WO2011107973A3 - Method for prediction of human iris color - Google Patents

Method for prediction of human iris color Download PDF

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Publication number
WO2011107973A3
WO2011107973A3 PCT/IB2011/050951 IB2011050951W WO2011107973A3 WO 2011107973 A3 WO2011107973 A3 WO 2011107973A3 IB 2011050951 W IB2011050951 W IB 2011050951W WO 2011107973 A3 WO2011107973 A3 WO 2011107973A3
Authority
WO
WIPO (PCT)
Prior art keywords
iris color
predicting
nucleic acid
prediction
human
Prior art date
Application number
PCT/IB2011/050951
Other languages
French (fr)
Other versions
WO2011107973A2 (en
Inventor
Manfred Heinz Kayser
Fan Liu
Albert Hofman
Andreas Gerardus Uitterlinden
Original Assignee
Erasmus University Medical Center Rotterdam
Identitas, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erasmus University Medical Center Rotterdam, Identitas, Inc. filed Critical Erasmus University Medical Center Rotterdam
Publication of WO2011107973A2 publication Critical patent/WO2011107973A2/en
Publication of WO2011107973A3 publication Critical patent/WO2011107973A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A method for predicting the iris color of a human, the method comprising: (a) obtaining a sample of the nucleic acid of the human; (b) genotyping the nucleic acid for the single nucleotide polymorphism (SNP) rs 12913832 or a polymorphic site which is in linkage disequilibrium with rs12913832 at an r2 value of at least 0.9; and genotyping the nucleic acid for at least one of the following polymorphisms: (i) a SNP selected from the group consisting of rs1800407, rs12896399, rs12203592, rs1325127, rs1393350, rs728405, rs1129038, and a polymorphic site which is in linkage disequilibrium with one of said SNPs at an r2 value of at least 0.5 (c) predicting at least one quantitative color parameter of the iris as a numericvariable based on the results of step (b), and thereby predicting the iris color.
PCT/IB2011/050951 2010-03-05 2011-03-07 Method for prediction of human iris color WO2011107973A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31124910P 2010-03-05 2010-03-05
US61/311,249 2010-03-05
US33133010P 2010-05-04 2010-05-04
US61/331,330 2010-05-04

Publications (2)

Publication Number Publication Date
WO2011107973A2 WO2011107973A2 (en) 2011-09-09
WO2011107973A3 true WO2011107973A3 (en) 2012-04-26

Family

ID=44542665

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/050951 WO2011107973A2 (en) 2010-03-05 2011-03-07 Method for prediction of human iris color

Country Status (1)

Country Link
WO (1) WO2011107973A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2012793A3 (en) * 2012-11-15 2014-04-09 Univerzita Karlova v Praze, Lékařská fakulta v Plzni Prediction method of visible phenotype markers and biogeographical origin, especially for forensic purposes
CN116087338B (en) * 2023-04-10 2023-07-14 四川省地质矿产勘查开发局一0六地质队 Construction method of rock brittle fracture precursor index

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080027756A1 (en) * 2006-06-30 2008-01-31 Richard Gabriel Systems and methods for identifying and tracking individuals

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080027756A1 (en) * 2006-06-30 2008-01-31 Richard Gabriel Systems and methods for identifying and tracking individuals

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STURM ET AL.: "A Single SNP in an Evolutionary Conserved Region within Intron 86 of the HERC2 Gene Determines Human Blue-Brown Eye Color.", AM J HUM GENET., vol. 82, February 2008 (2008-02-01), pages 424 - 431, XP009100453, DOI: doi:10.1016/j.ajhg.2007.11.005 *

Also Published As

Publication number Publication date
WO2011107973A2 (en) 2011-09-09

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