WO2011071952A2 - Dispositifs de transfert, ensembles de transfert et procédés permettant de transférer des contenus entre réservoirs - Google Patents

Dispositifs de transfert, ensembles de transfert et procédés permettant de transférer des contenus entre réservoirs Download PDF

Info

Publication number
WO2011071952A2
WO2011071952A2 PCT/US2010/059336 US2010059336W WO2011071952A2 WO 2011071952 A2 WO2011071952 A2 WO 2011071952A2 US 2010059336 W US2010059336 W US 2010059336W WO 2011071952 A2 WO2011071952 A2 WO 2011071952A2
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
reservoir
fluid transfer
transfer device
flow
Prior art date
Application number
PCT/US2010/059336
Other languages
English (en)
Other versions
WO2011071952A3 (fr
Inventor
Amir Genosar
Original Assignee
Aktivpak, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktivpak, Inc. filed Critical Aktivpak, Inc.
Publication of WO2011071952A2 publication Critical patent/WO2011071952A2/fr
Publication of WO2011071952A3 publication Critical patent/WO2011071952A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2017—Piercing means having three or more piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M2039/1061—Break-apart tubing connectors or couplings

Definitions

  • the present invention broadly relates to transfer devices, transfer assemblies and methods for transferring of contents between reservoirs.
  • the invention is particularly useful in the medical field for delivering beneficial agents to patients.
  • Fowles' US Patent Application 20080300570 teaches a reconstitution assembly that includes: a flexible bag containing a diluent; a drug vial containing a drug; a reconstitution device further comprising: a first sleeve connected to the first receptacle; a second sleeve connected to the second receptacle, the second sleeve being associated with the first sleeve and movable axialiy with respect thereto from an inactivated position to an activated position; a piercing member positioned in the sleeves, the piercing member providing a fiuid pathway between the bag and vial when the sleeves are in the activated position.
  • Capitaine's US Patent Application 20080177244 teaches a method and a set for transferring fluid between a first receptacle and a second receptacle.
  • the first receptacle is connected to an end of a first transfer body, a first sealing member preventing the fluid communication between these two elements.
  • the second receptacle is closed by a second sealing member.
  • the second receptacle is assembled with a fastening member provided at an end of a second transfer body which is in an inactivated position of the transfer set wherein at least a part of this body is partially inserted within the other end of the first transfer body.
  • Each transfer body has one central passage coaxial to accommodate at least one end of a mobile piercing member.
  • Vancaillie's US Patent Application 20080249499 teaches a medicant reconstitution system which has a generally flexible fluid bag with associated administration and reconstitution ports.
  • the reconstitution port is adapted for receiving a medicant container and the administration port is for administering a medical fluid to a patient,
  • the administration and reconstitution ports are integrated in a relatively rigid port structure.
  • the reconstitution port receives a piercing member which is rotatable to a selected position to establish fluid flow.
  • one of the reconstitution ports and piercing members includes a cutting edge, while the other includes a frangible member. Contact between the cutting edge and the frangible member opens the frangible member to establish fluid flow.
  • the referenced art above provides ways for forming fluid communication between an infusion bag containing a diluent and a vial containing an agent, but lacks a solution for creating an efficient transfer of the agent from the vial to the bag.
  • the vial contains a dry agent under vacuum conditions
  • diluent will flow into the vial through a relatively narrow passage and reconstitute the dry powder agent.
  • nothing in the above referenced art causes a systematic transfer of the reconstituted fluid back into the bag, and thus, uncertainty remains to the concentration of the agent that the patient will be receiving. It is therefore the purpose of the present invention to provide a system that will efficiently transfer the reconstituted agent from the vial to the second receptacle.
  • the above referenced art adds complexity and cost of manufacturing and requires an undesired shift in the caregiver practices. It is the purpose of the present invention to reduce the manufacturing cost and complexity and reduce the change in the caregiver practice to a minimum.
  • a fluid transfer device comprising a transfer body having first and second ported portions for attachment to first and second receptacles, respectively, A first flow passageway and at least a second flow passageway extend between the first and second ported portions.
  • the second flow passageway is preferably interrupted and comprises at least first and second passageway segments.
  • the first flow passageway is uninterrupted.
  • At least one of the first and second ported portions may comprise a piercing member and/or a threaded connector such as a Luer lock connector, a press fit connector, a barbed connector, or a tubed segment.
  • the first and second passageway segments may be joined to one another, for example, through a fluid transporter that is attachable in fluid communication between them.
  • the fluid transporter may comprise at least one movable member such as a compressible member, an expandable member, a plunger and barrel arrangement, a bellows, or a diaphragm.
  • a flow restrictor may be located within at least one of the first and second flow passageways, or externally of the transfer body.
  • Various types of flow restrictors may be employed, such as a valve, a check valve, an asymmetric solid protrusion which interferes with flow, a movable interference, or the like.
  • first and second flow passageways share a common inlet/ outlet port
  • one or both of the ported portions may comprise a nozzle that is configured to create a flow pattern such as a jet, a spray, a sprinkle, a swirl, or a pulsating flow.
  • At least one intermediate port may be located between the first and second ported portions for introducing a fluid into one of the flow passageways.
  • the fluid transfer assembly includes a transfer body as described above, first and second reservoirs that are attached to first and second ported portions, respectively, and a fluid transporter attached in fluid communication with the first and second passageway segments.
  • the first reservoir contains a first substance which may be a liquid, a paste, a gel, a slurry, a solution, a suspension, a solid, granules, pellets, loose powder, compressed powder, a cake, a lyophilized cake, or a gas.
  • the first substance may be evenly distributed within the first reservoir or situated within a region of the first reservoir.
  • the second reservoir contains a second substance which may be a liquid, a paste, a gel, a slurry, a solution, a suspension, or a gas.
  • Objects may be introduced into the first reservoir to enhance mixing of the first and second substances.
  • Either or both of the first and second reservoirs may he a rigid container, a flexible container, a medical device, or the like.
  • various devices such as a bottle, a vial, a tube comprising glass, plastic, ceramic, paper or metal; a bag, an infusion bag, a pouch, a sachet, a blister package, a bellows, a collapsible bottle; an infusion bottle comprising plastic or rubber; a syringe, and injector, or a cartridge.
  • At least one of the reservoirs comprises an interface for establishing fluid communication with the transfer body.
  • the interface may be a piercing member, a threaded connector, a press fit connector, a barbed connector, a septum, a vial adapter, corked connector, a flange, or a tube,
  • a coupler attaches the transfer body to at least one of the first and second reservoirs. In other arrangements the coupler is associated with one of the reservoirs or formed integrally with the transfer body.
  • At least a portion of one of the reservoirs may be encapsulated within an enclosure to provide a contaminant-free environment.
  • the first and second reservoirs and the fluid transfer device are disposed within a partitioned package having a first compartment for accommodating the first reservoir and the fluid transport device, a second, fluid-filled compartment that defines the second reservoir, and a partition extending therebetween.
  • the partition may be configured to interface the second reservoir to the transfer body through, for example, a fitment.
  • Methods are also provided for transferring the mixture from a first reservoir toward a second reservoir.
  • the method comprises ( 1) interposing a fluid transfer device between the reservoirs; (2) altering characteristics of the fluid transfer device so that it changes from a rest state to an accumulator state to change a volume of fluid therein; and (3) returning the fluid transfer device toward the rest state to urge mixture in the first reservoir to flow toward the second reservoir.
  • the contents of the reservoirs are merged to form the mixture by increasing the fluid volume within the fluid transfer device.
