WO2011078644A2 - Équipement de stimulation électromagnétique pour le traitement systémique au niveau du thorax de lésions chroniques, l'activation de l'angiogenèse et l'augmentation de la perméabilité vasculaire - Google Patents

Équipement de stimulation électromagnétique pour le traitement systémique au niveau du thorax de lésions chroniques, l'activation de l'angiogenèse et l'augmentation de la perméabilité vasculaire Download PDF

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Publication number
WO2011078644A2
WO2011078644A2 PCT/MX2011/000002 MX2011000002W WO2011078644A2 WO 2011078644 A2 WO2011078644 A2 WO 2011078644A2 MX 2011000002 W MX2011000002 W MX 2011000002W WO 2011078644 A2 WO2011078644 A2 WO 2011078644A2
Authority
WO
WIPO (PCT)
Prior art keywords
seat
electromagnetic stimulation
equipment
systemic treatment
further characterized
Prior art date
Application number
PCT/MX2011/000002
Other languages
English (en)
Spanish (es)
Other versions
WO2011078644A3 (fr
Inventor
Luis CAÑEDO DORANTES
Héctor LOPEZ AGUADO
Alvaro Zamudio Lara
Gregorio Serrano Luna
Carlos Soto Curiel
Citlali Diaz Gutierrez
Original Assignee
Alandra Medical S.A.P.I. De C.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alandra Medical S.A.P.I. De C.V. filed Critical Alandra Medical S.A.P.I. De C.V.
Publication of WO2011078644A2 publication Critical patent/WO2011078644A2/fr
Publication of WO2011078644A3 publication Critical patent/WO2011078644A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy

Definitions

  • the present invention relates to uniform electromagnetic field generators by means of Helmholtz coils, more specifically to a chair-shaped device with positions that generates a horizontal uniform electromagnetic field, by means of two flat rectangular Helmholtz coils placed on the sides of the chair, said field radiates the user's thorax sitting on it.
  • NMR nuclear magnetic resonance
  • Figure 1 is a top view of the chair-type equipment for irradiation of the chest with a uniform electromagnetic field, which induces changes at the cellular level in the user's bloodstream.
  • Figure 2 is a rear view showing the arrangement of the component parts of the chair for chest irradiation with electromagnetic field uniform.
  • Figure 3 is a side view showing the arrangement of the chair parts for chest irradiation with uniform electromagnetic field.
  • Figure 4 is a front view of the chair or chest equipment of the present invention, whose coils radiate the user's chest with a uniform magnetic field.
  • Figure 4A is a perspective view of the chair tilted backwards, with the horizontal actuator in all the extension.
  • Figure 4B is a perspective view of the chair in a retracted position or moved completely backwards; but raised to its highest position, the vertical actuator in its entirety.
  • Figure 5 shows the exploded chair of the present invention, most of the elements are presented in pairs.
  • Figures 6, 7, 8 and 9 show different views of the control console of the thorax equipment of the present invention.
  • Figure 10 shows the "H" diagram of the array of relays that control the direction of rotation of the motors that form the actuators with the gears.
  • Figure 11 shows the block diagram of the equipment self-calibration routine, said routine carries the calibration counter and allows the use of the equipment or chair of the present invention, by releasing the generation of the magnetic field.
  • Figure 12 shows the electrical control circuit of the calibration-activation system.
  • the Thorax equipment, type seat or chair has a metal frame and is used for treatments with electromagnetic fields for users with chronic wounds, said field is generated by two Helmholtz coils located on the sides of the chair at the user's chest, irradiation with electromagnetic field generates changes at the cellular level in the bloodstream of the User bringing with it benefits in wound healing.
  • the support structure On the base with rails the support structure is located so that the bearings thereof slide on the rails, on said support structure the seat and the back of the seat are placed, then the covers of the coils are fixed on the posts that support them, to which the coils were previously placed. Once placed, the separation between the covers is adjusted so that they remain parallel to each other. Subsequently, the coils are connected to the control console from which the connection to the current comes out.
  • On the inner covers of the coils is a grooved acrylic sheet that has a group of blue LEDs that light up in one direction and in reverse to simulate the generation of the magnetic field, due to a circuit that is found in the same control console.
  • the aforementioned computer controls the seating positions, determined by two actuators, one of them allows e!
  • the other actuator allows the seat to tilt so that the patient is in a relaxed position to receive treatment .
  • the seat height is determined so that even people of short stature can easily access the seat.
  • the temporary treatment or application of the electromagnetic field to users or patients with diabetic ulcers proposed in this application consists in the use of electromagnetic fields specially configured to selectively co-stimulate peripheral mononuclear cells, through increasing the intracellular calcium concentration, stimulate the synthesis of mycro-RNA and growth factors. Activated cells are transported through the blood to the particular lesion or chronic diabetic ulcer where these cells increase their adhesion to the endothelium, increase the permeability of the blood vessels and induce angiogenesis (growth of new blood vessels).
  • the Thorax equipment that has the shape of a chair with a metal tube frame and a parallel rail base where a structural carriage with bearings, the vast majority of its structural components in stainless steel, is moved, said equipment is controlled by a PC placed on a separate console; but with communication via cable with the controls of the chair equipment to radiate the thorax, in which a visual interface has been designed, with which it is possible to operate the equipment, so also within the memory of the control device it is possible to have the patient clinical record.
  • photographs of the chronic wounds in addition an image processing is performed, it is possible to monitor the condition of the wounds based on their size, this when performing the automatic measurement of the size by means of software .
  • the computer communicates with a USB type interface, which has several input / output ports, the PC has several relay modules which can communicate with each other, some examples are: actuators, field generator, microcontroller.
  • the user When a treatment is performed, that is, when the equipment is generating a magnetic field and is applied in the chest area, the user must write or choose the patient's name, adjust the treatment time. It is important that the field is applied to the Thorax level since that is where the bloodstream is greater in the human body, so the team seat has different positions, in the preferred modality it has two positions, in one it moves horizontally until it is between the coils, and the other one tilts the seat to place the user in the best location to receive the greatest field strength during irradiation, the displacement is in both directions, in this position the thorax will be located at the level of the coils. For the team to perform these movements or movements, two vertical and horizontal actuators located on a lower level of the seat are used.
  • An actuator is defined as a device that by activating a CD motor makes it possible for a plunger to have a linear displacement, in this case outward or inward.
  • the direction of movement will depend on the polarization to which the CD motor is subjected, which has the characteristic that by changing the polarity it is possible to reverse the rotation or direction of rotation thereof. Therefore, for the control of this, an "H" type circuit with four relays is used, which connects two motors to the same circuit, but they have relays in their connection, which makes it possible to select the desired motor.
  • the relays R1 to R4 are responsible for connecting the required polarization, this depending on the rotation or function required. For example, it is necessary to activate the relays R2, R3 and R5, and to have the relays R1, R4 and R6 shown in Figure 10 deactivated.
