WO2011097870A1 - 一体化共聚焦显微硬质内镜系统 - Google Patents

一体化共聚焦显微硬质内镜系统 Download PDF

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Publication number
WO2011097870A1
WO2011097870A1 PCT/CN2010/075583 CN2010075583W WO2011097870A1 WO 2011097870 A1 WO2011097870 A1 WO 2011097870A1 CN 2010075583 W CN2010075583 W CN 2010075583W WO 2011097870 A1 WO2011097870 A1 WO 2011097870A1
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Prior art keywords
confocal microscopic
confocal
integrated
microscopic
hard
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PCT/CN2010/075583
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English (en)
French (fr)
Inventor
乔铁
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广州市番禺区胆囊病研究所
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Priority claimed from CN201010116272A external-priority patent/CN101803902A/zh
Priority claimed from CN2010101162861A external-priority patent/CN101779947B/zh
Priority claimed from CN201010116274A external-priority patent/CN101803900A/zh
Priority claimed from CN201010116240A external-priority patent/CN101779972A/zh
Application filed by 广州市番禺区胆囊病研究所 filed Critical 广州市番禺区胆囊病研究所
Publication of WO2011097870A1 publication Critical patent/WO2011097870A1/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/307Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the urinary organs, e.g. urethroscopes, cystoscopes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • G02B21/002Scanning microscopes
    • G02B21/0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0028Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407Optical details
    • G02B23/2423Optical details of the distal end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/04Endoscopic instruments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062Arrangements for scanning
    • A61B5/0068Confocal scanning

Definitions

  • the invention relates to an integrated confocal microscopic rigid endoscope system, belonging to the field of medical instruments. Background technique
  • endoscopic technology has been widely used in clinical practice and has become an important tool for the diagnosis and treatment of diseases.
  • the endoscope can enter the human body through the natural hole of the human body or through the surgical incision.
  • the doctor can observe the lesion in the body through the endoscope, and take effective treatment.
  • the ultrastructure of cells cannot be observed by conventional endoscopes.
  • doctors often remove the diseased tissue from the human body and send it to the pathology department for morphological observation. This process takes a long time, and it is often difficult to accurately determine the biopsy site when taking biopsy, which is not conducive to timely clinical diagnosis and treatment.
  • confocal microscopy As a new imaging technology, confocal microscopy has been widely used in biological research. Its application fields have been extended to cytology, microbiology, developmental biology, genetics, neurobiology, physiology and In the research work of pathology and other disciplines, it has become an important tool for microscopic research in modern biology. Therefore, how to use confocal microscopy imaging technology, micro-laser technology and endoscopic technology to achieve accurate positioning and qualitative examination of patients in the case of living tissue is particularly urgent. Summary of the invention
  • the object of the present invention is to organically combine confocal microscopy technology with a hard endoscope to provide an integrated confocal microscopic hard endoscope system, which is integrated confocal display.
  • the micro-hard endoscope system enables the operator to accurately determine the biopsy site, while observing the macroscopic and microscopic conditions of the biopsy site, and performing on-the-spot analysis and detection of suspicious lesions at the same time of current operation and examination, overcoming the random biopsy Disadvantages can help improve clinical treatment and reduce medical costs.
  • the integrated confocal microscopic rigid endoscope system of the present invention comprises a confocal microscopic hard endoscope, a cold light source host, a system processor, an endoscopic image monitor, and a confocal microscopic display;
  • the confocal microscopic hard endoscope includes a surgical end and an operating end; the surgical end is integrated with a confocal microscopic laser head, a confocal microscope head, a light guiding fiber and an endoscope lens on the end surface thereof to form an integral body Confocal microscopic hard endoscope;
  • the operating end is provided with a cold light source input end and an image data output end, and the cold light source input end is connected to the cold light source host, the image a data output end and the endoscopic image monitor and the confocal microscopic display are respectively connected to the system processor, thereby
  • the image data collected by the endoscopic lens and the confocal microscope head are respectively transmitted to the endoscopic image monitor and the confocal micr
  • the integrated confocal microscopic rigid endoscope system of the present invention may further comprise a system keyboard, and the system keyboard is connected with the system processor to realize integrated confocal display through keyboard operation. Control of the micro-hard endoscope system.
  • control unit of the confocal microscopic hard endoscope may further be provided with a control unit, and the control unit is provided with a confocal micro switch, an image freeze switch and a zoom adjustment switch, Convenient for doctors to control confocal microscopy.
  • the system processor may include a camera host and a confocal microscope host, and the operation end of the confocal microscopic hard endoscope may further be provided with an eyepiece output end;
  • the output end and the endoscopic image monitor are coupled to the camera host, and the image data output end and the confocal microscopic display are coupled to the confocal microscope host.
  • the image data output end can be designed to be at an angle of 45 to the longitudinal central axis of the confocal microscopic rigid endoscope, thereby improving the stability and graspability of the surgical procedure.
  • the confocal microscopic hard endoscope may be a confocal microscopic hard electronic arthroscope, a confocal microscopic hard cholecystoscope, a confocal microscopic rigid cystoscope or a confocal microscopy. Hard hysteroscopy and so on.
  • the present invention has the following beneficial effects:
  • the integrated confocal microscopic hard endoscope system of the present invention introduces an advanced confocal microscopy technique based on a hard endoscope, and designs the hardware part of the confocal microscope system in a hard endoscope.
  • the external system processor In the external system processor, the original structure of the rigid endoscope is maintained, and the hard endoscope has a good handling shape, which can solve the inconvenience caused by the confocal display of the Microsoft endoscope due to the large volume of the hardware.
  • the integrated confocal microscopic rigid endoscope of the invention also has an instrument channel therethrough, which is a rigid endoscope with a surgical treatment function, and which maintains the characteristics of the hard working end, which is beneficial to Doctors use endoscopy for surgery, which is superior to soft endoscopes, especially for the treatment of lesions, and is rugged, low-cost, easy to clean and disinfect.
  • DRAWINGS 1 is a schematic structural view of an integrated confocal microscopic hard electronic arthroscope system according to an embodiment of the present invention.
  • 2 is a schematic view showing the end face structure of a confocal microscopic hard electronic arthroscope according to an embodiment of the present invention.
  • FIG. 3 is a schematic view showing the operation of the integrated confocal microscopic hard electronic arthroscope system according to an embodiment of the present invention
  • FIG. 4 is a schematic structural view of an integrated confocal microscopic hard gallbladder mirror system according to an embodiment of the present invention.
  • Fig. 5 is a schematic view showing the end face structure of a confocal microscopic hard gallbladder mirror according to an embodiment of the present invention.