  • Fluid volume within the fluid transfer device may also be increased to cause fluid within the second reservoir to enter a first passageway, mix with contents within the first reservoir, and enter at least a portion of the fluid transfer device via a second passageway.
  • decreasing fluid volume of the fluid transfer device causes the mixture to flow from the fluid transfer device toward the second reservoir.
  • the mixture enters the fluid transfer device via a first segment of the second passageway, and exits the fluid transport device via a second segment of the second passageway.
  • the fluid transfer device may he biased toward the rest state and its characteristics altered through pressurization,
  • an interface device interfaces the first and second reservoirs and may be moved by pressurizing at least a portion of the second reservoir to cause the fluid transfer device to couple the reservoirs in fluid communication with one another,
  • flow within the second passageway may be restricted and the fluid caused to flow in a cyclical manner within the fluid transfer device.
  • Figure 1 shows a portion of a preferred embodiment of the transfer device excluding the fluid transporter associated with a vial.
  • Figure 2 shows a portion of a preferred embodiment of the transfer device excluding the fluid transporter associated with a vial and a second receptacle.
  • Figure 3 shows a preferred embodiment of the transfer device associated with a vial where the passive fluid transporter is a piston and plunger arrangement and the flow in the flow loop goes from the fluid transporter to the vial.
  • Figure 4 shows a preferred embodiment of the transfer device associated with a vial where the passive fluid transporter is a piston and plunger arrangement and the flow in the flow loop goes from the vial to the fluid transporter.
  • Figure 5 shows a preferred embodiment of the transfer device associated with a vial where the passive fluid transporter comprises stretchable external walls like a balloon.
  • Figure 6 shows a preferred embodiment of the transfer device associated with a vial where the passive fluid transporter comprises rigid external walls and an internal collapsible member like a balloon.
  • Figure 7 shows a preferred embodiment of the transfer device associated with a vial where the passive fluid transporter is accommodated around the main axis of the transier device.
  • Figure 8 shows a preferred embodiment of the transfer device associated with a vial where the active fluid transporter comprises a manually operated piston and plunger pump.
  • Figure 9 shows a preferred embodiment of the transfer device associated with a vial where the active fluid transporter comprises a powered peristaltic pump
  • Figure 10 shows a portion of a preferred embodiment of the transfer device associated with a vial having separate outlet and inlet piercing members to the vial and the second receptacle.
  • Figure 11 shows a portion of a preferred embodiment of the transfer device associated with a vial having separate outlet and inlet piercing members to the vial and a common piercing member to the second receptacle.
  • Figure 12 shows a portion of a preferred embodiment of the transfer device associated with a vial illustrating a preferred valve arrangement
  • Figure 13 shows a preferred embodiment of the transier device associated with a vial and a second receptacle where the second receptacle forms an aseptic volume around the transier device.
  • Figure 14 shows a preferred embodiment of the transfer device associated with a vial and a second receptacle where the second receptacle forms an aseptic volume around the transfer device.
  • Figure 15 shows a preferred embodiment of the transfer de vice associated with a bag and a vial and where the transfer device comprises an air passage
  • Figure 16 shows a preferred embodiment of the transfer device associated with a syringe.
  • Figure 17 shows a preferred embodiment where the transfer device is sealed in an aseptic wrap.
  • Figure 18 shows a preferred embodiment of a kit where the transfer device and a syringe are included in an aseptic package.
  • Figure 19 shows a preferred embodiment where the pressure in the hag manipulates the transfer device to engage with the vial and the bag
  • Figure 1 illustrates a transfer device 10 attached to a first reservoir in a form of a vial 1, through a first ported portion 15.
  • the vial 1 comprises a rigid container 4 and a rubber septum 2 sealed against the spout of the rigid container 4 and is retained in its position by a crimped retaining ring 3.
  • the vial 1 contains a first substance which may he in various forms including liquid, gas, solid, suspension, gel, paste, slurry, loose dry powder, iyophiiized cake, granules, pellets, tablet or any other appropriate form known in the art.
  • at least one of the substances in the first and second receptacles is evenly distributed in the receptacle.
  • at least one of the substances in the first and second receptacle is situated in a region of said receptacle.
  • the transfer device 10 comprises a transfer body comprising an interface to the vial 1 , in a form of a first ported portion 15, comprising a vial piercing member for piercing the septum 2, and a vial adapter in the form of retaining cantilevers 12 that retain the vial 1 to the transfer device 10 when the vial piercing member 15 is engaged with the vial 1.
  • the transfer device 10 further comprises a second ported portion 14 comprising a piercing member, opposite to the vial piercing member 15, for engaging the transfer device 10 with a second receptacle.
  • said second receptacle is a flexible package such as infusion bag or infusion bottle.
  • the transfer device 10 further comprises a first flow passageway 16 extending between said first ported portion and said second ported portions, and a second interrupted flow passageway 17 extending between said first portion and said second ported portion, wherein the second interrupted flow passageway comprises first and second passageway segments 17' and 17".
  • first passageway 16 and second passageway 17 is an inlet passage, through which fluid from the second receptacle flows into the first receptacle to form a mixture.
  • the other is an outlet passage through which the mixture flows to the second receptacle.
  • Passageway 17 is interrupted by a discontinuation forming ports 19' and 19" where the fluid transporter is associated. Additional passageways and passageway segments may be incorporated in the transfer device.
  • connectors may be incorporated with at least one of the first ported portion 15 and the second ported portion 14 to attach and communicate with various types of receptacles, including a Luer connector, a Luer Lock connector, a press fit connector, a barbed connector, a threaded connector, a flange, a septum, a bionet, and a tube.
  • Figure 2 shows the embodiment 10 of Figure 1 associated with a second receptacle 21 in a form of an infusion bag.
  • a fitment 22 is sealed in a fluid tight fashion between the walls of the bag 21.
  • a septum 23 is accommodated in the fitment and seals the diluent 24 in the container when the bag 21 is not engagement with the transfer device 10.
  • the first receptacle, in a form of a vial 1, and the bag 21 are engaged with the transfer device during the perpetration for use of the second receptacle.
  • At least a portion of the vial 1, the transfer device 10, and the septum 23 of the bag 21 are maintained in an aseptic enclosure 25 to maintain the transfer device clean or sterile and prevent introduction of contaminants to the bag when septum 23 is pierced.
  • at least a portion of said transfer body and at least a portion of one of said first reservoir and said second reservoir is encapsulated within an enclosure to provide a contaminant free environment.
  • the second receptacle may be in various forms and fashions know in the art including a rigid container, a metal container, a glass container, a film package, a bag, a pouch, a blister; a molded plastic container such as a Polyethylene, Polypropylene, Polycarbonate, PET, COO, COP container; a rubber container or a combination of the above.
  • the second receptacle may be an infusion bag or infusion bottle. In some embodiments at least a portion of the device and a portion of die second receptacle are encapsulated together to avoid introduction of contamination to the second receptacle.
  • Figure 3 shows an arrangement of a transfer assembly where the transfer device 30 comprises a fluid transporter 31 attached in fluid communication with ports 19' and 19" and joining the first segment 17" and the second segment 17' to one another.
  • the fluid transporter is attachable in fluid communication with said at least first segment 17" and second segment 17' of the second passageway.
  • the fluid transporter 31 comprises an expandable volume arrangement comprising a stationary barrel 32 and a moveable member in the form of a plunger 33, where the plunger 33 is biased by spring 34 to deplete the fluid volume in the volume transfer assembly 31.
  • the fluid transporter 31 is connected to ports 19' and 19" via check valves 35' and 35", respectively, which dictate a unidirectional flow from the vial 1 to the fluid transporter 31, and from the fluid transporter 31 to the second receptacle port.
  • the check valves dictate an inlet passage 16 which introduces a fluid from the second receptacle into the vial; and an outlet passage which delivers the mixture to the second receptacle.
