WO2011049236A1 - Magnetic induction system and operating method for same - Google Patents

Abstract

Disclosed are a magnetic induction system and an operating method for same, by which magnetic force can be exerted deeply and widely in an arbitrary direction. The magnetic induction system is provided with a plurality of magnetic field generation means constituted by superconducting bulk magnets; a drive means for driving the plurality of magnetic field generation means at arbitrary positions and angles; and a drive control means for driving the drive means so that a resultant field of the plurality of magnetic field generation means inducts a magnetic complex to a desired region within a living body and setting the positions and angles of the plurality of magnetic field generation means. As a result, the magnetic complex is inducted to be focused on a cartilage defect portion.

Description

Magnetic guidance system and its operating method Import by reference

This application claims the priority of Japanese Patent Application No. 2009-244492 filed on October 23, 2009, and is incorporated herein by reference.

The present invention relates to a magnetic induction system in which a derivative to be provided with magnetic particles is guided and a method of operating the magnetic induction system.

For example, injured osteoclastitis, a disease in which bone injury or bone cartilage of the knee joint occurs due to injury or sports activity, and the cartilage of the joint peels off from the underlying bone with a thin piece of bone, Many occur inside the knees and are found in teenage children with weak osteochondral connectivity during the growth period. These subjects initially complained of knee pain and swelling, which was caused by walking and exercise. When it gets worse and progresses and bones and cartilage are liberated, there is a situation in which the knees feel stuck and cannot bend and stretch. Cartilage has no blood vessels or nerve tissue, and even if damaged, it does not return naturally. Conventionally, the bones behind the damaged part were intentionally injured with a drill and bleeded to expect tissue regeneration, or the method of transplanting multiple small cartilage to fill the fistula defect, The smooth state could not be reproduced.

Therefore, one example of a conventional regenerative medical treatment method for cartilage damage that can reproduce the original smooth state of the joint is 5-10 mm square of cartilage tissue in a portion of the patient's joint that is not weighted by an endoscope. The tissue is separated with an enzyme and the cells are taken out of the body. In a vessel made in the shape of the defect, the patient's serum is added to the medical collagen gel that matches the shape of the defect. Incubate for 3 weeks. This is surgically inserted into the defect, and the patient's periosteum is covered and sewn. One month-one and a half months, you can walk with full weight. With this method, when the patient's periosteum is sewed with a lid, the patient's knee needs to be cut wide by several tens of millimeters, which causes a problem of increasing physical burden on the patient.

Therefore, as a conventional treatment method that can reduce the physical burden on the patient, for example, a syringe that combines a complex of cells and magnetic particles used for the treatment of bone marrow mesenchymal stem cells and the like in the vicinity of the disease site in the patient's body Development of a regenerative medical technique that cures the damage of a site by injecting the same by applying a magnetic force from outside the body and concentrating the complex on the site of the disease is underway.

A donut-shaped solenoid coil magnet is used as a magnetic induction device that magnetically induces a derivative with magnetic particles used in medical treatment of diseases such as conventional cartilage damage using a magnetic field generated by a magnetic field generator. There has been proposed one in which a solenoid coil magnet is arranged so as to surround a diseased part of a patient (see, for example, Patent Document 1).

On the other hand, a permanent magnet is placed near the site of the disease in the patient's body, a magnetic force is applied in any direction, and a complex of cells and magnetic particles used for treatment is combined using, for example, a syringe. Development of a regenerative medical technique (see, for example, Patent Document 2) that injects into the body, concentrates the diseased part where the complex is to be concentrated, and cures the damage is underway.

On the other hand, for example, a magnetic drug, which is a complex of a therapeutic drug and magnetic particles, is dispensed into the patient's blood vessel with a syringe, and a magnetic field generator composed of a superconducting bulk magnet is placed around the bed on which the patient lies. Then, a magnet is assigned to the vascular bifurcation upstream of the patient's cancer cells and the vicinity of the cancer cells, and the magnetic drug that happens to pass through the magnetic field by the blood flow circulating in the subject's body is captured by the magnetic force, A method for increasing the residual density of the magnetic drug in the vicinity of the affected area (for example, see Patent Document 3) has been proposed.

JP 2007-151605 A JP 2006-325600 A JP 2007-297290 A

In a conventional magnetic induction device, when a magnetic field generator that generates a magnetic field necessary for magnetically guiding a derivative injected from outside the body of a patient is a solenoid coil magnet, the magnetic field of the solenoid coil magnet is around the coil. In the part, a strong magnetic field is generated around this, and a strong magnetic field is formed in a ring shape. For this reason, when the patient's foot is passed through the central space of the solenoid coil magnet and the inner side of the knee is placed in contact with the periphery of the coil circle, the magnetic action line is located at the center of the magnet in a circular cross section. Acts linearly from the radial direction. Therefore, for example, when the path connecting the infusion site of the derivative to the diseased part where the derivative is to be concentrated using a syringe does not coincide with the magnetic action line, that is, the knee whose surface to be concentrated is parallel to the circular cross section When the indirect cartilage corresponding to a side surface having a circular cross section of, for example, an angle of 45 degrees is present, there is a problem that the derivative cannot be concentrated on the diseased part.
In addition, the patient's own body may become an obstacle, and there is a problem that magnetic lines of force cannot be appropriately applied to the affected area.

