WO2011119062A1 - Composition possédant une action fongicide, antimicrobienne et antivirale (variantes) - Google Patents

Composition possédant une action fongicide, antimicrobienne et antivirale (variantes) Download PDF

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Publication number
WO2011119062A1
WO2011119062A1 PCT/RU2010/000125 RU2010000125W WO2011119062A1 WO 2011119062 A1 WO2011119062 A1 WO 2011119062A1 RU 2010000125 W RU2010000125 W RU 2010000125W WO 2011119062 A1 WO2011119062 A1 WO 2011119062A1
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WO
WIPO (PCT)
Prior art keywords
essential oil
oil
siberian
composition
water
Prior art date
Application number
PCT/RU2010/000125
Other languages
English (en)
Russian (ru)
Inventor
Александр Алексеевич ЕФРЕМОВ
Владимир Владимирович КОЛЕСНИК
Original Assignee
Общество С Ограниченной Ответственностью Научно - Производственный Центр "Bыcoкиe Texнoлoгии"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Общество С Ограниченной Ответственностью Научно - Производственный Центр "Bыcoкиe Texнoлoгии" filed Critical Общество С Ограниченной Ответственностью Научно - Производственный Центр "Bыcoкиe Texнoлoгии"
Priority to PCT/RU2010/000125 priority Critical patent/WO2011119062A1/fr
Publication of WO2011119062A1 publication Critical patent/WO2011119062A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/882—Acoraceae (Calamus family), e.g. sweetflag or Acorus calamus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Definitions

