WO2011053618A3 - Hydroxyl-terminated dendrimers - Google Patents

Hydroxyl-terminated dendrimers Download PDF

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Publication number
WO2011053618A3
WO2011053618A3 PCT/US2010/054202 US2010054202W WO2011053618A3 WO 2011053618 A3 WO2011053618 A3 WO 2011053618A3 US 2010054202 W US2010054202 W US 2010054202W WO 2011053618 A3 WO2011053618 A3 WO 2011053618A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxyl
agents
relates
present
pamam dendrimers
Prior art date
Application number
PCT/US2010/054202
Other languages
French (fr)
Other versions
WO2011053618A2 (en
Inventor
James R. Baker, Jr.
Yuehua Zhang
Original Assignee
The Regents Of The University Of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of Michigan filed Critical The Regents Of The University Of Michigan
Publication of WO2011053618A2 publication Critical patent/WO2011053618A2/en
Publication of WO2011053618A3 publication Critical patent/WO2011053618A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C08G83/004—After treatment of dendrimers

Abstract

The present invention relates to dendrimer synthesis, dendrimer compositions, and related methods of use. Specifically, the present invention relates to hydroxyl-terminated PAMAM dendrimers bearing, e.g., multiple terminal hydroxyl groups and/or terminal oligo (ethylene glycol) groups. In some embodiments, the hydroxyl-terminated PAMAM dendrimers are further conjugated with functional ligands (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents).
PCT/US2010/054202 2009-10-30 2010-10-27 Hydroxyl-terminated dendrimers WO2011053618A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25675909P 2009-10-30 2009-10-30
US61/256,759 2009-10-30

Publications (2)

Publication Number Publication Date
WO2011053618A2 WO2011053618A2 (en) 2011-05-05
WO2011053618A3 true WO2011053618A3 (en) 2011-09-22

Family

ID=43922967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/054202 WO2011053618A2 (en) 2009-10-30 2010-10-27 Hydroxyl-terminated dendrimers

Country Status (1)

Country Link
WO (1) WO2011053618A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252834B2 (en) 2008-03-12 2012-08-28 The Regents Of The University Of Michigan Dendrimer conjugates

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010039861A2 (en) 2008-09-30 2010-04-08 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010054321A2 (en) 2008-11-07 2010-05-14 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
CN102917699A (en) 2009-10-13 2013-02-06 密执安大学评议会 Dendrimer compositions and methods of synthesis
WO2011059586A2 (en) 2009-10-30 2011-05-19 The Regents Of The University Of Michigan Multifunctional small molecules
US9402911B2 (en) 2011-12-08 2016-08-02 The Regents Of The University Of Michigan Multifunctional small molecules
TWI598577B (en) * 2014-03-28 2017-09-11 Metallogenics Co Ltd Method for obtaining data for determining possibility of carcinogenesis of endometriotic ovarian cysts, and diagnostic apparatus thereof
CN104162175B (en) * 2014-06-18 2017-02-01 东华大学 Functionalized dendrimer-based SPECT-CT bimodal imaging contrast agent and preparation method thereof
WO2017075171A2 (en) * 2015-10-27 2017-05-04 The Johns Hopkins University Pamam dendrimer based cest imaging agents and uses thereof
US10858484B2 (en) 2016-05-23 2020-12-08 Ineb—Instituto Nacional De Engenharia Biomedica Biodegradable dendritic structure, methods and uses thereof
US11931418B2 (en) 2020-04-24 2024-03-19 Ashvattha Therapeutics, Inc. Methods of treating severe inflammation
WO2022016120A1 (en) * 2020-07-17 2022-01-20 Ashvattha Therapeutics, Inc. Dendrimer compositions and methods for drug delivery to injured kidney
CN113603885B (en) * 2021-07-23 2024-01-26 上海工程技术大学 Modified dendritic polyamide-amine, preparation method thereof and application thereof in damping chlorinated butyl rubber
WO2024044776A1 (en) * 2022-08-26 2024-02-29 The Johns Hopkins University Cannabinoid dendrimer compositions for targeted delivery

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020123609A1 (en) * 2000-09-29 2002-09-05 The Regents Of The University Of California Dendrimeric support or carrier macromolecule
US20050008571A1 (en) * 1997-09-23 2005-01-13 George Newkome Detection and functionalization of dendrimers
US20050214247A1 (en) * 2002-04-19 2005-09-29 Sunil Shaunak Glycodendrimers having biological activity
US20080045689A1 (en) * 2004-08-11 2008-02-21 Basf Aktiengesellschaft Patents, Trademarks And Licenses Method for Producing Highly-Branched Polyester Amides
US20090012035A1 (en) * 2007-06-29 2009-01-08 Government Of The United States Of America, Represented By The Secretary, Depa Dendrimer conjugates of agonists and antagonists of the gpcr superfamily

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050008571A1 (en) * 1997-09-23 2005-01-13 George Newkome Detection and functionalization of dendrimers
US20020123609A1 (en) * 2000-09-29 2002-09-05 The Regents Of The University Of California Dendrimeric support or carrier macromolecule
US20050214247A1 (en) * 2002-04-19 2005-09-29 Sunil Shaunak Glycodendrimers having biological activity
US20080045689A1 (en) * 2004-08-11 2008-02-21 Basf Aktiengesellschaft Patents, Trademarks And Licenses Method for Producing Highly-Branched Polyester Amides
US20090012035A1 (en) * 2007-06-29 2009-01-08 Government Of The United States Of America, Represented By The Secretary, Depa Dendrimer conjugates of agonists and antagonists of the gpcr superfamily

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WANG ET AL.: "Synthesis and Application of Carbohydrate-Containing Polymers", CHEM. MATER., vol. 14, 2002, pages 3232 - 3244 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8252834B2 (en) 2008-03-12 2012-08-28 The Regents Of The University Of Michigan Dendrimer conjugates
US8445528B2 (en) 2008-03-12 2013-05-21 The Regents Of The University Of Michigan Dendrimer conjugates

Also Published As

Publication number Publication date
WO2011053618A2 (en) 2011-05-05

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