  • Fig. 6 is a schematic view showing the surgical use of the integrated confocal microscopic hard gallbladder mirror system according to the embodiment of the present invention.
  • Figure 7 is a schematic view showing the structure of an integrated confocal microscopic rigid cystoscope system according to an embodiment of the present invention.
  • Fig. 8 is a schematic view showing the end face structure of a confocal microscopic rigid cystoscope according to an embodiment of the present invention.
  • FIG. 9 is a schematic view showing the surgical use of the integrated confocal microscopic rigid cystoscope system according to the embodiment of the present invention.
  • FIG. 10 is a schematic structural view of an integrated confocal microscopic hard hysteroscope system according to Embodiment 4 of the present invention.
  • FIG. 11 is a schematic view showing the end face structure of a confocal microscopic hard hysteroscope according to Embodiment 4 of the present invention. detailed description
  • Embodiment 1 Integrated Confocal Microscopic Hard Electronic Arthroscopy System
  • the integrated confocal microscopic hard electronic arthroscopy system of the present invention comprises a confocal microscopic hard electronic arthroscope 11, a cold light source host 12, a system processor 13, a system keyboard 14, and an internal Mirror image monitor 15 and confocal microscopy display 16.
  • the confocal microscopic hard electronic arthroscope 11 includes a surgical end 11A and an operating end 11B, wherein the operating end 11B is provided with a cold light source input end 111, an image data output end 112 and a control unit 113, and the length of the surgical end 11A It is about 150mm ⁇ 200mm and has a diameter of 8.0mm.
  • the system keyboard 14 is connected to the system processor 13, and the doctor can operate the system through the keyboard.
  • the cold light source input terminal 111 is connected to the cold light source host 12.
  • the image data output terminal 112, the endoscopic image monitor 15 and the confocal microscopic display 16 are respectively connected to the system processor 13 via data lines, thereby collecting endoscopic image data collected by the confocal microscopic hard electronic arthroscope 11.
  • the confocal microscopy image data is transmitted to the endoscopic image monitor 15 and the confocal microscopic display 16, respectively.
  • the control unit 113 is made of a waterproof and high temperature resistant material, and has a confocal microscopic switch, an image freeze switch and a zoom adjustment switch to facilitate the doctor's control of confocal microscopy.
  • the confocal microscopic hard electronic arthroscope 11 is further provided with an instrument passage 114 extending therethrough.
  • the mechanical passage 114 is a linear instrument passage having a diameter of 3.0 mm and an opening 115 at the end face of the surgical end 11A.
  • the image data output 112 is designed to be at an angle of 45 to the longitudinal center axis of the confocal microscopic arthroscope 11.
  • the confocal microscopic hard electronic arthroscope 11 is further integrated with a confocal microscopic laser head 116, a confocal microscope head 117, a light guiding optical fiber 118, and an endoscopic lens 119 on the end surface of the surgical end 11A.
  • a confocal microscopic laser head 116 a confocal microscope head 117
  • a light guiding optical fiber 118 a light guiding optical fiber 118
  • an endoscopic lens 119 on the end surface of the surgical end 11A.
  • the confocal microscopic hard electronic arthroscope 11 is mounted with a high-resolution CCD chip at the end of its surgical end 11A, which has a size of 1/4" and an effective pixel of at least 480,000.
  • the field angle is 100°.
  • the endoscopic image data collected by the endoscope lens 119 is transmitted to the endoscopic image monitor 15 through the image data output terminal 112 and the system processor 13, and the confocal microscope head 117 collects the confocal microscope. Image data is then transmitted to the confocal microscopy display 16 via image data output 112 and system processor 13.
  • FIG. 3 is a schematic view showing the surgical use of the integrated confocal microscopic hard electronic arthroscope system of the present embodiment.
  • the doctor Before surgery, the doctor needs to intravenously inject sodium fluorescein into the patient. During the operation, the doctor makes a small incision in the affected part of the patient's joint 17 and then inserts the confocal microscopic hard arthroscope 11 into it, and the endoscopic image monitor 15 can observe the lesion of the patient's joint.
  • the confocal microscopic laser head 116 of the confocal microscopic hard electronic arthroscope 11 can be caused to emit a blue laser having a wavelength of 488 nm by operating the control unit 113.
  • a clear confocal microscopy image is obtained on the confocal microscopy display 16 by interacting with the sodium fluorescein in the affected area of the patient's joint.
  • the doctor can perform a living body test with the help of the confocal microscopic hard electronic arthroscope 11, and immediately diagnose and treat the lesion of the joint tissue.
  • Example 2 Integrated confocal microscopic hard gallbladder mirror system
  • the integrated confocal microscopic hard gallbladder mirror system of the present invention comprises a confocal microscopic hard gallbladder mirror 21, a cold light source host 22, a camera host 23A, a confocal microscope host 23B, and a system. Keyboard 24, endoscopic image monitor 25 and confocal microscopy display 26.
  • the confocal microscopic hard gallbladder mirror 21 includes a surgical end 21A and an operating end 21B, wherein the operating end 21B is provided with a cold light source input end 211, an image data output end 212, an eyepiece output end 213 and a control unit 214, and the operation
  • the end 21 A has a length of about 250 mm to 300 mm and a diameter of 10 mm.
  • the system keyboard 24 is connected to the camera host 23 A and the confocal microscope host 23B, and the doctor can operate the system through the keyboard operation.
  • the cold light source input end 211 is connected to the cold light source host 22.
  • the eyepiece output end 213 is disposed on the longitudinal center axis of the confocal microscopic hard gallbladder mirror 21.
  • the eyepiece output end 213 and the endoscopic image monitor 25 are connected to the imaging host 23A via data lines, respectively, so that the endoscopic image data collected by the confocal microscopic hard gallbladder mirror 21 is transmitted to the endoscopic image monitor 25.
  • the image data output terminal 212 and the confocal microscopic display 26 are respectively connected to the confocal microscope host 23B through the data line, thereby transmitting the confocal microscopic image data collected by the confocal microscopic hard gallbladder mirror 21 to the confocal display.
  • On the microdisplay 26 On the microdisplay 26.
  • the control unit 214 is made of a waterproof and high temperature resistant material, and has a confocal microscopic switch, an image freeze switch and a zoom adjustment switch to facilitate the doctor to perform confocal microscopy control.
  • the confocal microhard cholecystoscope 21 is also provided with two instrument channels 215 extending therethrough and having a diameter of 2.8 mm.
  • the instrument channel 215 is provided with an opening 215' on the end face of the surgical end 21A.
