WO2011062471A3 - Disposable paraffin microvalve for biomedical applications - Google Patents

Disposable paraffin microvalve for biomedical applications Download PDF

Info

Publication number
WO2011062471A3
WO2011062471A3 PCT/MY2010/000237 MY2010000237W WO2011062471A3 WO 2011062471 A3 WO2011062471 A3 WO 2011062471A3 MY 2010000237 W MY2010000237 W MY 2010000237W WO 2011062471 A3 WO2011062471 A3 WO 2011062471A3
Authority
WO
WIPO (PCT)
Prior art keywords
microvalve
heat sensitive
sensitive plug
fluid path
biomedical applications
Prior art date
Application number
PCT/MY2010/000237
Other languages
French (fr)
Other versions
WO2011062471A2 (en
Inventor
Hing Wah Lee
Chia Sheng Daniel Bien
Original Assignee
Mimos Berhad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mimos Berhad filed Critical Mimos Berhad
Publication of WO2011062471A2 publication Critical patent/WO2011062471A2/en
Publication of WO2011062471A3 publication Critical patent/WO2011062471A3/en

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0005—Lift valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/003—Valves for single use only
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0036—Operating means specially adapted for microvalves operated by temperature variations
    • F16K99/0038—Operating means specially adapted for microvalves operated by temperature variations using shape memory alloys
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/12—Shape memory

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Metallurgy (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The present invention provides a microfluidic device (100) comprises an adapting unit; a microvalve (120) adapted to removably couple with the adapting unit, the microvalve (120) having a fluid path (124) and a heat sensitive plug (126), the heat sensitive plug (126) is disposed to block the fluid path (124), wherein the microvalve (120) is adapted to be normally-closed by default by the heat sensitive plug (126); and a heater (114) disposed on a position having a close proximity to the heat sensitive plug (126), wherein the heater (114) is operable to melt the heat sensitive plug (126). Once the heat sensitive plug (126) is molten to open the fluid path (124), the fluid path (124) is not re-closable and a replacement microvalve is required for a new use. A microvalve and a method of fabricating the same is also provided herewith.
PCT/MY2010/000237 2009-11-20 2010-10-29 Disposable paraffin microvalve for biomedical applications WO2011062471A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MYPI20094935 2009-11-20
MYPI20094935 MY150339A (en) 2009-11-20 2009-11-20 Disposable paraffin microvalve for biomedical applications

Publications (2)

Publication Number Publication Date
WO2011062471A2 WO2011062471A2 (en) 2011-05-26
WO2011062471A3 true WO2011062471A3 (en) 2011-11-17

Family

ID=44060229

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MY2010/000237 WO2011062471A2 (en) 2009-11-20 2010-10-29 Disposable paraffin microvalve for biomedical applications

Country Status (2)

Country Link
MY (1) MY150339A (en)
WO (1) WO2011062471A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8779533B2 (en) 2011-07-12 2014-07-15 Robert Bosch Gmbh MEMS with single use valve and method of operation
EP2786019B1 (en) 2011-11-16 2018-07-25 International Business Machines Corporation Microfluidic device with deformable valve
TWI489109B (en) * 2013-05-28 2015-06-21 Nat Univ Tsing Hua Calligraphy paper-based diagnostic specimen and its manufacturing method
CN103343092B (en) * 2013-07-19 2014-12-03 中国科学院上海微系统与信息技术研究所 Method for manufacturing digital PCR (polymerase chain reaction) chip based on mineral-oil saturated PDMS (polydimethylsiloxane) material
WO2018067379A1 (en) * 2016-10-03 2018-04-12 Terumo Bct, Inc. Centrifugal fluid separation device
CN109603929B (en) * 2018-11-09 2021-01-05 哈尔滨工业大学（深圳） Manufacturing method of valve on chip, micro-fluidic chip and liquid flow control method
US20240060178A1 (en) * 2022-08-16 2024-02-22 Raytheon Technologies Corporation In-situ solid chemical vapor deposition precursor delivery

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020037221A1 (en) * 2000-06-06 2002-03-28 Mastrangelo Carlos H. Thermally activated polymer device
US7195036B2 (en) * 2002-11-04 2007-03-27 The Regents Of The University Of Michigan Thermal micro-valves for micro-integrated devices
EP1884284A1 (en) * 2006-08-04 2008-02-06 Samsung Electronics Co., Ltd. Closing valve unit and reaction apparatus having closing valve

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020037221A1 (en) * 2000-06-06 2002-03-28 Mastrangelo Carlos H. Thermally activated polymer device
US7195036B2 (en) * 2002-11-04 2007-03-27 The Regents Of The University Of Michigan Thermal micro-valves for micro-integrated devices
EP1884284A1 (en) * 2006-08-04 2008-02-06 Samsung Electronics Co., Ltd. Closing valve unit and reaction apparatus having closing valve

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIU, R. H. ET AL.: "Single-use, thermally actuated paraffin valves for micro fluidic applications", SENSORS AND ACTUATORS B., vol. 98, no. 2-3, 15 March 2004 (2004-03-15), pages 328 - 336 *
YANG, B. ET AL.: "A latchable microvalve using phase change of paraffin wax", SENSORS AND ACTUATORS, vol. 134, no. 1, 28 February 2007 (2007-02-28), pages 194 - 200, XP005914408, DOI: doi:10.1016/j.sna.2006.07.017 *

Also Published As

Publication number Publication date
MY150339A (en) 2013-12-31
WO2011062471A2 (en) 2011-05-26

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