  • the invention relates to the pharmaceutical industry and may find application in the manufacture of therapeutic, prophylactic, cosmetic and sanitary-hygienic products such as sprays, as well as gels, balms, lotions and liquids with a disinfecting and healing effect with fungicidal, antimicrobial and virucidal effects.
  • the invention can find application in the rehabilitation of air in closed (residential) premises, to improve the human environment.
  • deodorizing compositions are known containing various components of natural origin, such as vegetable essential oils, natural waxes and resins, wheat and wood flour, citrus fruits, starch, etc. (DE patent, ⁇ 28233759, ⁇ 61 ⁇ 9/01, 1980).
  • a known method of saturating indoor air with medicinal substances consists in supplying air to the room using the duct, in which there is a source of medicinal and aromatic substances, the amount of which can be dosed (RU 2039576, IPC 6 A61 L9 / 14).
  • the closest in technical essence and the achieved effect to the proposed composition is an air freshener (patent ⁇ »2090212, IPC 6 A61 L9 / 01), characterized by a composition based on natural raw materials with fir aroma, including polyhydric and ethyl alcohols, has a virucidal effect against the influenza virus.
  • the known composition does not have a virucidal effect against influenza viruses of type A and B.
  • the objective of the invention is to provide a drug with high atimicrobial and antifungal activity with a prolonged action.
  • the technical result obtained by carrying out the invention is to create an antimicrobial agent with high bactericidal activity when using the product in minimal quantities and not having a toxic effect.
  • the bactericidal activity of essential oils has been known for a long time. Plant extracts and essential oils for aseptic purposes have been used in traditional medicine in many countries. The bactericidal properties of more than 1000 plant species (eucalyptus, bird cherry, poplar, mustard, etc.) are reported, some of them are used to prevent and treat inflammatory processes of the upper respiratory tract, dermatomycosis and other fungal infections.
  • essential oil vapors as therapeutic agents is known, but the best effect is achieved with a uniform distribution of the essential oil in the indoor air. This is achieved by using a mixture of essential oils with alcohol in the form of sprays. Vapors of essential oils in the air are capable of killing pathogenic microbes and bacteria, which leads to a healthier environment in enclosed spaces.
  • the specified technical result according to option 1 is achieved by the fact that, as a bactericidal base, essential oil of woody Siberian pine (cedar) is used, having a certain component composition, in certain proportions.
  • Siberian pine essential oil is obtained by steam distillation of fresh woody greens (paws) of Siberian pine for 40 hours. It's yellow green or bluish-yellow mobile fluid with a characteristic smell of coniferous essential oil.
  • the density of the Siberian pine essential oil is 0.8600-0.8850 g / cm 3 , the refractive index is 1.4680-1, 4750.
  • the oil contains (% mass):
  • the component composition of the essential oil and the finished composition is established using an Agilent Technologies 7890 GC System gas chromatography mass spectrometer with a 5975 C quadrupole mass spectrometer as a detector using a 30 m s capillary column phase 5% diphenyl-95% dimethylsiloxane with an inner diameter of 0.25 mm Chromatography conditions: isothermal mode at 50 ° C for three minutes, then a programmed temperature rise at a speed of 4 ° C / min to 270 ° C with exposure at a final temperature of 30 minutes.
  • the evaporator temperature is 280 ° ⁇
  • the temperature of the ionization chamber is 170 ° ⁇
  • the ionization energy is 70 eV.
  • the content of the components is calculated by peak areas, the identification of individual components is carried out by comparing the retention times and full mass spectra with the corresponding data of the components of the reference oils and pure compounds, as well as using linear retention indices.
  • Such a composition has a high bactericidal activity and kills up to 75% of the microbial communities of the human airborne environment, and this effect persists for 10-12 hours.
  • the specified technical result according to the first embodiment is achieved in that the composition having a fungicidal, antimicrobial and virucidal effect, containing a mixture of oil and water-soluble fractions, according to the invention, contains water and ethyl alcohol as a water-soluble fraction, and it contains pine essential oil as an oil fraction Siberian (cedar), which has at least 120 terpenoids in its composition, in the following ratio of components, mass. %:
  • the product is a mobile, clear, yellowish-blue liquid with the smell of terpene hydrocarbons.
  • the specified technical result according to the second embodiment is achieved in that the composition having a fungicidal, antimicrobial and virucidal effect, containing a mixture of oil and water-soluble fractions according to the invention, it contains water and ethyl alcohol as a water-soluble fraction, and it contains essential oil as an oil fraction Siberian pine (cedar), which has at least 120 terpenoids in its composition, and / or Siberian fir essential oil with at least 70 components taken equally, with the following ratio onentov, wt. %:
  • Siberian fir essential oil is obtained under the conditions of steam distillation of fresh woody green Siberian fir for 16-20 hours. It is a yellowish-green or bluish-zean mobile fluid with a characteristic smell of pine oil of conifers. Obtained within 16 hours, the essential oil from the woody greens of Siberian fir has a density of 0.9020-0.9120 g / cm, refractive index 1, 4650-1, 4730.
  • the component composition of Siberian fir essential oil consists of more than 70 components, the main of which are (% of mass):
  • alpha-bisabolol 1 0-3.0
  • Such a composition of Siberian fir essential oil provides its high bactericidal and bacteriostatic activity, complements the component composition of Siberian pine essential oil with other components, which complicates the habituation of environmental microorganisms and helps to prolong the bactericidal action of such compositions.
  • the specified technical result according to the third embodiment is achieved in that the composition having a fungicidal, antimicrobial and virucidal effect, containing a mixture of oil and water-soluble fractions according to the invention, it contains water and ethyl alcohol as a water-soluble fraction, and it contains essential oil as an oil fraction Siberian pine (cedar), which has at least 120 terpenoids, and / or Siberian fir essential oil with at least 70 components taken equally, and / or calamus root essential oil swamp the presence of not less than 100 components, the following component ratio, wt. %:
  • Essential oil of calamus root bog is obtained under conditions of steam distillation of dry raw materials for 10-18 hours. It is a yellowish-green or brown mobile fluid with a characteristic slightly sweet smell. Obtained within 18 hours, the essential oil from the woody greens of Siberian fir has a density of 0.9450-0.9550 g / cm, refractive index 1, 4890-1, 500.
  • Essential oil of calamus root obtained under conditions of steam distillation for 18 hours contains more than 100 components, the main of which are (% of mass):
  • composition of essential oil of calamus root provides a high bacteriostatic, fungistatic and anti-inflammatory activity, complements the component composition of Siberian pine and Siberian fir essential oils with other components, which complicates the habituation of environmental microorganisms and contributes to the prolongation of the bactericidal action of such compositions.
  • the proposed composition may additionally include one or more oils selected from the group consisting of sweet orange, bergamont, geranium, grapefruit oil, ylang-ylang oil, Atlas cedar, coriander, lemon oil, anise oil and, as an essential oil, juniper oil, tangerine, peppermint, lavender, sage, lemon balm, nutmeg, patchouli, rosemary, clove essential oil, pine, Yenisei thyme, yarrow, birch buds, valerian medica tween, oregano, tea tree, eucalyptus, with their next ratio of 0, 1 - 3.0%.
  • oils selected from the group consisting of sweet orange, bergamont, geranium, grapefruit oil, ylang-ylang oil, Atlas cedar, coriander, lemon oil, anise oil and, as an essential oil, juniper oil, tangerine, peppermint, lavender, sage, lemon balm, nutmeg, patchouli
  • the bactericidal activity of the obtained products was studied by the method of serial dilutions.
  • the degree of the test drug was judged by its minimum concentration, which causes a complete suppression of dehydrogenases of test culture cells after 1 hour of incubation in an incubator at a temperature of 37 ° C compared with the control.
  • the multiplicity of dilutions was taken equal to two.
  • Conditionally pathogenic microorganisms of the Enterobacteriacea family were selected as test objects: Enterobacter cloacea, Proteus vulgaris, Escherichia coli, Citrobacter freundii, Pseudomonas aeroginosa, Klebsiella pneumoniae. These microorganisms are one of the most common in the environment and are sanitary indicative. The research results are shown in table 1.
  • the present invention As a result of the use of the present invention, it becomes possible to expand the range of environmentally friendly highly effective fungicidal, antimicrobial and antiviral compositions based on natural phytoextract compounds having pronounced inactivating activity against pathogenic microorganisms (viruses, bacteria, fungi) and at the same time possessing a general strengthening and adaptogenic effect on the body human, and provides air purification in the most environmentally friendly way.
  • the use of the proposed composition provides the treatment and prevention of microbial etiology and closed space infections by physiological methods - exposure to pathogenic forms of microorganisms (bacteria, viruses and fungi, including molds) while enhancing the protective properties of the human body.
  • the formula of the proposed compositions can also be used in the form of creams, balms and health-improving gels for humans.

