WO2011066511A8 - Synthetic apoa-1 mimetic amphipathic peptides and methods of use thereof - Google Patents

Synthetic apoa-1 mimetic amphipathic peptides and methods of use thereof Download PDF

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Publication number
WO2011066511A8
WO2011066511A8 PCT/US2010/058230 US2010058230W WO2011066511A8 WO 2011066511 A8 WO2011066511 A8 WO 2011066511A8 US 2010058230 W US2010058230 W US 2010058230W WO 2011066511 A8 WO2011066511 A8 WO 2011066511A8
Authority
WO
WIPO (PCT)
Prior art keywords
methods
mimetic
disclosed
amphipathic peptides
peptides
Prior art date
Application number
PCT/US2010/058230
Other languages
French (fr)
Other versions
WO2011066511A1 (en
Inventor
Alan T. Remaley
Amar A. Sethi
Dmitri Sviridov
Original Assignee
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Baker Idi Heart & Diabetes Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Baker Idi Heart & Diabetes Institute filed Critical The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Publication of WO2011066511A1 publication Critical patent/WO2011066511A1/en
Publication of WO2011066511A8 publication Critical patent/WO2011066511A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices

Abstract

Disclosed herein are apolipoprotein A-I mimetic peptides and peptide analogs that promote lipid efflux as well as have anti-inflammatory and anti-oxidant properties. Also disclosed herein are methods of using the disclosed peptides to treat or inhibit dyslipidemic or vascular disorders, such as methods to treat or prevent cardiovascular disease including atherosclerosis.
PCT/US2010/058230 2009-11-30 2010-11-29 Synthetic apoa-1 mimetic amphipathic peptides and methods of use thereof WO2011066511A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26529109P 2009-11-30 2009-11-30
US61/265,291 2009-11-30

Publications (2)

Publication Number Publication Date
WO2011066511A1 WO2011066511A1 (en) 2011-06-03
WO2011066511A8 true WO2011066511A8 (en) 2011-07-07

Family

ID=43416521

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/058230 WO2011066511A1 (en) 2009-11-30 2010-11-29 Synthetic apoa-1 mimetic amphipathic peptides and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2011066511A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5933001B2 (en) * 2011-08-10 2016-06-08 コリア・アドヴァンスド・インスティテュート・オブ・サイエンス・アンド・テクノロジー Amphiphilic peptide-lipase conjugate with increased lipase activity and use thereof
AU2013299641A1 (en) * 2012-08-10 2015-03-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Drug delivery vehicle comprising conjugates between targeting polyamino acids and fatty acids
WO2015057583A1 (en) 2013-10-14 2015-04-23 The United States Of America, As Represented By The Secretary Treatment of chronic kidney disease with sahps
CN107106639A (en) * 2014-11-21 2017-08-29 芝加哥大学 Synthetic peptide
CN110160991B (en) * 2019-06-18 2021-12-14 山东艾科达生物科技有限公司 Kit for measuring serum amyloid A content by nephelometry
CN111879949B (en) * 2020-08-05 2021-11-09 中国科学院昆明动物研究所 Application of substance for detecting or regulating lactoferrin expression quantity in preparation of medicine or kit for preventing and/or treating cardiovascular and cerebrovascular diseases
EP4359432A2 (en) * 2021-06-23 2024-05-01 The United States of America, as represented by The Secretary, Department of Health and Human Services Short apoc-ii mimetic peptides and methods of use
CN114940711B (en) * 2021-10-25 2023-05-12 中山大学 Apolipoprotein A-I mimetic peptides and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (en) 1979-07-11 1985-06-05 味の素株式会社 blood substitute
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
DE3675588D1 (en) 1985-06-19 1990-12-20 Ajinomoto Kk HAEMOGLOBIN TIED TO A POLY (ALKENYLENE OXIDE).
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
JP3951062B2 (en) 1991-09-19 2007-08-01 ジェネンテック・インコーポレーテッド Expression of antibody fragments with cysteine present at least as a free thiol in E. coli for the production of bifunctional F (ab ') 2 antibodies
WO1996030570A1 (en) 1995-03-31 1996-10-03 Hyperion Catalysis International, Inc. Carbide nanofibrils and method of making same
WO1998009602A2 (en) 1996-09-05 1998-03-12 The Uab Research Foundation Anti-atherosclerotic peptides and a transgenic mouse model of atherosclerosis
US6695920B1 (en) 2001-06-27 2004-02-24 Advanced Cardiovascular Systems, Inc. Mandrel for supporting a stent and a method of using the mandrel to coat a stent
US6527863B1 (en) 2001-06-29 2003-03-04 Advanced Cardiovascular Systems, Inc. Support device for a stent and a method of using the same to coat a stent
EP1812474B1 (en) 2004-10-15 2010-05-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Multi-domain amphipathic helical peptides and methods of their use
EP2041174A2 (en) * 2006-06-16 2009-04-01 Lipid Sciences, Inc. Novel peptides that promote lipid efflux
WO2008094905A2 (en) * 2007-01-29 2008-08-07 Lipid Sciences, Inc. Encapsulated hdl mimetic peptides
JP5183349B2 (en) 2007-08-10 2013-04-17 キヤノン株式会社 Image reading apparatus, method for controlling the apparatus, and control program
US8936787B2 (en) * 2008-04-15 2015-01-20 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Peptides promoting lipid efflux

Also Published As

Publication number Publication date
WO2011066511A1 (en) 2011-06-03

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