WO2011112214A1 - Système irm interactif - Google Patents

Système irm interactif Download PDF

Info

Publication number
WO2011112214A1
WO2011112214A1 PCT/US2010/049016 US2010049016W WO2011112214A1 WO 2011112214 A1 WO2011112214 A1 WO 2011112214A1 US 2010049016 W US2010049016 W US 2010049016W WO 2011112214 A1 WO2011112214 A1 WO 2011112214A1
Authority
WO
WIPO (PCT)
Prior art keywords
subject
housing
display device
power
display
Prior art date
Application number
PCT/US2010/049016
Other languages
English (en)
Inventor
Milan Trcka
Robert Heller
Adam Bazih
Original Assignee
K-Space Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2010/027136 external-priority patent/WO2010105153A2/fr
Application filed by K-Space Llc filed Critical K-Space Llc
Publication of WO2011112214A1 publication Critical patent/WO2011112214A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/46—Arrangements for interfacing with the operator or the patient
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/01—Head-up displays
    • G02B27/017—Head mounted
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/283—Intercom or optical viewing arrangements, structurally associated with NMR apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4806—Functional imaging of brain activation

Definitions

  • Magnetic resonance imaging (“MRI”) systems and functional magnetic resonance imaging (“fMRI”) systems are widely used for diagnosing the physical condition of subjects. They are also used as a research tool for determining the effect of various stimuli on brain activity.
  • MRI Magnetic resonance imaging
  • fMRI functional magnetic resonance imaging
  • audio and/or video stimuli can be provided to a subject undergoing MRI. It is desirable to distract a subject from the MRI process, which can be claustrophobic due to tightly wound head coils. Thus, for even routine MRI, it is desirable that audio and/or visual stimuli be provided.
  • MRI systems that can provide such stimuli are known. See, for example U.S. Patent No. 5,877,732.
  • the system has two main components, a display device and an interface unit.
  • the display device is for use for a subject in an MRI chamber or zone, and comprises a frame sized to be wearable by the subject on the subject's head and a pair of visual displays supported by the frame for producing a subject viewable image.
  • Each visual display comprises a display housing and a display, preferably an OLED display.
  • a video input connector and a power input connector are supported by the frame for receiving video input and input power, respectively.
  • a magnetic shield for the visual displays the shield being substantially transparent to visible light.
  • a preferred shield comprises plastic coated with indium tin oxide.
  • data providing means is provided for the subject to provide data.
  • the data providing means can be an eye tracking system or a microphone, or other type of input device.
  • the display device other than OLEDs, contains substantially no magnetic material.
  • the power input connector typically includes solder, and preferably the solder contains no magnetic material.
  • the display device typically comprises a prism.
  • the frame is close to the subject's eyes so the image produced by the display device is less than 50 mm from the subject's eyes.
  • each visual display housing can independently be tilted relative to the frame, and the visual display housings can be moved independently closer or farther from the subject. Also, preferably, the visual display housings can be moved closer or farther apart from each other.
  • the interface unit is preferably portable and is for placement external to the MRI zone and is useful with the display device.
  • the interface unit comprises an interface housing, a power input, and the following components, all supported by the interface housing: a power input connector, a video input connector, an audio input connector, an audio output connector, a video output connector, a subject input connector, and a power output connector.
  • the audio output connector is for transmitting audio input to the audio input connector of the display device.
  • the video output connector is for transmitting video input to the video input connector of the display device.
  • the subject input connector is for receiving data from the subject.
  • the power output connector is for delivering power to the power input connector of the display device.
  • an RF shield affixed to at least a portion of the interface housing and a ground for the interface housing.
  • the audio input connector and the video input connector of the interface system are the same connector.
  • the audio input connector and the video input connector of the display device are the same connector.
  • Fig. 1 is a block diagram showing components of a system having features of the present invention
  • Fig. 2 is a block diagram of an interface unit for use in the system of Fig. 1;
  • Fig. 3 is a top down schematic view of the interface unit of Fig. 2;
  • Fig. 4 is a side schematic view of the interface unit of Fig. 2;
  • Fig. 5 is a block diagram of an audio/video interface of the interface unit of Fig. 2;
  • Fig. 6 is a schematic view of an audio/video display device for use with the system of
  • Fig. 7 is a perspective view of an audio/video device useful in the system of Fig. 1;
  • Fig. 8 shows an audio video device of Fig.7 on a subject
  • Fig.9 is a wiring diagram of the audio/video device
  • Fig. 10A is a perspective view of a video display for use in the system of Fig. 1;
  • Fig. 10B is a side elevation view of the display of Fig. 10A;
  • Fig. IOC schematically shows the video display of Fig. 10A
  • Fig. 11 shows a speaker system for use in the system of Fig. 1;
  • Fig. 12 shows a microphone for use in the system of Fig. 1;
  • Fig. 13A is a top plan schematic view of a call button for use in the system of Fig. 1;
  • Fig. 13B is a front schematic view of the call button of Fig. 13 A.
  • Fig. 13C shows components of the call box system of Fig. 13A.
  • Fig. 14 is a perspective view of a portable interface system for use with a display device worn by a subject in an MRI chamber.
  • Fig. 15 is a perspective view of a display device for use by a subject in an MRI environment.
  • a device for performing interaction with a subject in Magnetic Resonance Imaging (MRI) or functional Magnetic Resonance Imaging (fMRI) devices According to another embodiment of the present invention, there is provided a system for performing MRI or fMRI on a subject. According to another embodiment of the present invention, there is provided a method for performing MRI or fMRI on a subject. In one embodiment, the method comprises providing a device according to the present invention and using the device to perform magnetic resonance imaging on a subject.
