WO2011051158A1

WO2011051158A1 - Disinfecting cleaner

Info

Publication number: WO2011051158A1
Application number: PCT/EP2010/065866
Authority: WO
Inventors: Dirk Bockmühl; Stefanie Küch
Original assignee: Henkel Ag & Co. Kgaa
Priority date: 2009-10-30
Filing date: 2010-10-21
Publication date: 2011-05-05
Also published as: DE102009046239A1

Abstract

An antimicrobially active cleaning agent for hard surfaces contains monoethanolamine and at least one quaternary ammonium compound and is used for antimicrobially cleaning hard surfaces, wherein said cleaning agent can also be used in a spray dispenser.

Description

"Disinfecting cleaner"

The subject of this application is an antimicrobial cleaning agent for hard

Surfaces containing monoethanolamine and at least one quaternary ammonium compound.

Especially in humid or warm, humid rooms, where bacteria and molds find ideal growth conditions, not only the simple cleaning but also the antimicrobial treatment of hard surfaces is useful and desirable. In particular, mold fungi, especially Aspergillus niger, have proven to be persistent and are considered as

Harmful known. However, bacteria and other pathogens have also been identified as household health hazards so that it is generally considered desirable to reduce surface microbial contamination.

It has now been found that a cleaning agent containing monoethanolamine and at least one quaternary ammonium compound has a high antimicrobial activity against germs such as Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger.

An object of this application is therefore an antimicrobial hard surface cleaner containing monoethanolamine and at least one quaternary ammonium compound.

In the context of the present invention are fatty acids or fatty alcohols or their derivatives - unless otherwise stated - representative of branched or unbranched carboxylic acids or alcohols or their derivatives having preferably 6 to 22 carbon atoms. The former are particularly preferred for their vegetable base as based on renewable raw materials for environmental reasons, but without limiting the teaching of the invention to them. In particular, the oxo alcohols or their derivatives, which are obtainable, for example, by the RoELEN's oxo synthesis, can also be used correspondingly.

Whenever alkaline earth metals are referred to below as counter ions for monovalent anions, this means that the alkaline earth metal is naturally present only in half the amount of substance that is sufficient for charge equalization, such as the anion.

Substances which also serve as ingredients of cosmetic products are hereinafter referred to as appropriate according to the International Nomenclature Cosmetic Ingredient (INCI) nomenclature. Chemical compounds carry an INCI name in English, plant ingredients are listed only after Linne in Latin. So-called trivial names such as "water", "honey" or "sea salt" are also in Latin Language specified. The INCI names can be found in the "International Cosmetic Ingredient Dictionary and Handbook, Seventh Edition (1997)", The Cosmetic, Toiletry and Fragrance Association (CTFA), 10110, 17 ^th Street NW, Suite 300, Washington, DC 20036, USA, and more than 9,000 INCI names, as well as references to more than 37,000 trade names and technical names, including its associated names

Includes distributors from over 31 countries. The International Cosmetic Ingredient Dictionary and Handbook assigns to the ingredients one or more chemical classes, such as "polymer ethers", and one or more functions, such as "surfactants -cleaning agents", which in turn further explain it , These may also be referred to below.

The indication CAS means that the following sequence of numbers is a name of the Chemical Abstracts Service.

Unless otherwise stated, amounts given are percentages by weight (% by weight) of the total composition.

The terms sterilization, disinfection, sanitation, antimicrobial action and antimicrobial active ingredient in the context of the teaching of the invention have the usual meaning, for example, by KH Wallhäußer in "practice of sterilization, disinfection, preservation, germ identification, occupational hygiene" (5th ed. - Stuttgart; New York: Thieme, 1995)

is reproduced. While sterilization means the killing of all infectious germs, disinfection means the reduction of pathogens to a non-infectious level and, under sanitation, the greatest possible elimination of all - including those for humans

harmless saprophytic - to understand germs. Here, the extent of disinfection or sanitation depends on the antimicrobial effect of the applied agent, which decreases with decreasing content of antimicrobial agent or increasing dilution of the agent for use.

