WO2011110812A3 - Improvements in crystallisation - Google Patents

Improvements in crystallisation Download PDF

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Publication number
WO2011110812A3
WO2011110812A3 PCT/GB2011/000334 GB2011000334W WO2011110812A3 WO 2011110812 A3 WO2011110812 A3 WO 2011110812A3 GB 2011000334 W GB2011000334 W GB 2011000334W WO 2011110812 A3 WO2011110812 A3 WO 2011110812A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystal
depression
carrier member
microwell plate
chemicals
Prior art date
Application number
PCT/GB2011/000334
Other languages
French (fr)
Other versions
WO2011110812A4 (en
WO2011110812A2 (en
Inventor
Paul Reardon
Original Assignee
Swissci A.G.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Swissci A.G. filed Critical Swissci A.G.
Publication of WO2011110812A2 publication Critical patent/WO2011110812A2/en
Publication of WO2011110812A3 publication Critical patent/WO2011110812A3/en
Publication of WO2011110812A4 publication Critical patent/WO2011110812A4/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/06—Crystallising dishes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B01D9/0054—Use of anti-solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0077—Screening for crystallisation conditions or for crystal forms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C30B7/02—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Optical Measuring Cells (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

A sitting-drop microwell plate (10, 10A) has wells (11) for crystal-forming chemicals and adjacent to each well (11) a shelf-like depression (12, 12A) on which a biological or protein specimen will be located for the formation of a crystal by exposure to vapour from the chemicals. In accordance with the invention a carrier member in the form of a sheet or film (14) of a light-transmissive material or a capillary tube (19) is located on the base (20, 20A) of each depression (12, 12A) so that a crystal will form on or in the carrier member (14,19) and can thus be removed from the microwell plate (10, 10A) for analysis without handling the crystal.
PCT/GB2011/000334 2010-03-09 2011-03-09 Improvements in crystallisation WO2011110812A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1003853.7A GB201003853D0 (en) 2010-03-09 2010-03-09 Improvements in crystallisation
GB1003853.7 2010-03-09

Publications (3)

Publication Number Publication Date
WO2011110812A2 WO2011110812A2 (en) 2011-09-15
WO2011110812A3 true WO2011110812A3 (en) 2012-03-01
WO2011110812A4 WO2011110812A4 (en) 2012-04-12

Family

ID=42136666

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2011/000334 WO2011110812A2 (en) 2010-03-09 2011-03-09 Improvements in crystallisation

Country Status (2)

Country Link
GB (1) GB201003853D0 (en)
WO (1) WO2011110812A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108159730B (en) * 2017-12-27 2020-05-19 大连理工大学 High-throughput preparation platform and method for macromolecular crystals with precise continuous micron-sized structures

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130105A (en) * 1990-10-23 1992-07-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Protein crystal growth tray assembly
US5419278A (en) * 1994-05-25 1995-05-30 Carter; Daniel C. Vapor equilibration tray for growing protein crystals
EP1479794A2 (en) * 2003-05-22 2004-11-24 Hideaki Moriyama Apparatus and method for growing crystal, and apparatus and method for analysing crystal
WO2009043974A1 (en) * 2007-10-05 2009-04-09 Thermo Fisher Scientific Oy Crystallization tray

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2427688A (en) 2005-06-28 2007-01-03 Inogen S A Microwell plate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130105A (en) * 1990-10-23 1992-07-14 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Protein crystal growth tray assembly
US5419278A (en) * 1994-05-25 1995-05-30 Carter; Daniel C. Vapor equilibration tray for growing protein crystals
EP1479794A2 (en) * 2003-05-22 2004-11-24 Hideaki Moriyama Apparatus and method for growing crystal, and apparatus and method for analysing crystal
WO2009043974A1 (en) * 2007-10-05 2009-04-09 Thermo Fisher Scientific Oy Crystallization tray

Also Published As

Publication number Publication date
WO2011110812A4 (en) 2012-04-12
WO2011110812A2 (en) 2011-09-15
GB201003853D0 (en) 2010-04-21

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