  • fMRI-compatible and MRI-compatible refer to devices that are intended for use during fMRI and MRI procedures, respectively, such that neither the data recorded by the device nor the data recorded by the procedure are reasonably considered as detrimentally affected by the joint usage of fMRI or MRI in practice.
  • An MRI-compatible device does not guarantee fMRI-compatibility.
  • methods to make devices fMRI-compatible include, but are not limited to, use of non- ferromagnetic materials, such as plastic, to reduce attractive forces between the device and the superconducting magnet of the MRI scanner, and shielding to reduce electromagnetic interference that could corrupt the data measured device and corrupt the signal-to-noise ratio or contrast-to-noise ratio of the data.
  • the system 100 comprises a control room 102 and an MRI room 104, wherein the MRI room comprises a magnet bore 106.
  • the term "MRI room” also includes a room used for fMRI.
  • the control room 102 comprises a computer work station 108 optionally operated via a touch display screen 110 for controlling the system 100, a power supply 112, a video feed 114 providing video input, and an audio feed 116 providing audio input.
  • the video feed 114 and the audio feed 116 can be optionally connected to the computer work station 108 or to any other device capable of video or audio output such as a DVD player (not shown).
  • the MRI room 104 comprises an interface unit 118.
  • a portable audio visual system 120 such as a call button 122, a response device 124, and a manual controller such as a joystick 126, all of which are connected to the interface unit 118.
  • a call button 122 such as a call button 122
  • a response device 124 such as a response device 124
  • a manual controller such as a joystick 126
  • the computer work station 108 can be any conventional computer such as those provided by Dell®, Hewlett-Packard®, and others. It typically includes computer memory, USB ports, a printer, a monitor, a keyboard, and a mouse. Optionally the monitor can be in the form of the touch display screen 110.
  • the display touch screen 110 can be connected to the PC work station 108 through a standard USB connector 127.
  • the work station 108 communicates with the interface unit 118 through an optical communication line 128.
  • the power supply 112 provides external power to a power line 130 to the interface unit 118, and through the interface unit 118 to the magnet bore components.
  • the power can be 12 volt DC.
  • the optical connection line 128 is used for providing control signals and other input to the interface unit 118 and for receiving input obtained from a subject to the work station 108 to the control room.
  • a single cable is used for transmitting the power and the control signals to the MRI room and for transmitting input from the subjects to the control room 102.
  • the video feed 114 and the audio feed 116 are transmitted to the interface unit 118 through respective SVGA fiber optic lines 132 and 134.
  • Interface Unit
  • the interface unit 118 comprises a transformer 202 connected to the power supply 112, an interface computer 204 connected to the transformer 220, a magnetic shielding housing 206 surrounding the interface computer 204, a network interface 208 connected electronically to the interface computer 204 and connected to the computer workstation 108 via the optical Ethernet connection 128 using optical signals, a data storage unit 212 connected electronically to the interface computer 204, an auxiliary interface 214 connected electronically to the interface computer 204, and an audio/video goggle interface 216 connected electronically to the interface computer 204, wherein the interface unit 118 is sufficiently shielded by the magnetic shielding housing 206 that it can be used in the MRI room 104 exported to the MRI magnetic field.
  • the interface unit 118 optionally comprises a video capture card 218 connected to the interface computer 204, an optional eye tracker interface 220 connected electronically to the video capture card 218, a data acquisition unit 222 connected electronically to the interface computer 204, and an optional subject monitor receiver 224 connected electronically to the data acquisition unit 222.
  • the interface computer 204 comprises a circuit board 226 and a single board computer (SBC) 228.
  • the circuit board 226 is a printed circuit board and the SBC 228 is a mini- ⁇ motherboard, such as a CommellxM LV-679 available from Taiwan Commate Computer, Inc., 8F, No. 94, Sec. 1, Shin Tai Wu Rd., Hsin Chin, Taipei Hsien, Taiwan.
  • the interface computer 204 is loaded with active noise cancellation (ANC) software such as described in U.S. Patent No. 5,427,102 or U.S. Patent No. 5,440,641.
  • ANC active noise cancellation
  • This software enables a background audio input into the interface computer, software to produce an output sound that is a 180-degree phase- shift sound from the background audio input such that the output sound cancels the background audio input, and an audio output to deliver the output sound.
  • the subject benefits by not having the typical MRI noise around.
  • the administrator benefits through better research results, as the subject is less likely to move around.
  • the SBC 228 further comprises a DVI monitor output 229 for outputting video image to the computer work station 108.
  • the magnetic shielding housing 206 can comprise a computer housing 230 containing the interface unit 118 and a cooler 232 thermally connected to the interface computer 204 and to the data storage unit 212, which has a heat sink 236.
  • the cooler 232 comprises a high surface area grid to conduct heat to surrounding air.
  • the high surface area grid is comprised of aluminum and has dimensions 12.25" x 2.3" x 12".
  • the cooler 232 is thermally connected to the circuit board 226 by means of a thermally conductive gap filler, such as BerquistxM GP2500S20, available from The Berquist Company in Chanhassen, MN, measuring 6.7" x 6.7" x 0.2".
  • the interface computer 204 further comprises air and the cooler 232 further comprises a CPU cooler 234 in thermal contact with the circuit board 226, the air inside the interface computer 204, and the heat sink 236.
  • the cooler 232 further comprises a CPU cooler 234 in thermal contact with the circuit board 226, the air inside the interface computer 204, and the heat sink 236.
  • the network interface 204 is a converter box capable of converting the optical signal into a standard electronic signal for use in the interface computer 204.
  • the network interface 204 is a Copper Gigabit Ethernet to Small Form-factor Pluggables (SFP) Fan-less system and is connected to the interface computer 204 with a 1000-BaseT Ethernet connection and to the computer workstation 108 by a 1000-Base SX Gigabit Optical Ethernet cord.
  • the Copper Gigabit Ethernet to SFP Fan-less system can be an Allied Telesis® AT- MC1008/SP 1000T available from Allied Telesis, 19800 North Creek Parkway, Bothell WA.
