WO2011071845A1 - Dispositif d'administration de poudre et procédés de réalisation correspondants - Google Patents

Dispositif d'administration de poudre et procédés de réalisation correspondants Download PDF

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Publication number
WO2011071845A1
WO2011071845A1 PCT/US2010/059172 US2010059172W WO2011071845A1 WO 2011071845 A1 WO2011071845 A1 WO 2011071845A1 US 2010059172 W US2010059172 W US 2010059172W WO 2011071845 A1 WO2011071845 A1 WO 2011071845A1
Authority
WO
WIPO (PCT)
Prior art keywords
blister
inhaler
inhaler device
breaker
powder
Prior art date
Application number
PCT/US2010/059172
Other languages
English (en)
Inventor
John D. Parsons
Original Assignee
Meadwestvaco Calmar Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meadwestvaco Calmar Gmbh filed Critical Meadwestvaco Calmar Gmbh
Publication of WO2011071845A1 publication Critical patent/WO2011071845A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0003—Details of inhalators; Constructional features thereof with means for dispensing more than one drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/27—General characteristics of the apparatus preventing use
    • A61M2205/273—General characteristics of the apparatus preventing use preventing reuse, e.g. of disposables

Definitions

  • the present invention relates to inhalation devices and methods for using and making the same and more particularly to powder inhalation devices.
  • Inhalers and inhalation devices are well known and many different varieties are used to deliver powders or medicaments to a user during an inhalation process. While many different types of inhalers are available, many inhalers are complex devices which employ multiple parts and are expensive to make. The cost of such devices may restrict the use of such devices with certain medications or in certain locations, such as in third world countries. Therefore, it is desirable to develop simple inhalation devices which may be readily distributed and used and which may be cheaper to manufacture and distribute as compared to the devices currently available.
  • an inhaler device may include a hand-held inhaler containing a blister having a blister peel extending outside of the inhaler.
  • the blister peel may be pulled to remove the blister peel from a blister on an interior of the inhaler such that a powder or product contained within the blister is exposed.
  • the inhaler may be reused by placing another blister in the inhaler and repeating the use process.
  • an inhaler device may include an inhaler having a blister breaker and a position into which a blister may be inserted into the inhaler.
  • the blister breaker may be used to break the blister and empty the contents of the blister into an interior portion of the inhaler.
  • a user may insert an open end of the inhaler into their mouth and inhale, thereby drawing air into the inhaler where it mixes with the powder or other product from the blister and is ingested into the user's mouth and lungs.
  • the inhaler may be reused by placing another blister in the inhaler and repeating the use process.
  • a blister breaker configured with an inhaler may be used to punch a hole through, tear, or otherwise empty a blister when the blister breaker is pushed into an interior portion of the inhaler.
  • An inhaler device may be formed, sized, or otherwise shaped as a whistle.
  • FIG. 1 illustrates a cross-sectional view of an inhaler device according to various embodiments of the invention
  • FIG. 2 illustrates an inhaler device according to various embodiments of the invention
  • FIG. 3 illustrates an inhaler device according to various embodiments of the invention
  • FIG. 4 illustrates a cross-sectional view of an inhaler device according to various embodiments of the invention
  • FIG. 5 illustrates a cross-sectional view of an inhaler device according to various embodiments of the invention
  • FIG. 6 illustrates a cross-sectional view of an inhaler device according to various embodiments of the invention
  • FIG. 7 illustrates an inhaler device and blister according to various embodiments of the invention
  • FIG. 8 illustrates a cross-sectional view of an inhaler device according to various embodiments of the invention
  • FIG. 9 illustrates an inhaler device according to various embodiments of the invention
  • FIG. 10 illustrates a cross-sectional view of an inhaler device according to various embodiments of the invention.
  • FIG. 11 illustrates a cross-sectional view of an inhaler device according to various embodiments of the invention.
  • FIG. 12 illustrates an inhaler device according to various embodiments of the invention.
  • an inhaler device 100 may include a handheld device configured with a breakable blister containing a powder or other product for inhalation.
  • a user may inhale on the inhaler device 100, drawing the released powder or other product into the user's body or lungs.
  • FIGS. 1 through 4 An inhaler device 100 according to certain embodiments of the invention is illustrated in FIGS. 1 through 4.
  • the inhaler device 100 may include an inhaler 110 and a blister 140.
  • the inhaler 110 may include one or more air intake holes 120 A and one or more inhaler holes 120B.
  • the blister 140 may include a blister peel 150, a blister body 152 and one or more compartments 155 formed in the blister body 152.
