WO2011051967A3 - Compositions pharmaceutiques contenant du mycophénolate et leurs procédés de préparation - Google Patents

Compositions pharmaceutiques contenant du mycophénolate et leurs procédés de préparation Download PDF

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Publication number
WO2011051967A3
WO2011051967A3 PCT/IN2010/000688 IN2010000688W WO2011051967A3 WO 2011051967 A3 WO2011051967 A3 WO 2011051967A3 IN 2010000688 W IN2010000688 W IN 2010000688W WO 2011051967 A3 WO2011051967 A3 WO 2011051967A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical compositions
mycophenolate
preparing
processes
core
Prior art date
Application number
PCT/IN2010/000688
Other languages
English (en)
Other versions
WO2011051967A2 (fr
Inventor
Arun Prasad
Krishna Prasad
Vermula Sathyanarayana
Ashok Rampal
Original Assignee
Alkem Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkem Laboratories Ltd filed Critical Alkem Laboratories Ltd
Publication of WO2011051967A2 publication Critical patent/WO2011051967A2/fr
Publication of WO2011051967A3 publication Critical patent/WO2011051967A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un procédé de préparation de compositions pharmaceutiques de mycophénolate gastrorésistantes, un sel ou un promédicament de celles-ci, lesdites compositions étant préparées pour libérer au moins environ 10% en poids de mycophénolate dans un milieu acide de 0,1 N HCl, pH 1,2.
PCT/IN2010/000688 2009-10-23 2010-10-22 Compositions pharmaceutiques contenant du mycophénolate et leurs procédés de préparation WO2011051967A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1706MU2009 2009-10-23
IN1706/MUM/2009 2009-10-23

Publications (2)

Publication Number Publication Date
WO2011051967A2 WO2011051967A2 (fr) 2011-05-05
WO2011051967A3 true WO2011051967A3 (fr) 2011-06-16

Family

ID=43922727

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000688 WO2011051967A2 (fr) 2009-10-23 2010-10-22 Compositions pharmaceutiques contenant du mycophénolate et leurs procédés de préparation

Country Status (1)

Country Link
WO (1) WO2011051967A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117164657A (zh) 2014-08-12 2023-12-05 莫纳什大学 定向淋巴的前药
US11738087B2 (en) 2015-09-08 2023-08-29 Monash University Lymph directing prodrugs
US11883497B2 (en) 2017-08-29 2024-01-30 Puretech Lyt, Inc. Lymphatic system-directing lipid prodrugs
EP3727362A4 (fr) * 2017-12-19 2021-10-06 PureTech LYT, Inc. Promédicaments lipidiques d'acide mycophénolique et leurs utilisations
US11608345B1 (en) 2017-12-19 2023-03-21 Puretech Lyt, Inc. Lipid prodrugs of rapamycin and its analogs and uses thereof
US11304954B2 (en) 2017-12-19 2022-04-19 Puretech Lyt, Inc. Lipid prodrugs of mycophenolic acid and uses thereof
CA3166908A1 (fr) 2020-02-05 2021-08-12 Daniel Kenneth BONNER Promedicaments lipidiques de neurosteroides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038689A2 (fr) * 1996-04-12 1997-10-23 Novartis Ag Compositions pharmaceutiques a delitage enterique et a base de mycophenolate
WO2003032978A1 (fr) * 2001-10-17 2003-04-24 Novartis Ag Compositions pharmaceutiques comprenant de l'acide mycophenolique ou un sel mycophenolate
WO2009110005A2 (fr) * 2008-03-05 2009-09-11 Panacea Biotec Limited Compositions pharmaceutiques à libération modifiée comprenant du mycophénolate et procédés pour celles-ci

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038689A2 (fr) * 1996-04-12 1997-10-23 Novartis Ag Compositions pharmaceutiques a delitage enterique et a base de mycophenolate
US6306900B1 (en) * 1996-04-12 2001-10-23 Novartis Ag Enteric coated pharmaceutical compositions
WO2003032978A1 (fr) * 2001-10-17 2003-04-24 Novartis Ag Compositions pharmaceutiques comprenant de l'acide mycophenolique ou un sel mycophenolate
WO2009110005A2 (fr) * 2008-03-05 2009-09-11 Panacea Biotec Limited Compositions pharmaceutiques à libération modifiée comprenant du mycophénolate et procédés pour celles-ci

Also Published As

Publication number Publication date
WO2011051967A2 (fr) 2011-05-05

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