WO2011084721A3 - Molécule cationique et procédé d'utilisation - Google Patents

Molécule cationique et procédé d'utilisation Download PDF

Info

Publication number
WO2011084721A3
WO2011084721A3 PCT/US2010/061184 US2010061184W WO2011084721A3 WO 2011084721 A3 WO2011084721 A3 WO 2011084721A3 US 2010061184 W US2010061184 W US 2010061184W WO 2011084721 A3 WO2011084721 A3 WO 2011084721A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
cationic molecule
useful
therapeutics
cationic
Prior art date
Application number
PCT/US2010/061184
Other languages
English (en)
Other versions
WO2011084721A2 (fr
Inventor
Kunyuan Cui
Dong Liang
David Sweedler
Original Assignee
Agave Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agave Pharma Inc filed Critical Agave Pharma Inc
Publication of WO2011084721A2 publication Critical patent/WO2011084721A2/fr
Publication of WO2011084721A3 publication Critical patent/WO2011084721A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives

Abstract

La présente invention concerne des lipides cationiques et des compositions comprenant ceux-ci qui sont utiles lorsqu'ils sont combinés avec des agents thérapeutiques, et dans le diagnostic et le traitement de maladies et d'affections. Les composés de lipide cationique et les compositions comprenant ceux-ci sont utiles pour l'administration d'agents tels que des agents thérapeutiques d'acide nucléique à des cellules, des tissus, des organes, et des sujets.
PCT/US2010/061184 2009-12-21 2010-12-19 Molécule cationique et procédé d'utilisation WO2011084721A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28868509P 2009-12-21 2009-12-21
US61/288,685 2009-12-21
US29797410P 2010-01-25 2010-01-25
US61/297,974 2010-01-25

Publications (2)

Publication Number Publication Date
WO2011084721A2 WO2011084721A2 (fr) 2011-07-14
WO2011084721A3 true WO2011084721A3 (fr) 2011-09-09

Family

ID=44306078

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/061184 WO2011084721A2 (fr) 2009-12-21 2010-12-19 Molécule cationique et procédé d'utilisation

Country Status (1)

Country Link
WO (1) WO2011084721A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102985548B (zh) * 2009-05-16 2016-10-26 崔坤元 用于递送治疗分子的包含阳离子两亲物和辅脂质的组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877220A (en) * 1997-03-06 1999-03-02 Genta, Incorporated Amide-based oligomeric cationic lipids
US6127170A (en) * 1994-09-28 2000-10-03 American Home Products Corporation Multifunctional complexes for gene transfer into cells comprising a nucleic acid bound to a polyamine and having a endosome disruption agent
WO2008137470A1 (fr) * 2007-05-01 2008-11-13 Pgr-Solutions Polyamines lipophiles à chaînes multiples

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127170A (en) * 1994-09-28 2000-10-03 American Home Products Corporation Multifunctional complexes for gene transfer into cells comprising a nucleic acid bound to a polyamine and having a endosome disruption agent
US5877220A (en) * 1997-03-06 1999-03-02 Genta, Incorporated Amide-based oligomeric cationic lipids
WO2008137470A1 (fr) * 2007-05-01 2008-11-13 Pgr-Solutions Polyamines lipophiles à chaînes multiples

Also Published As

Publication number Publication date
WO2011084721A2 (fr) 2011-07-14

Similar Documents

Publication Publication Date Title
WO2008137758A3 (fr) Lipides d'acides aminés et leurs utilisations
WO2009149418A3 (fr) Nouvelles compositions pour l’administration in vivo d’agents arni
WO2011091065A3 (fr) Nanostructures synthétiques comprenant des acides nucléiques et/ou d'autres entités
IL244945B (en) Cationic lipid, lipid formulations including it and their use in the preparation of therapeutic agents for administration to cells
WO2006084209A3 (fr) Produits de synthese d'expression d'arni
WO2012075040A3 (fr) Arnm pour l'utilisation dans le traitement de maladies génétiques humaines
WO2010147655A3 (fr) Compositions et procédés se rapportant à des véhicules d'administration d'acides nucléiques
EP4124346A3 (fr) Compositions et procédés de traitement de maladies
BRPI0815613A2 (pt) Composições lipossômicas para administração in vivo de compostos de ácido borônico.
GB2472964A (en) Vectors for delivery of light-sensitive proteins and methods of use
WO2010059253A3 (fr) Procédés et compositions pour la délivrance localisée d'agents
NZ618734A (en) Polyunsaturated fatty acids for the treatment of diseases related to cardiovascular, metabolic and inflammatory disease areas
WO2011060049A3 (fr) Antagonistes, de type spiro-oxindole, de l'oncoprotéine mdm2
MX2010003299A (es) Oligonucleotidos muy cortos (micromirs).
WO2008057930A3 (fr) Méthodes destinées à traiter la douleur neuropathique à l'aide d'agonistes des récepteurs de l'acide rétinoïque
WO2011131693A3 (fr) Compositions et procédés permettant l'administration sélective de molécules d'oligonucléotides à des types de neurones spécifiques
EA032867B9 (ru) Оптимизированная с помощью эндосомолитических средств система доставки in vivo конъюгатов нуклеиновой кислоты
WO2011053901A3 (fr) Nanostructures magnetiques utilisees en tant qu'agents theranostiques
WO2009120919A3 (fr) Formes galéniques de fénofibrate
WO2012008860A3 (fr) Enzymes nitroréductases bactériennes et procédés associés
WO2009151907A3 (fr) Compositions et procédés permettant d'utiliser des cellules pour traiter le tissu cardiaque
WO2009135178A3 (fr) Procédés de production et d'utilisation d'érythrocytes chargés d'une substance (s-les) pour l'observation et le traitement de l'hémodynamique vasculaire
WO2012158780A3 (fr) Signature du cancer du poumon
BR112014008700A2 (pt) composições úteis no tratamento de nefropatia e processos para preparação das mesmas
WO2010136508A3 (fr) Ciblage de cellules souches

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10842671

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10842671

Country of ref document: EP

Kind code of ref document: A2