  • the blister 140 may be sealed within the inhaler 110 and a portion of the blister peel 150 may extend through the inhaler 110 to an exterior thereof.
  • a user may grip, support, or otherwise hold the inhaler 110.
  • the blister peel 150 may be removed or separated from the blister body 152 by applying a force to the blister body 152 away from the inhaler 1 10 or by other conventional means.
  • the blister peel 150 is removed from the blister body 152, the compartment 155 is exposed and a powder or other product contained in the compartment 155 is also exposed.
  • the user may place their mouth over the one or more inhaler holes 120B and inhale.
  • the inhaler 110 may include one or more walls on an interior portion of the inhaler 110.
  • the one or more walls may be positioned to accomplish any of the following: secure the blister 140, support the blister 140, direct the blister peel 150 removal, create turbulence upon inhalation, or for any other purpose as desired.
  • an inhaler device 100 may include a top portion 111 and a bottom portion 115 as illustrated in FIG. 3.
  • the top portion 111 and the bottom portion 115 may meet along a joint 113.
  • the joint 113 may be positioned or located in any desired location.
  • the top portion 111 and bottom portion 115 may be sealed, glued, fitted, welded, or otherwise joined together along at least a portion of the joint 113.
  • An inhaler device 100 may be constructed by supporting a blister 140 on a bottom portion 115 or top portion 111 of the inhaler 110 and positioning the opposite portion of the inhaler 1 10 over the blister 140 such that at least a portion of the blister peel 150 extends out a hole formed in the inhaler 110.
  • the top portion 1 11 and the bottom portion 115 may then be joined, such as by glue, weld, seal, snap fit, or other method as desired.
  • the top portion 111 and the bottom portion 115 may be removeably fitted together such that the top portion 111 and the bottom portion 115 may be separated to allow a user to insert a blister 140 into the inhaler 110.
  • the inhaler 110 may be used multiple times. The user may also wash or otherwise sterilize each of the top portion 111 and bottom portion 115 when separated to allow for multiple uses of the inhaler 110 as desired.
  • multiple compartments 155 may be formed in the blister 150 such that when the blister peel 150 is peeled away from the blister compartments 155, multiple powders or other products are exposed or released.
  • two or more blisters 152 may be contained within the inhaler 110 and two or more blister peels 150 may be removed from the two or more blisters 152 at the same time to reveal two or more compartments 155.
  • two or more powders or other products may be mixed together during the inhalation or use of the inhaler device 100.
  • the number of air intake holes 120 A, the number of inhaler holes 120B or the number of both the air intake holes 120 A and the inhaler holes 120B may be optimized to provide a desired air flow through the inhaler 1 10.
  • the sizes of air intake holes 120 A, inhaler holes 120B, or both air intake holes 120 A and inhaler holes 120B may be altered to provide a desired air flow through the inhaler 110.
  • An inhaler 110 may be molded from a resin or plastic material or formed from any other desired material.
  • a top portion 1 11 and a bottom portion 115 of the inhaler 110 may be molded from a resin and then assembled with a blister 140 to form the inhaler device 100.
  • FIGS. 1 through 4 While a particular shape for an inhaler 100 according to embodiments of the invention is illustrated in FIGS. 1 through 4, it is understood that other shapes may be used as well and that an inhaler 100 of any shape and size may be configured according to
  • the inhaler device 200 may include an inhaler 210 and a blister 240.
  • the inhaler 210 may be configured in the shape of a whistle or any other configuration.
  • the inhaler 210 may also include one or more shelves, walls, supports, or other configurations on an interior of the inhaler 210 such that the one or more shelves, walls, supports, or other configurations may support a blister 240 when inserted in the inhaler 210 or direct airflow through the inhaler 210.
  • a blister 240 may include a blister body 252 and one or more compartments 255 formed in the blister body 252.
  • a blister peel 250 or covering may be secured to the blister body 252 and may cover the one or more compartments 255 such that a medication or other product may be contained in the one or more compartments 255.
  • a powdered medication may be retained in a blister 240 compartment 255 by the blister peel 250.
  • the inhaler device 200 includes an inhaler 210 shaped as a whistle.
  • a hole in a rear portion of the inhaler 210 allows a blister 240 to be inserted into an interior of the inhaler 210.
  • the hole in the inhaler 210 where the blister 240 may be inserted may also allow air to flow into an interior of the inhaler 210. This is especially true when a user sucks on an open end of the inhaler 210 or inhales with the inhaler 210 in their mouth. While the hole in the inhaler 210 is illustrated in a rear portion of the inhaler 210, it is understood that the hole for inserting the blister may be positioned in other portions of the inhaler 210.
