WO2011124243A2

WO2011124243A2 - Microbiologically stable, easily applicable preparation comprising thickening agents

Info

Publication number: WO2011124243A2
Application number: PCT/EP2010/005377
Authority: WO
Inventors: Manuela Köhler; Jens Schulz; Alexander Filbry; Rainer Kröpke; Horst Argembeaux; Anke Pilzner
Original assignee: Beiersdorf Ag
Priority date: 2010-03-29
Filing date: 2010-09-02
Publication date: 2011-10-13
Also published as: EP2563479A2; DE102010013272A1; WO2011124243A3

Abstract

The invention relates to cosmetic or dermatological preparations comprising at least one thickening substance, said preparations having improved sensory properties and sufficient microbiological stability due to the addition of benzethonium chloride, methylisothiazolinone, piroctone olamine and/or lauroyl ethyl arginate.

Description

Microbiologically stable application-friendly preparation with thickeners

The invention includes cosmetic or dermatological preparations with

Benzethonium chloride, methylisothiazolinone, Piroctone olamine and / or lauroylethylarginate and one or more thickening substances.

Multi-component systems such as solutions, emulsions or suspensions are frequently adjusted or thickened to higher viscosities for reasons of economy or performance or for reasons of stability. Thus, e.g. can be achieved by increasing the viscosity of the external or internal phase of emulsions or suspensions that the time to demixing of the components of such a system can be significantly extended, which manifests itself in an extension of the storage time. By

Increasing the viscosity is improved even in many products their uniform distribution, especially on uneven surfaces. This applies in particular to skincare and pharmaceutical ointments on the skin.

The temperature behavior of the polymers is an important property. In general, polymers exhibit high viscosity at low temperatures and low viscosity at high temperatures. However, such polymers are often desirable which thicken above certain temperatures but remain pumpable and processible at low temperatures in solution, i. are also easy to use.

Known as such thickeners are, for example, cellulose ethers and others

Cellulose derivatives (e.g., carboxymethyl cellulose, hydroxyethyl cellulose), gelatin, starch and starch derivatives, sodium alginates, fatty acid polyethylene glycol esters, agar-agar, tragacanth or dextrins.

However, the thickeners mentioned show a variety of disadvantages in the application. Thus, e.g. the cellulose derivatives or generally based on natural raw materials and the resulting formulations very susceptible to bacteria. That the addition of thickeners in cosmetic preparations often increases the requirements with regard to their microbiological stability.

Another problem arises due to the applications and manipulations of such thickened preparations.

For example, fatty acid polyethylene glycol ester tends to be in the presence of water

Hydrolysis, the resulting insoluble fatty acids cause undesirable turbidity. Thickening agents of natural origin (for example agar-agar or tragacanth) have, depending on their origin, highly fluctuating composition, so that a

production-technical consistency is difficult to provide. In terms of application, these preparations are also due to the formation of unpleasant, "thread-pulling" gels.

A particular problem with the thickening of cosmetic preparations is that the preparations become sticky due to the addition of the polymeric thickener and tend to "pull threads." The increasing stickiness makes the products sensory unattractive, and stickiness and the tendency to "pull threads" are also difficult the removal from the storage vessel. These phenomena are particularly unpleasant for gelatinous preparations and for preparations which contain water-soluble and / or

water-dispersible thickeners or stabilizers.

Cosmetic or dermatological preparations can be easily characterized with regard to these sensor criteria.

0.4 g of a formulation stored at 25 ° C is applied between thumb and forefinger. The formulation is gently squeezed and the fingers apart. The process is performed 3 times at a speed of 2 movements per second. The length of the tip or the length of the product thread formed is evaluated.

The division depending on the forming thread is then: length of the lace / product thread> 2 cm -> strong threads pulling length of the tip / product thread 1-2 cm - pulling threads length of the tip / product thread <1 cm - low thread pulling length of Thread / product thread <0.5 cm not pulling threads

That Preparations with a thread formation of less than 0.5 cm are considered "non-stringy" and thus cosmetically user-friendly or sensory-acceptable.

Another problem in the production of cosmetic preparations is evident in the combination with thickening substances. These lead in particular in the

Spray application for clogging the spray devices.