  • the equipment calibration process begins once the chest equipment of the present invention is turned on.
  • the PC sends a signal via a USB interface, which connects to a microcontroller and activates the "PC calibrates” module.
  • the micro activates by default and through a relay a voltage of the transformer that is in the "Field Generator”.
  • Upon activating said supply voltage it will be rectified and passed through a tank-type circuit with which the coils are fed to generate the electromagnetic field. Once the magnetic field is present between the space defined by the two coils, said field is monitored by a sensor, which consists of a small coil that produces a voltage at its ends.
  • Said voltage must be amplified to higher levels in order to be able to convert it from VAC to VRMS and measured, for the amplification an operational amplifier is used in its non-inverting configuration with variable gain to be able to adjust the amplification level.
  • the amplified AC signal is converted to RMS, that is, to a CD voltage. This, through a special circuit (AD536). Once the signal is converted, it is evaluated and it is verified that it is within the previously established ranges, these ranges ensure that the generated field is adequate according to the pre-established parameters.
  • the microcontroller selects the activation of another voltage in the field generator, and this will be done depending on whether the signal is below or above the allowed range, that is, if the intensity of field is lower the voltage increases, if the field strength is higher the voltage decreases.
  • the cycle is repetitive so that it is possible to generate the field strength within the allowed range, the microcontroller stores the relay number that generates the voltage that must be selected and then communicates with the PC to inform that the calibration test has been performed successfully and that the start button will be activated. Otherwise, the equipment cannot be used and shows on the screen that the equipment requires service to establish the appropriate calibration to the necessary and sufficient parameters.
  • the PC sends an activation signal of the microcontroller by means of the "active PC" input, whereby the microcontroller activates the voltage level stored in memory.
  • the patient's information will be stored in the patient's clinical file.
  • the PC has a timer that takes the time in descending form and that can be observed on the screen, it is possible to pause the operation if the user or patient requires it, or if necessary stop the treatment.
  • the start time, the set application time, and the time at which it ended will be stored in the user's file.
  • the microcontroller has been set or preset a usage time. This carries a counter, whose result is stored in an EEPROM memory. This adder is Increase each time you are asked to perform the calibration test. That is, if the micro detects that it must perform its calibration test, it first verifies the value it has stored in memory and compares it with the result of the counter (which is also in memory). If the counter obtains a result lower than the preset, then it proceeds to perform the calibration algorithm mentioned above; otherwise, the microcontroller communicates with the PC and informs you that the calibration has not been performed. Therefore, the ⁇ lnicio> button is not activated and it is informed on the screen that maintenance service is required.
  • the maintenance technician must reset the microcontroller counter, this by programming it, or by means of a special pin connection, and with the application of voltage pulses, with which it will be possible to erase the result of the counter in EEPROM memory . By doing this, it is possible to reuse the equipment.
  • an acrylic grid which will be illuminated by a series of blue LEDs.
  • the LEDs When the equipment is in operation, the LEDs will begin to illuminate said grid in one direction, while there is a treatment or application of field strength.
  • the purpose of lighting is to give the patient the feeling that the electromagnetic field flows.
  • Figure 1 shows a top view of the chair or equipment for irradiation with electromagnetic field of the present invention, said chair with a total length of 1.56m in its positioning means on a flat surface, the width is relevant in the space for seat (4) of 53.5cm and a distance between rails (9) for the car of 68cm, the magnets are placed on the sides at a distance from each other of 62.0cm above the level of the seat, they are located inside each of the pair of fiberglass covers (7) which in turn have an external slotted acrylic cover (6) with a plurality of LEDs that light up to simulate the magnetic field flux and a pair of support structures formed by horizontal and vertical strings, one of them is the horizontal top string (10);
  • the seat frame has two tubular end rectangles (11) that serve as fasteners as handles for when the user sits and rises from the chair (1) of the present invention; the lower rails (9) through which the carriage runs are connected at the rear by means of a crossbar (12) that provides them with structural strength for stability; on the other hand the covers
  • the backrest (2) of foamed plastic is narrower than the seat with a width of 47cm and has a plastic head (3) in the upper central section, the seat can move forward and backward, lean forward and backward with in order to achieve a better and more comfortable irradiation position for the user.
  • the carriage rail guides are covered by two housings
  • Figure 2 is a rear view of the chest equipment of the present application, in this view you can see the full height of the chair with a total of 1.21 m, the seat located at a height of 53cm and the magnets at 69cm; This figure shows the lateral structural frame with the upper ropes (10) and the posts
  • the structural support (15) of the backrest (2) with the plastic head (3), the crossbar (5) that joins the magnets, attached to the side structure of the chair, can be seen in the foreground of the seat (4) are the structural and displacement mechanisms thereof, the crossbar (20) for the support of the seat, the arm "z" (21) that serves as a guide to the footstool (24) that moves through the actuators through guides, the vertical actuator (19) moves the seat tilt mechanism, the horizontal actuator (18) moves the seat forward and backwards through the rails (9) where the structural posts (17) that support the seat assembly rest, the rails provided with covers (26) that protect them from dust and foreign elements.
  • FIG. 3 is a side view of the equipment of the present application where mainly the structural support and the foot rail are shown that allows the seat to lean forward or backward;