  • the 1000-Base SX Gigabit Optical Ethernet cord can be an Opticis North America® CAB- DVIFO-30MM available from 330 Richmond St., Chatham, Ontario, Canada.
  • the data storage unit 212 is a solid-state hard drive without moving parts and is connected to the heat sink 236.
  • the solid-state hard drive can be an Intel® SSD 80 GB storage unit, available from Intel Corporation, 2200 Mission College Blvd, Santa Clara, CA.
  • the data storage unit 212 is connected to the interface computer 204 by a serial ATA (SATA) connection.
  • SATA serial ATA
  • Solid-state hard drives are better for use in the MRI room due to their lack of moving parts. Typical hard drives have electric motors that can interfere with MRI and fMRI.
  • the auxiliary interface 214 is connected to the interface computer 204 through a standard two-way electronic communication means, such as a USB cable or wirelessly.
  • the auxiliary interface 214 comprises a circuit to convert between electrical and optical signals and communication means to send and receive an optical signal through fiber optic cables.
  • An example of the communication means is a photodiode circuit, light-emitting diode (LED), or photodetector, such as an Industrial Fiber Optics® IF-E96 for converting electrical signals into optical signals and an Industrial Fiber Optics® IF-D95 for converting optical signals into electrical signals, both available from Industrial Fiber Optics, Inc., 1725 West 1st Street, Tempe, AZ.
  • the interface unit 118 includes an audio/video goggle interface 216, shown in Figure 5.
  • the audio/video goggle interface 216 comprises a non-magnetic male electrical connector 302 connected to the SBC 228; a Digital Visual Interface (DVI) connector 304 connected to the control room 102; a front panel (FP) audio connector 306 connected to the control room 102; an interface system 308 connected to the DVI connector 304, to the FP audio connector 306, and to the non-magnetic male electrical connector 302; a non-magnetic female electrical connector 310 electrically connected to the interface system 308; and a fiber connector 312 electrically connected to the interface system 308.
  • DVI Digital Visual Interface
  • FP front panel
  • the non-magnetic male electrical connector 302 and the non-magnetic female electrical connector 310 are ITT Cannon® D-Subminiature non-magnetic connectors available from ITT Interconnect Solutions, 5288 Valley Industrial Blvd S, Shakopee, MN.
  • the DVI connector 304 is configured to receive video information from the video feed 114, while the FP audio connector 306 is configured to receive audio information from the audio feed 116.
  • the non-magnetic male electrical connector 302 is configured to have a plurality of electrical connections with the SBC, including an SBC video signal connection 314, an SBC communication signal connection 316, an SBC audio signal connection 318, a microphone SBC connection 320, and a power connection 322.
  • the interface system 308 comprises a DVI to Super Video Graphics Array (SVGA) converter 324 connected to the DVI connector 304 through a DVI cable 305; a video selector 326 connected to the DVI to SVGA converter 324 through an SVGA cable and connected to the SBC video signal connection 314 through a cable communicating SVGA, color, and synchronicity video information; an interface controller 328 connected to the SBC communication signal connection 316 by a two-way connection cable, such as a USB cable; a control logic 330 connected to the interface controller 328; a digital to analog converter (DAC) 332 connected to the control logic 330 with an interface such as a two-wire interface (TWI) or serial peripheral interface (SPI); a fiber receiver DAC 334 connected to the FP audio connector 306 by an optical cable and configured to convert an optical audio signal to an electric signal; an audio mixer 336 connected to the fiber receiver DAC 334 and to the SBC audio signal connection 318, configured to combine the two audio signals into one electrical signal;
  • the first electro-optical converter 344 is an Industrial Fiber Optics® IF-E96 and the second electro-optical converter 346 is an Industrial Fiber Optics® IF-D95, both available from Industrial Fiber Optics, Inc., 1725 West 1st Street, Tempe, AZ.
  • the non-magnetic female electrical connector 310 is configured to have plurality of electrical connections with the audio/video goggle interface 216, such as a display drive 348 connected to the video selector 326 through a video cable such as SVGA to communicate video signal, a display control 350 connected to the control logic 330, a voltage output 352 connected to the DAC 332, a speaker connection 354 connected to the speaker amp 338, a microphone connection 356 connected to the communication line microphone amplifier 340, and a goggle power connection 358 connected to the regulator 342.
  • the fiber connector 312 comprises a call button connector 360 connected to the first electro-optical converter 344 and to the second electro-optical converter 346.
  • audio/video goggle interface 216 further comprises a noise cancellation connection 362 in the non-magnetic female electrical connector 310; and a noise canceling microphone interface 364 located in the interface system 308 and connected to the noise cancellation connection 362, to the control logic 330, and to the audio mixer 336 in such a way as to deliver background noise for active noise cancellation from the interface computer 204 in an audio output.
  • the video capture card 218 is a Commell® mini-PCI, available from Taiwan Commate Computer, Inc., 8F, No. 94, Sec. 1, Shin Tai Wu Rd., Hsin Chin, Taipei Hsien, Taiwan, and is connected to the eye tracker interface 220 through a NTSC Video cable.
  • the eye tracker interface 220 is capable of receiving video image from a fiber optic cable and converting the signal from the fiber optic cable into an electrical signal.
  • the data acquisition unit 222 is a 16 channel National Instruments® DAQ NI PCIe-6259, available from National Instruments Corp., 11500 N Mopac Expwy., Austin, TX, and is connected to the interface computer 204 through a Peripheral Component Interconnect Express (PCIe) connection.
  • PCIe Peripheral Component Interconnect Express
  • the data acquisition unit 222 is configured to receive both digital and analog electrical signals from the subject monitor receiver 224.
  • the subject monitor receiver 224 is capable of receiving signals from the subject regarding the subject's heart rate, respiration, temperature, oxygen levels, and brain electrical activity according to methods known in the art, such as U.S. Patent No. 6,731,976, and U.S. Patent No. 6,533,733.