In addition to these performance and sensory properties, cosmetic preparations must also be formulated for long-term stability against microbial contamination. Microbial stability has so far been solved by the addition of preservatives. Known preservatives are the compounds known as parabens, in particular 4-hydroxybenzoic acid and its esters, methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylparaben, phenylparaben.

Furthermore, phenoxyethanol, ethylene glycol monophenyl ether, phenyl glycol,

Phenoxetol ^® , known for the preservation of cosmetic products.

Providing preparations without preservatives, however, is a desire of consumers.

Other known auxiliaries for microbial stabilization are benzethonium chloride, lauroiethyiarginate, octopirox and methylisothiazolinone.

Benzethonium chloride, benzyl-dimethyl- (4- {2- [4- (1, 1, 3,3-tetramethylbutyl) -phenoxy] -ethoxy} -ethyl) -ammonium chloride, of the structure

shows how many quaternary ammonium compounds have biocidal properties.

As a disinfectant it is used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts can

Benzethonium chloride in concentrations of 7-11% included.

In cosmetics, the use of benzethonium chloride is known, as described, for example, in WO 2007015243 A1, WO 2004034964 A1, EP 1310234 A1, WO 2002008377 A1.

Laurylethylarginate, Lauroyiethyiarginat or also referred to as Ethyl lauroyl arginate HCl, for example as Aminat G from Vedeqsa, Inc., is available as

Preservative used in cosmetic preparations.

Aminate-G (INCI: glycerol and ethyl lauroyl arginate HCl) shows a large antimicrobial spectrum and is among others. as an additive in food FDA tested (see for example WO

2008133724 A1).

Piroctone Olamine, 1-Hydroxy-4-methyl-6- (2,4,4-trimethylpentyl) -2 (1 / - /) - pyridone, also known as octopirox, is an antimicrobial that is used as a preservative and z. B. is used in shampoos as anti-dandruff. Octopirox is well tolerated by the skin and physiologically indifferent.

Octopirox has the structure

Methylisothiazolinone (2-methyl-2H-isothiazol-3-one (MIT)) is a class of compounds with high microbicidal activity, which is mainly used for the preservation of technical products and only a few cosmetic products.

In cosmetic preparations, methylisothiazolinone is described, for example, in US Pat. No. 6,511,673 or EP 1,488,699 A1 in combination with parabens or phenoxyethanol.

Further uses of methylisothiazolinone are disclosed in EP 1525797 A1, EP 1527684 A1, EP 1527685 A1, EP 1621076 A1.

With regard to increasing health impairments and allergies and the urge of consumers for more ecologically compatible cosmetics, there is the problem that these preparations must still have sufficient stability and above all skin compatibility and sufficiently acceptable sensors.

Furthermore, a simple replacement or avoidance of parabens and / or phenoxyethanol is not readily possible without sacrificing stability and performance.

It is therefore an object to provide cosmetic or dermatological preparations which enable the use of thickening substances without sacrificing sensory acceptance and ease of use, in particular without any loss of applicability by means of spraying devices. At the same time it is the

Task that these preparations then also have a sufficient microbiological stability and preferably do not include parabens or phenoxyethanols.

Additional task is that these preparations are microbially stable, skin, hair and user-friendly formulated. The invention encompasses cosmetic or dermatological preparations

Benzethonium chloride, methylisothiazolinone, Piroctone olamine and / or Lauroylethylarginat in combination with one or more thickening substances.

The proportion of benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate is preferably in the range of 0.01 to 5 wt.%, In particular in the range of 0.1 to 2 wt.%, Based on the total mass of the preparation to choose.

In the preparation advantageously several, i. two, three or all, the fabrics

Benzethonium chloride, methylisothiazolinone, Piroctone olamine and / or Lauroylethylarginat be included.

In preparations for cleaning the skin and / or cleaning and / or care of the hair are preferably benzethonium chloride and / or Lauroylethylarginat included.

Thickening substances, also called thickeners, are substances or compounds which cause a change in the viscosity of the preparations they contain compared to the same preparation without the thickener.