  • the image data output 212 is designed to be at an angle of 45 to the longitudinal center axis of the confocal microhard cholecystoscope 21. As shown in FIG.
  • the confocal microscopic hard gallbladder mirror 21 is further integrated with a confocal microscopic laser head 216, a confocal microscope head 217, a light guiding fiber 218, and an endoscope lens 219 on the end surface of the surgical end 21A. Thereby forming an integrated confocal microscopic hard gallbladder mirror.
  • the endoscope lens 219 adopts an optical lens with a diameter of 2.8 mm, and the acquired endoscopic image data is transmitted to the endoscopic image monitor 25 through the eyepiece output end 213 and the camera host 23 A, and the confocal microscope head 217 collects a total of The focused microscopic image data is transmitted to the confocal microscopy display 26 via the image data output 212 and confocal microscope host 23B.
  • Fig. 6 is a schematic view showing the surgical use of the integrated confocal microscopic hard gallbladder mirror system of the present embodiment.
  • the doctor Before surgery, the doctor needs to inject fluorescein intravenously into the patient. During the surgical operation, the doctor makes a small incision at the bottom 27 of the patient's gallbladder, and then inserts the confocal microhard cholecystoscope 21 into it, and the endoscopic image monitor 25 can observe the stone in the patient's gallbladder, and All of the stones in the gallbladder can be removed through the instrument channel 215.
  • the confocal microscopy laser head 216 of the confocal microscopic hard gallbladder mirror 21 can emit a blue laser having a wavelength of 488 nm by operating the control unit 214, the blue laser and the patient's gallbladder.
  • a clear confocal microscopy image can be obtained on the confocal microscopy display 26 by the action of the sodium fluorescein phase in the mucosal tissue.
  • the doctor can perform a living body test with the help of the confocal microscopic hard cholangioscope 21, and immediately diagnose and treat the lesion of the gallbladder mucosa.
  • Example 3 Integrated Confocal Microscopy Hard Cystoscope System
  • the integrated confocal microscopic rigid cystoscope system of the present invention comprises a confocal microscopic rigid cystoscope 31, a cold light source host 32, a camera host 33A, a confocal microscope host 33B, and a system. Keyboard 34, endoscopic image monitor 35 and confocal microscopy display 36.
  • the confocal microscopic rigid cystoscope 31 includes a surgical end 31A and an operating end 31B.
  • the operating end 31B is provided with a cold light source input end 311, an image data output end 312, an eyepiece output end 313 and a control unit 314.
  • the outer side of 31A is surrounded by a sheath portion 310, and the sheath portion 310 is further provided with a water inlet passage 3101 and a water outlet passage 3102 extending therethrough, and the end portion of the sheath portion 310 is curved and blunt.
  • the length of the surgical end 31A is approximately 220 mm to 270 mm and the diameter is 9.0 mm; and the sheath portion 310 has a length of approximately 180 mm to 220 mm and a diameter of 10.0 mm.
  • the system keyboard 34 is connected to the camera host 33A and the confocal microscope host 33B, and the doctor can operate the system by keyboard operation.
  • the cold light source input end 311 is coupled to the cold light source host 32.
  • the eyepiece output 313 is disposed on the longitudinal center axis of the confocal microscopic rigid cystoscope 31.
  • the eyepiece output end 313 and the endoscopic image monitor 35 are connected to the imaging host 33A via data lines, respectively, so that the endoscopic image data collected by the confocal microscopic rigid cystoscope 31 is transmitted to the endoscopic image monitor 35.
  • the image data output terminal 312 and the confocal microscopic display 36 are respectively connected to the confocal microscope host 33B through the data line, thereby transmitting the confocal microscopic image data collected by the confocal microscopic rigid cystoscope 31 to the confocal display.
  • On the microdisplay 36 On the microdisplay 36.
  • the control unit 314 is made of a waterproof and high temperature resistant material, and is provided with a confocal microscopic switch, an image freeze switch and a zoom adjustment switch to facilitate the doctor to perform confocal microscopy control.
  • Confocal microhard The cystoscope 31 is also provided with three instrument passages 315 extending therethrough and having a diameter of 2.0 mm.
  • the instrument passage 315 is provided with an opening 315' on the end face of the surgical end 31A.
  • the image data output 312 is designed to be at an angle of 45 to the longitudinal center axis of the confocal microscopic rigid cystoscope 31.
  • the confocal microscopic rigid cystoscope 31 further integrates a confocal microscopic laser head 316, a confocal microscope head 317, a light guiding optical fiber 318, and an endoscopic lens 319 on the end surface of the surgical end 31A.
  • the endoscope lens 319 adopts an optical lens with a diameter of 1.9 mm
  • the acquired endoscopic image data is transmitted to the endoscopic image monitor 35 through the eyepiece output terminal 313 and the camera host 33A
  • the confocal microscope head 317 collects the confocal lens.
  • the microscopic image data is transmitted to the confocal microscopy display 36 via the image data output 312 and the confocal microscope host 33B.
  • Fig. 9 is a schematic view showing the surgical use of the integrated confocal microscopic rigid cystoscope system according to the embodiment.
  • the doctor Before surgery, the doctor needs to inject fluorescein intravenously into the patient.
  • the doctor inserts the confocal microscopic rigid cystoscope 31 into the bladder cavity 37 from the patient's urethral opening, and the lesion in the bladder cavity 37 is observed by the endoscopic image monitor 35.
  • the confocal microscopic laser head 316 of the confocal microscopic rigid cystoscope 31 can emit a blue laser having a wavelength of 488 nm by operating the control unit 314, the blue laser and the patient
  • a clear confocal microscopy image can be obtained on the confocal microscopy display 36 by the action of the sodium fluorescein phase in the mucosal tissue of the bladder wall.
  • the doctor can perform a living body test with the help of the confocal microscopic rigid cystoscope 31, and immediately diagnose and treat the lesions of the mucosa of the bladder wall.
  • Example 4 Integrated Confocal Microsurgical Hard Hysteroscopic System
  • the integrated confocal microhard hysteroscopy system of the present invention comprises a confocal microscopic hard hysteroscope 41, a cold light source host 42, a camera host 43A, and a confocal microscope host 43B.
  • the confocal microscopic hard hysteroscope 41 includes a surgical end 41A and an operating end 41B.
  • the operating end 41B is provided with a cold light source input end 411, an image data output end 412, an eyepiece output end 413 and a control unit 414.
  • the outer side of the end 41A is surrounded by a sheath portion 410.
