WO2011080505A3 - Method of growing phage for commercial use - Google Patents
Method of growing phage for commercial use Download PDFInfo
- Publication number
- WO2011080505A3 WO2011080505A3 PCT/GB2010/002341 GB2010002341W WO2011080505A3 WO 2011080505 A3 WO2011080505 A3 WO 2011080505A3 GB 2010002341 W GB2010002341 W GB 2010002341W WO 2011080505 A3 WO2011080505 A3 WO 2011080505A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- phage
- growing
- modified
- industrial
- commercial use
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/08—Reducing the nucleic acid content
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10311—Siphoviridae
- C12N2795/10351—Methods of production or purification of viral material
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention relates to methods of obtaining bacteriophage ('phage'), such as lambda phage, for industrial uses, such as for use in commercial vaccine production. There is also provided a novel bacterium, such as Escherichia coli (E. coli) which has been modified for growing phage in a manner which improves the general and environmental safety of said phage. The invention also relates to the use of a modified bacterium for growing phage for industrial purposes. Finally, the invention also provides modified phage, which are designed for growth in industrial and/or environmental safety.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29036209P | 2009-12-28 | 2009-12-28 | |
US61/290,362 | 2009-12-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011080505A2 WO2011080505A2 (en) | 2011-07-07 |
WO2011080505A3 true WO2011080505A3 (en) | 2011-08-25 |
Family
ID=43638606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2010/002341 WO2011080505A2 (en) | 2009-12-28 | 2010-12-24 | Method of growing phage for commercial use |
Country Status (1)
Country | Link |
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WO (1) | WO2011080505A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2018290278B2 (en) | 2017-06-21 | 2022-12-15 | Synlogic Operating Company, Inc. | Bacteria for the treatment of disorders |
CN109251899B (en) * | 2018-09-30 | 2021-08-03 | 南京医科大学 | Drug-resistant coliphage and application thereof |
CN111607602A (en) * | 2020-06-11 | 2020-09-01 | 华东理工大学 | Method for reliably and stably producing polyol |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003076583A2 (en) * | 2002-03-06 | 2003-09-18 | Musc Foundation For Research Development | Genetically engineered phage and the use of genetically engineered phage to deliver nucleic acid to bacteria |
WO2007015704A2 (en) * | 2004-10-29 | 2007-02-08 | University Of Rochester | Modified bacteriophage vectors and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4139561B2 (en) | 1997-12-05 | 2008-08-27 | ユーロペーイシェ ラボラトリウム フュール モレキュラーバイオロジー(イーエムビーエル) | Novel DNA cloning method |
AU3480999A (en) | 1998-04-08 | 1999-10-25 | Robert Massey | Targeting of specific cell types for removal by the immune system |
WO1999066061A1 (en) | 1998-06-18 | 1999-12-23 | Dnavec Research, Inc. | Nucleic acid transfer phage |
US6355412B1 (en) | 1999-07-09 | 2002-03-12 | The European Molecular Biology Laboratory | Methods and compositions for directed cloning and subcloning using homologous recombination |
AT408949B (en) | 2000-07-25 | 2002-04-25 | Petrovic Dragan Dipl Ing | VASCULAR ANCHORING DEVICE |
GB0107319D0 (en) | 2001-03-23 | 2001-05-16 | Moredun Res Inst | Bacteriophage-mediated immunisation |
US6989265B2 (en) | 2002-01-23 | 2006-01-24 | Wisconsin Alumni Research Foundation | Bacteria with reduced genome |
EP2196214A1 (en) | 2003-12-17 | 2010-06-16 | The Catholic University Of America | Method for making an immunogenic composition with Hoc fusion proteins and/or Soc fusion proteins |
US8178339B2 (en) | 2005-08-20 | 2012-05-15 | Scarab Genomics Llc | Reduced genome E. coli |