  • the audio/video goggle system 120 is connected to the audio/video goggle interface 216 through an electronic cable having a second non-magnetic male connector 502 with a ground connection 503 and comprises a visual display 504, a sound transmission system 506 connected to the second non-magnetic male connector 502 through audio cables 507, and a microphone system 508.
  • the second non-magnetic male connector 502 connects to the non-magnetic female connector 310.
  • the visual display 504 is connected to the audio/video goggle interface 216 through cables communicating video information 509 and comprises a left display 510; a right display 512; a display logic 514 connected to the second non-magnetic male connector 502 through logic cables 515, to the left display 510, and to the right display 512; and a plurality of voltage controllers 516 connected to the second non-magnetic male connector 502 through voltage cables 517, to the left display 510, and to the right display 512.
  • the audio/video goggle system 120 optionally further comprises an eye tracker system 518 that is connected to the optional eye tracker interface 220.
  • the microphone system 508 is connected to the second nonmagnetic male connector 502 through a microphone cable 519.
  • the left display 510 and right display 512 each further comprise an organic light-emitting diode (OLED) system or other LED system 520 for receiving and transmitting video images, a prism or mirror system 522 for receiving video images from the OLED system or LED system 520, and a diopter adjustment mechanism 524 for adjusting the distance between the prism or mirror system 522 and the OLED system or LED system 520.
  • the diopter adjustment mechanism 524 can be manual, such as a threaded rod, or can comprise a non-magnetic motor, such as a miniature piezoelectric micromotor, such as a Squiggle® motor.
  • the prism or mirror system 522 receives the video signal from the OLED system or LED system 520 and transmits it to the subject without the need for a lens.
  • the OLED system or LED system 520 and the prism or mirror system 522 used can be an eMagin® WF05 optics module, comprising an active matrix OLED-on-Silicon microdisplay, available from eMagin Corporation, 10500 NE 8th Street, Bellevue, WA. This module is the preferred display mechanism since its display does not degrade in magnetic fields up to at least 7 Tesla.
  • the sound transmission system 506 can especially be seen in Figure 11.
  • the sound transmission system 506 used is a modified version of a Mallory Sonalert Products® PT- 2060WQ, available from Mallory Sonalert Products, Inc., 4411 South High School Road, Indianapolis, IN, and comprises a piezoelectric speaker 526 that converts an electric signal to an acoustic audio signal, an acoustic waveguide 528 receiving the audio signal and attached to the piezoelectric speaker 526, and an earpiece 530 attached to the acoustic waveguide 528 and located proximal to a subject's ear.
  • the Mallory Sonalert Products® PT-2060WQ is modified through wire-stripping and magnetically shielding with a material capable of magnetic shielding, such as mylar or copper braiding.
  • the sound transmission system 506 can also further comprise ceramic speakers.
  • the sound transmission system 506 further comprises noise cancellation microphones 532 that pick up MRI background noise. These noise cancellation microphones 532 deliver an audio signal to the audio/video goggle interface 216 through noise cancellation cables 533, shown in Figure 9.
  • the microphone system 508 can especially be seen in Figure 12.
  • the microphone system 508 used is a non-magnetic microelectromechanical system (MEMS) microphone 534 connected to the microprocessor through an acoustic waveguide 536, wherein the acoustic waveguide 536 is configured to have an opening near the subject's mouth for receiving verbal communication.
  • MEMS microelectromechanical system
  • the MEMS microphone 534 is an analog output single chip MEMS microphone with an integrated transducer and associated circuitry on a single piece of silicon, such as an Akustica® AKU1126, available from Akustica, Inc., 2835 East Carson Street, Suite 301, Pittsburg, PA, and modified through wire-stripping and magnetically shielding with a material capable of magnetic shielding, such as mylar or copper braiding.
  • the visual display 504, sound transmission system 506, and microphone system 508 are a unitary unit having the general shape of binocular goggles, and the audio/video goggle system 120 further comprises an inter-pupillary adjustment mechanism.
  • the inter-pupillary adjustment mechanism can be manual, such as a threaded rod, or comprise a nonmagnetic motor.
  • the audio/video goggle system 120 is mounted to a face module made of a biocompatible non-magnetic material, such as flexible plastic, silicone, or polyurethane.
  • the audio/video goggle system 120 further comprises a removable shield 538 for placement on the unitary unit between the unitary unit and the subject.
  • the audio/video goggle system 120 further comprises a strap securing the audio/video goggle system 120 to the subject.
  • the audio/video goggle system 120 is connected to the audio/video goggle interface 216 through a single 37-pin cable, as shown in Figure 9.
  • the single cable can also be magnetically shielded through braided shielding as is known in the art and has the advantage of minimizing interference with the MRI or fMRI.
  • the call button 122 can especially be seen in Figures 13A-C.
  • the call button 122 comprises a first fiber optic cable 602 having a first end and an opposed second end, wherein the first end is closer to the subject than to the control room 102; a second fiber optic cable 604 having a first end and an opposed second end, wherein the first end is closer to the subject than to the control room 102; a housing 606 holding the first end of the first fiber optic cable 602 and the first end of the second fiber optic cable 604 in such a way as to make the first end of the first fiber optic cable 602 and the first end of the second fiber optic cable 604 proximal to each other using a base 607 and a fiber support 608 so that there is an optical path between the two fiber optic cables; a light interruption mechanism 610 within the housing 606 such as a mirror or prism that is configured to come between the first end of the first fiber optic cable and the first end of the second fiber optic cable; a disk 612 attached to the light interruption mechanism 610, located
  • the first fiber optic cable 602 and the second fiber optic cable 604 are connected to the call button connector 360 of the audio/video goggle interface 216.
  • the first fiber optic cable 602 receives an optical input from the audio/video goggle interface 216 and transmits it to the second fiber optic cable 604.
  • the response device 124 comprises at least one input button.
