WO2011125075A3 - A gastro- retentive delivery of macrolide - Google Patents

A gastro- retentive delivery of macrolide Download PDF

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Publication number
WO2011125075A3
WO2011125075A3 PCT/IN2011/000241 IN2011000241W WO2011125075A3 WO 2011125075 A3 WO2011125075 A3 WO 2011125075A3 IN 2011000241 W IN2011000241 W IN 2011000241W WO 2011125075 A3 WO2011125075 A3 WO 2011125075A3
Authority
WO
WIPO (PCT)
Prior art keywords
macrolide
gastro
retentive delivery
retentive
delivery
Prior art date
Application number
PCT/IN2011/000241
Other languages
French (fr)
Other versions
WO2011125075A2 (en
Inventor
Nandan Mohan Chandavarkar
Kour Chand Jindal
Rajkumar Malayandi
Original Assignee
Fdc Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fdc Limited filed Critical Fdc Limited
Publication of WO2011125075A2 publication Critical patent/WO2011125075A2/en
Publication of WO2011125075A3 publication Critical patent/WO2011125075A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

Disclosed herein is a novel gastroretentive delivery system of macrolide consisting of a hydrophilic swellable floating matrix system either alone or in combination with a bioadhesive system, which comprises super-disintegrants together with hydrophilic polymers and in-situ gelling agents to improve the gastroretention of dosage forms.
PCT/IN2011/000241 2010-04-08 2011-04-07 A novel gastroretentive delivery of macrolide WO2011125075A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1181/MUM/2010 2010-04-08
IN1181MU2010 2010-04-08

Publications (2)

Publication Number Publication Date
WO2011125075A2 WO2011125075A2 (en) 2011-10-13
WO2011125075A3 true WO2011125075A3 (en) 2011-12-22

Family

ID=44629167

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000241 WO2011125075A2 (en) 2010-04-08 2011-04-07 A novel gastroretentive delivery of macrolide

Country Status (1)

Country Link
WO (1) WO2011125075A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3829640A4 (en) * 2018-08-01 2022-05-25 McMaster University Methods for inhibiting microbe growth

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523095A (en) * 1993-12-15 1996-06-04 Eastman Chemical Company Controlled release matrix system using cellulose acetate/polyvinylpyrrolidone blends
US6068859A (en) * 1994-05-06 2000-05-30 Pfizer Inc. Controlled-release dosage forms of Azithromycin
WO2002017885A2 (en) * 2000-08-29 2002-03-07 Ranbaxy Laboratories Limited Controlled release formulation of erythromycin or a derivative thereof
WO2003105810A1 (en) * 2002-06-14 2003-12-24 Andrx Corporation Pharmaceutical compositions for drugs having ph-dependentsolubility
US20040142035A1 (en) * 2003-01-03 2004-07-22 Rong-Kun Chang Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics
WO2005007074A2 (en) * 2003-07-21 2005-01-27 Bio-Dar Ltd. Gellan gum based oral controlled release dosage forms- a novel platform technology for gastric retention
EP2283824A1 (en) * 2009-07-30 2011-02-16 Special Products Line S.p.A. Compositions and formulations based on swellable matrices for sustained release of poorly soluble drugs such as clarithromycin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01002634A (en) 1998-09-14 2002-06-04 Ranbaxy Lab Ltd Orally administered controlled drug delivery system providing temporal and spatial control.
US6984403B2 (en) 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523095A (en) * 1993-12-15 1996-06-04 Eastman Chemical Company Controlled release matrix system using cellulose acetate/polyvinylpyrrolidone blends
US6068859A (en) * 1994-05-06 2000-05-30 Pfizer Inc. Controlled-release dosage forms of Azithromycin
WO2002017885A2 (en) * 2000-08-29 2002-03-07 Ranbaxy Laboratories Limited Controlled release formulation of erythromycin or a derivative thereof
WO2003105810A1 (en) * 2002-06-14 2003-12-24 Andrx Corporation Pharmaceutical compositions for drugs having ph-dependentsolubility
US20040142035A1 (en) * 2003-01-03 2004-07-22 Rong-Kun Chang Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics
WO2005007074A2 (en) * 2003-07-21 2005-01-27 Bio-Dar Ltd. Gellan gum based oral controlled release dosage forms- a novel platform technology for gastric retention
EP2283824A1 (en) * 2009-07-30 2011-02-16 Special Products Line S.p.A. Compositions and formulations based on swellable matrices for sustained release of poorly soluble drugs such as clarithromycin

Also Published As

Publication number Publication date
WO2011125075A2 (en) 2011-10-13

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