WO2011109009A1 - Ensemble vis à os constitué d'un matériau non uniforme - Google Patents

Ensemble vis à os constitué d'un matériau non uniforme Download PDF

Info

Publication number
WO2011109009A1
WO2011109009A1 PCT/US2010/025739 US2010025739W WO2011109009A1 WO 2011109009 A1 WO2011109009 A1 WO 2011109009A1 US 2010025739 W US2010025739 W US 2010025739W WO 2011109009 A1 WO2011109009 A1 WO 2011109009A1
Authority
WO
WIPO (PCT)
Prior art keywords
screw
housing
collet
bone anchor
coupling
Prior art date
Application number
PCT/US2010/025739
Other languages
English (en)
Inventor
John Carbone
Original Assignee
K2M, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by K2M, Inc. filed Critical K2M, Inc.
Priority to PCT/US2010/025739 priority Critical patent/WO2011109009A1/fr
Publication of WO2011109009A1 publication Critical patent/WO2011109009A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
    • A61B17/7035—Screws or hooks, wherein a rod-clamping part and a bone-anchoring part can pivot relative to each other
    • A61B17/7037—Screws or hooks, wherein a rod-clamping part and a bone-anchoring part can pivot relative to each other wherein pivoting is blocked when the rod is clamped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/866—Material or manufacture