  • the second receptacle is a flexible container and the elevation of pressure at the second ported portion 14 may be achieved by squeezing said flexible container.
  • the valve 35' prevents fluid from flowing in outlet passage 17' toward the fluid transporter 31. Flow is established through inlet passage 16 into the vial, through the first receptacle port 15 in the vial piercing member 15, and mixes with the content of the vial 1 to form a mixture, The mixture flows from the vial 1 to the fluid transporter 3 1 through the first ported portion 15, and the outlet passage 17" and check valve 35".
  • the term mixture as used in this text may relate to, but not be limited to, a dilution, a blend, a suspension, a composition, and a multi-phase fluid.
  • the inlet port of the first passageway 16 to the first receptacle 1 is configured to create a desired flow pattern or direction to extend the mixing of the product of the first receptacle with the product of the second receptacle.
  • the inlet port may comprise a nozzle configured to form a jet, a spray, a swirl and a pulsating flow.
  • the flow pattern is caused by impinging the inlet flow to the first receptacle against an impinging object.
  • the pressure may be dropped by releasing a squeeze of the container, A transfer cycle is completed with each pressurization and depressurization of the second receptacle in which the volume of the fluid transporter is advanced in the transfer loop formed by articulation in the following order of: the second ported portion 15, inlet passage 16, the first receptacle port, the vial volume, back to the first receptacle port, through outlet passage's first portion 17", fluid transporter 31 , and outlet passage's second portion 17' back to the second receptacle (not shown) through the second ported portion 14.
  • the fluid transporter 31 may have any desired volume suitable for effective mixing and transferring of the mixture to the second receptacle in a transfer cycle.
  • the transfer cycle can be repeated several times to ensure a proper transfer of the substance from the vial 1 to the second receptacle (not shown).
  • the device is shown with flow restrictor in the fluid passageway in the form of check valves 35' and 35".
  • the transfer of fluids according to this disclosure can be accomplished with flow restrictors that do not necessarily seal and completely prevent back flow, but rather enhance flow in one direction versus the other direction.
  • the transfer cycle may be less efficient in the sense that more transfer cycles may be required to achieve a satisfying level of transfer of the beneficial agent from the first receptacle to the second receptacle.
  • the flow restrictor may be merely an object presented in the flow passage such as a labyrinth. Examples of non-symmetric labyrinth are practiced in commercial irrigation drippers.
  • the flow restrictor(s) may be disposed in the transfer device body including within the first passageway 16 and the second passageway segments 17' and 17".
  • the flow restrictor(s) may be located externally of said transfer body including in the fluid transporter 31, and/or associated with the first and second ported portions 14, 15,
  • Figure 3 illustrates a fluid transfer device and assembly for transferring a beneficial agent from a first receptacle to a second receptacle, comprising: a first ported portion made to deliver and receive fluid from the first receptacle; a second ported portion made to deliver and receive fluid from the second receptacle; an inlet passage and an outlet passage communicating between said first ported portion and said second receptacle port; at least one fluid transporter disposed in the passageway between the first ported portion and said second receptacle port, made to receive fluid from at least one of the inlet passage and the outlet passage; and at least one flow restrictor disposed between said first ported portion and said second ported portion to generally dictate a unidirectional flow in said passageways,
  • the inlet passage is made to deliver fluid from the second receptacle to the first receptacle and form a mixture with the beneficial agent.
  • the outlet passage is made to receive the mixture from the first receptacle, and the arrangement is such that when fluid pressure at the second ported portion is higher than the fluid pressure at the fluid transporter, fluid from the passageway will be received at the fluid transporter, and when fluid pressure at the second ported portion is lower than the fluid pressure at the fluid transporter, said mixture will be dispensed from said second receptacle port.
  • Figure 3 generally teaches a fluid transfer assembly for use in transferring contents between receptacles, comprising a transfer body, having a first ported portion 15 for attachment to a first reservoir that contains a first substance; a second ported portion 14 for attachment to a second reservoir that contains a second substance; a first flow passageway 16 extending between said first ported portion and said second ported portion; and a second interrupted flow passageway 17 extending between said first portion and said second ported portion.
  • the second interrupted flow passageway comprises at least first passageway 17" and second 17' passageway segments.
  • a first receptacle 1 is attached to said first ported portion, and a second receptacle is attached to said second ported portion (not shown).
  • a fluid transporter 31 is attached in fluid communication with said at least first passageway 17' and second 17" passageway segments,
  • the first receptacle 1 may be selected from various type of containers or reservoirs known in the art including a rigid container, a flexible container, a medical device, glass vial, a plastic vial such as vials made from COO or COP, a bag, a pouch, a blister, an elastic container, a rubber container, a blow molded container, a bottle, a vial, a tube comprising glass, a tube comprising plastic, a tube comprising ceramic, a tube comprising paper, a tube comprising metal, a bag, an infusion bag, a pouch, a sachet, a blister package, a bellows, a collapsible bottle, an infusion bottle comprising plastic, an infusion bottle comprising rubber, a syringe, an injector, a cartridge, or any combination of the above.
  • At least one member of the fluid transporter contracts in response to compression and release of the flexible package, respectively.
  • the fluid volume of the fluid transporter expands when fluid is received at the second receptacle port.
  • the fluid transporter accumulates fluid from said passageway when the fluid pressure at the second ported portion is raised to be higher than the fluid pressure at the fluid transporter.
  • the first ported portion is made to create a desired flow pattern in the form of at least one of a jet, sprinkle, squirt, spray, whirl, swirl, or pulsations.
  • At least one mixing enhancing object is received at the first receptacle from the first ported portion when the last is introduced into the first receptacle.
  • the mixing enhancing object(s) are rigid or elastic objects that move around the first receptacle when flow is introduced to the container and impinge, shear, increase the momentum of the flow, or otherwise enhance the mixing of the beneficial agent with the fluid from the first receptacle.
  • the mixing enhancing objects can be in the form of beads, pellets, granules, chips or other form that may be beneficial to enhance the mixing.
  • the mixing enhancing objects can be stored in the inlet passage or mounted at the leading portion of the first receptacle port.
  • the arrangement is such that the mixing enhancing objects are prevented from entering the outlet passage to avoid them reaching the second receptacle.
  • the mixing enhancing objects are made from an inert material that will not have a chemical or composition effect on the mixture that returns to the second receptacle.
  • at least one of the first ported portion and the second ported portion comprises a piercing member for introducing the port into a container.
  • other coupling means are provided to form fluid communication between at least one of the first ported portion and the second receptacle port, including a press fit connector, a barb connector, a Luer connector, a Luer lock connector, or any other coupling means known in the art, or a combination of the above.
  • the present disclosure provides a method for transferring fluid from a firs t receptacle to a second receptacle by expanding and contracting a fluid transporter in the flow passage between the first and the second receptacles. Furthermore the present invention provides a method where the expansion and contraction of the fluid transporter is achieved by squeezing and releasing the second receptacle. In some embodiments, the present disclosure provides a method for transferring a beneficial agent from a first receptacle to a second receptacle where squeezing the first receptacle causes a transfer cycle.
  • an indicator is provided to illustrate the displacement of the plunger as an indication to the performance of the transfer cycle.
  • the indicator is associated with the plunger 33 that indicates that a certain fluid volume was squeezed from the second receptacle to the fluid transporter 31.
  • a counter is associated with the plunger 33 that counts the number of successful transfer cycles performed.