  • the sheath portion 410 is further provided with a water inlet passage 4101 and a water outlet passage 4102 extending therethrough, and the end portion of the sheath portion 410 is of a blunt design.
  • the length of the surgical end 41A is approximately 250 mm to 300 mm, and the diameter is 10.0 mm; and the diameter of the sheath portion 410 is 12.0 mm.
  • the system keyboard 44 is connected to the camera host 43A and the confocal microscope host 43B, and the doctor can operate the system by keyboard operation.
  • the cold light source input terminal 411 is coupled to the cold light source host 42.
  • the eyepiece output end 413 is disposed on the longitudinal center axis of the confocal microscopic hard hysteroscope 41.
  • the eyepiece output end 413 and the endoscopic image monitor 45 are respectively connected to the camera host 43A through the data line, thereby transmitting the endoscopic image data collected by the confocal microscopic hard hysteroscope 41 to the endoscopic image monitor 45.
  • the image data output terminal 412 and the confocal microscopic display 46 are respectively connected to the confocal microscope host 43B via data lines, thereby The confocal microscopy image data acquired by the focused microhard hysteroscope 41 is transmitted to the confocal microscopic display 46.
  • the control unit 414 is made of a waterproof and high temperature resistant material, and is provided with a confocal microscopic switch, an image freeze switch and a zoom adjustment switch to facilitate the doctor to perform confocal microscopy control.
  • the confocal microscopic hard hysteroscope 41 is also provided with two instrument channels 415 extending therethrough and having a diameter of 2.8 mm.
  • the instrument channel 415 is provided with an opening 415' on the end face of the surgical end 41A.
  • the image data output 412 is designed to be at an angle of 45 to the longitudinal center axis of the confocal microscopic hard hysteroscope 41.
  • the confocal microscopic hard hysteroscope 41 is further integrated with a confocal microscopic laser head 416, a confocal microscope head 417, a light guiding optical fiber 418, and an endoscopic lens 419 on the end surface of the surgical end 41A.
  • a confocal microscopic laser head 416 a confocal microscope head 417
  • a light guiding optical fiber 418 a light guiding optical fiber 418
  • an endoscopic lens 419 on the end surface of the surgical end 41A.
  • the endoscope lens 419 is an optical lens having a diameter of 2.8 mm, and the acquired endoscopic image data is transmitted to the endoscopic image monitor 45 through the eyepiece output terminal 413 and the camera host 43 A, and the confocal microscope head 417 collects a total of The focused microscopic image data is transmitted to the confocal microscopic display 46 via the image data output 412 and the confocal microscope host 43B.

Description

一体化共聚焦显微硬质内镜系统 技术领域
本发明涉及一种一体化共聚焦显微硬质内镜系统, 属于医疗器械领域。 背景技术
目前, 内窥镜技术在临床上已经得到广泛的应用, 成为诊治疾病的一项重要工具。 内窥 镜可以经人体的天然孔道或者经手术切口进入人体内, 医生通过内窥镜可观察到体内的病变 情况, 从而采取有效的治疗手段。 然而, 通过传统的内窥镜尚无法观察到细胞的超微结构, 对于不能确诊、 需要进行活检的情况, 医生往往通过手术从人体内取出病变组织, 再送到病 理科进行形态学观察。 这个过程需要花费较长的时间, 而且取活检时往往难以准确确定活检 部位, 不利于临床及时诊断和治疗。