Definitions

  • the present disclosure relates to bone anchors and, more particularly, to pedicle screw assemblies made from non-uniform materials.
  • fixation devices such as bone pins, anchors, or screws placed in bone across a discontinuity (e.g., a fracture) in the bone, bone fragments, adjacent vertebrae, or joints.
  • fixation devices can be connected by a rod to maintain a desired spatial relationship.
  • these fixation devices may be permanently implanted.
  • fixation devices may be implanted only as a temporary means of stabilizing or fixing the bones or bone fragments. It is also common that fixation devices that are intended to be permanently implanted require subsequent modifications as the dynamics of a patient's condition warrant.
  • Atty. Docket: 1449-175 any type of spinal fixation device, including both taper lock style screws and set screw style screws.
  • the screw itself may need to be formed of a less rigid, bone interface material.
  • a screw made of a titanium alloy such as Ti-6A1-4V has been shown to be very compatible as a bone interface material.
  • a bone anchor in accordance with the present disclosure, includes a screw and a housing assembly.
  • the screw has a threaded shank portion and a head portion.
  • the housing assembly has a passageway extending therethrough.
  • a saddle is defined within the proximal end of the housing assembly and is configured to retain a portion of a rod therein.
  • the distal end of the housing assembly is configured to securely engage the head portion of the screw such that the screw is rotatable and/or pivotable with respect to the housing, At least a portion of the screw and at least a portion of the housing assembly are made of different material.
  • the entire housing assembly is made from cobalt chrome.
  • only a portion of the housing assembly is made from cobalt chrome.
  • the entire screw may be made from titanium or another biocompatible material.
  • the housing assembly includes a housing part, a coupling, an insert, and a set screw.
  • the housing part includes two proximally extending fingers defining the saddle therebetween.
  • the coupling is disposable within the housing part and is configured to engage the head portion of the screw.
  • the insert is configured to engage the housing part to secure the coupling and the head portion of the screw therebetween.
  • the set screw is configured to engage the housing part and to secure the screw in position.
  • the housing assembly includes a collet, a coupling, and a pin.
  • the collet has an opening extending therethrough and includes two proximally extending fingers defining the saddle therebetween.
  • the collet is configured to accept, through its distal end, the head portion of the screw.
  • the head portion of the screw is partially insertable into the opening in the collet.
  • the coupling also has an opening extending therethrough.
  • the coupling is configured to pass proximally over the shank portion of the screw to ultimately surround the collet, thereby securing the head portion of the screw between the collet and the coupling.
  • the pin is configured to engage the collet with the coupling to thereby secure the collet and the coupling to each other.
  • FIG. 1 is an exploded perspective view of a bone anchor assembly according to the present disclosure
  • Fig. 2 is a side view of the bone anchor of Fig. 1;
  • Fig. 3 is a side, cross-sectional view of the bone anchor of Fig. 2, taken across section line 3-3;
  • FIG. 4 is an exploded perspective view of a bone anchor assembly in accordance with another embodiment of the present disclosure.
  • FIG. 5 is a side view of the bone anchor of Fig. 4.
  • Fig. 6 is a side, cross-sectional view of the bone anchor of Fig. 2 taken across section line 6-6. UTILITY PATENT APPLICATION
  • a bone anchor 100 including a pedicle screw 1 10, a coupling 130, an insert 150, a housing 170, and a locking element 1 0.
  • the coupling 130 is positioned at a proximal end 11 1 of the pedicle screw 1 10 and the housing 170 is positioned over the coupling 130 and pedicle screw 1 10.
  • the insert 150 is then passed over the distal end 112 of the pedicle screw 1 10 and is translated distally along the shaft 1 16 of the screw 1 10 towards the housing 170.
  • the insert 150 is then engaged with a distal end 170a of the housing 170 to hold the bone anchor 100 together.
  • the locking element 190 may then be engaged with a proximal portion 170b of the housing 170 to lock the screw 1 10 in place.
  • the screw may be a top loading screw, such that an insert would not be required.
  • the screw would first be inserted through the housing.
  • the housing would be configured such that the head of the screw is inhibited from passing through the distal end of the housing.
  • the locking element may then be engaged with the housing to lock the screw in place.
  • the distal end 170a of housing 170 includes an annular body portion 172 having an opening 171 therethrough.
  • the proximal end 170b of housing 170 has a pair of upstanding fingers 174, defining a U-shaped saddle therebetween.
  • the saddle 176 is configured for receiving a portion of a rod member (not shown).
  • the opening 171 defined at distal end 170a of body portion 172 includes a generally helical thread 173 on the inner surface of body 172. Thread 173 is adapted to threadingly engage a corresponding thread 156 of the insert 150, as will be described in greater detail below.
  • each of the fingers 174 extending from housing 170 includes a portion of a generally helical thread 175 formed on the inner surface of the fingers 174.
  • the thread 175 is UTILITY PATENT APPLICATION
  • Atty. Docket: 1449-175 configured for threadably engaging a corresponding thread 192 on locking element 190.
  • the locking element 190 may be a set screw 1 0.
  • the locking element 190 may be any other threaded component or wedge component (see, for example,
  • the opening 171 at the distal end 170a of housing 170 is capable of partially receiving the coupling 130 and the pedicle screw 110, while not allowing the coupling 130 or the pedicle screw 1 10 to pass completely therethrough.