Preferred thickeners are selected from the group of fatty alcohols or

Hydroxyfettalkohole having 12 to 22 and preferably 16 to 18 carbon atoms and partial glycerides, fatty acids or hydroxy fatty acids. Preference is given to a combination of these substances with alkyl oligoglucosides and / or fatty acid N-methylglucamides of the same chain length and / or polyglycerol poly-12-hydroxystearates. Suitable thickeners are

for example, Aerosil types (hydrophilic silicic acids), polysaccharides, in particular xanthan gum, guar guar, agar agar, carageenan, alginates and tyloses,

Carboxymethylcellulose and hydroxyethylcellulose, also higher molecular weight polyethylene glycol mono- and diesters of fatty acids, ammonium acryloyldimethyltaurate / VP copolymer, polyacrylates, (eg Carbopols and Pemulen types from Goodrich, Sigma's Synthalene ™, Keltrol grades from Kelco, Sepigel types from Seppic; Salcare types of Allied Colloids), polyacrylamides, polymers, polyvinyl alcohol and polyvinylpyrrolidone.

As thickeners for W / O emulsions, metal salts of fatty acids, e.g. Magnesium, aluminum and / or zinc stearate or ricinoleate are preferably used.

As thickeners for surfactant-containing preparations, in particular those which have a proportion of Anionentensiden, fatty acid amides and / or ethoxylated fatty acid esters and / or ethoxylated fatty alcohols can be preferably used.

Other thickeners are suitable cationic polymers, such as cationic cellulose derivatives, such as quaternized hydroxyethyl cellulose, referred to under the name Polymer JR 400 ™ available from Amerchol is cationic starch, copolymers of

Diallylammonium salts and acrylamides, quaternized vinylpyrrolidone / vinyllmidazole polymers, e.g. Luviquat ™ (BASF), condensation products of polyglycols and amines, quaternized collagen polypeptides such as lauryldimonium

Hydroxypropyl Hydrolyzed Collagen (e.g., Lamequat ™ L / Grünau), quaternized

Wheat polypeptides, polyethylenimine, cationic silicone polymers, e.g. Amodimethicones, copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine (Cartaretine ™ / Sandoz), copolymers of acrylic acid with dimethyldiallylammonium chloride (Merquat ™ 550 / Chemviron), polyamino-polyamides, e.g. described in FR 2252840 A and their crosslinked water-soluble polymers, cationic chitin derivatives such as quaternized chitosan, optionally microcrystalline distributed, condensation products of dihaloalkylene, such as. Dibromobutane with bis-dialkylamines, e.g. Bis-dimethylamino-1, 3-propane, cationic guar gum, e.g. Jaguar ™ CBS, Jaguar ™ C-17, Jaguar ™ C-16 from Celanese, quaternized ammonium salt polymers, e.g. Mirapol ™ A-15, Mirapol ™ AD-1, Mirapol ™ AZ-1 from Miranol.

Further thickeners are anionic, zwitterionic, amphoteric and nonionic polymers, such as, for example, vinyl acetate / crotonic acid copolymers, vinylpyrrolidone / vinyl acrylate copolymers, vinyl acetate / butyl maleate / isobornyl acrylate copolymers,

Methyl vinyl ether / maleic anhydride copolymers and their esters, uncrosslinked and polyols crosslinked with polyols, acrylamidopropyltrimethylammonium chloride / acrylate copolymers, octylacrylamide / methyl methacrylate tert.butylaminoethyl methacrylate / 2-hydroxypropyl methacrylate copolymers, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymers, vinylpyrrolidone / dimethylaminoethyl methacrylate / vinylcaprolactam Terpolymers and optionally derivatized cellulose ethers; microchstalline cellulose and silicones.

Other suitable polymers and thickeners are listed in Cosmetic Toiletries 108, 95 (1993).

Particularly preferred thickeners include xanthan gum, carageenan, alginates and tyloses, carboxymethyl cellulose, microcrystalline cellulose and hydroxyethyl cellulose, polyacrylates (e.g., Carbopols ™ and Pemulen types from Noveon).

Surprisingly, the thickeners can be used in combination with the substances according to the invention, benzethonium chloride, methylisothiazolinone, piroctone olamine and / or

Lauroylethylarginat, use in the preparation without this to the lengthiness, i. pull to the strings that leads to formulations.