  • Each button is constructed in a similar way to the call button 122 and comprises a first fiber optic cable having a first end and an opposed second end, wherein the first end is closer to the subject than to the control room 102; a second fiber optic cable having a first end and an opposed second end, wherein the first end is closer to the subject than to the control room 102; a housing holding the first end of the first fiber optic cable and the first end of the second fiber optic cable in such a way as to make the first end of the first fiber optic cable and the first end of the second fiber optic cable proximal to each other using a base and a fiber support so that there is an optical path between the two fiber optic cables; a light interruption mechanism within the housing such as a mirror or prism that is configured to come between the first end of the first fiber optic cable and the first end of the second fiber optic cable; a disk attached to the light interruption mechanism, located outside of the housing, and configured in such a way that a subject blocks the optical path
  • the manual controller, or joystick, 126 is constructed in a similar way to the call button 122 and comprises a first fiber optic cable having a first end and an opposed second end, wherein the first end is closer to the subject than to the control room 102; a second fiber optic cable having a first end and an opposed second end, wherein the first end is closer to the subject than to the control room 102; a housing holding the first end of the first fiber optic cable and the first end of the second fiber optic cable in such a way as to make the first end of the first fiber optic cable and the first end of the second fiber optic cable proximal to each other using a base and a fiber support so that there is an optical path between the two fiber optic cables; a light interruption mechanism within the housing such as a mirror or prism that is configured to come between the first end of the first fiber optic cable and the first end of the second fiber optic cable in an incremental way; a hand-held control stick attached to the light interruption mechanism, located outside of the housing, and configured in such a way that a subject partially blocks
  • the joystick 126 comprises a first plurality of fiber optic cables, wherein each fiber optic cable of the first plurality of fiber optic cables has a first end and an opposed second end, wherein the first end of each of the fiber optic cables is closer to the subject than to the control room 102; a second plurality of fiber optic cables, wherein each fiber optic cable of the second plurality has a corresponding fiber optic cable of the first plurality and forms a pair, wherein each fiber optic cable of the second plurality of fiber optic cables has a first end and an opposed second end, wherein the first end of each of the fiber optic cables is closer to the subject than to the control room 102; a housing holding the first end of each of the fiber optic cables in such a way as to make the first end of each fiber optic cable of the second plurality proximal to the first end of each corresponding fiber optic cable of the first plurality using a base and a fiber support so that there is an optical path between each pair of fiber optic cables forming a plurality of optical paths; a light interruption mechanism
  • an audio adjustment mechanism comprising a first plurality of fiber optic cables, wherein each fiber optic cable of the first plurality of fiber optic cables has a first end and an opposed second end, wherein the first end of each of the fiber optic cables is closer to the subject than to the control room 102; a second plurality of fiber optic cables, wherein each fiber optic cable of the second plurality has a corresponding fiber optic cable of the first plurality and forms a pair, wherein each fiber optic cable of the second plurality of fiber optic cables has a first end and an opposed second end, wherein the first end of each of the fiber optic cables is closer to the subject than to the control room 102; a housing holding the first end of each of the fiber optic cables in such a way as to make the first end of each fiber optic cable of the second plurality proximal to the first end of each corresponding fiber optic cable of the first plurality using a base and a fiber support so that there is an optical path between each pair of fiber optic cables forming a plurality of optical paths; a first plurality of fiber optic
  • FIG. 14 there is shown a perspective view of a portable interface system 1400 for use with a display device 1500 worn by a subject in an MRI chamber.
  • the term "portable” refers to a mechanical device or electrical apparatus manufactured in smaller and lighter form than normal, thereby easier to be carried about by a single person.
  • the portable interface system 1400 can comprise a housing 1402, a power input connector supported by the housing, 1406 a video input connector 1406 supported by the housing, an audio input connector 1406 supported by the housing, an audio out put connector 1406 supported by the housing 1402 for transmitting audio input to the display device 1500, a video output connector 1406 supported by the housing 1402vfor transmitting video input to the display device 1500, a subject input connector 1406 supported by the housing 1500 for receiving input from the subject, a power output connector 1404 supported by the housing 1402 for delivering power to the display device 1500, an RF shield 119 affixed to at least a portion of the housing 1402 and a connector for grounding the RF shield 119 and the housing 1402.
  • the system 1400 comprises a processor, memory and storage.
  • the storage contains non-transitory instructions to process the inputs and outputs from the system 1400.
  • the processor performs tasks autonomously in accordance with the programs in storage or in response to commands received from the control room 102.
  • the RF shield 119 and the housing 1402 are grounded to create an electrical waveguide with the cable shielding to conduct any stray electrical emissions back to the portable interface system 1400 and then to electrical ground.
  • the power input and output connectors are the same connector.
  • the video input connector 1406, audio input connector 1406, audio out put connector 1406, video output connector 1406 and subject input connector 1406 are the same connector.
  • the portable interface system 1400 also comprises a power filtering system 112 in the housing 1402.
  • the power filtering system takes standard electrical power and reduces the noise and stray RF emissions found in commonly supplied power, to provide power to the remote components, such as, for example, the display device 1500.
  • the reduced noise power is more transparent to the MRI or fMRI thereby increasing the resolution of the resulting images.
  • the power filtering system 112 can also regulate voltage frequencies and amplitudes supplied to various components of the system 1400 and convert power input from alternating current to direct current.