  • the distal portion 170a of housing 170 is configured to retain the coupling 130 and head portion 1 18 of screw 110 therein.
  • the coupling 130 has a generally annular body 132 at a distal end 131 thereof and an annular flange 134 at a proximal end 133 thereof.
  • the annular body 132 is shown having a hexagonally-shaped outer surface that tapers distally from the annular flange 134 to the distal end 131 of the coupling 130.
  • the annular body 132 be configured in different arrangements.
  • a plurality of outwardly extending knobs may be provided extending from the annular body 132.
  • the annular flange 134 disposed at the proximal end 133 of the coupling 130, has an outer diameter that is greater than the outer diameter of the body portion 132.
  • a recess 136 is formed in the proximal end of the coupling 130.
  • the recess 136 is configured and adapted for releasable engagement with a driving tool (not shown), as is known in the art.
  • the recess 136 is illustrated with a six-pointed star pattern, other suitable configurations corresponding to the driving tool to be used are also contemplated.
  • the pedicle screw 110 includes a shank 116 having a helical thread 114 formed thereon.
  • a cutting portion 113 is formed at a distal end 1 12 of the pedicle screw 110.
  • portion 1 18 is located at a proximal end 1 1 1 of the pedicle screw 1 10.
  • Head portion 1 18 is generally hemi-spherical in shape wherein the flat end of the hemisphere forms the proximal end 1 19 of the head portion 1 18.
  • a recess 120 is defined within the flat, proximal end 1 19 of the head portion 1 18.
  • the inner surface of the recess 120 tapers inwardly and distally and is hexagonal in shape, such that the outer surface of the body 132 of the coupling 130 and the inner surface of recess 120 of the head portion 1 18 are complementary to one another.
  • both the inner surface of the head portion 1 18 of the screw 1 10 and the outer surface of the body portion 132 of the coupling 130 may define different shapes or arrangements, as long as they are complementary to one another.
  • the head portion 1 18 would include a complementary configuration, e.g., a plurality of segments having gaps therebetween such that each gap is adapted to releasably receive a knob therein. Due to the complementary-shaped configuration, when the coupling
  • the coupling 130 is engaged within the recess 120 of the head portion 1 18 of screw 1 10, the coupling 130 and the pedicle screw 110 are rotatably coupled to one another such that rotation of the coupling 130 causes a corresponding rotation of the pedicle screw 110.
  • the insert 150 is an annular ring 152 having an opening
  • the opening 154 has a diameter that is greater than the shank
  • a generally helical thread 156 is disposed on the outer surface of the annular ring 152.
  • the threads 156 are configured to mate with the threads 173 defined on the inner proximal surface of the housing 170 (Fig. 3).
  • coupling 130 and head portion 118 are engaged via their respective complementary-shaped hexagonal surfaces. As a result, the coupling 130 is slidably received in the recess 120.
  • the tapered outer surface of body portion 132 mates with the tapered inner surface of the recess
  • the coupling 130 and the pedicle screw 1 10 are inserted into the housing 170.
  • the distal opening 171 in the housing 170 has a greater diameter than the outer diameters of either the head 1 18 or the coupling 130.
  • the insert 150 is then slid over the shank 1 16 of the pedicle screw 1 10 and threaded, or wedged, onto the distal end 170a of the housing 170.
  • the opening 154 of the insert 150 has a diameter that is less than that of the head 1 18 of the pedicle screw 1 10, thereby inhibiting the pedicle screw 1 10 from passing through the opening 154 of the insert 150.
  • the pedicle screw 1 10 and the coupling 130 are retained in the housing 170 and thereby form the assembled bone anchor 100.
  • the pedicle screw 1 10 is rotatable and pivotable in relation to the housing 170.
  • a rod member (not shown) is placed in the saddle 176 and is retained within the housing 170 using a locking, or set screw 190. As the set screw 190 is tightened against the rod member (not UTILITY PATENT APPLICATION
  • the rod member presses against the coupling 130, thereby pressing the head 118 of the pedicle screw 10 against the inner surfaces of the insert 150 and securing the pedicle screw 110 in position (i.e. locking the screw in place).
  • a bone anchor 200 is provided.
  • the bone anchor 200 includes a pedicle screw 210, a pin 230, an outer collet 250, and an inner collet 270.
  • the outer collet 250 includes an annular body portion 252 having an opening 254 extending axially therethrough.
  • the outer collet 250 includes a plurality of fingers 256 that extend proximally from the outer collet 250 and define a saddle 258 having a generally U-shaped configuration.
  • the U-shaped saddle 258 is configured and dimensioned for receiving a portion of a rod member (not shown), similar to saddle 176 of bone anchor 100.
  • the inner collet 270 has a generally cylindrical body portion 272 with an opening 274 extending axially therethrough.
  • a pair of upstanding wings 276 defines a saddle 278 having a generally U-shaped configuration.
  • the saddle 278 of inner collet 270, along with saddle 258 of outer collet 250, is configured and dimensioned for receiving a rod member (not shown).
  • the body portion 272 includes a slot 273 that extends from the nadir of the saddle 278 towards the distal end of the body portion 272 and essentially bisects the body portion 272 along a central axis, thereby defining left and right sections of the body portion 272.
  • the slot 273 does not extend all the way through the body portion 272.
  • This arrangement permits each of the wings 276 to flex towards and away from each other, thereby varying the dimensions of the saddle 278 according to the flexure of the wings 276. As the wings 276 are moved closer to each other, the saddle 278 decreases in size. On the other hand, when the wings 276 are moved away from each other, the saddle 278 increases in size. Allowing the saddle 278 to vary in size permits the inner collet 270 to accommodate rods (not shown) having differing diameters. Additionally, the UTILITY PATENT APPLICATION