共聚焦显微技术作为一种崭新的成像技术, 已经在生物学研究中得到广泛的应用, 目前 其应用领域已经扩展到细胞学、 微生物学、 发育生物学、 遗传学、 神经生物学、 生理和病理 学等学科的研究工作中, 成为现代生物学微观研究的重要工具。 因此, 如何将共聚焦显微成 像技术、 显微激光技术与内窥镜技术结合使用, 实现在活体组织的情况下准确定位、 定性地 对患者进行详尽的检查尤为迫切。 发明内容
为了克服上述现有技术的不足, 本发明的目的在于将共聚焦显微技术与硬质内镜进行有 机结合, 提供一种一体化共聚焦显微硬质内镜系统, 该一体化共聚焦显微硬质内镜系统能够 使操作者准确地确定活检部位, 同时观察到活检部位的宏观情况与微观情况, 在当前操作及 检查的同时对可疑病变进行即时的分析与检测, 克服随机活检带来的弊端, 有助于提高临床 的治疗效果并降低医疗成本。
本发明的目的是通过以下技术方案实现的:
本发明所述的一体化共聚焦显微硬质内镜系统, 包括有共聚焦显微硬质内镜、 冷光源主 机、 系统处理机、 内镜影像监视器和共聚焦显微显示器; 所述的共聚焦显微硬质内镜包括手 术端和操作端; 所述的手术端在其端面上集成有共聚焦显微激光头、 共聚焦显微镜头、 导光 光纤和内镜镜头, 从而形成一体化的共聚焦显微硬质内镜; 所述的操作端上设有冷光源输入 端和图像数据输出端, 所述的冷光源输入端与所述的冷光源主机相连接, 所述的图像数据输 出端以及所述的内镜影像监视器和共聚焦显微显示器分别与所述的系统处理机相连接, 从而 将内镜镜头和共聚焦显微镜头采集到的图像数据分别传送到内镜影像监视器和共聚焦显微显 示器上; 所述的共聚焦显微硬质内镜还设有若干贯穿其中并且在其手术端的端面上设有开口 的器械通道。
本发明所述的一体化共聚焦显微硬质内镜系统, 还可以包括有系统键盘, 所述的系统键 盘与所述的系统处理机相连接, 以通过键盘操作实现对一体化共聚焦显微硬质内镜系统的操 控。
在本发明中, 所述的共聚焦显微硬质内镜的操作端上还可以设有控制单元, 所述的控制 单元上设有共聚焦显微开关、 图像冻结开关和缩放调节开关, 以方便医生进行共聚焦显微的 控制。
在本发明中, 所述的系统处理机可包括有摄像主机和共聚焦显微主机, 所述的共聚焦显 微硬质内镜的操作端上还可以设有目镜输出端; 所述的目镜输出端和内镜影像监视器与所述 的摄像主机相连接, 所述的图像数据输出端和共聚焦显微显示器与所述的共聚焦显微主机相 连接。
在本发明中, 所述的图像数据输出端可以设计为与共聚焦显微硬质内镜的纵向中轴线成 45°角, 从而提高手术操作过程的稳定性和把握性。
在本发明中, 所述的共聚焦显微硬质内镜可以是共聚焦显微硬质电子关节镜、 共聚焦显 微硬质胆囊镜、 共聚焦显微硬质膀胱镜或者共聚焦显微硬质宫腔镜等。
与现有技术相比, 本发明具有以下有益效果:
本发明所述的一体化共聚焦显微硬质内镜系统是在硬质内镜的基础上引入先进的共聚焦 显微技术, 把共聚焦显微系统的硬件部分设计在硬质内镜之外的系统处理机中, 保持了硬质 内镜原有的结构, 而硬质内镜具有良好操控性的形状, 可以解决共聚焦显微软质内镜由于硬 件部分体积较大引起的操作不便。 本发明所述的一体化共聚焦显微硬质内镜还设有贯穿其中 的器械通道, 是带有手术治疗功能的硬质内镜, 而且其保持了硬质工作端部的特点, 有利于 医生使用内镜进行手术, 操控性比软质内镜更为优秀, 特别是对发现病灶的治疗上更容易掌 握, 并且坚固耐用、 成本低、 易于清洗和消毒。
医生通过操作本发明所述的一体化共聚焦显微硬质内镜系统, 在共聚焦显微激光头发出 的波长为 488nm的蓝色激光和患者体内的荧光素钠的共同作用下, 能够即时记录细胞内的动 态, 进行活体检测, 对相关器官组织的病变部位进行诊断和治疗。 通过本系统, 医生可以同 时观察到器官组织的宏观情况和微观情况, 为医生进行实时的细胞活检提供了新的平台。 附图说明 图 1是本发明实施例 所述的一体化共聚焦显微硬质电子关节镜系统的结构示意图。 图 2是本发明实施例 所述的共聚焦显微硬质电子关节镜的端面结构示意图。
图 3是本发明实施例 所述的一体化共聚焦显微硬质电子关节镜系统手术使用示意图 ( 图 4是本发明实施例 所述的一体化共聚焦显微硬质胆囊镜系统的结构示意图。
图 5是本发明实施例 所述的共聚焦显微硬质胆囊镜的端面结构示意图。
图 6是本发明实施例 所述的一体化共聚焦显微硬质胆囊镜系统手术使用示意图。 图 7是本发明实施例 所述的一体化共聚焦显微硬质膀胱镜系统的结构示意图。
图 8是本发明实施例 所述的共聚焦显微硬质膀胱镜的端面结构示意图。
图 9是本发明实施例 所述的一体化共聚焦显微硬质膀胱镜系统手术使用示意图。 图 10是本发明实施例四所述的一体化共聚焦显微硬质宫腔镜系统的结构示意图。
图 11是本发明实施例四所述的共聚焦显微硬质宫腔镜的端面结构示意图。 具体实施方式
下面结合附图对本发明的具体实施方式作进一步的详述。 实施例一: 一体化共聚焦显微硬质电子关节镜系统
如图 1所示, 本发明所述的一体化共聚焦显微硬质电子关节镜系统包括共聚焦显微硬质 电子关节镜 11、 冷光源主机 12、 系统处理机 13、 系统键盘 14、 内镜影像监视器 15和共聚焦 显微显示器 16。 共聚焦显微硬质电子关节镜 11包括有手术端 11A和操作端 11B, 其中, 操 作端 11B上设有冷光源输入端 111、 图像数据输出端 112和控制单元 113, 而手术端 11A的 长度约为 150mm〜200mm, 直径 8.0mm。 系统键盘 14与系统处理机 13相连接, 医生可通 过键盘操作, 实现对本系统的操控。 冷光源输入端 111与冷光源主机 12相连接。 图像数据输 出端 112、 内镜影像监视器 15和共聚焦显微显示器 16分别通过数据线与系统处理机 13相连 接,从而将共聚焦显微硬质电子关节镜 11采集到的内镜图像数据和共聚焦显微图像数据分别 传送到内镜影像监视器 15和共聚焦显微显示器 16上。 控制单元 113采用防水和耐高温的材 料制备而成, 其上还设有共聚焦显微开关、 图像冻结开关和缩放调节开关, 以方便医生进行 共聚焦显微的控制。 共聚焦显微硬质电子关节镜 11还设有一条贯穿其中的器械通道 114, 器 械通道 114为直线型器械通道, 其直径 3.0mm, 并在手术端 11A的端面上设有开口 115。 而为了提高手术操作过程的稳定性和把握性, 图像数据输出端 112设计为与共聚焦显微硬质 电子关节镜 11的纵向中轴线成 45°角。
如图 2所示,共聚焦显微硬质电子关节镜 11在其手术端 11A的端面上还集成有共聚焦显 微激光头 116、 共聚焦显微镜头 117、 导光光纤 118和内镜镜头 119, 从而形成一体化的共聚 焦显微硬质电子关节镜。共聚焦显微硬质电子关节镜 11在其手术端 11A的端部安装有高分辨 率的 CCD芯片, 该 CCD芯片的尺寸 1/4" 、 有效像素至少为 48万。 内镜镜头 119的视场 角 100° 。 内镜镜头 119采集到的内镜图像数据通过图像数据输出端 112和系统处理机 13 传送到内镜影像监视器 15上,而共聚焦显微镜头 117采集到的共聚焦显微图像数据则通过图 像数据输出端 112和系统处理机 13传送到共聚焦显微显示器 16上。