The discharge of the preparations according to the invention by a dispenser works perfectly over a wide temperature range of + 5 ° C to + 60 ° C, which in Considering the presented thickening properties and stickiness was not expected.

This is surprisingly achieved by the inventive agents, benzethonium chloride,

Methylisothiazolinone, Piroctone Olamine and / or Lauroylethylarginat enabled. However, agents which are not actually known to have a viscosity or tackiness affect the sliding properties of the entire formulation in such a way that the adhesion of the compositions containing them to surfaces is positively influenced. Thus, it is also to be explained that the adhesion to the surfaces in the dispenser systems is positively influenced, so that a pumpability can be ensured over a wide temperature range.

For comparison, for example, shows a cosmetic preparation with parabens or phenoxyethanol and a thickener, here xanthan gum, an unacceptable stickiness.

If instead of the known preservatives paraben or phenoxyethanol, a substance according to the invention, such as benzethonium chloride, is used in the otherwise identical preparation, the tackiness is surprisingly greatly improved, as the following comparison shows.

Raw material (in% by weight) Recipe A Recipe B

Ethyl hexyl cinnamate 0.5 0.5

Octocrylene 3.0 3.0

Ethylhexylsalicylic acid ester 4.0 4.0

To- 2.5 2.5

Ethylhexyloxyphenolmethoxyphenyltriazin

hydrogenated coconut oil glycerides 2.0 2.0

Phenoxyethanol 0.6 -

C12-15 alkyl benzoate 3.0 3.0

C18-36 fatty acid triglycerides 1, 0 1, 0

Vitamin E acetate 1, 0 1, 0

Diethylhexylbutamidotriazone 2.0 2.0

linear silicone oil 3.0 3.0

Acrylate / C 10-30 Alkyl Acrylate Crosspolymer 0.4 0.4

Xanthan gum 0.9 0.9

Citric acid 0.1 0.1

EDTA sodium salt 1, 0 1, 0

Glycerol 4.4 4.4 Sodium citrate 0.17 0.17

Glucosylrutin 0.25 0.25

Ethanol 3.0 3.0

Methylparaben 0.4 -

Benzethonium Chloride - 2.0

Water ad 100 ad 100

Length of top / product thread of recipe A = 1, 8 cm length of top / product thread of formula B = 0.4 cm

The "threading" is to be classified in the preparation B according to the invention as "not pulling threads".

Accordingly, benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate can advantageously be used in cosmetic or dermatological preparations comprising one or more thickening substances for improving the

sensory properties of the preparation can be used.

It is furthermore surprising that the preparations containing the substances according to the invention, benzethonium chloride, methylisothiazolinone, piroctone olamine and / or

Lauroylethylarginat, instead of parabens and / or phenoyethanol have sufficient microbial stability.

Figure 1 impressively demonstrates this microbial stability.

As part of the biofilm assay, biofilm inhibition at 0h as well as the biofilm-dissolving effect at 24h by a color reaction in the

Microplate scale examined. The measurement results of the active substances investigated are related to the positive control (PK1). Neither ethylparaben nor methylparaben showed efficacy. In comparison, benzethonium chloride,

Methylisothiazolinone, Piroctone Olamine and Lauroylethylarginat a very good biofilm-inhibiting activity. In addition, for benzethonium chloride and

Lauroylethylarginate a very good biofilm-dissolving effect can be shown. Even with Piroctone Olamine, Methylisothiazolinone a slight biofilm dissolution could be achieved.

In the conventional antibacterial agents distinguishes the bacteriostatic and the bactericidal effect. In the latter, the bacteria are killed by the drug. The bacteriostatic effect, however, prevents the proliferation of bacteria. The preservatives used in cosmetic formulations to prevent bacterial contamination are usually among the bactericidal agents. The use of classic antimicrobial agents, however, on the one hand affects the skin flora and, on the other hand, resistance developments are increasingly being observed in recent years. In contrast to conventional antimicrobial agents, the anti-biofilm agents do not directly interfere with the bacterial metabolism, but merely prevent or dissolve the formation of the bacteria-protecting biofilm. Resistance development is therefore excluded.

