WO2011053565A3 - Compositions and methods for detecting a tauopathy - Google Patents
Compositions and methods for detecting a tauopathy Download PDFInfo
- Publication number
- WO2011053565A3 WO2011053565A3 PCT/US2010/054026 US2010054026W WO2011053565A3 WO 2011053565 A3 WO2011053565 A3 WO 2011053565A3 US 2010054026 W US2010054026 W US 2010054026W WO 2011053565 A3 WO2011053565 A3 WO 2011053565A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- tauopathy
- detecting
- compositions
- subject
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
Abstract
The invention provides antibodies that specifically bind human tau proteins and compositions containing the antibodies. Further provided are methods for obtaining the antibody, methods for detecting a tauopathy in a subject and methods for detecting an agent for treating a tauopathy in a subject.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25613509P | 2009-10-29 | 2009-10-29 | |
US61/256,135 | 2009-10-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011053565A2 WO2011053565A2 (en) | 2011-05-05 |
WO2011053565A3 true WO2011053565A3 (en) | 2011-09-09 |
Family
ID=43922961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/054026 WO2011053565A2 (en) | 2009-10-29 | 2010-10-26 | Compositions and methods for detecting a tauopathy |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011053565A2 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2686550T3 (en) | 2010-10-11 | 2018-10-18 | Biogen International Neuroscience Gmbh | Human anti-tau antibodies |
SG10201912964PA (en) * | 2011-09-19 | 2020-02-27 | Axon Neuroscience Se | Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease |
MX2015008024A (en) | 2012-12-21 | 2016-08-08 | Biogen Int Neuroscience Gmbh | Human anti-tau antibodies. |
EA035943B1 (en) | 2013-03-13 | 2020-09-03 | Протена Биосайенсес Лимитед | Antibody binding to human tau protein |
PL3083680T3 (en) | 2013-12-20 | 2020-06-29 | F. Hoffmann-La Roche Ag | Humanized anti-tau(ps422) antibodies and methods of use |
AR100978A1 (en) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | ANTI-Tau HUMANIZED ANTIBODY BRAIN LAUNCHERS (pS422) AND USES OF THE SAME |
US9862763B2 (en) | 2015-06-24 | 2018-01-09 | Hoffmann-La Roche Inc. | Humanized anti-tau(pS422) antibodies and methods of use |
CA3022515A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
US10752679B2 (en) | 2016-05-02 | 2020-08-25 | Prothena Biosciences Limited | Tau immunotherapy |
CN110881274A (en) | 2017-05-02 | 2020-03-13 | 普罗塞纳生物科学有限公司 | Antibodies recognizing TAU |
PE20212324A1 (en) | 2019-03-03 | 2021-12-14 | Prothena Biosciences Ltd | ANTIBODIES THAT RECOGNIZE TAU |
CN111521817B (en) * | 2020-04-24 | 2022-03-01 | 首都医科大学附属北京胸科医院 | Method for identifying protein phosphorylation sites |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6121003A (en) * | 1994-07-29 | 2000-09-19 | Innogentics N.V. | Monoclonal antibodies specific for an epitope of phosphorylated tau, and their use |
US6500674B1 (en) * | 1993-12-21 | 2002-12-31 | Innogenetics N.V. | Method for the diagnosis of brain/neurological disease using monoclonal antibodies specific for PHF-tau, hybridomas secreting them, and antigen recognition by these antibodies and their applications |
US20030143760A1 (en) * | 1992-12-14 | 2003-07-31 | Innogenetics S.A. | Monoclonal antibodies directed against the microtubule-associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and their applications |
US20060008853A1 (en) * | 1991-10-25 | 2006-01-12 | N.V. Innogenetics S.A. | Monoclonal antibodies directed against the microtubule-associated protein tau and method of detecting the same |
US20070134724A1 (en) * | 2005-08-04 | 2007-06-14 | Peter Davies | Phosphorylation of tau by abl |
-
2010
- 2010-10-26 WO PCT/US2010/054026 patent/WO2011053565A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060008853A1 (en) * | 1991-10-25 | 2006-01-12 | N.V. Innogenetics S.A. | Monoclonal antibodies directed against the microtubule-associated protein tau and method of detecting the same |
US20030143760A1 (en) * | 1992-12-14 | 2003-07-31 | Innogenetics S.A. | Monoclonal antibodies directed against the microtubule-associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and their applications |
US6500674B1 (en) * | 1993-12-21 | 2002-12-31 | Innogenetics N.V. | Method for the diagnosis of brain/neurological disease using monoclonal antibodies specific for PHF-tau, hybridomas secreting them, and antigen recognition by these antibodies and their applications |
US6121003A (en) * | 1994-07-29 | 2000-09-19 | Innogentics N.V. | Monoclonal antibodies specific for an epitope of phosphorylated tau, and their use |
US20070134724A1 (en) * | 2005-08-04 | 2007-06-14 | Peter Davies | Phosphorylation of tau by abl |
Non-Patent Citations (1)
Title |
---|
REYNOLDS ET AL.: "Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry: Differences In Vitro Between the Mitogen-Activated Protein Kinases ERK2, c-Jun N-Terminal Kinase and P38, and Glycogen Synthase Kanase-3beta", THE JOURNAL OF NEUROCHEMISTRY, vol. 72, no. 4, 2000, pages 1587 - 1595 * |
Also Published As
Publication number | Publication date |
---|---|
WO2011053565A2 (en) | 2011-05-05 |
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