US8754015B2 (en) | 2006-11-21 | 2014-06-17 | University Of Rochester | Modified phage for displaying post-translationally modified proteins and uses thereof |
MX2010011373A (en) | 2008-04-22 | 2010-11-12 | Cytos Biotechnology Ag | Vaccine compositions for the treatment of dengue fever and uses thereof. |
-
2010
- 2010-12-24 WO PCT/GB2010/002341 patent/WO2011080505A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003076583A2 (en) * | 2002-03-06 | 2003-09-18 | Musc Foundation For Research Development | Genetically engineered phage and the use of genetically engineered phage to deliver nucleic acid to bacteria |
WO2007015704A2 (en) * | 2004-10-29 | 2007-02-08 | University Of Rochester | Modified bacteriophage vectors and uses thereof |
Non-Patent Citations (11)
Title |
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BABA TOMOYA ET AL: "Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection.", MOLECULAR SYSTEMS BIOLOGY, vol. 2, 21 February 2006 (2006-02-21), XP002628975, ISSN: 1744-4292, DOI: 10.1038/msb4100050 * |
E. COLI GENETIC RESOURCES AT YALE CGSC, THE COLI GENETIC STOCK CENTER: "Strain JW4279-1", XP002628984, Retrieved from the Internet <URL:http://cgsc.biology.yale.edu/Strain.php?ID=109347> [retrieved on 20110315] * |
GUPTA A ET AL: "High-density Functional Display of Proteins on Bacteriophage Lambda", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 334, no. 2, 21 November 2003 (2003-11-21), pages 241 - 254, XP004470972, ISSN: 0022-2836, DOI: DOI:10.1016/J.JMB.2003.09.033 * |
HANDA NAOFUMI ET AL: "ERRATUM: Type III restriction is alleviated by bacteriophage (RecE) homologous recombination function but enhanced by bacterial (RecBCD) function", JOURNAL OF BACTERIOLOGY, vol. 187, no. 21, February 2007 (2007-02-01), pages 1180, XP002628980, ISSN: 0021-9193 * |
HANDA NAOFUMI ET AL: "Type III restriction is alleviated by bacteriophage (RecE) homologous recombination function but enhanced by bacterial (RecBCD) function", JOURNAL OF BACTERIOLOGY, vol. 187, no. 21, November 2005 (2005-11-01), pages 7362 - 7373, XP002628979, ISSN: 0021-9193 * |
JEPSON C D ET AL: "Bacteriophage lambda is a highly stable DNA vaccine delivery vehicle", VACCINE, ELSEVIER LTD, GB, vol. 22, no. 19, 23 June 2004 (2004-06-23), pages 2413 - 2419, XP004515458, ISSN: 0264-410X, DOI: DOI:10.1016/J.VACCINE.2003.11.065 * |
LANKES H A ET AL: "In vivo gene delivery and expression by bacteriophage lambda vectors", JOURNAL OF APPLIED MICROBIOLOGY, vol. 102, no. 5, May 2007 (2007-05-01), pages 1337 - 1349, XP002628981, ISSN: 1364-5072 * |
MORADPOUR ZAHRA ET AL: "Genetically engineered phage harbouring the lethal catabolite gene activator protein gene with an inducer-independent promoter for biocontrol of Escherichia coli.", FEMS MICROBIOLOGY LETTERS JUL 2009 LNKD- PUBMED:19459966, vol. 296, no. 1, July 2009 (2009-07-01), pages 67 - 71, XP002628982, ISSN: 1574-6968 * |
NOVAGEN: "Bacteriophage CE6", NOVAGEN TECHNICAL BULLETIN, no. 7, February 1994 (1994-02-01), pages 1 - 2, XP002628977, Retrieved from the Internet <URL:http://www.ebiotrade.com/buyf/productsf/Novagen/69390-000.pdf> [retrieved on 20110315] * |
SAMBROOK JOSEPH ET AL: "Molecular cloning: A laboratory manual", vol. 1, 2001, COLD SPRING HARBOR LABORATORY PRESS, 10 SKYLINE DRIVE, PLAINVIEW, NY, 11803-2500, USA, ISBN: 0-87969-577-3, ISSN: null, article "Chapter 2: Bacteriophage Lambda and its vectors", pages: 2.28 - 2.29, XP002628976 * |
SIMMON V F ET AL: "Degradation of bacteriophage lambda deoxyribonucleic acid after restriction by Escherichia coli K-12.", JOURNAL OF BACTERIOLOGY, vol. 112, no. 1, October 1972 (1972-10-01), pages 161 - 169, XP002628978, ISSN: 0021-9193 * |
Also Published As
Publication number | Publication date |
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WO2011080505A2 (en) | 2011-07-07 |
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