  • the body portion 272 of inner collet 270 may include a plurality of grooves (not explicitly shown) that extend to the distal end of the body portion 272 and which are open at the distal end of the body portion 272.
  • the grooves extend vertically into each of the wings 276, and define front and rear portions of the body portion 272.
  • the grooves permit the front and rear sections of the body portion 272 to flex relative to one another along the axis defined by the slot 273.
  • the body portion 272 also includes a plurality of notches 277 that are open at the distal end of the body portion 272 and extend towards the wings 276.
  • the notches 277 in combination with the slot 273 and the grooves (not shown), allow arcuate sections of the body portion 272 to flex inwardly and outwardly in response to compressive and tensile forces applied to the inner collet 270.
  • the pedicle screw 210 includes a shank portion 216 having a helical thread 214 formed thereon.
  • a cutting portion 213 (Fig. 5) is formed at a distal end 212 of the pedicle screw 210.
  • a generally spherical head portion 218 is disposed at a proximal end 211 of the pedicle screw 210.
  • the head portion 218 includes a plurality of grooves 236 formed thereon and has an outer diameter that is greater than the outer diameter of the shank 216.
  • a recess 220 is formed on the proximal end 219 of the head 218, a recess 220 is formed.
  • the recess 220 is shown defining a six-pointed star configuration for receiving the operative end of a suitable driving tool (not shown), but it is contemplated that other configurations may be used.
  • a neck 217 extends between a distal end 221 of the head portion 218 and the helical thread 214 at the proximal end 211 of the shaft 216. As configured, the neck 217 is unthreaded. As shown, at least a portion of the diameter of the neck 217 is less than the diameter of the head 218 and the major diameter of the threaded portion 214 of the shank 216.
  • the inner collet 270 is seated atop the head 218 of pedicle screw 210.
  • the opening 274 at the distal end of the inner collet 270 is dimensioned and configured for receiving the head portion 218 of screw 210, as discussed above.
  • the inner collet 270 and the head 218 are rotatable and pivotable in relation to each other, thereby allowing the pedicle screw 210 to be repositioned in a plurality of orientations relative to the inner collet 270.
  • the combination of the inner collet 270 and pedicle screw 210 is inserted into the outer collet 250, which is passed over the distal end 212 of the shaft 216 and moved proximally along the shaft 216 to engage the inner collet 270.
  • the pin 230 is inserted through aperture 259 of the outer collet 250 and through slot 279 of inner collet 270 to align the inner collet 270 and the outer collet 250 for maintaining a fixed relationship
  • the pedicle screw 210 is rotatable and pivotable in relation to the inner collet 270 and the outer collet 250, which are fixed relative to one another by pin
  • the rotatable and pivotable relationship between the outer collet 250 and the screw 210 allows the screw 210 to be driven in response to a driver tool (not shown) which engages the outer collet 250 (via recess 238) even if the screw 210 is disposed at an angle relative to the outer collet 250.
  • the bone anchors 100, 200 may be composed of a range of materials.
  • Biocompatible materials include, but are not limited to, titanium, titanium alloys, stainless steel, cobalt chrome and cobalt chrome alloys, ultra high molecular weight polyethylene, PEEK (polyetheretherketone), and other polymers such as polycarbonate urethane may be used.
  • PEEK polyetheretherketone
  • other polymers such as polycarbonate urethane may be used.
  • spinal surgery strong, stiff rods, e.g.,
  • CoCr rods are used to help correct the spinal deformity.
  • the housing portion of the screw assembly may splay open or allow the rod to slip or turn in the saddle.
  • the housing, or saddle portion is formed from a strong material that provides a greater holding force on the rod.
  • CoCr is a preferred material for forming the housing portion due to its strength and stiffness.
  • CoCr Cobalt Chrome
  • the preferred material for forming the screw shank is titanium, due to its lower modulus of elasticity and
  • the screw shank and the housing from different materials, according to the requirements for those specific parts.
  • the sub- components of the housing e.g., the coupling, insert, and/or collet, need not be made from the same material.
  • the housing and set screw be made from CoCr
  • the other sub-components of the housing assembly may be made from titanium, depending on the intended usage of the bone anchor.
  • bone anchor 100 is formed from titanium or a titanium alloy while at least the housing part 170 is made of CoCr.
  • the housing part 170 is made from CoCr, which reduces splay and helps prevent the rod from slipping within the saddle 178 due to the strength and stiffness of CoCr. Further, the strength of CoCr allows housing part 170 to have a reduced thickness, or volume, while maintaining the structural integrity of the housing part 170.
  • the screw 1 10, on the other hand, is constructed from titanium, which facilitates insertion and retention within bone due to its elasticity and biocompatible properties.
  • the coupling 130, the insert 150, and the set screw 190 may each be made from one of CoCr, titanium or, titanium alloy.
  • screw 210 is made from titanium or titanium alloy, while the inner collet 270 and the outer collet 250 UTILITY PATENT APPLICATION
  • Atty. Docket: 1449-175 are made from either cobalt chrome (CoCr), titanium, or titanium alloy.
  • CoCr cobalt chrome
  • Other materials are also contemplated for forming the components of bone anchors 100, 200, such that different materials may be used to form any or all of the components based upon the desired characteristics, e.g., strength or elasticity, of the specific component.

