WO2011124234A1 - Réparation d'adn fragmenté et traitement d'une intoxication aux métaux lourds par injection intraveineuse de nano-hydroxyapatite - Google Patents

Réparation d'adn fragmenté et traitement d'une intoxication aux métaux lourds par injection intraveineuse de nano-hydroxyapatite Download PDF

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Publication number
WO2011124234A1
WO2011124234A1 PCT/EG2010/000019 EG2010000019W WO2011124234A1 WO 2011124234 A1 WO2011124234 A1 WO 2011124234A1 EG 2010000019 W EG2010000019 W EG 2010000019W WO 2011124234 A1 WO2011124234 A1 WO 2011124234A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxyapatite
nano
heavy metal
intravenous injection
repair
Prior art date
Application number
PCT/EG2010/000019
Other languages
English (en)
Inventor
Eman Ismail Abd El-Gawad
Sameh Abd El-Hamid Ismail Awwad
Original Assignee
Eman Ismail Abd El-Gawad
Sameh Abd El-Hamid Ismail Awwad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eman Ismail Abd El-Gawad, Sameh Abd El-Hamid Ismail Awwad filed Critical Eman Ismail Abd El-Gawad
Priority to EP10720528A priority Critical patent/EP2574171A1/fr
Publication of WO2011124234A1 publication Critical patent/WO2011124234A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Definitions

  • heart, liver and thyroid function enzymes were evaluated as markers of general health and the results confirmed the bio-safe usage of this synthesized material.
  • the same experiment was repeated with another concentration of nano-hydroxyapatite and the results were the same for three years and all the tested animals treated still alive with a good health until the date of issue.

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nous avons synthétisé de la nano-hydroxyapatite par complexion organique-inorganique. Ledit produit a été injecté par voie intraveineuse à des rats après exposition de ces derniers à une DL50 d'un métal lourd toxique. La nano-hydroxyapatite préparée est parvenue à réparer l'ADN fragmenté dans les 48 heures ayant suivi l'injection d'une seule dose sans aucun effet secondaire. Les enzymes fonctionnelles du cœur, du foie et de la thyroïde ont également été étudiées et les résultats ont confirmé que ce produit est sans danger d'un point de vue biologique. En conséquence, la nano-hydroxyapatite ainsi préparée peut être utilisée sans risque par injection intraveineuse de doses adaptées pour le traitement de diverses maladies comme le cancer, les intoxications et l'ostéoporose.
PCT/EG2010/000019 2010-04-07 2010-04-14 Réparation d'adn fragmenté et traitement d'une intoxication aux métaux lourds par injection intraveineuse de nano-hydroxyapatite WO2011124234A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10720528A EP2574171A1 (fr) 2010-04-07 2010-04-14 Réparation d'adn fragmenté et traitement d'une intoxication aux métaux lourds par injection intraveineuse de nano-hydroxyapatite

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EG2010040557 2010-04-07
EG2010040557 2010-04-07

Publications (1)

Publication Number Publication Date
WO2011124234A1 true WO2011124234A1 (fr) 2011-10-13

Family

ID=42321208

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EG2010/000019 WO2011124234A1 (fr) 2010-04-07 2010-04-14 Réparation d'adn fragmenté et traitement d'une intoxication aux métaux lourds par injection intraveineuse de nano-hydroxyapatite

Country Status (2)

Country Link
EP (1) EP2574171A1 (fr)
WO (1) WO2011124234A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000026153A1 (fr) * 1998-10-30 2000-05-11 Huff Carl L Procede de traitement de la contamination par les metaux lourds
US20020187959A1 (en) * 1999-02-23 2002-12-12 Isaac Eliaz Compositions and methods for treating mammals with modified alginates and modified pectins
WO2007084858A2 (fr) * 2006-01-12 2007-07-26 Rutgers, The State University Synthèse d'hydroxyapatite biomimétique

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000026153A1 (fr) * 1998-10-30 2000-05-11 Huff Carl L Procede de traitement de la contamination par les metaux lourds
US20020187959A1 (en) * 1999-02-23 2002-12-12 Isaac Eliaz Compositions and methods for treating mammals with modified alginates and modified pectins
WO2007084858A2 (fr) * 2006-01-12 2007-07-26 Rutgers, The State University Synthèse d'hydroxyapatite biomimétique

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2006, KITIKOVA, N. V. ET AL: "Pharmacological effects of calcium phosphate preparations in experimental lead intoxication", XP002592566, retrieved from STN Database accession no. 2006:380624 *
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 5 August 2008 (2008-08-05), LI Y ET AL: "Current application of hydroxyapatite nanoparticles in tumor field", XP002592567, Database accession no. EMB-2008537486 *
TOKSIKOLOGICHESKII VESTNIK , (1), 12-16 CODEN: TOVEFN; ISSN: 0869-7922, 2006 *

Also Published As

Publication number Publication date
EP2574171A1 (fr) 2013-04-03

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