  • the inhaler 210 may include one or more flexible blister breakers 280. As illustrated in FIGS. 5 through 7, a blister breaker 280 may be integrated with a top portion of the inhaler 210. While the blister breaker 280 configuration illustrated in FIGS. 5 through 7 may be used, other blister breaker 280 configurations, placements, or positioning may also be used. A blister breaker 280 may be used to break, open, tear, or otherwise empty the contents of a blister 240 into an interior portion of the inhaler 210 where it may mix with air and be inhaled by a user.
  • the inhaler device 200 illustrated in FIGS. 5 through 7 may be used in the following manner: A user may insert a blister 240 containing a powder or other product into a hole in a rear portion of the inhaler 210. Once inserted, the blister 240 may be broken or torn when a user presses on the blister breaker 280. A user may supply sufficient force to the blister breaker 280 required to break or tear the blister 240. Once torn or broken, the contents of the blister 240 are dumped or dropped into an interior portion of the inhaler 210. The user may suck on, or inhale, with the open front portion of the inhaler 210 in their mouth. The inhalation by the user may pull air through the hole in which the blister 240 is inserted or other access hole or vent, and mix the air and powder or product. The turbulent air and powder mixture is inhaled into the user's mouth and lungs.
  • the inhaler device 200 illustrated in FIGS. 5 through 7 may be reused as desired. Once a blister 240 is inserted, it may be removed from the inhaler 210. Once the contents of the inhaler 210 are inhaled or otherwise disposed of, the inhaler 210 may be cleaned and reused, sterilized and reused, or reused by inserting another blister 240 into the inhaler 210 and repeating the use.
  • An inhaler 210 as illustrate in FIGS. 5 through 7 may be formed of one or more molded parts. For instance, a top portion including the blister breaker 280 may be molded and fitted to, welded, snapped, glued, or otherwise attached to a bottom portion. Alternatively, the inhaler 210 may be molded in other configurations and assembled as desired.
  • the inhaler 210 of the inhaler device 200 may include a blister breaker 280 configured to tear through or punch through a blister 240 as illustrated.
  • the blister breaker 280 may be configured as a button that a user may press to break the blister 240 or a compartment 255 within a blister 240.
  • the blister breaker 280 may also include one or more holes configured to allow air to pass into an interior of the inhaler 210 once the blister 240 is broken.
  • a blister breaker 280 may also include one or more ridges or clips which retain the blister breaker 280 in a de-activated position and require a user to exert a certain pre-determined force to overcome the ridges or clips. The force required to overcome the ridges or clips may be sufficient to supply enough force to a blister 240 to release the powder or product from the blister 240.
  • the blister breaker 280 may include one or more ridges or clips which will retain the blister breaker 280 in an activated position once the blister breaker 280 is activated.
  • the inhaler device 200 illustrated in FIGS. 8 through 12 is configured to be a monodose-type device, or single-use device.
  • the inhaler 210 may be configured to contain a blister 240 such that the blister 240 is not removable. Once used, the inhaler device 200 may be disposed of as desired.
  • An inhaler device 200 as illustrated in FIGS. 8 through 12 may be used by a user in the following manner: A user may activate the inhaler device 200 by pressing on the blister breaker 280 such that the blister 240 contained inside the inhaler 210 is broken and its contents are released into an interior of the inhaler 210. An open end of the inhaler 210 may be placed in the user's mouth and the user may inhale. The act of inhaling may draw air into an interior of the inhaler 210 through the holes in the blister breaker 280 and the air may be mixed with the powder or product released from the blister 240. The turbulent air and powder mixture may exit the inhaler 210 through the open end into the user's mouth and lungs.
  • the inhaler 210 illustrated in FIGS. 8 through 12 may be molded or formed of multiple parts such that a blister 240 may be inserted into the inhaler 210 and removed after use. The inhaler 210 may then be cleaned, sterilized, or otherwise made suitable for repeat use and a new blister 240 may be inserted into the inhaler 210.
  • blisters 240 used with the inhaler devices 200 illustrated in FIGS. 5 through 12 may include one or more compartments 255 or partitions such that two or more powders or products may be mixed upon the breakage of the blister 240 within the inhaler 210.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un dispositif d'inhalation (100), qui comprend un inhalateur (110) conçu pour recevoir un emballage-coque (140) contenant une poudre ou un autre produit et pour rompre l'emballage coque lors de son actionnement, libérant ainsi la poudre ou l'autre produit destiné à être inhalé par un utilisateur.
PCT/US2010/059172 2009-12-08 2010-12-07 Dispositif d'administration de poudre et procédés de réalisation correspondants WO2011071845A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26762009P 2009-12-08 2009-12-08
US61/267,620 2009-12-08