In addition, when the magnetic field generator is a permanent magnet, the magnetic force of the permanent magnet abruptly attenuates as it moves away from the magnet surface. Therefore, when the diseased site is 5 cm away from the permanent magnet installation location, the derivative is concentrated on the diseased part. There was a problem that it was difficult to do.

On the other hand, a magnetic drug, which is a complex of a therapeutic drug and magnetic particles combined, for example, a complex of cells and magnetic particles used for the treatment of bone marrow mesenchymal stem cells, etc., is administered to the patient's blood vessel with a syringe or the like. However, when a magnetic drug is induced using a superconducting bulk magnet as a magnetic field generator, there is a problem that the magnetic drug cannot be magnetically induced in a cartilage injury disease part or the like where blood vessels do not communicate.

The present invention has been made in view of such problems, and an object of the present invention is to provide a magnetic guidance system capable of guiding a derivative to a desired position in a subject.
Another object of the present invention is to apply an appropriate magnetic force to a complicated part such as the inside of a knee or a narrow part, even when the patient's own body becomes an obstacle, It is an object of the present invention to provide a magnetic induction system that can guide a derivative to a desired position, can be easily moved, and can be installed in a narrow space as compared with the conventional case.

(1. Magnetic induction system)
(First aspect)
In order to achieve the above object, a magnetic induction system of the present invention is provided. The magnetic induction system according to the first aspect of the present invention includes a plurality of probe-like magnetic field generating means and a magnetic field generating means so that a synthetic magnetic field generated by the plurality of magnetic field generating means acts on a desired site in the living body. And a drive control means for controlling the drive means so that the plurality of magnetic field generating means have the positions and angles calculated by the calculation means.

The “magnetic field generating means” has a probe-like shape, and preferably includes a superconducting bulk magnet device. The magnetic field generating end of the magnetic field generating means is arranged with its position and direction freely adjusted near the body surface of the living body. It can be moved along the body surface in the vicinity of the body surface, and can be used accurately according to the body shape and posture of the living body. For example, it is possible to move and stop at any narrow position such as the back of the knee or the side, and adjust and arrange so that the magnetic field lines deeply act on the patient's diseased part at an arbitrary angle. Is also possible. The plurality of “magnetic field generating means” can magnetically induce the magnetic composite in an arbitrary direction by changing the direction and magnitude of the resultant force vector of the magnetic force by changing the magnetic field strength and direction of each magnetic field generating means.

The magnetic field generating means may be configured to include a “superconducting bulk magnet” in order to generate a magnetic field. The magnetic field generation surface of a superconducting bulk magnet can generate several tens to several hundreds times stronger magnetic force than a permanent magnet of the same size, so it can be injected outside the blood vessel in the body and near the diseased part with a syringe. It is possible to induce the complex in a high density in a cartilage defect where it is desired to concentrate. Since the superconducting bulk magnet is small and lightweight, it is suitable for use in the magnetic induction system of the present application that can be placed in a narrow space.

The composition of the superconducting bulk magnet is preferably a bulk magnet capable of obtaining a high critical current density of 10000 A / cm ² at a liquid nitrogen temperature of 77 K or higher and a sufficient trapping magnetic field under a 3 T magnetic field. For example, a bulk magnet having a composition of RE-Ba-Cu-O (RE: rare earth element) is more preferable. Specifically, (Nd, Eu, Gd) -Ba-Cu-O, Gd-Ba-Cu-O, or Y-Ba-Cu-O is more preferable.

Also, in order to improve the thermal conductivity, an aluminum rod may be inserted into a hole provided in the superconducting bulk magnet to be combined, or a shape memory alloy ring may be attached. Further, a superconducting bulk magnet may be impregnated with a low melting point alloy such as resin or wood metal to improve mechanical strength. Furthermore, you may use the superconducting bulk magnet which employ | adopted all of the structure which inserts said aluminum rod, combines, the structure which attaches a shape memory alloy ring, and the structure which impregnates a low melting-point alloy.