Quaternary ammonium compound

The agent of the invention contains at least one quaternary ammonium compound which contributes to the antimicrobial efficacy of the agent. Suitable cationic surfactants of the formula (R ') are, for example, (R ") (R"') (R ^IV) N ⁺ X ^"in which R 'to R ^IV four identical or different, in particular two long and two short chain, Alkyl radicals and X ^"are an anion, in particular a halide ion, for example, didecyl-dimethyl-ammonium chloride, alkyl-benzyl-didecyl-ammonium chloride and mixtures thereof. Particularly suitable, however, are quaternary ammonium compounds of the abovementioned formula in which R 'and R "are two identical or different short-chain alkyl radicals, preferably methyl, R'" is a relatively long-chain alkyl radical, R ^{IV is} an aromatic radical and X ^"is an anion, in particular a halide ion. Benzalkonium chloride is particularly preferably used. Benzalkonium chlorides or

Alkylbenzyldimethylammonium chlorides (INCI: Benzalkonium Chloride) with a C ₈ -18 -alkyl radical can be prepared, like all quaternary ammonium compounds, by reacting a tertiary amine with an alkylating agent, in this case benzyl chloride. They have cation surfactants

Properties on. Above all, they are characterized by their bactericidal action, which can develop optimally in formulations with a pH of 6 to 9. They are, for example, under the trade names ^® Acetide offered (Thor Biocides) Barquat ^® (Lonza), Empigen ^® (Huntsman) or ^® Rewoquat (Witco).

The agent according to the invention contains the quaternary ammonium compound, preferably

Benzalkonium chloride, preferably in an amount of 0.01 to 10 wt .-%, preferably 0, 1 to 5.0 wt .-%.

Monoethanolamine

The cleaning agent according to the invention also contains monoethanolamine. The

Monoethanolamine is preferably contained in an amount of 0.01 to 10 wt .-%, preferably 0, 1 to 5.0 wt .-%.

amine oxide

In a preferred embodiment, the agent according to the invention further contains at least one amine oxide, preferably one or more C ₈ -C ₈ amine oxides. Here, with a Ci are particularly preferred such as lauryl dimethyl amine oxide ₂ chain, which (Clariant) or Standamox PL (Cognis) is sold for example under the trade name Genaminox LA, or cocodimethylamine oxide. The amine oxide is preferably present in amounts of from 0 to 15% by weight, in particular from 0.1 to 5% by weight, in the cleaning agent.

surfactants

In addition to the amine oxide, the cleaning agent according to the invention may contain further anionic, nonionic or amphoteric surfactants. Among the nonionic surfactants herein are C ₈ -C particularly preferably ₈ alcohol polyglycol ethers, ie ethoxylated and / or propoxylated alcohols having 8 to 18 carbon atoms in the alkyl moiety and 2 to 15 ethylene oxide (EO) and / or

Propylene oxide units (PO), C ₈ -C ₈ -carboxylic acid polyglycol esters having 2 to 15 EO, for example tallow fatty acid + 6-EO esters, ethoxylated fatty acid amides having 12 to 18 C atoms in the fatty acid moiety and 2 to 8 EO and long-chain alkylpolyglycosides having 8 to 14 C atoms in the alkyl moiety and 1 to 3 glycoside units. Examples of such surfactants are oleyl-cetyl alcohol with 5 EO, nonylphenol with 10 EO, lauric acid diethanolamide and Kokosalkylpolyglucosid with an average of 1, 4 glucose units. Preferred anionic surfactants in the context of this invention are C ₈ -C ₈ -alkylbenzenesulfonates, in particular having about 12 C atoms in the alkyl moiety, C ₈ -C ₂ 0-alkanesulfonates, C ₈ -C ₈ -monoalkyl sulfates, C ₈ -C ₈ -alkyl polyglycol ether sulfates 2 to 6 ethylene oxide units (EO) in the ether portion and sulfosuccinic mono- and di-C ₈ -C ₈ -alkyl esters. Furthermore, C ₈ -C can nate ₈ -a-Olefinsulfo-, C ₈ -C ₈ sulfonated fatty acids, especially dodecyl benzene sulfonate, C ₈ -C ₂₂ - Carbonsäureamidethersulfate, C ₈ -C ₈ -Alkylpolyglykolethercarboxylate, C ₈ -C ₈ -N Acyltauride, C ₈ - Ci ₈ -N-sarcosinates and C ₈ -C ₈ alkyl isethionates or mixtures thereof.

The anionic surfactants are preferably used as sodium salts, but may also be present as other alkali or alkaline earth metal salts, for example magnesium salts, and in the form of ammonium or mono-, di-, tri- or tetraalkylammonium salts, in the case of the sulfonates also in the form their corresponding acid, eg Dodecylbenzenesulfonic.