  • the chair of the present application shows a pair of tubular upper lateral chassis in stainless steel with rope a horizontal upper rope (10), a double tubular post (16) attached to the base formed by a rail (9) arranged on each side of the chair, said rail allows the chair to move back and forth with the user sitting on it, each rail is covered by a longitudinal housing with cover (28) for the wheels at each end;
  • the upper frame supports the cover (7) in fiberglass that contains the magnets inside, the pair of magnets located opposite each other separated by a distance of 62.0cm by an acrylic rear crossbar (5) said magnets radiate the user sitting on (4) and the backrest (2), with the head resting on the plastic head (3) at the upper end of the backrest supported by a pair of preformed tubes (15), the seat and backrest are supported by a pair of posts (17) with a crossbar at the upper ends that allows the
  • FIG 4 is a front view of the equipment of the present application shows the location in pairs of the structure of the upper frame with the upper rope (10), the fiberglass covers (7) containing inside them the said magnets covered by the crossbar (5), the central backrest (2) and seat (4) that just the user's body in the treatment or irradiation period, the seat is placed on top of a base or footstool (24) with degrees of freedom to move by means of the pair of arms "z" (21) that serve as guides for the movement of the footstool, in the displacement the front roller (22) also cooperates, the mentioned movements are energized by the actuators such as the vertical (19), the entire seat assembly is supported by the pair of posts (17) that together form a carriage that can be moved on a pair of rails (9), said rails with upper housings that have covers for their ends wheels (26 and 28).
  • the actuators such as the vertical (19)
  • the entire seat assembly is supported by the pair of posts (17) that together form a carriage that can be moved on a pair of rails (9), said rail
  • Figure 4A shows an isometric view with the chair tilted in the rearward position, the vertical actuator in maximum extension position to force the arm "z" footstool guide (21) to travel the entire guide (23) and be placed at the front end to extend the footstool (24) as much as possible and that the front end of the seat (4) be raised upwards and that the seat support on the crossbar rotate to tilt the backrest (2) backwards, in this raised position the user can hold each of the front frames (11) of the seat structure, said structure supported by the post (17).
  • Figure 4B is a perspective view of the chair in its retracted position backwards and with the horizontal seat in which the footstool is located just below it (4) and the carriage of the seat structure to the rear end of the rails (9) always covering the wheels with which it slides by means of the covers (28), in this position the front roller (22) is under the footstool and the frame (11) seems to be ahead of the seat;
  • one side of the chair has also been removed for the purpose of clarity in showing the structure of the seat and its movement with the actuators; in this position the vertical actuator is in a retracted position, that is, the chair seat is at its lowest level and the arm "z" of footstool (21) is located at the other end of the footstools,
  • the horizontal actuator (18) is also retracted, consequently the piston (18 a) is also retracted, forcing the cross member (40) to travel backwards.
  • the seat (4) is in a horizontal position and the backrest (2) through the transverse axis resting on the upper end of the posts (17) has not been forced to make a turn.
  • the side elements as cover for magnet (7) the frame with the pair of posts (16) and the upper rope
  • Figure 5 shows the exploded view of the chair or equipment of the present application showing all the component parts of said chair, the crossbar (5), the tubular support for the backrest (15), the head of the end of the backrest, the backrest (2), seat (4), footstool (24) and roller (22); the following elements to be mentioned are in pairs such as the magnet cover (7), the cover cover (6) for it, the footstool rail (23), the "z" arm of the footstool guide (21), the actuators (19 and 18) vertical and horizontal, respectively, the rail (9) where the carriage of the chair of the present invention slides.
  • Figures 6 to 9 show different views of the chair control furniture of the present invention
  • Figure 6 is a front view showing the structure vertical (61), the cover cover (62) the crossbar (63) of the same structure (61);
  • Figure 7 is a side view where the vertical structure (61), the cover cover (62) and the end cross member (63) are indicated; in the lower section it has another lower structure (65) that defines a compartment with a front cover and two side covers (64), the side covers in acrylic material, the base is on two horizontal lateral supports.
  • Figure 8 shows in a top view part of the vertical structure (61), the cover cover (62) with the upper cross member (63).
  • Figure (9) shows a perspective of the control cabinet with the front cover (68), a side cover (64), the side support (65) on two rear wheels (66) that serve to change the control location and two front lifting bolts (67) that serve as stops to prevent the slipping of said control;
  • This figure also shows the vertical structure (61) and the cover (62).
  • the control is carried out by means of a visual interface through a computer using a Phidget card (PH1018) connected through a USB port with eight digital input channels, eight analog input channels and eight output channels.
  • Phidget card PH1018
  • Figure 10 shows the circuit in "H" type bridge configuration in which the actuators containing direct current motors are connected, which, when the voltage is inverted, reverses the direction of rotation, said motors are fed with a 24 V signal / 5A, with the "H” circuit it is possible to control the direction of rotation of the actuator motor.
  • the circuit uses six relays as shown in the figure, configurations can be made to activate the selected motor and in the sense of preference, in each relay a switch-type transistor operated by the PC is used to activate different relays.
  • Figure 11 shows the block diagram of the equipment activation calibration system of the present application, said calibration controlled by a microcontroller that detects the magnetic field produced by the coil, amplifies the signal and converts Vrms whose signal returns to the microcontroller to allow activation of the magnetic field to begin irradiation or treatment.
  • the PC calibrates (C), receives the response (R) and activates the field generator (A) in the cycle represented in this figure.
  • Figure 12 represents the control circuit of the chest equipment of the present invention, where the control command is carried out by the microcontroller to which all the circuits involved in the present application are connected.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Magnetic Treatment Devices (AREA)