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  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention a trait à un ancrage d'os qui comprend une vis dotée d'une partie de tige filetée et d'une partie de tête et un boîtier. Au moins la partie de tige filetée est constituée de titane ou d'un alliage de titane et au moins une partie du boîtier est constituée d'un matériau plus résistant tel que le chrome et le cobalt. Le boîtier est équipé d'une voie de passage s'étendant à travers celui-ci et d'une extrémité proximale ainsi que d'une extrémité distale. Une selle est définie à l'intérieur de l'extrémité proximale du boîtier et est configurée de manière à retenir une partie de la tige à l'intérieur de celle-ci. L'extrémité distale du boîtier est configurée de manière à mettre en prise de façon ferme la partie de tête de la vis de sorte que la vis est tournante et/ou pivotante par rapport au boîtier.
PCT/US2010/025739 2010-03-01 2010-03-01 Ensemble vis à os constitué d'un matériau non uniforme WO2011109009A1 (fr)

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PCT/US2010/025739 WO2011109009A1 (fr) 2010-03-01 2010-03-01 Ensemble vis à os constitué d'un matériau non uniforme

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PCT/US2010/025739 WO2011109009A1 (fr) 2010-03-01 2010-03-01 Ensemble vis à os constitué d'un matériau non uniforme

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014111555A1 (fr) * 2013-01-21 2014-07-24 Aesculap Ag Système d'implant et élément de fixation pour un système d'implant
US9713488B2 (en) 2008-02-04 2017-07-25 Medos International Sarl Methods for correction of spinal deformities
US9724130B2 (en) 2013-03-14 2017-08-08 Medos International Sarl Locking compression members for use with bone anchor assemblies and methods
US9724145B2 (en) 2013-03-14 2017-08-08 Medos International Sarl Bone anchor assemblies with multiple component bottom loading bone anchors
US9775660B2 (en) 2013-03-14 2017-10-03 DePuy Synthes Products, Inc. Bottom-loading bone anchor assemblies and methods
US9782204B2 (en) 2012-09-28 2017-10-10 Medos International Sarl Bone anchor assemblies
US9918747B2 (en) 2013-03-14 2018-03-20 DePuy Synthes Products, Inc. Bone anchor assemblies and methods with improved locking
US10342582B2 (en) 2013-03-14 2019-07-09 DePuy Synthes Products, Inc. Bone anchor assemblies and methods with improved locking
US10363073B2 (en) 2016-07-13 2019-07-30 Medos International Sàrl Bone anchor assemblies and related instrumentation
US10463402B2 (en) 2016-07-13 2019-11-05 Medos International Sàrl Bone anchor assemblies and related instrumentation
US10568667B2 (en) 2016-07-13 2020-02-25 Medos International Sàrl Bone anchor assemblies and related instrumentation
US10874438B2 (en) 2016-07-13 2020-12-29 Medos International Sarl Bone anchor assemblies and related instrumentation
US12127766B2 (en) 2021-03-05 2024-10-29 Medos International Sàrl Selectively locking polyaxial screw