图 3是本实施例所述的一体化共聚焦显微硬质电子关节镜系统的手术使用示意图。 手术 前, 医生需要先对患者静脉注射荧光素钠。进行手术操作时, 医生在患者关节患处 17做一微 小切口, 然后将共聚焦显微硬质电子关节镜 11插入其内, 通过内镜影像监视器 15可观察到 患者关节患处 17的病变情况。 需要检测患者关节患处 17的组织性质时, 可通过操作控制单 元 113,使共聚焦显微硬质电子关节镜 11的共聚焦显微激光头 116发出波长为 488nm的蓝色 激光, 该蓝色激光与患者关节患处 17中的荧光素钠相作用, 即可在共聚焦显微显示器 16上 获得清晰的共聚焦显微图像。 由此, 医生能够在共聚焦显微硬质电子关节镜 11的帮助下进行 活体检测, 即时对关节组织的病变部位进行诊断和治疗。 实施例二: 一体化共聚焦显微硬质胆囊镜系统
如图 4所示, 本发明所述的一体化共聚焦显微硬质胆囊镜系统包括共聚焦显微硬质胆囊 镜 21、 冷光源主机 22、 摄像主机 23A、 共聚焦显微主机 23B、 系统键盘 24、 内镜影像监视器 25和共聚焦显微显示器 26。 共聚焦显微硬质胆囊镜 21包括有手术端 21A和操作端 21B, 其 中, 操作端 21B上设有冷光源输入端 211、 图像数据输出端 212、 目镜输出端 213和控制单元 214,而手术端 21 A的长度约为 250mm〜300mm,直径 10mm。系统键盘 24与摄像主机 23 A 和共聚焦显微主机 23B相连接, 医生可通过键盘操作, 实现对本系统的操控。 冷光源输入端 211与冷光源主机 22相连接。 目镜输出端 213设置于共聚焦显微硬质胆囊镜 21的纵向中轴 线上。 目镜输出端 213和内镜影像监视器 25分别通过数据线与摄像主机 23A相连接, 从而 将共聚焦显微硬质胆囊镜 21采集到的内镜图像数据传送到内镜影像监视器 25上。 图像数据 输出端 212和共聚焦显微显示器 26分别通过数据线与共聚焦显微主机 23B相连接, 从而将 共聚焦显微硬质胆囊镜 21采集到的共聚焦显微图像数据传送到共聚焦显微显示器 26上。 控 制单元 214采用防水和耐高温的材料制备而成, 其上还设有共聚焦显微开关、 图像冻结开关 和缩放调节开关, 以方便医生进行共聚焦显微的控制。共聚焦显微硬质胆囊镜 21还设有两条 贯穿其中并且直径 2.8mm的器械通道 215, 器械通道 215在手术端 21A的端面上设有开口 215'。 为了提高手术操作过程的稳定性和把握性, 图像数据输出端 212设计为与共聚焦显微 硬质胆囊镜 21的纵向中轴线成 45°角。 如图 5所示, 共聚焦显微硬质胆囊镜 21在其手术端 21A的端面上还集成有共聚焦显微 激光头 216、 共聚焦显微镜头 217、 导光光纤 218和内镜镜头 219, 从而形成一体化的共聚焦 显微硬质胆囊镜。 内镜镜头 219采用直径 2.8mm的光学镜头, 其采集到的内镜图像数据通 过目镜输出端 213和摄像主机 23 A传送到内镜影像监视器 25上, 而共聚焦显微镜头 217采 集到的共聚焦显微图像数据则通过图像数据输出端 212和共聚焦显微主机 23B传送到共聚焦 显微显示器 26上。
图 6是本实施例所述的一体化共聚焦显微硬质胆囊镜系统的手术使用示意图。 手术前, 医生需要先对患者静脉注射荧光素钠。进行手术操作时, 医生在患者胆囊底部 27处做一微小 切口, 然后将共聚焦显微硬质胆囊镜 21插入其内, 通过内镜影像监视器 25可观察到患者胆 囊内的结石情况, 并且通过器械通道 215可将胆囊内的结石全部取出。 需要检测患者的胆囊 粘膜组织时,可通过操作控制单元 214,使共聚焦显微硬质胆囊镜 21的共聚焦显微激光头 216 发出波长为 488nm的蓝色激光, 该蓝色激光与患者胆囊粘膜组织内的荧光素钠相作用, 即可 在共聚焦显微显示器 26上获得清晰的共聚焦显微图像。 由此, 医生能够在共聚焦显微硬质胆 囊镜 21的帮助下进行活体检测, 即时对胆囊粘膜组织的病变部位进行诊断和治疗。 实施例三: 一体化共聚焦显微硬质膀胱镜系统
如图 7所示, 本发明所述的一体化共聚焦显微硬质膀胱镜系统包括共聚焦显微硬质膀胱 镜 31、 冷光源主机 32、 摄像主机 33A、 共聚焦显微主机 33B、 系统键盘 34、 内镜影像监视器 35和共聚焦显微显示器 36。 共聚焦显微硬质膀胱镜 31包括有手术端 31A和操作端 31B, 其 中, 操作端 31B上设有冷光源输入端 311、 图像数据输出端 312、 目镜输出端 313和控制单元 314, 手术端 31A的外侧包围有鞘管部分 310, 鞘管部分 310上还设有贯穿其中的进水通道 3101和出水通道 3102, 鞘管部分 310的端部呈弯曲钝状。 手术端 31A的长度约为 220mm〜 270mm, 直径 9.0mm; 而鞘管部分 310的长度约为 180mm〜220mm, 直径 10.0mm。 系统 键盘 34与摄像主机 33A和共聚焦显微主机 33B相连接, 医生可通过键盘操作, 实现对本系 统的操控。冷光源输入端 311与冷光源主机 32相连接。 目镜输出端 313设置于共聚焦显微硬 质膀胱镜 31的纵向中轴线上。 目镜输出端 313和内镜影像监视器 35分别通过数据线与摄像 主机 33A相连接, 从而将共聚焦显微硬质膀胱镜 31采集到的内镜图像数据传送到内镜影像 监视器 35上。 图像数据输出端 312和共聚焦显微显示器 36分别通过数据线与共聚焦显微主 机 33B相连接, 从而将共聚焦显微硬质膀胱镜 31采集到的共聚焦显微图像数据传送到共聚 焦显微显示器 36上。控制单元 314采用防水和耐高温的材料制备而成, 其上还设有共聚焦显 微开关、 图像冻结开关和缩放调节开关, 以方便医生进行共聚焦显微的控制。 共聚焦显微硬 质膀胱镜 31还设有三条贯穿其中并且直径 2.0mm的器械通道 315, 器械通道 315在手术端 31A的端面上设有开口 315'。为了提高手术操作过程的稳定性和把握性,图像数据输出端 312 设计为与共聚焦显微硬质膀胱镜 31的纵向中轴线成 45°角。
如图 8所示, 共聚焦显微硬质膀胱镜 31在其手术端 31A的端面上还集成有共聚焦显微 激光头 316、 共聚焦显微镜头 317、 导光光纤 318和内镜镜头 319, 从而形成一体化的共聚焦 显微硬质膀胱镜。 内镜镜头 319采用直径 1.9mm的光学镜头, 其采集到的内镜图像数据通 过目镜输出端 313和摄像主机 33A传送到内镜影像监视器 35上, 而共聚焦显微镜头 317采 集到的共聚焦显微图像数据则通过图像数据输出端 312和共聚焦显微主机 33B传送到共聚焦 显微显示器 36上。
图 9是本实施例所述的一体化共聚焦显微硬质膀胱镜系统的手术使用示意图。 手术前, 医生需要先对患者静脉注射荧光素钠。进行手术操作时, 医生将共聚焦显微硬质膀胱镜 31从 患者的尿道口插入膀胱腔 37内,通过内镜影像监视器 35可观察到患者膀胱腔 37内的病变情 况。 需要检测患者的膀胱壁粘膜组织时, 可通过操作控制单元 314, 使共聚焦显微硬质膀胱 镜 31的共聚焦显微激光头 316发出波长为 488nm的蓝色激光, 该蓝色激光与患者膀胱壁粘 膜组织内的荧光素钠相作用, 即可在共聚焦显微显示器 36上获得清晰的共聚焦显微图像。 由 此, 医生能够在共聚焦显微硬质膀胱镜 31的帮助下进行活体检测, 即时对膀胱壁粘膜组织的 病变部位进行诊断和治疗。 实施例四: 一体化共聚焦显微硬质宫腔镜系统