The test shown in Figure 1 was carried out with Staphylococcus epidermidis, a for

People with normal immunological defense little dangerous germ. Staphylococcus epidermidis (syn., Staphylococcus albus, Micrococcus epidermidis, Staphylococcus saprophyticus) is a gram-positive, plasma-coagulase-negative, saprophagic bacterium that colonizes human skin and mucous membranes. Furthermore, it is found on foods and also settles on polymeric surfaces (e.g., packaging). But in

Hospital, in immunocompromised people, he may, if dirty, cause serious illness.

S. epidermidis has a wide spectrum of antibiotic resistance. This is especially true against penicillin and methicilfin. The proportion of resistant strains is now 70%.

Therefore, it is the ideal bacterium to show the beneficial effect of the cosmetic preparations according to the invention.

Accordingly, the preparations according to the invention are preferably paraben and / or

Phenoxyethanolfrei and still have sufficient microbial stability.

Paraben-free or phenoxyethanol-free means that the proportion of parabens and / or phenoxyethanol is less than 1% by weight, based on the total mass of the preparation.

The proportion of parabens and phenoxyethanol is 0% by weight.

The cosmetic preparations according to the invention may further cosmetic

Excipients and other active ingredients, such as are commonly used in such preparations, for. As substances for preventing foaming, dyes and color pigments, thickeners, moisturizing and / or moisturizing substances, fats, oils, waxes or other conventional ingredients of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives provided that the additive does not impair the required properties in terms of microbiological stability and skin and hair compatibility. The preparations according to the invention may advantageously be in the form of aqueous gels, aqueous-alcoholic solutions, O / W or W / O emulsions of soft, semi-soft or solid consistency, microemulsions, W / O / W or O / W / O emulsions. ideal

Forms of application in this context are face creams, serums, make-up, foundation, body lotions, body milks, hand cream, deodorant scooter, deodorant stick, deodorant aerosol, deodorant sprayer.

The use in rinse-off products such as shampoos, shower gels or hand wash gels are also preferred.

The following examples show cosmetic preparations with acceptable tackiness, i. an improved sensory property compared to preparations without the agents according to the invention.

The numbers are parts by weight based on the total mass of the preparation.

W / O emulsions,

1 2 3 4 5

Triglycerol diisostearate 1, 0 0.5 0.25 2.0 3.0

Diglycerol dipolyhydroxystearate 1, 0 1, 5 1, 75 3.0 2.0

Paraffin oil 12.5 10.0 8.0 5.0 11, 5

Vaseline 8.0 6.0 5.0 12.0 2.5 hydrogenated coconut glycerides 2.0 1, 0 2.5 5.0 0.25

Decyl oleate 0.5 0.75 ^ 1, 2.0 2.0 0.25

Octyldodecanol 0.5 1, 0.75 3.0 0.25

Aluminum stearate 0.4 0.3 0.6 1, 0.05

Dicaprylyl carbonate 0.1 0.05 0.15 0.5 1, 0 hydrogenated castor oil 0.5 0.75 1, 0 2.5 5.0

Magnesium sulfate 0.5 0.6 0.5 0.7 1, 0 Glycerine 3.0 5.0 10.0 15.0 1, 5

Citric acid 0.2 0.1 0.2 0.3 1, 0

Sodium citrate 0.2 0.05 0.4 0.3 2.0

Perfume q.s, q.s, q.s, q.s, q, s,

Ethanol 2.0 5.0 - -

Caprylic / Capric Acid Triglyceride 2.0 2.5 3.0 5.0 0.5

Methylisothiazolinone - 0.10 - 0.06 -

Benzethonium chloride 2.0 - - 0, 15 -

Piroctonolamine - - 0.25 0, 15 -

Lauroylethylarginate - - - 0.15 1, 75

Water ad 100 ad 100 ad 100 ad 100 ad 100

W / O emulsions,

6 7 8 9 10

PEG-30 dipolyhydroxystearate - 0.5 0.25 - 3.0

Lanolin Alcohol 1, 0 1, 5 1, 75 3.0 ~

Paraffin oil 12.5 10.0, 8.0 5.0 10.5

Hydrogenated polyisobutene 0.5 0.75 1, 2.0 2.0 0.25

Octyldodecanol 0.5 1, 0.75 3.0 0.25

Zinc stearate 0.4 0.3 0.6 1, 0.05 Dicaprylyl carbonate 0.1 0.05 0.15 0.5 1.0 hydrogenated castor oil 0.5 0.75 1.0 2.5 5.0

