WO2011120040A3 - Thrombin inhibiting compositions - Google Patents

Thrombin inhibiting compositions Download PDF

Info

Publication number
WO2011120040A3
WO2011120040A3 PCT/US2011/030190 US2011030190W WO2011120040A3 WO 2011120040 A3 WO2011120040 A3 WO 2011120040A3 US 2011030190 W US2011030190 W US 2011030190W WO 2011120040 A3 WO2011120040 A3 WO 2011120040A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibiting compositions
thrombin inhibiting
thrombin
thrombosis
compositions
Prior art date
Application number
PCT/US2011/030190
Other languages
French (fr)
Other versions
WO2011120040A2 (en
Inventor
Marcel Thurk
Andreas Schwienhorst
Original Assignee
Matrix Pharma Inc.
Geraghty, Erin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Pharma Inc., Geraghty, Erin filed Critical Matrix Pharma Inc.
Publication of WO2011120040A2 publication Critical patent/WO2011120040A2/en
Publication of WO2011120040A3 publication Critical patent/WO2011120040A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compounds and methods of treating or preventing thrombosis or a thrombosis-associated disease.
PCT/US2011/030190 2010-03-26 2011-03-28 Thrombin inhibiting compositions WO2011120040A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31793810P 2010-03-26 2010-03-26
US61/317,938 2010-03-26

Publications (2)

Publication Number Publication Date
WO2011120040A2 WO2011120040A2 (en) 2011-09-29
WO2011120040A3 true WO2011120040A3 (en) 2011-12-29

Family

ID=44673909

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/030190 WO2011120040A2 (en) 2010-03-26 2011-03-28 Thrombin inhibiting compositions

Country Status (1)

Country Link
WO (1) WO2011120040A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455671B1 (en) * 1994-06-17 2002-09-24 Abbott Laboratories Thrombin inhibitors, the preparation and use thereof
US7081447B2 (en) * 2001-09-10 2006-07-25 Novel Science International Gmbh Organic compounds with biological activity as thrombin inhibitors and use thereof
US7423021B2 (en) * 2003-01-15 2008-09-09 Nsci Novel Science International Gmbh Peptidic thrombin inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455671B1 (en) * 1994-06-17 2002-09-24 Abbott Laboratories Thrombin inhibitors, the preparation and use thereof
US7081447B2 (en) * 2001-09-10 2006-07-25 Novel Science International Gmbh Organic compounds with biological activity as thrombin inhibitors and use thereof
US7423021B2 (en) * 2003-01-15 2008-09-09 Nsci Novel Science International Gmbh Peptidic thrombin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DANIEL RIESTER ET AL.: "Thrombin inhibitors identified by computer-assisted multiparameter design", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, no. 24, 2005, pages 8597 - 8602 *

Also Published As

Publication number Publication date
WO2011120040A2 (en) 2011-09-29

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