  • the portable interface system 1400 can be placed inside the MRI or fMRI chamber or the system 1400 can be placed in the control room.
  • the power and data connections are passed through the barrier between the control room 102 and the MRI chamber 106 and connected to the display device 1500.
  • a data cable 1408 is provided, the data cable being a fiber optic cable that transmits and receives eye tracking data, audio information, video information and control signals.
  • the fiber optic cable 1408 is preferably connected to the portable interface system 1400 by a single connector 1406.
  • the data cable connector 1406 and power connector 1404 are non-magnetic and the cables 1408 and 1410 are further shielded to reduce any RF or magnetic interference with the MRI or fMRI.
  • non-magnetic refers substances that are negligibly affected by magnetic fields and are not capable of being magnetized such as copper, aluminum, brass, and plastic.
  • materials that are magnetic are nickel, iron, cobalt, gadolinium and their alloys
  • the display device 1500 comprises a frame 1502 that is adjustable to fit on the subjects head comfortably, a pair of visual displays 1504 and 1506 that are attachable to the frame 1502.
  • the visual displays 1504 and 1506 produce images for viewing by the subject during the MRI or fMRI.
  • the images can be used to either relax the subject or to present the subject with information requiring a response, such as during an experiment.
  • the images are produced by OLED displays 520 that have been modified. The modifications include removal of all magnetic components and replacing the components with non-magnetic components to be transparent to the MRI.
  • connections to the OLEDs 520 are made with non- magnetic solder such as 96Sn-4Ag alloy or any other RHOS compliant solder.
  • the visual displays 1504 and 1506 are adjusted to be proximate to the subject for optimum viewing. In a preferred embodiment the distance is not more than 50mm.
  • the visual displays 1504 and 1506 can comprise speakers, microphones and eye tracking devices within the same visual displays 1504 and 1506.
  • the speakers can be in the form of ceramic ear buds that can be attached to the visual displays 1504 and 1506 to provide better quality sound to the subject.
  • the single data cable 1408 can transmit to and receive from the subject various information, such as, for example, audio information, visual information and eye tracking information among others.
  • a single power cable 1410 supplies the power required to run the visual displays 1504 and 1506 and all other equipment located in the visual displays 1504 and 1506. All the components housed inside the visual displays 1504 and 1506, other than the OLEDs 520, contain substantially no magnetic material to prevent interference with the MRI.
  • the OLEDs 520 because of the process of manufacture, contain some magnetic and RF generating material. To reduce the interference with the MRI, the OLEDs 520 are shielded using a polyester foil coated with Indium-Tin Oxide.
  • each OLED 520 is magnified by a prism 1510 and 1512 in each visual display 1502 and 1504, respectively.
  • Each visual display 1502 and 1504 can independently be tilted and swiveled relative to the frame so the subject obtains maximum benefit from the visual displays 1502 and 1504. Additionally, the inter-pupillary distance and distance from the subject's eyes can also be independently moved.
  • a system for use in an MRI device used with a subject comprising:
  • an interface comprising a microprocessor for receiving a video input and an audio input, and for receiving subject generated sound input and subject generated control input;
  • a visual display for receiving from the interface the video input and for displaying to the subject visual images
  • the video display comprising left and right displays and first adjustment means for adjusting the distance between the left and right displays, each display comprising:
  • an OLED for receiving the video input and transmitting video images
  • a prism receiving the video images from the OLED
  • a sound transmission system wearable by the subject wherein the sound transmission system receives the audio input and the sound suppression signal from the interface;
  • a microphone system for receiving subject generated sound for transmission to the interface as subject generated sound input;
  • a subject monitor receiver in the interface for receiving physiological information about a subject.
  • system is sufficiently shielded that it can be used in an MRI room.
  • the visual display, the sound transmission system, and the microphone system are a single subject wearable unit having the general shape of binocular goggles.
  • the subject controllable input device comprises a button, light input guide, light output guide, and a mirror reflecting input light from the light input guide to the light output guide.
  • the sound transmission system comprises a pair of ceramic speakers proximate to the visual display, a sound transmitting flexible tube from each speaker to a respective ear bud.
  • the microphone system comprises a microphone proximate to the visual display and a flexible tube sufficiently long to be proximate to a subject's mouth.
  • An MRI system for administering MRI to subjects comprising:
  • an interface in the MRI room for receiving control signals and audio and video inputs and power from the control room, and for transmitting input from subjects to the control room;
  • a single cable for transmitting the power and the control signals to the MRI room, and for transmitting input from subjects to the control room.
  • a visual display for use by a subject in an MRI comprising left and right displays and distance adjustment means for adjusting the distance between the left and right displays, each display comprising:
  • an OLED for receiving the video input and transmitting video images
  • a prism receiving the video images from the OLED.
  • An MRI system for administering MRI to subjects comprising:
  • a shielded interface unit in the MRI room for receiving a video input and an audio input and control signals from the control room, and for receiving subject generated sound input and subject generated control input;
  • a visual display for receiving from the interface unit the video input and for displaying to the subject in the MRI room visual images;
  • a sound transmission system for providing sound to the subject in the MRI room, wherein the sound transmission system receives the audio input and the sound suppression signal from the interface unit;
  • a microphone system in the MRI room for receiving subject generated sound for transmission to the interface unit as subject generated sound input;
  • a subject monitor receiver in the interface unit for receiving physiological information about a subject.