Abstract

L'invention concerne un équipement de thorax pour l'application de champ électromagnétique dans le traitement de lésions chroniques, lequel est constitué d'un dispositif de type siège à dossier et assise qui peut être positionnée de manière automatique au moyen de moteurs qui actionnent des pistons à déplacement linéaire, l'équipement complet étant commandé au moyen d'un PC et d'une interface visuelle qui permet de déployer des données de l'historique clinique du patient, du dossier clinique, la surveillance de lésions relativement à la réduction de leur taille après application du traitement; le champ magnétique étant généré au moyen de deux bobines Helmholtz rectangulaires placées sur les côtés du thorax, l'interface communiquant avec le PC par un port USB présentant une série de ports d'entrée et sortie pour communiquer avec les actionneurs, générateurs de champ et microcontrôleur.
PCT/MX2011/000002 2009-12-21 2011-01-05 Équipement de stimulation électromagnétique pour le traitement systémique au niveau du thorax de lésions chroniques, l'activation de l'angiogenèse et l'augmentation de la perméabilité vasculaire WO2011078644A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXMX/A/2010/000096 2009-12-21
MX2010000096 2009-12-21

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Publication Number Publication Date
WO2011078644A2 true WO2011078644A2 (fr) 2011-06-30
WO2011078644A3 WO2011078644A3 (fr) 2011-11-24

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PCT/MX2011/000002 WO2011078644A2 (fr) 2009-12-21 2011-01-05 Équipement de stimulation électromagnétique pour le traitement systémique au niveau du thorax de lésions chroniques, l'activation de l'angiogenèse et l'augmentation de la perméabilité vasculaire

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428366A (en) * 1981-05-06 1984-01-31 Alfred B. Kurtz Electromagnetic apparatus and method for the reduction of serum glucose levels
US6099459A (en) * 1998-09-04 2000-08-08 Jacobson; Jerry I. Magnetic field generating device and method of generating and applying a magnetic field for treatment of specified conditions
WO2001015770A2 (fr) * 1999-08-27 2001-03-08 Luis Canedo Procede electromagnetique permettant de traiter des lesions liees a une perfusion sanguine inadaptee, une denervation partielle, une perte tissulaire, la douleur, un oedeme, une inflammation et infection
US20080139871A1 (en) * 2004-02-06 2008-06-12 Axel Muntermann Apparatus for Treatment With Magnetic Fields

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428366A (en) * 1981-05-06 1984-01-31 Alfred B. Kurtz Electromagnetic apparatus and method for the reduction of serum glucose levels
US6099459A (en) * 1998-09-04 2000-08-08 Jacobson; Jerry I. Magnetic field generating device and method of generating and applying a magnetic field for treatment of specified conditions
WO2001015770A2 (fr) * 1999-08-27 2001-03-08 Luis Canedo Procede electromagnetique permettant de traiter des lesions liees a une perfusion sanguine inadaptee, une denervation partielle, une perte tissulaire, la douleur, un oedeme, une inflammation et infection
US20080139871A1 (en) * 2004-02-06 2008-06-12 Axel Muntermann Apparatus for Treatment With Magnetic Fields

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TREJO NUNEZ A D ET AL.: 'Treatment of diabetic foot ulcers through systemic effects of extremely low frequency electromagnetic fields' AIP CONFERENCE PROCEEDINGS vol. 1032, 2008, USA, pages 291 - 294 *

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