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090182384A1 (en) * 2008-01-14 2009-07-16 Warsaw Orthopedic, Inc. Material combinations for medical device implants

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090182384A1 (en) * 2008-01-14 2009-07-16 Warsaw Orthopedic, Inc. Material combinations for medical device implants

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10201377B2 (en) 2008-02-04 2019-02-12 Medos International Sarl Methods for correction of spinal deformities
US9713488B2 (en) 2008-02-04 2017-07-25 Medos International Sarl Methods for correction of spinal deformities
US10987145B2 (en) 2008-02-04 2021-04-27 Medos International Sarl Methods for correction of spinal deformities
US10786284B2 (en) 2012-09-28 2020-09-29 Medos International Sarl Bone anchor assemblies
US9782204B2 (en) 2012-09-28 2017-10-10 Medos International Sarl Bone anchor assemblies
US10226282B2 (en) 2012-09-28 2019-03-12 Medos International Sarl Bone anchor assemblies
WO2014111555A1 (fr) * 2013-01-21 2014-07-24 Aesculap Ag Système d'implant et élément de fixation pour un système d'implant
US10987138B2 (en) 2013-03-14 2021-04-27 Medos International Sari Locking compression members for use with bone anchor assemblies and methods
US11311318B2 (en) 2013-03-14 2022-04-26 DePuy Synthes Products, Inc. Bone anchor assemblies and methods with improved locking
US10238441B2 (en) 2013-03-14 2019-03-26 Medos International Sàrl Bottom-loading bone anchor assemblies and methods
US10321938B2 (en) 2013-03-14 2019-06-18 Medos International Sàrl Locking compression members for use with bone anchor assemblies and methods
US10342582B2 (en) 2013-03-14 2019-07-09 DePuy Synthes Products, Inc. Bone anchor assemblies and methods with improved locking
US12082852B2 (en) 2013-03-14 2024-09-10 Medos International Sàrl Locking compression members for use with bone anchor assemblies and methods
US10413342B2 (en) 2013-03-14 2019-09-17 Medos International Sárl Bone anchor assemblies with multiple component bottom loading bone anchors
US9918747B2 (en) 2013-03-14 2018-03-20 DePuy Synthes Products, Inc. Bone anchor assemblies and methods with improved locking
US9724130B2 (en) 2013-03-14 2017-08-08 Medos International Sarl Locking compression members for use with bone anchor assemblies and methods
US9775660B2 (en) 2013-03-14 2017-10-03 DePuy Synthes Products, Inc. Bottom-loading bone anchor assemblies and methods
US9724145B2 (en) 2013-03-14 2017-08-08 Medos International Sarl Bone anchor assemblies with multiple component bottom loading bone anchors
US10874438B2 (en) 2016-07-13 2020-12-29 Medos International Sarl Bone anchor assemblies and related instrumentation
US10568667B2 (en) 2016-07-13 2020-02-25 Medos International Sàrl Bone anchor assemblies and related instrumentation
US10463402B2 (en) 2016-07-13 2019-11-05 Medos International Sàrl Bone anchor assemblies and related instrumentation
US11839411B2 (en) 2016-07-13 2023-12-12 Medos International Sarl Bone anchor assemblies and related instrumentation
US10363073B2 (en) 2016-07-13 2019-07-30 Medos International Sàrl Bone anchor assemblies and related instrumentation
US12127766B2 (en) 2021-03-05 2024-10-29 Medos International Sàrl Selectively locking polyaxial screw

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