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Human Computer Interaction (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

L'invention concerne un système IRM comprenant une unité d'interface qui possède un boîtier mis à la terre recouvert d'un blindage antiparasite non magnétique qui peut être situé dans la salle d'IRM, ou de préférence dans la salle de contrôle. Le boîtier comprend un système informatique, un système de transmission sonore, un système de poursuite oculaire, un système de microphone, un système de filtrage d'énergie et des connecteurs non magnétiques pour un câble de données et un câble d'alimentation, chacun d'eux étant remplaçable. L'unité d'interface fournit également des vidéos et des sons aux sujets, et peut recevoir des réponses du sujet. Des écrans de visualisation sont connectés à l'unité d'interface pour recevoir et afficher des images visuelles à l'attention du sujet. L'écran de visualisation possède un matériau magnétique minimal et présente la forme et la taille générale de lunettes, ce qui permet de le porter. Un câble de données unique et un câble d'alimentation unique sont connectés à l'écran de visualisation pour fournir de l'énergie et envoyer/recevoir des données.
PCT/US2010/049016 2010-03-12 2010-09-15 Système irm interactif WO2011112214A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
USPCT/US2010/027136 2010-03-12
PCT/US2010/027136 WO2010105153A2 (fr) 2009-03-13 2010-03-12 Système interactif d'irm et système d'élimination et soulagement d'anxiété d'un sujet à usage médical