如图 10所示,本发明所述的一体化共聚焦显微硬质宫腔镜系统包括共聚焦显微硬质宫腔 镜 41、 冷光源主机 42、 摄像主机 43A、 共聚焦显微主机 43B、 系统键盘 44、 内镜影像监视器 45和共聚焦显微显示器 46。 共聚焦显微硬质宫腔镜 41包括有手术端 41A和操作端 41B, 其 中, 操作端 41B上设有冷光源输入端 411、 图像数据输出端 412、 目镜输出端 413和控制单元 414, 手术端 41A的外侧包围有鞘管部分 410, 鞘管部分 410上还设有贯穿其中的进水通道 4101和出水通道 4102, 鞘管部分 410的端部为钝状设计。 手术端 41A的长度约为 250mm〜 300mm, 直径 10.0mm; 鞘管部分 410的直径 12.0mm。 系统键盘 44与摄像主机 43 A和共 聚焦显微主机 43B相连接, 医生可通过键盘操作, 实现对本系统的操控。 冷光源输入端 411 与冷光源主机 42相连接。 而目镜输出端 413设置于共聚焦显微硬质宫腔镜 41的纵向中轴线 上。 目镜输出端 413和内镜影像监视器 45分别通过数据线与摄像主机 43A相连接, 从而将 共聚焦显微硬质宫腔镜 41采集到的内镜图像数据传送到内镜影像监视器 45上。 图像数据输 出端 412和共聚焦显微显示器 46分别通过数据线与共聚焦显微主机 43B相连接, 从而将共 聚焦显微硬质宫腔镜 41采集到的共聚焦显微图像数据传送到共聚焦显微显示器 46上。 控制 单元 414采用防水和耐高温的材料制备而成, 其上还设有共聚焦显微开关、 图像冻结开关和 缩放调节开关, 以方便医生进行共聚焦显微的控制。共聚焦显微硬质宫腔镜 41还设有两条贯 穿其中并且直径 2.8mm 的器械通道 415, 器械通道 415在手术端 41A的端面上设有开口 415'。 为了提高手术操作过程的稳定性和把握性, 图像数据输出端 412设计为与共聚焦显微 硬质宫腔镜 41的纵向中轴线成 45°角。
如图 11所示, 共聚焦显微硬质宫腔镜 41在其手术端 41A的端面上还集成有共聚焦显微 激光头 416、 共聚焦显微镜头 417、 导光光纤 418和内镜镜头 419, 从而形成一体化的共聚焦 显微硬质宫腔镜。 内镜镜头 419采用直径 2.8mm的光学镜头, 其采集到的内镜图像数据通 过目镜输出端 413和摄像主机 43 A传送到内镜影像监视器 45上, 而共聚焦显微镜头 417采 集到的共聚焦显微图像数据则通过图像数据输出端 412和共聚焦显微主机 43B传送到共聚焦 显微显示器 46上。

Claims

权 利 要 求 书
1、 一体化共聚焦显微硬质内镜系统, 其特征在于: 包括共聚焦显微硬质内镜、 冷光源主 机、 系统处理机、 内镜影像监视器和共聚焦显微显示器; 所述的共聚焦显微硬质内镜包括手 术端和操作端; 所述的手术端在其端面上集成有共聚焦显微激光头、 共聚焦显微镜头、 导光 光纤和内镜镜头, 从而形成一体化的共聚焦显微硬质内镜; 所述的操作端上设有冷光源输入 端和图像数据输出端, 所述的冷光源输入端与所述的冷光源主机相连接, 所述的图像数据输 出端以及所述的内镜影像监视器和共聚焦显微显示器分别与所述的系统处理机相连接, 从而 将内镜镜头和共聚焦显微镜头采集到的图像数据分别传送到内镜影像监视器和共聚焦显微显 示器上; 所述的共聚焦显微硬质内镜还设有若干贯穿其中并且在其手术端的端面上设有开口 的器械通道。
2、根据权利要求 1所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的一体化 共聚焦显微硬质内镜系统还包括有系统键盘, 所述的系统键盘与所述的系统处理机相连接, 以通过键盘操作实现对一体化共聚焦显微硬质内镜系统的操控。
3、根据权利要求 1所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚焦 显微硬质内镜的操作端上还设有控制单元, 所述的控制单元上设有共聚焦显微开关、 图像冻 结开关和缩放调节开关。
4、根据权利要求 1所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的系统处 理机包括有摄像主机和共聚焦显微主机; 所述的共聚焦显微硬质内镜的操作端上还设有目镜 输出端, 位于其纵向中轴线上; 所述的目镜输出端和内镜影像监视器与所述的摄像主机相连 接, 所述的图像数据输出端和共聚焦显微显示器与所述的共聚焦显微主机相连接。
5、根据权利要求 1所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的图像数 据输出端与共聚焦显微硬质内镜的纵向中轴线成 45°角。
6、根据权利要求 1所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚焦 显微硬质内镜为共聚焦显微硬质电子关节镜。
7、根据权利要求 6所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚焦 显微硬质电子关节镜在其手术端的端部安装有 CCD芯片,所述的 CCD芯片尺寸 1/4" 、有 效像素至少为 48万; 所述的内镜镜头的视场角 100° 。
8、根据权利要求 6所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚焦 显微硬质电子关节镜的手术端的长度为 150mm〜200mm, 直径 8.0mm; 所述的器械通道为 直线型器械通道, 且直径 3.0mm。
9、根据权利要求 4所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚焦 显微硬质内镜为共聚焦显微硬质胆囊镜。
10、 根据权利要求 9所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述共聚焦 显微硬质胆囊镜的内镜镜头采用直径 2.8mm的光学镜头。
11、 根据权利要求 9所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚 焦显微硬质胆囊镜的手术端的长度为 250mm〜300mm, 直径 10.0mm; 所述的器械通道的 直径 2.8mm。
12、 根据权利要求 4所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚 焦显微硬质内镜为共聚焦显微硬质膀胱镜。
13、根据权利要求 12所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚 焦显微硬质膀胱镜还包括有包围在所述手术端外侧的鞘管部分, 所述的鞘管部分设有贯穿其 中的进水通道和出水通道, 鞘管部分的端部呈弯曲钝状。
14、根据权利要求 13所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚 焦显微硬质膀胱镜的手术端的长度为 220mm〜270mm, 直径 9.0mm; 所述的鞘管部分的长 度为 180mm〜220mm, 直径 10.0mm; 所述的器械通道的直径 2.0mm。
15、根据权利要求 12所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述共聚焦 显微硬质膀胱镜的内镜镜头采用直径 1.9mm的光学镜头。
16、 根据权利要求 4所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚 焦显微硬质内镜为共聚焦显微硬质宫腔镜。
17、根据权利要求 16所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚 焦显微硬质宫腔镜还包括有包围在所述手术端外侧的鞘管部分, 所述的鞘管部分设有贯穿其 中的进水通道和出水通道, 鞘管部分的端部为钝状设计。