Suitable amphoteric surfactants are, for example, betaines of the formula (R ^v ) (R ^v ') (R ^v ") N ⁺ CH ₂ COO ^- , in which R ^{v is} an alkyl radical optionally interrupted by hetero atoms or heteroatom groups having 8 to 25, preferably 10 to 21 carbon atoms and R ^VI and R ^v "are identical or different alkyl radicals having 1 to 3 carbon atoms, in particular C ₁ -C ₈ -alkyl-d in ethylcarboxymethyl betaine and C ₁ -C ₇ -alkylamidopropyl-d in ethylcarboxymethyl betaine ,

The further surfactants are preferably present in amounts of from 0.1 to 10% by weight, in particular from 0.2 to 5% by weight.

bases

The composition according to the invention may contain further basic components customary in detergents. As a further alkaline component is preferably alkali or

Alkaline earth metal hydroxide, in particular at least one alkali metal hydroxide, more preferably sodium and / or potassium hydroxide, most preferably sodium hydroxide, in amounts of 0, 1 to 10 wt .-%, preferably in amounts of 0.1 to 4 wt .-%.

Water-soluble organic solvent

As a further component, the cleaning agent according to the invention may contain one or more water-soluble organic solvents. These are preferably mono- or polyvalent CI_ ₆ alcohols and / or glycol ether (ether). Particularly preferred among the alcohols are the following compounds named according to INCI: Alcohol (ethanol), n-butyl alcohol, t-butyl alcohol, butylene glycol, diethylene glycol, dipropylene glycol, glycol, hexanediol, 1, 2,6-hexanetriol, Hexyl alcohol, hexylene glycol, isopentyl diol, isopropyl alcohol (/ so-propanol), methyl alcohol, methyl propane diol, neopentyl glycol, pentylene glycol,

Propanediol, propyl alcohol (n-propanol), propylene glycol. The alcohol is preferably selected from the group consisting of methanol, ethanol, isoropanol, n-propanol, n-butanol, Ethanediol, propanediol and mixtures thereof, particularly preferred are ethanol and isopropanol, especially ethanol. Preferably used glycol ethers are sufficiently water-soluble compounds having up to 10 C atoms in the molecule, especially

Ethylene glycol monobutyl ether, propylene glycol monobutyl ether, diethylene glycol monobutyl ether, propylene glycol monotertiary butyl ether and propylene glycol monoethyl ether, of which, in turn, ethylene glycol monobutyl ether and propylene glycol monobutyl ether are preferred.

The water-soluble organic solvent is preferably contained in amounts of 0.4 to 30 wt .-%, particularly preferably 1 to 10 wt .-%, in particular 2 to 5 wt .-%.

Other antimicrobial agents:

The cleaning agent according to the invention may contain one or more further antimicrobial agents. Antimicrobial agents from the groups of alcohols, aldehydes, antimicrobial acids or their salts, for example, are suitable according to the invention.

Carboxylic acid esters, acid amides, phenols, phenol derivatives, diphenyls, diphenylalkanes,

Urea derivatives, oxygen, nitrogen acetals and formals, benzamidines, isothiazoles and their derivatives such as isothiazolines and isothiazolinones, phthalimide derivatives, pyridine derivatives, antimicrobial surface-active compounds, guanidines, antimicrobial amphoteric compounds (amphiphilic biocides), quinolines, 1, 2-dibromo-2 , 4-dicyanobutane, iodo-2-propynyl-butyl-carbamate, iodine, iodophores and peroxides. Preferred antimicrobial agents are preferably selected from the group comprising ethanol, n-propanol, i-propanol, 1,3-butanediol, phenoxyethanol, 1,2-propylene glycol, glycerol, undecylenic acid, citric acid, lactic acid, benzoic acid, salicylic acid, thymol, Benzyl 4-chlorophenol, 2,2'-methylenebis (6-bromo-4-chlorophenol), 2,4,4'-trichloro-2'-hydroxydiphenyl ether, N- (4-chlorophenyl) -N- ( 3,4-dichlorophenyl) urea, N, N '- (1, 10-decanediyldi-1-pyridinyl-4-ylidene) bis (1-octanamine) dihydrochloride, N, N'-bis (4- Chlorophenyl) -3,12-diimino-2,4,1,1,13-tetraazatetradecandiimidamide, guanidines.

Auxiliaries and additives

The cleaning agent according to the invention can also one or more further in

Detergents contain conventional auxiliaries and additives. These are preferably selected from the group comprising dyes, perfume, thickening agents, preservatives, complexing agents for alkaline earth ions, enzymes, bleaching systems and antistatic agents. The auxiliaries and additives are contained in customary quantities, in total in an amount of preferably from 0.1 to 5% by weight, in particular from 0.1 to 2% by weight.

Finally, the agent according to the invention contains water in amounts of from 1 to 95% by weight, preferably from 70 to 95% by weight. PH value

The agent according to the invention is adjusted to a pH of 7 to 14, preferably 8 to 12.5.