  • the counter may include indication illustrating count up or count down number or with other graphic or colors that facilitates the indication of a successful transfer procedure.
  • At least one of the substances in the first and second receptacle is evenly distributed in the receptacle. In some embodiments at least one of the substances in the first and second receptacle is situated in a region of said receptacle.
  • Receptacle may include a reservoir and a container.
  • Figure 4a shows a further preferred embodiment 40 mostly similar to the embodiment of Figure 3 with the exception that the flow restrictors, in the form of check valves 35' and 35", are reversed such that the transfer loop is established in an opposite flow direction to that of embodiment 30. The resulting transfer process is similar to that of embodiment 30 of Fi gure 3.
  • embodiment 40 is shown when pressure is raised at the second ported portion 14.
  • Check valve 35" is closed and check valve 35' opens establishing a fluid flow from the second receptacle (not shown) to the fluid transporter 31.
  • embodiment 40 is shown when the pressure at the second ported portion 14 is reduced.
  • Check valve 35' closes and check valve 35" opens establishing flow from the fluid transporter 31 to the vial 1 and out toward the second receptacle (not shown) via passage portion 16, completing a transfer cycle of one fluid transporter 31 volume.
  • Figure 5a shows another preferred embodiment 50 of the transfer device and assembly mostly similar to embodiment 40 of Figure 4 with the exception that the fluid transporter 51 comprises a movable member between a rest state and a fluid accumulation state, said fluid transporter being biased in the rest state.
  • the moveable member is an expandable member having a stretchable wall 52.
  • the stretchable wall 52 may be in a form of a balloon, a diaphragm, a bellows or other expandable wail arrangements known in the art.
  • the device is shown at the rest state prior or post a transfer cycle where the fluid transporter is a depleted position.
  • the stretchable wall 52 is mounted on a core sleeve such that it remains stretched at the depleted position. This arrangement allows sufficient pressure to the fluid forcing a known volume at each transfer cycle.
  • the transfer device 50 is shown when pressure is developed at the inlet port of the second ported portion 14. Flow is established from the second receptacle to the fluid transporter 51 via passage portion 17', causing the stretchable wall 52 to stretch and expand the fluid transporter 51 fluid volume, and accumulate fluid from the second receptacle.
  • the transfer device is shown when the pressure at the second ported portion 14 is reduced, The stretch able wall 52 forces the fluid out of the fluid transporter 51 back to the second receptacle through vial 1 , as the movable member is biased to the rest state of the fluid transporter.
  • More generally device 50 presents a preferred embodiment where said fluid transporter 51 comprises an expandable member, allowing for fluid to be received at the fluid transporter.
  • Figure 6a shows another preferred embodiment 60, mostly similar to embodiment 50, with the exception that the fluid transporter 61 comprises a rigid external wall 62 and a movable member in the form of an inner compressible member 63 moveable between a rest state and a fluid accumulation state, said fluid transporter being biased in the rest state.
  • the compressible member 63 can be a gas filled rubber ball or balloon, a closed cell foam portion, or other compressible members known in the art.
  • the device is shown at the rest state prior or post a transfer cycle where the transfer compressible member is expanded and the fluid volume of the fluid transporter 61 is depleted.
  • the transfer device 60 is shown at the accumulated state, when pressure is built at the second ported portion 14, and flow is established from the second receptacle to the fluid transporter 61 via passage portion 17', causing the compressible member to compress expanding the fluid volume of the fluid transporter 61, and accumulating fluid from the second receptacle.
  • the transfer device is shown as the fluid transporter 61 returns to its rest state, when the pressure at the second ported portion 14 is reduced.
  • the compressible member 62 expands forcing the fluid out of the fluid transporter 61 back to the second receptacle through vial 1 , as the moveable member returns toward its rest state.
  • More generally device 60 presents a preferred embodiment where the fluid transporter comprises a contractible member, allowing for fluid to be received at the fluid transporter.
  • Figure 7a shows another preferred embodiment 70 of the transfer device 73 mostly similar to the transfer device 50 of Figure 5 with the exception that the moveable member is an expandable member of the fluid transporter 71, in the form of a stretchable wail 72, accommodated around the longitudinal axis of the transport device 73,
  • the assembly 70 is shown at the rest state prior or post a transfer cycle where the stretchable wall 72 is substantially at rest.
  • the transfer device 70 is shown, where the fluid transporter is moving toward the accumulated state, when pressure is built at the second ported portion 14. Flow is established from the second receptacle to the fluid transporter 71 via passage portion 17', causing the stretchable wall 72 to stretch and expand the fluid transporter 71 volume.
  • the transfer device is shown, as the fluid transporter is biased toward the rest state, when pressure is reduced at the second receptacle port.
  • the stretchable wall 72 forces the fluid out of the fluid transporter 71 back to the second receptacle through vial 1.
  • Figure 8a shows a further preferred embodiment 80 of the transfer device mostly similar to embodiment 40 of Figure 4 with the exception that the plunger 82 of the fluid transporter 81 is manually and directly manipulated to change the volume of the fluid transporter 81 , and to cause for fluid transfer from the first receptacle to the second receptacle.
  • the fluid transporter is shown at the depleted position.
  • FIG. 8 illustrated an arrangement where the fluid transporter is a manually operated pump.
  • a pump at the fluid transporter may be selected of the group including a powered pump, an electric pump, a turbo pump, a vein pump, a peristaltic pump, a volumetric pump, a siphon pump or other pumps known in the art.
  • More generally device 80 presents a preferred embodiment where the fluid transporter is directly manipulated to receive fluid from the second receptacle at the second ported portion and to deliver mixture to the second receptacle at the second receptacle port, in some embodiments the fluid transporter comprises at least one of a plunger and barrel arrangement, or a bellows that is directly manipulated to change the fluid volume of the volume transfer assembly.
  • the diluent container in this embodiment can be a rigid container since it does not have to be pressurized to cause the transfer of fluid from the vial.
  • the container can be a metal container, a glass container, a rigid plastic container such as container made of Polyethylene, Polypropylene, Polycarbonate, PET, COO, COP container.
  • This embodiment and other possible embodiments of the present disclosure pro vide a method where the expansion and contraction of the fluid transporter is achieved by a back and fourth operation of a syringe.
  • Figure 9a shows a further preferred embodiment 90 where the fluid transporter 91 comprises a rotary peristaltic pump 92 connected to ports 19' and 19" of passage portion 17.
  • Figure 9b shows the embodiment 90 when the pump 92 is activated causing fluid from the diluent container (not shown) to continuously flow through the transfer loop and effectively transfer the content of the vial 1 to the diluent container.
  • the rotation of the pump can be powered by various means including an electric motor, a manually operated pulley and rope, a manual lever, or other powering means known in the art. Other types of pumps may be incorporated in place of the rotary peristaltic pump.
  • device 90 presents a preferred embodiment where the fluid transporter is directly manipulated to receive fluid from the second receptacle at the second ported portion and to deliver mixture to the second receptacle at the second receptacle port.
  • the fluid transporter comprises a pump.
  • Figure 10 shows a portion of another preferred embodiment 100 of the transfer device mostly similar to embodiment 10 of Figure 1 with the exception that the spikes 14 and 15 (of Figure 1) with the inlet and outlet port are replaced by an inlet needle and an outlet needle 14' and 14" and 15' and 15" respectively,
  • the needle may be an integral protrusion of the body of the transfer device 100 or separate needles assembled to the body of the transfer device 100.
  • the needles have the capacity to reduce the force required to engage the transport device 100 with the vial 1 and the diluent container (not shown).
  • at least one of the first ported portion and the second ported portion comprises a separate protrusion or piercing member that protrudes into the container for the inlet passage and the outlet passage.
  • FIG. 1 a portion of another preferred embodiment 1 10 is shown, mostly similar to embodiment 100 of Figure 10 with the exception that needles 14' and 14" (of Figure 10) are replaced with a common needle 1 11.
