キングダム リサーチ アンド イノベーション MicroRNA targeting agents for the treatment of heart disease
CN109498642A (en) * 2018-12-21 2019-03-22 复旦大学附属中山医院 A kind of target therapeutic agent of microvascular lesion caused by Infected with Coxsackievirus B 3
CN115961025B (en) * 2020-06-30 2023-07-18 苏州大学附属第二医院 Application of circular RNA in preparation of products related to myocardial hypertrophy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009058818A2 (en) * 2007-10-29 2009-05-07 The Board Of Regents Of The University Of Texas System Compositions comprising a micro-rna and methods of their use in regulating cardiac remodeling
WO2009106367A1 (en) * 2008-02-27 2009-09-03 Julius Maximilians-Universität Würzburg Microrna (mirna) and downstream targets for diagnostic and therapeutic purposes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009058818A2 (en) * 2007-10-29 2009-05-07 The Board Of Regents Of The University Of Texas System Compositions comprising a micro-rna and methods of their use in regulating cardiac remodeling
WO2009106367A1 (en) * 2008-02-27 2009-09-03 Julius Maximilians-Universität Würzburg Microrna (mirna) and downstream targets for diagnostic and therapeutic purposes

Also Published As

Publication number Publication date
WO2011126842A2 (en) 2011-10-13

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