Abstract

L'invention appartient au domaine de l'industrie chimique et pharmaceutique et concerne une composition possédant une action fongicide, antimicrobienne et antivirale (variantes). La composition comprend les composants suivants : dans une première variante, une huile essentielle de pin sibérien, de l'alcool éthylique et de l'eau distillée; dans une deuxième variante, une huile essentielle de sapin sibérien, une huile essentielle de pin sibérien, de l'alcool éthylique et de l'eau distillée; dans une troisième variante, une huile essentielle d'acore aromatique, une huile essentielle de sapin sibérien, une huile essentielle de pin sibérien, de l'alcool éthylique et de l'eau distillée. L'utilisation de cette composition assure le traitement et la prévention des infections d'étiologique microbienne et des contaminations d'espace clos grâce à l'action contre les formes pathogènes de micro-organismes et le renforcement des défenses immunitaires de l'homme.
PCT/RU2010/000125 2010-03-22 2010-03-22 Composition possédant une action fongicide, antimicrobienne et antivirale (variantes) WO2011119062A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/RU2010/000125 WO2011119062A1 (fr) 2010-03-22 2010-03-22 Composition possédant une action fongicide, antimicrobienne et antivirale (variantes)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2010/000125 WO2011119062A1 (fr) 2010-03-22 2010-03-22 Composition possédant une action fongicide, antimicrobienne et antivirale (variantes)

Publications (1)

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WO2011119062A1 true WO2011119062A1 (fr) 2011-09-29

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2622994C2 (ru) * 2015-10-06 2017-06-21 Владимир Владимирович Колесник Способ повышения иммунитета человека и композиция для его осуществления
RU2647836C1 (ru) * 2016-10-27 2018-03-19 Митче Анастасия Евгеньевна Композиция для обеззараживания и ароматизации воздуха
RU2697200C1 (ru) * 2018-09-25 2019-08-13 Владимир Владимирович Колесник Способ аэрозольной дезинфекции закрытых помещений

Citations (3)

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Publication number Priority date Publication date Assignee Title
RU2104660C1 (ru) * 1996-12-30 1998-02-20 Александр Михайлович Савелов-Дерябин Биологически активная добавка "виватон с"
RU2281781C1 (ru) * 2005-02-14 2006-08-20 Государственное образовательное учреждение высшего профессионального образования Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Средство для лечения мочекаменной болезни
RU2372096C1 (ru) * 2008-05-30 2009-11-10 Светлана Александровна Чубатова Композиция с фунгицидным, антимикробным и вирулецидным действием на основе фитоэкстрактов (варианты)

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
RU2104660C1 (ru) * 1996-12-30 1998-02-20 Александр Михайлович Савелов-Дерябин Биологически активная добавка "виватон с"
RU2281781C1 (ru) * 2005-02-14 2006-08-20 Государственное образовательное учреждение высшего профессионального образования Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Средство для лечения мочекаменной болезни
RU2372096C1 (ru) * 2008-05-30 2009-11-10 Светлана Александровна Чубатова Композиция с фунгицидным, антимикробным и вирулецидным действием на основе фитоэкстрактов (варианты)

Non-Patent Citations (1)

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Title
KOSEV P.A.: "Polny spravochnik lekarstvennykh rastenii", POLNY SPRAVOCHNIK LEKARSTVENNYKH RASTENII, 2001, pages 760 - 761 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2622994C2 (ru) * 2015-10-06 2017-06-21 Владимир Владимирович Колесник Способ повышения иммунитета человека и композиция для его осуществления
RU2647836C1 (ru) * 2016-10-27 2018-03-19 Митче Анастасия Евгеньевна Композиция для обеззараживания и ароматизации воздуха
WO2018080338A1 (fr) * 2016-10-27 2018-05-03 Евгений Тимофеевич РОДИОНОВ Composition pour la décontamination et l'aromatisation d'air
RU2697200C1 (ru) * 2018-09-25 2019-08-13 Владимир Владимирович Колесник Способ аэрозольной дезинфекции закрытых помещений

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