  • a portion of the inlet passage and the outlet passage are a common passage.
  • a portion of said first flow passageway merges with at least a portion of said second interrupted flow passageway.
  • the first passageway 16 and the second interrupted passageway share a common inlet/outlet port.
  • Figure 12a shows another embodiment of the fluid transport device with a preferred arrangement of the check valves 53' and 53",
  • the first ported portion 15 comprises a co- annular arrangement of the inlet passageway portion to the vial 17", and the outlet passage portion of the reservoir 16.
  • a resilient member 121 forms check valve 53' by sealing a circular lateral protrusion against the wall of passage portion 17' which leads from the second receptacle (not shown) to the fluid transporter 122.
  • the resilient member 121 also forms check valve 53" between the vial 1 and the second receptacle (not shown),
  • the check valve 53" has a duckbill valve fashion.
  • the central passageway is not interrupted. Although a check valve is presented in the central flow passageway 16, the flow entering this passageway
  • Figure 12b shows the transfer device 120 when pressure is built up at the second ported portion 14.
  • the pressure in the passage portion 17' causes the sealing protrusion of the valve 53' to collapse toward the center allowing the fluid from the second receptacle to fill the fluid transporter 122.
  • the pressure in the second receptacle causes the check valve 53" to collapse inward and seal tighter, preventing flow up passage portion 16 to the vial 1.
  • Figure 12c shows the transfer device 120 when the pressure at the second ported portion is damped.
  • the stretchabie wall 123 pressurizes the fluid in the fluid transporter 122.
  • This pressure differential on check valve 53' presses the circular sealing protrusion of the resilient member 121 to press tightly against the wail of the passage portion 17' preventing flow from the fluid transporter 122 to the second receptacle through passage portion 17'.
  • the pressure differential on valve 53" causes the duckbill valve to open allowing flow from the fluid transporter 122 to return to the flexible reservoir through the vial 1.
  • the central passageway is non-interrupted. Although a check valve is presented in the central flow passageway 16, the flow entering this passageway at the first ported portion 15 flows directly to the second ported portion 14.
  • the flow passageway 17 is interrupted as the flow coming up the first segment 17' from the second ported portion is diverted into the fluid transporter 122 before continuing to the first ported portion.
  • Figure 12 emphasizes that the check valves can be positioned in various locations along the transfer loop and contribute to similar functionality as described in former figures. It will be obvious to those skilled in the art that in order to direct the flow in one direction through the passages 16 and 17 it is not necessary to achieve a hermetic seal at the valves, and it would be sufficient to create unidirectional flow restriction at these locations.
  • Figure 13 shows an assembly of the transfer device 120 of Figure 12 with an infusion bag 13 1.
  • the bag is separated into a first compartment 133 accommodating the first receptacle, and a second compartment thai serves as the second receptacle, A fitment, incorporating a septum, is disposed at the seal separating between the first compartment 133 and the second compartment.
  • the first compartment 133 maintains the transfer device clean or sterile and prevents contamination of the product in the first and second receptacles.
  • the engagement of the transfer device 120 with the vial 1 and the transfer device 120 and the bag 131 is achieved by displacing the vial toward the first receptacle along the axis of the vial.
  • This axial displacement can be performed in various ways, including manipulation of the vial through the wall of the package compartment 133; reaching the vial through a designated openable section in the wall of the first compartment; removing a designated portion of the wall of the first compartment 133 such as a removal of a an easy-peel adhered portion which was weakly welded over an open window in the wail of the first compartment 133; by activating a powered or spring load mechanism that can perform the axial displacement action, or by a device or apparatus made to cause this displacement.
  • a desiccant component may be disposed in the first compartment 133 to maintain a dry environment around the first receptacle.
  • a label, infusion set or component of such, and package insert may be included in the first compartment 133, or in a third compartment,
  • this embodiment presents a package, divided into at least a first compartment and a second compartment, separated by a divider (i.e., partition) such that, said first compartment provides the second receptacle, and the second compartment provides an enclosure for the fluid transport device.
  • the arrangement is such that the second ported portion is introduced to the second compartment through the divider.
  • the divider comprises a fitment, in some embodiments the fitment comprises a septum through which the second ported portion is introduced from said first compartment to said second compartment.
  • the transfer device can be manipulated through the wall of said package.
  • Figure 13 illustrates a fluid transfer assembly wherein the first and second reservoirs and said fluid transfer device are disposed within a partition package 130 having a first compartment 133 for accommodating the first reservoir and the fluid transport device 120, a second, fluid-filled compartment defining said second reservoir, and a partition 132 extending therebetween.
  • the partition 132 is configured to interface the second reservoir to said transfer body.
  • the partition 132 may include a fitment for interfacing said second reservoir to said transfer body.
  • Figure 14 shows a further preferred embodiment 140 mostly similar to embodiment 130 of Figure 13 with the exception that the fitment 22 prolongs sideways across the bag 141 and provides the separation between the first compartment 133 and the second compartment.
  • the extended fitment 22 provides structural support to the bag and allows accommodation of various components of the transier device 120 in a firm fashion on the fitment 22.
  • this embodiment presents a package that is divided into at least a first compartment and a second compartment, separated by a divider such that, said first compartment provides the second receptacle, and the second compartment provides an enclosure for the fluid transport device.
  • the arrangement is such that the second ported portion is introduced to the second compartment through said divider.
  • said divider comprises a fitment.
  • the fitment comprises a septum through which the second ported portion is introduced from said first compartment to said second compartment.
  • the fitment provides the entire divider.
  • said transfer device can be manipulated through the wal l of said package.
  • Figure 15 shows another preferred embodiment.
  • An air passage 152 communicates between the first compartment 133 and the fluid transporter 153.
  • the flow in the passage is controlled by a release valve 153 which opens when the pressure in the second receptacle drops under a predefined threshold pressure.
  • the air flow passage 152 allows for replacement of fluid in the transfer device with sterile air such that portion of the remaining fluid may be transferred to the second receptacle.
  • the air flow in the air flow passage can be controlled in various ways including: a) a pressure release valve 153 activated when the suction from the diluent container exceeds a predefined threshold (such predefined threshold can be the suction imposed by an infusion set when the bag is emptied out); b) a pressure imposed by a person that squeezes the first compartment 133 and pressurized the sterile air in it; or c) a manually operated vaive that prevents the air flow into the transfer device at an undesired time.
  • a pressure release valve 153 activated when the suction from the diluent container exceeds a predefined threshold (such predefined threshold can be the suction imposed by an infusion set when the bag is emptied out); b) a pressure imposed by a person that squeezes the first compartment 133 and pressurized the sterile air in it; or c) a manually operated vaive that prevents the air flow into the transfer device at an undesired time.
  • this device 150
  • FIG. 16 a further preferred embodiment 160 is shown in which the transfer device 150 of Figure 15 is confined in a sealed sterile bag.
  • the diluent port 161 is adapted to receive a syringe 162 with diluent.
  • the transfer cycle is completed when the plunger 163 is retracted either by directly pulling the plunger 163 or by the pressure imposed by the fluid transporter 151.
  • a further pull back of the plunger 163 drops the pressure in the fluid transporter under a predefined pressure threshold which opens the valve 153 in the air passage 152 allowing sterile air to replace the mixture in the vial 1.
  • Figure 17 shows another preferred embodiment 170 mostly similar to embodiment 130 of Figure 13 with the exception that the aseptic compartment 133 is formed by a separate enclosure 171 which is sealed to fitment 122. In some manufacturing settings it will be more practical to prepare the transfer device assembly 120 with the sealed container 171 prior to the integration with the infusion bag.