Microcrystalline cellulose 0.5 1.0 0.75 0.25 0.1

Magnesium sulfate 0.5 0.6 0.5 0.7 1.0

Glycerine 3.0 5.0 10.0 15.0 1.5

Citric acid 0.2 0.1 0.2 0.3 1.0

Perfume q, s, q, s, q, s, q, s, q.s,

1,3 butylene glycol 2,0 - 5,0 - -

Caprylic / Capric Acid Triglyceride 2.0 2.5 3.0 5.0 0.5

Silicone Elastomer Gel 5.0 - 3.0 -

Methylisothiazolinone - 0.10 - 0.06 -

Benzethonium Chloride 2.0 - - 0.15 -.

Piroctonolamine - - 0.25 0.15 -

Lauroylethylarginate - - - 0.15 1.75

Talc - 0.05 0.1

Water ad 100 ad 100 ad 100 ad 100 ad 100

W / S-emulsion

11 12 13 14 15

Cetyl PEG / PPG-10/1 Dimethicone 1.0 - - 3.0 5.0

Cylomethicone + PEG / PPG-18/18 dimethicone 10.0 12.5 25

(90:10) cyclic silicone oil (cyclomethicone) 12.5 15 22.0 20.0 15.5 linear silicone oil (dimethicone) 5.0 13.0 5.0 12.0 15.0 hydrogenated polyisobutene 0.5 0.75 1, 0 2 , 0 0.25

Octyldodecanol 0.5 1, 0.75 3.0 0.25

Panthenol 0,5 1, 0 0,75 0,25 0, 1

Sodium chloride 2.0 0.6 2.5 0.7 1, 0

Glycerine 3.0 5.0 10.0 15.0 1, 5

Citric acid 0.2 0, 1 0.2 0.3 1, 0

Sodium citrate 1, 0 0.1 0.4 0.9 2.5

Perfume q.s, q, s, q, s, q.s, q, s,

Microcrystalline cellulose 1, 0 0, 1 0.5 0.25 0.1

Methylisothiazolinone - 0, 10 - 0.06 -

Benzethonium chloride 2.0 - - 0.15 -

Piroctonolamine - - 0.25 0, 15 -

Lauroylethylarginate - - - 0.15 1, 75 modified starch - 2.5 - 0, 15 -

Water ad 100 ad 100 ad 100 ad 100 ad 100

W / S emulsions

16 17 18 19 20

Cetyl PEG / PPG-10/1 Dimethicone 1, 0 - - 3.0 5.0

Cylomethicone + PEG / PPG-18/18 Dimethicone 10.0 12.5 25 - (90:10)

cyclic silicone oil (cyclomethicone) 12.5 15 8.0 20.0 17.5 linear silicone oil (dimethicone) 5.0 13.0 5.0 12.0 15.0 hydrogenated polyisobutene 0.5 0.75 1, 0 2 , 0 0.25

Octyldodecanol 0.5 1, 0.75 3.0 0.25

Panthenol 0,5 1, 0 0,75 0,25 0,1

Sodium chloride 2.0 0.6 2.5 0.7 1, 0

Glycerine 3.0 5.0 10.0 15.0 1, 5

Lactic acid 0.2 0.1 0.2 - -

Sodium lactate 0.2 1, 0 0.05 - -

Perfume q, s, q, s, q, s, q, s, q, s,

Microcrystalline cellulose 1, 0 0.1 1, 5 2.5 0.1

Stearyl dimethicone 0.5 0.7 -

Methylisothiazolinone - 0.10 - 0.06 -

Benzethonium Chloride 2.0 - - 0.15 -.