Publications (1)

Publication Number Publication Date
WO2011112214A1 true WO2011112214A1 (fr) 2011-09-15

Family

ID=44572410

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/049016 WO2011112214A1 (fr) 2010-03-12 2010-09-15 Système irm interactif

Country Status (1)

Country Link
WO (1) WO2011112214A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10162022B2 (en) 2013-12-13 2018-12-25 Koninklijke Philips N.V. Low cost magnetic resonance safe touchscreen display
WO2023183286A1 (fr) * 2022-03-21 2023-09-28 Ceretype Neuroscience, Inc. Synchronisation de dispositif d'imagerie acoustique

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5412419A (en) * 1991-02-11 1995-05-02 Susana Ziarati Magnetic resonance imaging compatible audio and video system
US5877732A (en) * 1994-04-13 1999-03-02 Resonance Technology Co. Three-dimensional high resolution MRI video and audio system and method
US6320384B1 (en) * 1996-12-23 2001-11-20 David F. Doty Thermal buffering of cross-coils in high-power NMR decoupling
US20020163486A1 (en) * 1993-10-22 2002-11-07 Peter A. Ronzani Head-mounted display system
US20050036087A1 (en) * 2003-08-13 2005-02-17 Che-Kuei Mai Liquid crystal display device
US20070069976A1 (en) * 2005-09-26 2007-03-29 Willins Bruce A Method and system for interface between head mounted display and handheld device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5412419A (en) * 1991-02-11 1995-05-02 Susana Ziarati Magnetic resonance imaging compatible audio and video system
US20020163486A1 (en) * 1993-10-22 2002-11-07 Peter A. Ronzani Head-mounted display system
US5877732A (en) * 1994-04-13 1999-03-02 Resonance Technology Co. Three-dimensional high resolution MRI video and audio system and method
US6320384B1 (en) * 1996-12-23 2001-11-20 David F. Doty Thermal buffering of cross-coils in high-power NMR decoupling
US20050036087A1 (en) * 2003-08-13 2005-02-17 Che-Kuei Mai Liquid crystal display device
US20070069976A1 (en) * 2005-09-26 2007-03-29 Willins Bruce A Method and system for interface between head mounted display and handheld device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10162022B2 (en) 2013-12-13 2018-12-25 Koninklijke Philips N.V. Low cost magnetic resonance safe touchscreen display
WO2023183286A1 (fr) * 2022-03-21 2023-09-28 Ceretype Neuroscience, Inc. Synchronisation de dispositif d'imagerie acoustique

Similar Documents

Publication Publication Date Title
US20100234722A1 (en) Interactive mri system
US20100231483A1 (en) Interactive mri system and subject anxiety relief distraction system for medical use
US5877732A (en) Three-dimensional high resolution MRI video and audio system and method
EP3029550B1 (fr) Système de réalité virtuelle
US8363861B2 (en) Entertainment system for use during the operation of a magnetic resonance imaging device
US6774929B1 (en) Shielded video projection system for MRI
US8174569B2 (en) Image display apparatus
WO2017119788A1 (fr) Visiocasque électronique
US5414459A (en) Fiber optic video glasses and projection system
US8554304B2 (en) MRI compatible visual system that provides high resolution images in an MRI device
US20050273000A1 (en) Method and apparatus for providing a stimulus in magnetic resonance imaging system
US20120013525A1 (en) Interactive mri system
CN105093536B (zh) 显示设备和电子设备
US9787750B2 (en) Universal interface system for MRI applications
JP2012520152A5 (fr)
CN106901739B (zh) 一种用于功能磁共振成像的虚拟现实刺激装置
US10820839B2 (en) Electronic tablet for use in MRI
WO2008120152A1 (fr) Dispositif de transmission d'image optique
WO2011112214A1 (fr) Système irm interactif
JP2017151576A (ja) 訓練装置、訓練方法、プログラム
CN217772338U (zh) 一种图像展示装置、成像装置以及磁共振检查系统
CN113939760A (zh) 非侵入性头戴式设备
CN220913622U (zh) 一种核磁共振成像仪兼容的虚拟现实设备
US20170242482A1 (en) Training device, corresponding area specifying method, and program
CN116234491A (zh) 凭借导电底座的右腿驱动

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10847613

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10847613

Country of ref document: EP

Kind code of ref document: A1