  • Figure 18 shows another preferred embodiment 180 mostly similar to embodiment 160 of Figure 16, with the exception that the second receptacle 181. extends to form an aseptic compartment 182 around the syringe 162.
  • the syringe can be operated through the flexible wall or the compartment 182 can be opened such that a user could reach and operate the syringe 162.
  • Figure 19 shows another preferred embodiment where the engagement of the transfer device 120 with the second receptacle 195, and. the engagement of the transfer device 120 and the vial 1 during activation is automatically achieved by pressurizing the second receptacle 195.
  • Fitment 22 has a central opening to receive a piston-like moveable member 191 which accommodates the second receptacle's septum 23, and is movable along the axis of the vial 1.
  • a rolling membrane 192 seals between the fitment 22 and the moveable member 191 in a fluid tight fashion, and accommodates vertical travel of the moveable member 191.
  • Enclosure 193 of the fitment 22 accommodates the vial 1 and prevents travel of the vial 1 away from the second receptacle 195.
  • Extension 131 of the bag provides a sterile zone around the transfer device 120 and the vial 1.
  • a safety catch 194 needs to be removed to allow the moveable member 191 to travel.
  • the safety catch can be manipulated through the wall of the first compartment or by direct access.
  • an average hand squeeze of an infusion bag can generate a pressure greater than 0.6 bar above the ambient, pressure, and with a given 10 square surface effective surface area of the movable member 191 that pressure translates to 6Kg which is sufficient to force the engagement of the transfer device 120 as described above.
  • the retaining cantilevers 12 will latch the vial and retain the engagement throughout the use of the device.
  • a mechanical latch will retain the transfer device in the upper position.
  • a spring will be incorporated to bias the transport device 120 to the lower travel position of the moveable member 191.
  • This embodiment 190 presents a preferred embodiment where pressurizing the fluid at the second receptacle causes a portion of the second receptacle wall to displace and cause at least one of engaging the first ported portion with said first receptacle and the second ported portion with the second receptacle.
  • an enclosure 193 provides the aseptic barrier to the sterile zone 199 such that the first compartment sterile zone 133 can be avoided. It will be obvious to those skilled in the art that other forms of sealing between the fitment 22 and the movable member 191 can replace the rolling membrane, including an G-ring arrangement.
  • Figure 20 shows an arrangement of the transfer device body 200 where the uninterrupted first passageway 16 provides the uptake channel from the second reservoir to the first reservoir, and a second passageway 17" provides the return from the first reservoir the fluid transporter.
  • Mixing enhancing objects 201 in the form of spherical beads are disposed in the first passageway 16.
  • the arrangement is such that the flow of fluid from the second reservoir to the first reservoir through passageway 16 will carry the beads 201 into the second reservoir, where the beads will enhance the mixing of the fluid from the second reservoir with the substance in the first reservoir.
  • the first ported portion 15 comprises a plurality of openings toward the second passageway portion 17", the size of which is limited such that the beads 201 entering the first reservoir will not be able to exit the first reservoir toward the second reservoir.
  • the substance in the first reservoir is a lyophilized cake joined to the walls of the first reservoir and the mixing enhancing objects 201 enhance the removal dissolution of said cake by applying extended impact and shearing force.
  • the substance in the first reservoir may be viscous fluid in which case the momentum of the beads will enhance the penetration of the fluid from the second reservoir with the substance in the first reservoir.
  • the momentum to the mixing enhancing objects may he provided in various ways including a swirl flow pattern of the flow from the first passageway, or by agitation of the first reservoir after the mixing enhancing objects entered it.
  • the mixing enhancing objects may be formed in various shapes including spheres, pyramids, cubes, chips, rods, etc.
  • the mixing enhancing objects may have different surface finish including polished, rough, abrasive, coarse, granular, ragged, or spiky.
  • the mixing enhancing objects may be made from various materials including metals such as stainless steel or plastics such as polypropylene, polyethylene, polycarbonate, COC, or COP, A cap, a plug, a seal, a dissolvable membrane or plug maybe placed on the first ported portion to prevent to maintain the mixing enhancing object in the first passageway until the time of use.
  • the mixing enhancing objects are not disposed in the first passageway but rather arranged in a dedicated space in the first ported portion 15.
  • the mixing enhancing objects are arranged on the outer surface of the first ported portion 15.
  • a second ported portion 14 of the transfer device body 210 is shown illustrating an arrangement of a symmetric flow restrictors 21 1 in the first passageway 16.
  • the flow restrictors 211 have the form of a saw tooth/teeth protruding into the passageway, dictating higher flow resistance to flow traveling downward, toward the ported end of the second ported portion 14, than flow traveling upward in fluid passageway 16, from the ported end of the second ported portion 14. While the flow restrictors 21 1 do not prevent backflow in the first passageway 16, they impose a general flux of the fluid from the second ported portion 14, up first passageway 16, into the first reservoir and down the second passageway.
  • the flow restrictors may be formed in various shapes to increase turbulence and flow shear when flow is present in one direction in the fluid passageways and minimize the flow resistance when flow is present in the opposite direction in the fluid passageways.
  • the flow restrictor may be located at any portion of the transfer device body 210, such as in the second flow passage 17' or external to the transfer device body 210 such as in the fluid transporter (not shown).
  • the flow restrictor can be fixed objects as illustrated in this figure or movable. Referring now to Figure 22a another configuration of the transfer device body 220 is illustrated where movable flow restrictors 221 are disposed at the first passageway 16.
  • the flow restrictors 221 are in a form of cantilever amis anchored in the first passageway wall.
  • the transfer device 220 is illustrated showing how the flow restrictors 221 are moved when fluid flows upwardly in the first passageway 16, from the ported end of the second ported portion 14.
  • the cantilever arms are bent such that the interference with the flow is reduced and the result is that flow in the passageway is restricted less when upward flow is present than when downward flow is present, thereby the flow in one direction.
  • the flow restrictor may be located at any portion of the transfer device body 210, such as in the second flow passage 17' or external to the transfer device body 210 such as in the fluid transporter (not shown). It will be obvious to those skilled in the art that several other restrictors can be implemented to enhance the flow flux in a desired direction in the transfer device.
  • the transfer device can be situated in any direction and relation to the fluid in the second receptacle including above, under, or along side the fluid in the second receptacle.
  • air, water vapor or other substances in a gas state form a bubble in the second receptacle.
  • the port can be situated, or the container can be oriented to gravitate the bubble away from said port.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Loading And Unloading Of Fuel Tanks Or Ships (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention fournit divers modes de réalisation qui ont trait au transfert de contenus entre réservoirs. Certains modes de réalisation fournissent un dispositif de transfert de fluide comprenant un corps de transfert doté de première et seconde parties à orifice destinées à être attachées à des premier et second réservoirs, respectivement, et une pluralité de voies de passage d'écoulement s'étendant entre les parties à orifice. Selon d'autres agencements, la présente invention a trait à un ensemble de transfert de fluide qui incorpore le corps de transfert, les réservoirs attachés aux parties à orifice et un dispositif de transport de fluide établissant une communication fluidique entre ces derniers, par exemple en s'attachant aux premier et second segments de voie de passage de l'une des voies de passage d'écoulement. La présente invention a également trait à des procédés permettant de transférer des contenus entre réservoirs.
PCT/US2010/059336 2009-12-07 2010-12-07 Dispositifs de transfert, ensembles de transfert et procédés permettant de transférer des contenus entre réservoirs WO2011071952A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26712909P 2009-12-07 2009-12-07
US61/267,129 2009-12-07

