WO2011090317A3 - Imidazopyrazinone derivatives with apoptosis inducing activity on cells - Google Patents

Imidazopyrazinone derivatives with apoptosis inducing activity on cells Download PDF

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Publication number
WO2011090317A3
WO2011090317A3 PCT/KR2011/000392 KR2011000392W WO2011090317A3 WO 2011090317 A3 WO2011090317 A3 WO 2011090317A3 KR 2011000392 W KR2011000392 W KR 2011000392W WO 2011090317 A3 WO2011090317 A3 WO 2011090317A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
inducing activity
apoptosis inducing
imidazopyrazinone
derivatives
Prior art date
Application number
PCT/KR2011/000392
Other languages
French (fr)
Other versions
WO2011090317A2 (en
Inventor
In Hwan Bae
Mi Ae Jun
Ji Young Song
Hae Kyoung Ju
Tae Hun Song
Ju Hyun Cho
Eun Kyung Kweon
Young Gil Ahn
Cheol Kyung Kim
Maeng Sup Kim
Original Assignee
Hanmi Holdings Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Holdings Co., Ltd. filed Critical Hanmi Holdings Co., Ltd.
Publication of WO2011090317A2 publication Critical patent/WO2011090317A2/en
Publication of WO2011090317A3 publication Critical patent/WO2011090317A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided is a pharmaceutical composition comprising, as an active ingredient, an imidazopyrazinone derivative of formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof, which is effective in the prevention and treatment of cancer, inflammation, autoimmune diseases and neurodegenerative disorders which are induced by the overexpression of inhibitor of apoptosis proteins (IAPs).
PCT/KR2011/000392 2010-01-19 2011-01-19 Imidazopyrazinone derivatives with apoptosis inducing activity on cells WO2011090317A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0004600 2010-01-19
KR1020100004600A KR101230851B1 (en) 2010-01-19 2010-01-19 Imidazopyrazinone derivatives with apoptosis inducing activity on cells

Publications (2)

Publication Number Publication Date
WO2011090317A2 WO2011090317A2 (en) 2011-07-28
WO2011090317A3 true WO2011090317A3 (en) 2012-01-05

Family

ID=44307392

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/000392 WO2011090317A2 (en) 2010-01-19 2011-01-19 Imidazopyrazinone derivatives with apoptosis inducing activity on cells

Country Status (2)

Country Link
KR (1) KR101230851B1 (en)
WO (1) WO2011090317A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY33794A (en) 2010-12-13 2012-07-31 Novartis Ag DIMERIC INHIBITORS OF THE IAP
AU2021358007A1 (en) * 2020-10-05 2023-06-01 Genesis Molecular Technologies, Inc. Topical agents for dermatological applications
WO2024102752A1 (en) * 2022-11-08 2024-05-16 Parmedics, Inc. Small molecule modulators of par2 and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610299A (en) * 1993-01-06 1997-03-11 Neurogen Corporation Certain aryl substituted imidazopyrazinones; a new class of GABA brain receptor ligands
US20040180898A1 (en) * 2003-03-03 2004-09-16 Bang-Chi Chen Processes for preparing imidazoquinoxalinones, heterocyclic-substituted imidazopyrazinones, imidazoquinoxalines and heterocyclic-substituted imidazopyrazines
US20060014744A1 (en) * 2002-11-02 2006-01-19 Carling William R Midazopyrazinones and imidazotriazinones derivates as gaba-a receptor anxiolytic

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610299A (en) * 1993-01-06 1997-03-11 Neurogen Corporation Certain aryl substituted imidazopyrazinones; a new class of GABA brain receptor ligands
US20060014744A1 (en) * 2002-11-02 2006-01-19 Carling William R Midazopyrazinones and imidazotriazinones derivates as gaba-a receptor anxiolytic
US20040180898A1 (en) * 2003-03-03 2004-09-16 Bang-Chi Chen Processes for preparing imidazoquinoxalinones, heterocyclic-substituted imidazopyrazinones, imidazoquinoxalines and heterocyclic-substituted imidazopyrazines

Also Published As

Publication number Publication date
KR101230851B1 (en) 2013-02-07
KR20110085036A (en) 2011-07-27
WO2011090317A2 (en) 2011-07-28

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