The composition according to the invention is particularly suitable for spraying, producing a stable foam. A second subject of the invention is therefore a product of the detergent and a spray bottle. The spray dispenser is preferably a manually activated spray dispenser, in particular selected from the group comprising aerosol spray dispensers, even pressure-building spray dispensers, pump spray dispensers and trigger spray dispensers, in particular

Pump spray dispenser and trigger spray dispenser with a transparent polyethylene or polyethylene terephthalate container. Such trigger bottles are offered, for example, by Afa Polytec. The spray head is preferably equipped with a foam nozzle.

In addition, the agent may also be filled into a corresponding aerosol spray bottle with the addition of a suitable propellant (e.g., n-butane or a propane / butane mixture). However, such a spray dispenser is less preferred.

Another subject of the invention is accordingly a product of a

aqueous cleaning agent according to the invention and a spray dispenser, in particular from an inventive aqueous cleaning agent and a trigger bottle with foam nozzle or a pump foam dispenser.

The compositions of the invention are preferably used for antimicrobial cleaning of hard surfaces. Hard surfaces in the context of this application are windows, mirrors and other glass surfaces, surfaces made of ceramic, plastic, stone, metal or wood and lacquered wood, which are found in household and commercial, such as bathroom ceramics, kitchen surfaces or floors.

A third subject of the invention is therefore the use of an aqueous cleaning agent according to the invention or of a product according to the invention for the antimicrobial cleaning of hard surfaces.

The active ingredient combination of monoethanolamine and at least one quaternary

Ammonium compound may be used to prepare a cleaning agent for antimicrobial

Treatment of hard surfaces can be used. The active ingredient combination may preferably further contain at least one amine oxide.

Another subject of the invention is therefore the use of a combination of

Monoethanolamine and at least one quaternary ammonium compound for the preparation of a cleaning agent for the antimicrobial treatment of hard surfaces. Examples

A total of ten aqueous solutions of various drug combinations were formulated which were suitable for incorporation in hard surface cleaners. These

Active compound combinations each comprise at least one active substance from the group consisting of amine oxides (lauryl dimethylamine oxide), monoethanolamine, quaternary ammonium compounds (benzalkonium chloride) and amphiphilic biocides (Rewocid ^®). The compositions can be taken from the table below, the quantities in wt .-% are active substance. The compositions were each supplemented with water to 100%.

To test the antimicrobial efficacy, tests were carried out in accordance with the European test standards EN 1275 (bacteria) and EN 1040 (fungi). The corresponding logarithmic germ number reductions can be taken from the following table:

It can be seen that only compositions A6 and A8, containing both monoethanolamine and the quaternary ammonium compound, produced a satisfactory reduction in germ number (log4 or even log5) over all four test bacteria. While the effect against Pseudomonas aeruginosa was given in all cases, especially

Staphylococcus aureus and especially Aspergillus niger a difficulty for the

Drug combinations that are outside the present invention.

Claims

claims

1. An antimicrobial cleaning agent for hard surfaces, characterized in that it contains monoethanolamine and at least one quaternary ammonium compound.

2. Cleaning agent according to claim 1, characterized in that it continues

contains at least one amine oxide.

3. Cleaning agent according to one of claims 1 and 2, characterized in that it contains monoethanolamine in an amount of 0.01 to 10 wt .-%, preferably 0, 1 to 5 wt .-%.

4. Cleaning agent according to one of claims 1 to 3, characterized in that it contains the at least one quaternary ammonium compound in an amount of 0.01 to 10 wt .-%, preferably 0, 1 to 5 wt .-%.

5. Cleaning agent according to one of the preceding claims, characterized in that it contains at least one amine oxide in an amount of 0 to 15 wt .-%, preferably 0, 1 to 5 wt .-%.

6. Detergent according to one of the preceding claims, characterized in that it contains further typical in cleaning agents for hard surfaces ingredients, auxiliaries and additives, preferably selected from the group comprising solvents, other surfactants, pH adjusting agents (bases, acids), others antibacterial agents, preservatives, solubilizers, complexing agents, enzymes, viscosity regulators, dyes, fragrances and mixtures thereof.

7. Product of a cleaning agent according to one of the preceding claims and a spray dispenser, in particular of an aqueous cleaning agent according to one of the preceding claims and a trigger bottle with foam nozzle or a pump foam dispenser.

8. Use of a cleaning agent according to any one of claims 1 to 6 or a product according to claim 7 for the antimicrobial cleaning of hard surfaces.

9. Use of a combination of monoethanolamine and at least one quaternary ammonium compound for the preparation of a cleaning agent for the antimicrobial treatment of hard surfaces.