Publications (1)

Publication Number Publication Date
WO2011071845A1 true WO2011071845A1 (fr) 2011-06-16

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PCT/US2010/059172 WO2011071845A1 (fr) 2009-12-08 2010-12-07 Dispositif d'administration de poudre et procédés de réalisation correspondants

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018007287A3 (fr) * 2016-07-04 2018-03-01 Alfred Von Schuckmann Dispositif de délivrance d'une substance pouvant être évacuée par l'air

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998034663A1 (fr) * 1997-02-07 1998-08-13 Astra Aktiebolag (Publ) Inhalateur jetable
WO2007129128A1 (fr) * 2006-05-09 2007-11-15 Dimitrios Pentafragas Amélioration apportée à un inhalateur de poudre sèche
WO2007129127A1 (fr) * 2006-05-09 2007-11-15 Dimitrios Pentafragas Dispositif d'inhalation de poudre sèche pour l'administration simultanée de plusieurs médicaments
WO2008101992A1 (fr) * 2007-02-21 2008-08-28 Novo Nordisk A/S Dispositif de génération d'aérosol avec régulation du débit d'air
US20090084379A1 (en) * 2007-10-02 2009-04-02 Baxter International Inc. Dry powder inhaler
DE102008023376A1 (de) * 2008-05-13 2009-11-19 Alfred Von Schuckmann Spender für in einer gesonderten Verpackung enthaltenen, pulverförmigen Massen

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998034663A1 (fr) * 1997-02-07 1998-08-13 Astra Aktiebolag (Publ) Inhalateur jetable
WO2007129128A1 (fr) * 2006-05-09 2007-11-15 Dimitrios Pentafragas Amélioration apportée à un inhalateur de poudre sèche
WO2007129127A1 (fr) * 2006-05-09 2007-11-15 Dimitrios Pentafragas Dispositif d'inhalation de poudre sèche pour l'administration simultanée de plusieurs médicaments
WO2008101992A1 (fr) * 2007-02-21 2008-08-28 Novo Nordisk A/S Dispositif de génération d'aérosol avec régulation du débit d'air
US20090084379A1 (en) * 2007-10-02 2009-04-02 Baxter International Inc. Dry powder inhaler
DE102008023376A1 (de) * 2008-05-13 2009-11-19 Alfred Von Schuckmann Spender für in einer gesonderten Verpackung enthaltenen, pulverförmigen Massen

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018007287A3 (fr) * 2016-07-04 2018-03-01 Alfred Von Schuckmann Dispositif de délivrance d'une substance pouvant être évacuée par l'air
CN109475712A (zh) * 2016-07-04 2019-03-15 艾尔弗雷德.冯舒克曼 用于输出可经空气排放的物质的设备

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