Publications (2)

Publication Number Publication Date
WO2011071952A2 true WO2011071952A2 (fr) 2011-06-16
WO2011071952A3 WO2011071952A3 (fr) 2011-10-27

Family

ID=44146150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/059336 WO2011071952A2 (fr) 2009-12-07 2010-12-07 Dispositifs de transfert, ensembles de transfert et procédés permettant de transférer des contenus entre réservoirs

Country Status (1)

Country Link
WO (1) WO2011071952A2 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104337523A (zh) * 2014-10-24 2015-02-11 苏州仁捷瑞自动化科技有限公司 能自动抽吸的注射器
EP2962676A1 (fr) * 2014-07-02 2016-01-06 Paolo Gobbi Frattini S.r.l. Emballage souple avec une chambre hermétique stérile pour la reconstitution et l'administration d'un fluide médical ou de substances nutritives instillables dans le corps d'un patient
US9662621B2 (en) 2012-03-09 2017-05-30 Sensile Pat Ag Drug reconstitution system
EP3427781A3 (fr) * 2017-07-11 2019-05-01 Pharma Resources GmbH Médicament et système de dispositif pour des thérapies d'aérosol sous pression dans un espace creux d'un mammifère
WO2019086595A1 (fr) * 2017-11-02 2019-05-09 F. Hoffmann-La Roche Ag Dispositif pour transférer un liquide d'un premier flacon à un second flacon
JP2019181181A (ja) * 2018-03-30 2019-10-24 アディエンヌ ファーマ アンド バイオテック エスエイＡｄｉｅｎｎｅｐｈａｒｍａ ＆ Ｂｉｏｔｅｃｈ Ｓａ 点滴又は注射によって患者に投与される液状の薬剤又は栄養物質の投与量を再構成するための圧力補償器を含む滅菌フレキシブルパッケージ
WO2019245960A1 (fr) * 2018-06-18 2019-12-26 Baxter International Inc. Système de reconstitution pour administrer un médicament via un flacon à vide poussé
IT201900002745A1 (it) * 2019-02-26 2020-08-26 Adienne Pharma & Biotech Sa “Confezione sterile o sterilizzata per l’erogazione di sostanze medicinali o nutrizionali”
JP2020534964A (ja) * 2017-09-29 2020-12-03 ウェスト ファーマ サービシーズ イスラエル リミテッド 通気式雌型瓶アダプターの対を含む二重瓶アダプター集合体

