WO2011057160A3 - Method to improve the immunogenicity of vaccine antigens by modification of cleavage sites in hiv-1 gp 120 - Google Patents

Method to improve the immunogenicity of vaccine antigens by modification of cleavage sites in hiv-1 gp 120 Download PDF

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Publication number
WO2011057160A3
WO2011057160A3 PCT/US2010/055747 US2010055747W WO2011057160A3 WO 2011057160 A3 WO2011057160 A3 WO 2011057160A3 US 2010055747 W US2010055747 W US 2010055747W WO 2011057160 A3 WO2011057160 A3 WO 2011057160A3
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WO
WIPO (PCT)
Prior art keywords
immunogenicity
cleavage sites
hiv
vaccine antigens
modification
Prior art date
Application number
PCT/US2010/055747
Other languages
French (fr)
Other versions
WO2011057160A2 (en
WO2011057160A8 (en
Inventor
Philip Berman
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Priority to US13/079,472 priority Critical patent/US9782472B2/en
Publication of WO2011057160A2 publication Critical patent/WO2011057160A2/en
Publication of WO2011057160A8 publication Critical patent/WO2011057160A8/en
Publication of WO2011057160A3 publication Critical patent/WO2011057160A3/en
Priority to US15/694,388 priority patent/US10201603B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed are novel methods for altering the immunogenicity of vaccine antigens by mutation of cleavage sites recognized by proteases involved in antigen presentation and processing. Also disclosed are therapeutic compositions, vaccines and methods for treating or preventing HIV and other viral diseases.
PCT/US2010/055747 2008-10-04 2010-11-05 Method to improve the immunogenicity of vaccine antigens by modification of cleavage sites in hiv-1 gp 120 WO2011057160A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/079,472 US9782472B2 (en) 2008-10-04 2011-04-04 Therapeutic compositions and methods for treating HIV including identification and manipulation of particular domains associated with immunogenicity
US15/694,388 US10201603B2 (en) 2008-10-04 2017-09-01 Therapeutic compositions and methods for treating HIV including identification and manipulation of particular domains associated with immunogenicity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25883309P 2009-11-06 2009-11-06
US61/258,833 2009-11-06

Related Child Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2010/053637 Continuation-In-Part WO2011050222A2 (en) 2008-10-04 2010-10-22 Therapeutic compositions that disrupt the hydrogen bonded ring structure in gp41 and methods for treating hiv
US13/079,472 Continuation-In-Part US9782472B2 (en) 2008-10-04 2011-04-04 Therapeutic compositions and methods for treating HIV including identification and manipulation of particular domains associated with immunogenicity

Publications (3)

Publication Number Publication Date
WO2011057160A2 WO2011057160A2 (en) 2011-05-12
WO2011057160A8 WO2011057160A8 (en) 2011-08-18
WO2011057160A3 true WO2011057160A3 (en) 2011-10-27

Family

ID=43970799

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/055747 WO2011057160A2 (en) 2008-10-04 2010-11-05 Method to improve the immunogenicity of vaccine antigens by modification of cleavage sites in hiv-1 gp 120

Country Status (1)

Country Link
WO (1) WO2011057160A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015084986A1 (en) * 2013-12-03 2015-06-11 The Johns Hopkins University Methods of evaluating immunodominant epitopes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030091594A1 (en) * 1999-05-24 2003-05-15 University Of Pennsylvania CD4-independent HIV envelope proteins as vaccines and therapeutics
US20040191269A1 (en) * 2002-12-03 2004-09-30 Shan Lu Polyvalent, primary HIV-1 glycoprotein DNA vaccines and vaccination methods
US20080032921A1 (en) * 2006-05-18 2008-02-07 Pharmexa Inc. Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions
WO2009121914A1 (en) * 2008-04-02 2009-10-08 Novartis Ag Substituted piperidines as therapeutic compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030091594A1 (en) * 1999-05-24 2003-05-15 University Of Pennsylvania CD4-independent HIV envelope proteins as vaccines and therapeutics
US20040191269A1 (en) * 2002-12-03 2004-09-30 Shan Lu Polyvalent, primary HIV-1 glycoprotein DNA vaccines and vaccination methods
US20080032921A1 (en) * 2006-05-18 2008-02-07 Pharmexa Inc. Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions
WO2009121914A1 (en) * 2008-04-02 2009-10-08 Novartis Ag Substituted piperidines as therapeutic compounds

Also Published As

Publication number Publication date
WO2011057160A2 (en) 2011-05-12
WO2011057160A8 (en) 2011-08-18

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