WO2011112970A3 - Compositions and methods for bioconjugation to quantum dots - Google Patents

Compositions and methods for bioconjugation to quantum dots Download PDF

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Publication number
WO2011112970A3
WO2011112970A3 PCT/US2011/028154 US2011028154W WO2011112970A3 WO 2011112970 A3 WO2011112970 A3 WO 2011112970A3 US 2011028154 W US2011028154 W US 2011028154W WO 2011112970 A3 WO2011112970 A3 WO 2011112970A3
Authority
WO
WIPO (PCT)
Prior art keywords
quantum dots
methods
bioconjugation
compositions
orthoganl
Prior art date
Application number
PCT/US2011/028154
Other languages
French (fr)
Other versions
WO2011112970A2 (en
Inventor
Hee-Sun Han
Scott A. Hilderbrand
Neal K. Devaraj
Ralph Weissleder
Moungi G. Bawendi
Original Assignee
The General Hospital Corporation
Massachusetts Institute Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The General Hospital Corporation, Massachusetts Institute Of Technology filed Critical The General Hospital Corporation
Publication of WO2011112970A2 publication Critical patent/WO2011112970A2/en
Publication of WO2011112970A3 publication Critical patent/WO2011112970A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
    • A61K49/0067—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle quantum dots, fluorescent nanocrystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C08G65/3348—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing nitrogen in addition to sulfur
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/02—Compositions of unspecified macromolecular compounds characterised by the presence of specified groups, e.g. terminal or pendant functional groups
    • C08L101/025—Compositions of unspecified macromolecular compounds characterised by the presence of specified groups, e.g. terminal or pendant functional groups containing nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

The present disclosure provides for bio-orthoganl and modular conjugation methods for efficient coupling of organic compounds to quantum dots.
PCT/US2011/028154 2010-03-11 2011-03-11 Compositions and methods for bioconjugation to quantum dots WO2011112970A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31278510P 2010-03-11 2010-03-11
US61/312,785 2010-03-11

Publications (2)

Publication Number Publication Date
WO2011112970A2 WO2011112970A2 (en) 2011-09-15
WO2011112970A3 true WO2011112970A3 (en) 2012-01-19

Family

ID=44564151

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/028154 WO2011112970A2 (en) 2010-03-11 2011-03-11 Compositions and methods for bioconjugation to quantum dots

Country Status (1)

Country Link
WO (1) WO2011112970A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6479022B2 (en) 2014-01-14 2019-03-06 ヨーロピアン モレキュラー バイオロジー ラボラトリーＥｕｒｏｐｅａｎ Ｍｏｌｅｃｕｌａｒ Ｂｉｏｌｏｇｙ Ｌａｂｏｒａｔｏｒｙ Multiple cycloaddition reactions for molecular labeling
CN109490523A (en) * 2018-10-22 2019-03-19 北京纳晶生物科技有限公司 Method for the nano material of label, nucleic acid probe and nucleic acid and nano material coupling
WO2020108781A1 (en) * 2018-11-30 2020-06-04 Cnm Technologies Gmbh Immobilisation of receptor molecules on surfaces by tetrazine ligation
CN112098380B (en) * 2020-08-21 2022-06-03 四川大学华西医院 Biological analysis method based on quantum dot selective recognition reaction and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060173362A1 (en) * 2004-10-08 2006-08-03 The Cleveland Clinic Foundation And Vanderbilt University Methods of medical imaging using quantum dots
US20090209508A1 (en) * 2005-05-16 2009-08-20 Universite De Geneve Compounds for Photochemotherapy
US20100025640A1 (en) * 2007-05-02 2010-02-04 Andrij Pich Loading quantum dots into thermo-responsive microgels by reversible transfer from organic solvents to water

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060173362A1 (en) * 2004-10-08 2006-08-03 The Cleveland Clinic Foundation And Vanderbilt University Methods of medical imaging using quantum dots
US20090209508A1 (en) * 2005-05-16 2009-08-20 Universite De Geneve Compounds for Photochemotherapy
US20100025640A1 (en) * 2007-05-02 2010-02-04 Andrij Pich Loading quantum dots into thermo-responsive microgels by reversible transfer from organic solvents to water

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
W J PARAK ET AL.: "Conjugation of DNA to Silanized Colloidal Semiconductor Nanocrystalline Quantum Dots", CHEM. MATER., vol. 14, 2002, pages 2113 - 2119 *

Also Published As

Publication number Publication date
WO2011112970A2 (en) 2011-09-15

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