Piroctonolamine - - 0.25 0.15 -

Lauroylethylarginate - - - 0.15 1, 75 modified starch - 2.5 - 0.15 -

Water ad 100 ad 100 ad 100 ad 100 ad 100

Silicone in water emulsion

Bis-PEG / PPG-16/16 PEG / PPG16 / 16 1, 0 2.0 8.0 3.0 5.0 Dimethicone, caprylic / capric triglyceride

cyclic silicone oil (cyclomethicone) 12.5 15 25.0 10.0 7.5 linear silicone oil (dimethicone) 5.0 15.0 5.0 12.0 15.0

Octyldodecanol 0.5 1, 0.75 3.0 0.25

Glycerin 5.0 7.5 10.0 3.0 1, 0

Panthenol 0,5 1, 0 0,75 0,25 0, 1

Perfume q.s, q.s, q, s, q, s, q, s,

Magnesium Stearate 1, 0 0.5 2.5 3.7 5.5

Stearyl dimethicone 0.5 0.7 - - -

Methylisothiazolinone - 0.10 - 0.06 -

Benzethonium chloride 2.0 - - 0.15 -

Piroctonolamine - - 0.25 0.15 -

Lauroylethylarginate - - - 0.15 1, 75 modified starch - 2.5 - 0.15 -

Water ad 100 ad 100 ad 100 ad 100 ad 100

O W emulsion

26 27 28 29 30

Glyceryl sterate citrate 1, 0 1, 5 1, 5 0.5 0.25

Cetyl stearyl alcohol 2.5 5 0.5 2.0 1, 5

Ethylhexyl methoxycinnamate 5.0 3.0 2.0 2.0 5.0 Ethylhexylglycerol 1 - 0.5 l -

Aluminum Chlorohydrate - 1 0.02 1 -

Ethanol - - 3.0 1 -

Ammonium acryloyldimethyltaurate / VP 0.5 0.75 0.5 2.0 0.25 Copolymer

Blue, water-soluble dye (Blue No.1) 0.5 1, 0 0.4 3.0 0.25

Carbomer - - 0.2 - 0.1

Phosphated starch 1, 0 - 4.0 - 0.5

8-hexadecene-1, 16-dicarboxylic acid 0.5 0.75 1, 0 1, 5 2.5

Octyl dodecanol 0.5-1.0-0.2

Caprylic / Capric Triglyceride - - 1, 0 - 0.5

Myristyl myristate - 1, 5 1, 0 2,5 -

Perfume q-s, q, s, q, s, q, s, q, s,

Sea salt - - 0,01 0,5 -

Methylisothiazolinone - 0.10 - 0.06 -

Benzethonium chloride 2.0 - - 0.15 -

Piroctonolamine - -. 0,25 0, 15 -

Lauroylethylarginate - - - 0.15 1, 75

Glycerol 5 10 7.5 15 7.5

Tocopherol acetate 0.5 0.25 0.5 0.1 -

Titanium dioxide - 2.5 1, 2 0.15 ~

Water ad 100 ad 100 ad 100 ad 100 ad 100 O W emulsion

31 32 33 34 35

Polyethylene glycol (21) stearyl ether 1 - 2.5 2 1, 5

Polyethylene glycol (2) stearyl ether 1-5.5 3 7.5

Cetearyl glucoside - 8 - - -

Cyclomethicone 12.5 15 28.0 25.0 17.5

Dimethicone 5.0 13.0 5.0 12.0 15.0

Behenyl alcohol 3 2 - 1 -

Stearyl alcohol 3 2 - 2 -

Cetylstearyl alcohol 3 4 - - 2 hydrogenated polyisobutene 0.5 0.75 1, 2.0 2.0 0.25