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104621A (en) * 1986-03-26 1992-04-14 Beckman Instruments, Inc. Automated multi-purpose analytical chemistry processing center and laboratory work station
US20050072800A1 (en) * 2003-09-19 2005-04-07 Smith Clyde M. Fluid powered proportioning pump and post-mix beverage dispenser system using same
US20060259195A1 (en) * 2004-12-22 2006-11-16 Eliuk Walter W Automated pharmacy admixture system (APAS)
US20080058991A1 (en) * 2006-09-05 2008-03-06 Samsung Electronics Co., Ltd. Microfluidic system and apparatus and method of controlling the same
US20090171316A1 (en) * 2007-12-21 2009-07-02 Carticept Medical, Inc. Method of treating a joint using an articular injection system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104621A (en) * 1986-03-26 1992-04-14 Beckman Instruments, Inc. Automated multi-purpose analytical chemistry processing center and laboratory work station
US20050072800A1 (en) * 2003-09-19 2005-04-07 Smith Clyde M. Fluid powered proportioning pump and post-mix beverage dispenser system using same
US20060259195A1 (en) * 2004-12-22 2006-11-16 Eliuk Walter W Automated pharmacy admixture system (APAS)
US20080058991A1 (en) * 2006-09-05 2008-03-06 Samsung Electronics Co., Ltd. Microfluidic system and apparatus and method of controlling the same
US20090171316A1 (en) * 2007-12-21 2009-07-02 Carticept Medical, Inc. Method of treating a joint using an articular injection system

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9662621B2 (en) 2012-03-09 2017-05-30 Sensile Pat Ag Drug reconstitution system
EP2962676A1 (fr) * 2014-07-02 2016-01-06 Paolo Gobbi Frattini S.r.l. Emballage souple avec une chambre hermétique stérile pour la reconstitution et l'administration d'un fluide médical ou de substances nutritives instillables dans le corps d'un patient
US10010481B2 (en) 2014-07-02 2018-07-03 Paolo Gobbi Frattini S.R.L. Flexible package with a sealed sterile chamber for the reconsitution and administration of fluid medicinal or nutritional substances instillable into the body of a patient
CN104337523A (zh) * 2014-10-24 2015-02-11 苏州仁捷瑞自动化科技有限公司 能自动抽吸的注射器
EP3427781A3 (fr) * 2017-07-11 2019-05-01 Pharma Resources GmbH Médicament et système de dispositif pour des thérapies d'aérosol sous pression dans un espace creux d'un mammifère
JP2020534964A (ja) * 2017-09-29 2020-12-03 ウェスト ファーマ サービシーズ イスラエル リミテッド 通気式雌型瓶アダプターの対を含む二重瓶アダプター集合体
JP7137620B2 (ja) 2017-09-29 2022-09-14 ウェスト ファーマ サービシーズ イスラエル リミテッド 通気式雌型瓶アダプターの対を含む二重瓶アダプター集合体
WO2019086595A1 (fr) * 2017-11-02 2019-05-09 F. Hoffmann-La Roche Ag Dispositif pour transférer un liquide d'un premier flacon à un second flacon
US11951073B2 (en) 2017-11-02 2024-04-09 Hoffmann-La Roche Inc. Device for transferring a liquid from a first vial to a second vial
JP2019181181A (ja) * 2018-03-30 2019-10-24 アディエンヌ ファーマ アンド バイオテック エスエイＡｄｉｅｎｎｅｐｈａｒｍａ ＆ Ｂｉｏｔｅｃｈ Ｓａ 点滴又は注射によって患者に投与される液状の薬剤又は栄養物質の投与量を再構成するための圧力補償器を含む滅菌フレキシブルパッケージ
JP7179660B2 (ja) 2018-03-30 2022-11-29 アディエンヌ ファーマ アンド バイオテック エスエイ 点滴又は注射によって患者に投与される液状の薬剤又は栄養物質の投与量を再構成するための圧力補償器を含む滅菌フレキシブルパッケージ
CN112261929A (zh) * 2018-06-18 2021-01-22 巴克斯特国际公司 通过高真空小瓶给药的重构系统
WO2019245960A1 (fr) * 2018-06-18 2019-12-26 Baxter International Inc. Système de reconstitution pour administrer un médicament via un flacon à vide poussé
EP3701928A1 (fr) * 2019-02-26 2020-09-02 ADIENNE Pharma & Biotech SA Emballage stérile ou stérilisé pour l'administration de substances médicinales ou nutritionnelles.
US20200268607A1 (en) * 2019-02-26 2020-08-27 Adienne Pharma & Biotech Sa Sterile and sterilized package for administration of medicinal or nutritional substances
IT201900002745A1 (it) * 2019-02-26 2020-08-26 Adienne Pharma & Biotech Sa “Confezione sterile o sterilizzata per l’erogazione di sostanze medicinali o nutrizionali”
IL272633B1 (en) * 2019-02-26 2024-01-01 Adienne Pharma & Biotech Sa A sterile or disinfected package for administering medical or nutritional substances
IL272633B2 (en) * 2019-02-26 2024-05-01 Adienne Pharma & Biotech Sa A sterile or disinfected package for administering medical or nutritional substances

Also Published As

Publication number Publication date
WO2011071952A3 (fr) 2011-10-27

Similar Documents

Publication Publication Date Title
WO2011071952A2 (fr) Dispositifs de transfert, ensembles de transfert et procédés permettant de transférer des contenus entre réservoirs
AU2021277726B2 (en) Priming apparatus and method
CN107580489B (zh) 加压气体驱动的药剂转移和再悬浮设备和方法
KR101507841B1 (ko) 위험 약물의 무-오염 이전을 위한 방법 및 장치
US6228065B1 (en) Displacement activated medical check valve
US5398851A (en) Liquid delivery device
AU700372B2 (en) Apparatus and methods for multiple fluid infusion
JP4963790B2 (ja) 自動準備ｉｖ溶液投与システム
JP6062871B2 (ja) 曝露防止カバー、これを備える曝露防止カバーモジュール、薬液供給システム、及び薬液供給方法
CA2796516C (fr) Sac d'infusion dote d'un systeme de rincage integre
JP2018102943A (ja) 無菌カートリッジおよび分配装置
KR100569223B1 (ko) 일체형 수액용기
CN102482023A (zh) 用于无菌混合物质的包装产品、插入件和隔室及其使用方法
KR20150116860A (ko) 개량된 폐쇄 약물 전달 시스템
CN101466344A (zh) 药液调制用套件
CN102985050A (zh) 医疗用药液移送器
US5257986A (en) Container for the separate sterile storage of at least two substances and for mixing said substances
CA2343343A1 (fr) Adaptateur pour melanger et injecter des preparations
JP2003265608A (ja) 回収器具
JP6325608B2 (ja) 有益剤の送達装置と共に使用するカートリッジ
EP0522107A1 (fr) Systeme permettant d'elaborer des solutions parenterales sur le lieu d'utilisation, loin d'un milieu sterile.
JPH10248928A (ja) 薬液供給具およびプライミング装置
WO2008005933A2 (fr) Systèmes et procédés pour la dilution d'un concentré de boisson
JP2006136615A (ja) 透析用剤収納容器
JPH0966093A (ja) 連通針及びそれを用いた医療用容器

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10836572

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase in:

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10836572

Country of ref document: EP

Kind code of ref document: A2