WO2011091410A8 - Antagonistes de trpv4 - Google Patents

Antagonistes de trpv4 Download PDF

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Publication number
WO2011091410A8
WO2011091410A8 PCT/US2011/022380 US2011022380W WO2011091410A8 WO 2011091410 A8 WO2011091410 A8 WO 2011091410A8 US 2011022380 W US2011022380 W US 2011022380W WO 2011091410 A8 WO2011091410 A8 WO 2011091410A8
Authority
WO
WIPO (PCT)
Prior art keywords
trpv4 antagonists
trpv4
antagonists
indole
pharmaceutical compositions
Prior art date
Application number
PCT/US2011/022380
Other languages
English (en)
Other versions
WO2011091410A1 (fr
Inventor
Hilary Schneck Eidam
Ryan Michael Fox
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of WO2011091410A1 publication Critical patent/WO2011091410A1/fr
Publication of WO2011091410A8 publication Critical patent/WO2011091410A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La présente invention concerne des analogues d'indole ou de benzothiophène, des compositions pharmaceutiques contenant ceux-ci et leur utilisation en tant qu'antagonistes de TRPV4.
PCT/US2011/022380 2010-01-25 2011-01-25 Antagonistes de trpv4 WO2011091410A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29786410P 2010-01-25 2010-01-25
US61/297,864 2010-01-25

Publications (2)

Publication Number Publication Date
WO2011091410A1 WO2011091410A1 (fr) 2011-07-28
WO2011091410A8 true WO2011091410A8 (fr) 2011-11-24

Family

ID=44307279

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/022380 WO2011091410A1 (fr) 2010-01-25 2011-01-25 Antagonistes de trpv4

Country Status (1)

Country Link
WO (1) WO2011091410A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499533B2 (en) 2012-03-27 2016-11-22 Shionogi & Co., Ltd. Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity
WO2015046193A1 (fr) 2013-09-25 2015-04-02 塩野義製薬株式会社 Dérivé amine hétérocyclique aromatique présentant une activité inhibitrice de trpv4
JP2017525777A (ja) * 2014-08-28 2017-09-07 エックス−ケム，インコーポレーテッド 可溶性エポキシドヒドロラーゼ阻害剤及びこれらの使用
AU2015374118B2 (en) 2014-12-29 2020-07-23 The Trustees Of The University Of Pennsylvania Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
EP4183415A1 (fr) 2020-07-16 2023-05-24 RaQualia Pharma Inc. Inhibiteur de trpv4 en tant que médicament thérapeutique pour une maladie oculaire

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1796793A4 (fr) * 2004-09-07 2009-08-05 Smithkline Beecham Corp Nouveaux composes
US20080318945A1 (en) * 2005-12-15 2008-12-25 Casillas Linda N Novel Compounds

Also Published As

Publication number Publication date
WO2011091410A1 (fr) 2011-07-28

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