Octyldodecanol 0.5 1, 0.75 3.0 0.25

Xanthan gum 0.35 0.5 1, 0.75 0.15

Glycerin 5 10 15 3 7.5

Methylisothiazolinone - 0.10 - 0.06 -

Benzethonium chloride 2.0 - - 0.15 -

Piroctonolamine - - 0.25 0.15 -

Lauroylethylarginate - - - 0.15 1, 75

Panthenol 0,5 1, 0 0,75 0,25 0,1

Perfume q, s, q, s, qs, qs, q, s, modified starch 0.5 - - 0.15 ~

O / W emulsion

36 37 38 39 40

Glyceryl sterate citrate 1, 0 0.5 0.1 0.5 0.3

Polyethylene glycol (20) cetearyl ether 1.0.0 1, 0 5 - -

Triglycerol methyl glucose distearate - - - - 2.5

Cyclomethicone - - - 1 ~

Dimethicone 0.5 3.0 0.75 1, 5 0.2

Behenyl alcohol 1 - 2 1 0.2

Dicaprylyl carbonate 3 5 10 15 5

Stearyl alcohol - - - 1 0.2

Cetylstearyl alcohol - - 1 1 0.2

Tocopherol 0.5 0.5 0.75 0.25 0.1

Octyl dodecanol 0.5-0.75 3.0 0.25

Panthenol 0,5 - 0,75 0,25 0,1

Carbomer 0.05 0.35 0.15 0.1 0.75

Perfume q.s, q.s, q.s, q, s, q.s,

Methylisothiazolinone - 0.10 - 0.06 -

Benzethonium chloride 2.0 - - 0.15 -

Piroctonolamine - - 0.25 0.15 -

Lauroylethylarginate - - - 0.15 1, 75 Sorbitol 10 - - 5 -

Butylene glycol - - - 5 10

Propylene Glycol - - 10 5 -

Glycerol - 7.5 - - -

Water ad 100 ad 100 ad 100 ad 100 ad 100

O W emulsion

41 42 43 44 45

Glyceryl sterate citrate 1, 0 0.75 0.1 0.5 0.3

Polyethylene glycol (20) cetearyl ether 1, 0 - 2 1, 5 -

Triglycerol methyl glucose distearate - 5.5 - 2.5

Ethyl butylacetylaminopropionate 5 10 15 20 7.5

Cyclomethicone 2 4 6 1 3

Dimethicone - 0.5 0.75 - -

Behenyl alcohol 1 - 2 1 0.2

Stearyl alcohol - 1 - 1 0.2

Cetylstearyl alcohol - - 1 1 0.2 white medicinal oil 0,5 0,75 1, 0 2,0 0,25

Octyldodecanol 0.5 1, 0.75 3.0 0.25

Panthenol 0,5 1, 0 0,75 0,25 0,1

Carbomer 0.05 0.1 0.15 0.1 0.44

Perfume q, s, q, s, q, s, q, s, q, s, Dicaprylyl carbonate 3 5 10 15 5

Methylisothiazolinone - 0.10 - 0.06 -

Benzethonium chloride 2.0 - - 0.15 -

Piroctonolamine - - 0.25 0.15 -

Lauroylethylarginate - - - 0.15 1, 75

Tocopherol 0.5 1, 0.75 0.25 0.1

Caprylic / Capric Triglyceride 1 2 3 5 10 modified starch - 2.5 - 0.15 -

Glycerol 3 5 8 12 10

Water ad 100 ad 100 ad 100 ad 100 ad 100

Claims

claims

1. Cosmetic or dermatological, paraben and / or phenoxyethanolfreie preparation comprising benzethonium chloride, ethylisothiazolinone, Piroctone olamine and / or Lauroylethylarginat in combination with one or more thickening substances.

2. Preparation according to claim 1, characterized in that as thickening substances xanthan gum, carageenan, alginates, tyloses, carboxymethylcellulose, microcrystalline cellulose, hydroxyethylcellulose and / or polyacrylates are selected.

3. Preparation according to claim 1 or 2, characterized in that the proportion of

Benzethonium chloride, methylisothiazolinone, Piroctonolamine and / or Lauroylethylarginat in the range of 0.01 to 5 wt.%, In particular in the range of 0.1 to 2 wt.%, Based on the total mass of the preparation is selected.

4. Preparation according to one of the preceding claims, characterized in that two, three or all of the substances benzethonium chloride, Methylisothiazolinone, Piroctone olamine and / or Lauroylethylarginat are included.

5. Preparations according to one of the preceding claims suitable for cleaning the skin and / or cleaning and / or care of the hair comprising benzethonium chloride and / or lauroylarginate.

6. Use of Benzethonium Chloride, Methylisothiazolinone, Piroctone Olamine

and / or lauroylethylarginate in cosmetic or dermatological preparations comprising one or more thickening substances for improving the sensory properties of the preparation.

7. Use according to claim 6, characterized in that the preparation

Paraben free and / or phenoxyethanolfrei.