18、根据权利要求 17所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述的共聚 焦显微硬质宫腔镜的手术端的长度为 250mm〜300mm, 直径 10.0mm; 所述的鞘管部分的 直径 12.0mm; 所述的器械通道的直径 2.8mm。
19、根据权利要求 16所述的一体化共聚焦显微硬质内镜系统, 其特征在于: 所述共聚焦 显微硬质宫腔镜的内镜镜头采用直径 2.8mm的光学镜头。
PCT/CN2010/075583 2010-02-12 2010-07-30 一体化共聚焦显微硬质内镜系统 WO2011097870A1 (zh)

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Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001050955A1 (en) * 2000-01-14 2001-07-19 Flock Stephen T Improved endoscopic imaging and treatment of anatomic structures
US20070236782A1 (en) * 2006-04-05 2007-10-11 Pentax Corporation Confocal endoscope system
JP2007289231A (ja) * 2006-04-21 2007-11-08 Pentax Corp 内視鏡システム
JP2007304313A (ja) * 2006-05-11 2007-11-22 Pentax Corp 共焦点内視鏡による拡大観察部位特定方法
US20080200764A1 (en) * 2007-02-15 2008-08-21 Pentax Corporation Endoscope system
CN101390769A (zh) * 2008-10-10 2009-03-25 乔铁 硬质超声胆囊内镜系统及方法
CN101449963A (zh) * 2008-12-29 2009-06-10 浙江大学 激光共聚焦显微内窥镜
CN101518455A (zh) * 2008-11-05 2009-09-02 广州宝胆医疗器械科技有限公司 硬质超声宫腔镜系统
CN201333028Y (zh) * 2009-02-27 2009-10-28 广州宝胆医疗器械科技有限公司 一种带鞘管的多操作通道腹腔镜系统
CN101606852A (zh) * 2009-06-30 2009-12-23 广州宝胆医疗器械科技有限公司 超声膀胱镜
CN101773380A (zh) * 2010-02-04 2010-07-14 广州宝胆医疗器械科技有限公司 共聚焦显微硬质胆囊镜系统
CN101779946A (zh) * 2010-02-04 2010-07-21 广州宝胆医疗器械科技有限公司 共聚焦显微硬质膀胱镜系统
CN101779947A (zh) * 2010-02-12 2010-07-21 广州市番禺区胆囊病研究所 一体化共聚焦显微硬质电子关节镜系统
CN101779972A (zh) * 2010-02-12 2010-07-21 广州市番禺区胆囊病研究所 一体化共聚焦显微硬质胆囊镜系统
CN101785657A (zh) * 2010-02-04 2010-07-28 广州宝胆医疗器械科技有限公司 共聚焦显微硬质宫腔镜系统
CN101785658A (zh) * 2010-02-04 2010-07-28 广州宝胆医疗器械科技有限公司 共聚焦显微硬质电子关节镜系统

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001050955A1 (en) * 2000-01-14 2001-07-19 Flock Stephen T Improved endoscopic imaging and treatment of anatomic structures
US20070236782A1 (en) * 2006-04-05 2007-10-11 Pentax Corporation Confocal endoscope system
JP2007289231A (ja) * 2006-04-21 2007-11-08 Pentax Corp 内視鏡システム
JP2007304313A (ja) * 2006-05-11 2007-11-22 Pentax Corp 共焦点内視鏡による拡大観察部位特定方法
US20080200764A1 (en) * 2007-02-15 2008-08-21 Pentax Corporation Endoscope system
CN101390769A (zh) * 2008-10-10 2009-03-25 乔铁 硬质超声胆囊内镜系统及方法
CN101518455A (zh) * 2008-11-05 2009-09-02 广州宝胆医疗器械科技有限公司 硬质超声宫腔镜系统
CN101449963A (zh) * 2008-12-29 2009-06-10 浙江大学 激光共聚焦显微内窥镜
CN201333028Y (zh) * 2009-02-27 2009-10-28 广州宝胆医疗器械科技有限公司 一种带鞘管的多操作通道腹腔镜系统
CN101606852A (zh) * 2009-06-30 2009-12-23 广州宝胆医疗器械科技有限公司 超声膀胱镜
CN101773380A (zh) * 2010-02-04 2010-07-14 广州宝胆医疗器械科技有限公司 共聚焦显微硬质胆囊镜系统
CN101779946A (zh) * 2010-02-04 2010-07-21 广州宝胆医疗器械科技有限公司 共聚焦显微硬质膀胱镜系统
CN101785657A (zh) * 2010-02-04 2010-07-28 广州宝胆医疗器械科技有限公司 共聚焦显微硬质宫腔镜系统
CN101785658A (zh) * 2010-02-04 2010-07-28 广州宝胆医疗器械科技有限公司 共聚焦显微硬质电子关节镜系统
CN101779947A (zh) * 2010-02-12 2010-07-21 广州市番禺区胆囊病研究所 一体化共聚焦显微硬质电子关节镜系统
CN101779972A (zh) * 2010-02-12 2010-07-21 广州市番禺区胆囊病研究所 一体化共聚焦显微硬质胆囊镜系统

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADRIAN L. POLGLASE ET AL: "Pentax confocal endomicroscope: a novel imaging device for in vivo histology of the upper and lower gastrointestinal tract", EXPERT REV.MED.DEVICES, vol. 3, no. 5, 2006 *
RALF KIESSLICH ET AL: "Endoscopic Confocal Imaging", CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, vol. 3, no. 7, July 2005 (2005-07-01), pages S58 - S60 *

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