WO2011098458A3 - Method for reconstructing a histological volume and measuring device - Google Patents

Method for reconstructing a histological volume and measuring device Download PDF

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Publication number
WO2011098458A3
WO2011098458A3 PCT/EP2011/051839 EP2011051839W WO2011098458A3 WO 2011098458 A3 WO2011098458 A3 WO 2011098458A3 EP 2011051839 W EP2011051839 W EP 2011051839W WO 2011098458 A3 WO2011098458 A3 WO 2011098458A3
Authority
WO
WIPO (PCT)
Prior art keywords
histological
sectional
volume
tissue sample
recorded
Prior art date
Application number
PCT/EP2011/051839
Other languages
German (de)
French (fr)
Other versions
WO2011098458A2 (en
Inventor
Martin Groher
Jose Gardiazabal-Schilling
Marco Feuerstein
Tim Hauke Heibel
Original Assignee
Technische Universität München
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universität München filed Critical Technische Universität München
Publication of WO2011098458A2 publication Critical patent/WO2011098458A2/en
Publication of WO2011098458A3 publication Critical patent/WO2011098458A3/en

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Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T19/00—Manipulating 3D models or images for computer graphics
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/33—Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2200/00—Indexing scheme for image data processing or generation, in general
    • G06T2200/08—Indexing scheme for image data processing or generation, in general involving all processing steps from image acquisition to 3D model generation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10016—Video; Image sequence
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2210/00—Indexing scheme for image generation or computer graphics
    • G06T2210/41—Medical

Abstract

The invention provides a measuring system and to a method for reconstructing a histological volume from a stack of consecutive sectional images of a tissue sample. After the tissue sample has been provided, a reference image of the cross-sectional surface of the tissue sample is recorded and stored. A histological layer is removed from the cross-sectional surface of the tissue sample by means of a microtome and mounted on a substrate. A sectional image of the histological layer mounted on the substrate is then recorded. The recorded sectional image is geometrically aligned with the stored reference image and the aligned sectional image is associated with at least one further recorded sectional image of a histological layer in order to combine sectional images which have been associated with each other and aligned to form the histological volume.
PCT/EP2011/051839 2010-02-09 2011-02-08 Method for reconstructing a histological volume and measuring device WO2011098458A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102010007264.8 2010-02-09
DE102010007264 2010-02-09
DE102010037059.2 2010-08-18
DE102010037059 2010-08-18

Publications (2)

Publication Number Publication Date
WO2011098458A2 WO2011098458A2 (en) 2011-08-18
WO2011098458A3 true WO2011098458A3 (en) 2012-09-07

Family

ID=44368218

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/051839 WO2011098458A2 (en) 2010-02-09 2011-02-08 Method for reconstructing a histological volume and measuring device

Country Status (1)

Country Link
WO (1) WO2011098458A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113848085A (en) * 2021-08-12 2021-12-28 澎立检测技术(上海)有限公司 Pathological hard tissue section system

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANONYM: "Bildregistrierung", 11 December 2009 (2009-12-11), pages 1 - 4, XP002678900, Retrieved from the Internet <URL:http://de.wikipedia.org/w/index.php?title=Bildregistrierung&oldid=67855808> [retrieved on 20120720] *
ANONYMOUS: "AxioCam MRc 5 - Digitale Freiräume", 17 July 2009 (2009-07-17), pages 1 - 6, XP055031344, Retrieved from the Internet <URL:http://www.zeiss.de/C125792900358A3F/0/3A3822FEC18F415DC12579E5002DED90/$FILE/48-0026_D.pdf> [retrieved on 20120629] *
DAUGUET J ET AL: "Three-dimensional reconstruction of stained histological slices and 3D non-linear registration with in-vivo MRI for whole baboon brain", JOURNAL OF NEUROSCIENCE METHODS, ELSEVIER SCIENCE PUBLISHER B.V., AMSTERDAM, NL, vol. 164, no. 1, 15 August 2007 (2007-08-15), pages 191 - 204, XP026021017, ISSN: 0165-0270, [retrieved on 20070815], DOI: 10.1016/J.JNEUMETH.2007.04.017 *
DEUTINGER SUSANNE TINA: "Zum Einfluss elektromagnetischer Befeldung mit Mobilfunkstrahlen auf die Zahl der CA1-Neuronen im Hippocampus der Ratte", 17 July 2009 (2009-07-17), pages 1 - 108, XP055029298, Retrieved from the Internet <URL:http://edoc.ub.uni-muenchen.de/10635/1/Deutinger_Tina_Susanne.pdf> [retrieved on 20120608] *
S. OURSELIN ET AL: "Reconstructing a 3D structure from serial histological sections", IMAGE AND VISION COMPUTING 19 (2000) 25-31, 31 December 2000 (2000-12-31), pages 25 - 31, XP055029377, Retrieved from the Internet <URL:http://ac.els-cdn.com/S0262885600000524/1-s2.0-S0262885600000524-main.pdf?_tid=a55d9c40c458d8c8179eaf7784718cbf&acdnat=1339164048_93056714d476d4697b91a83a014df2ee> [retrieved on 20120608] *
TOM NEUBERT: "MIKROTOM - Image Acquisition Software", 21 March 2005 (2005-03-21), pages 1 - 10, XP055028783, Retrieved from the Internet <URL:http://www2.fz-juelich.de/zel/datapool/page/152/mikrotom.pdf> [retrieved on 20120604] *

Also Published As

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