“Drive means” can drive a plurality of magnetic field generating means. Here, the term “plurality” means two or three or more, but preferably two from the viewpoint of ease of control. The driving means supports the magnetic field generating means and has a function capable of arranging the magnetic field generating end in a free position and a free direction in the vicinity of the body surface of the living body. The drive means having the function can adjust the magnetic field generating means so that the magnetic lines of force act deeply in the body at an arbitrary angle with respect to the diseased part of the patient without moving the patient. As the drive means, a general drive motor or the like can be used, and a configuration including a “magnet holder”, “arm”, “rotary joint”, “cart”, and the like is conceivable. The bed can be moved to a predetermined position by the carriage, and the position of the magnetic field generating means can be adjusted by the arm and the rotary joint. By the driving means, the superconducting bulk magnet can be moved / stationary or continuously adjusted to an arbitrary narrow position such as the back of the knee or the side surface.

The “calculation means” can calculate the position and angle of the magnetic field generation means so that the synthetic magnetic field guides the magnetic complex to a desired site in the living body. The calculation means is composed of a CPU, a main memory, a RAM, and the like.

In the memory of the computing means, the relationship between the position and angle of the magnetic field generating means determined in advance based on experiments and the synthesized magnetic field generated from the position and angle of the magnetic field generating means is mapped, and the table or map is displayed. It may be stored. The calculation means can calculate the position and angle of the magnetic field generation means with reference to the data mapped in the memory.

Further, the position and angle of the magnetic field generation means may be automatically calculated using a function stored in advance in the memory of the calculation means. The calculation means can calculate the position and angle of the magnetic field generation means by inputting data of a desired position where the synthetic magnetic field is to be generated into a function stored in the memory.

The “drive control means” has a function capable of controlling the drive means so as to guide the magnetic bead induced substance complex to a desired position in the body by a synthetic magnetic field of a plurality of magnetic field generating means. The calculation means calculates the position and angle of the magnetic field generation means so as to form the combined magnetic field of the plurality of magnetic field generation means at a desired site in the living body, and the drive control means calculates the multiple magnetic field generation means. The drive of the drive means is controlled so that the position and angle calculated by the means are obtained. As a control method, control via a wireless signal or a wired cable can be considered.

The desired part in the living body where the synthetic magnetic field is formed is, for example, the articular cartilage part in the living body. The desired part is a diseased part or a part to be examined of a patient, and can be, for example, a cartilage defect part where a defect part exists. Here, the site where the magnetic complex can be guided in the magnetic guidance system is not limited to the cartilage defect, and any site in the patient's body such as a specific organ can be assumed. For example, a magnetic complex can be guided to an affected part by applying an appropriate magnetic force to a specific narrow part such as a cartilage defect part of a knee joint or a complicated part such as the inside of a knee or a narrow part. it can. Further, the route through which the magnetic complex can be induced is not limited to a portion where blood vessels and nerves exist, and can be set to a cartilage portion where blood vessels and nerves do not exist.

In the magnetic induction system of the present invention, it is possible to separately provide an “injection apparatus” having a function for injecting the magnetic bead induced substance complex into the body. It is conceivable to use a general syringe as the injection device. In addition, the said injection apparatus does not necessarily need to be integrated with a magnetic guidance system, and can also be set as the structure of a separate apparatus.

The “magnetic complex” is, for example, a magnetic bead induced substance complex composed of a magnetic bead made of a magnetic material and an induced substance. The “magnetic bead induced substance complex” is characterized by including a magnetic material produced for the purpose of being guided to a desired position in the body by a magnetic induction device. As an example of the method for generating the above-mentioned magnetic bead-inducible substance complex, the patient's own mesenchymal stem cells that change into the patient's bone, cartilage, muscle, etc. are taken out of the body and used as a contrast agent or the like. For example, a method may be considered in which a peptide or the like is coated on the surface, and both are mixed in a liquid for a predetermined time, and stem cells and magnetite fine particles are complexed and produced via the peptide.

In the magnetic induction system according to the present invention, the case where a complex in which cells and magnetic particles used for treatment are combined is used as the magnetic complex, but the magnetic complex includes magnetic particles and anticancer agents, etc. Any substance may be used as long as it has a therapeutic effect on a diseased part made of an effective substance in the body. In addition, the magnetic guidance system according to the present invention can be used not only for treating a diseased part but also for examining or diagnosing a living body of a subject. For example, using the magnetic guidance system according to the present invention, a magnetic complex for testing or diagnosis may be guided to a test site or a diagnostic site in a subject's living body.

(Second aspect)
The magnetic induction system according to the second aspect of the present invention further includes homopolar control means capable of controlling the drive means in an arrangement in which the magnetic poles of the plurality of magnetic field generating means repel each other at a desired part of the living body. . The magnetic poles at the magnetic field generation ends of the plurality of magnetic field generation means are the same.

The “homopolar control means” has a function capable of controlling the drive means in an arrangement in which magnetic fields generated from a plurality of magnetic field generating means repel each other in the magnetic field application region of the living body. A plurality of magnetic field generating means generates a magnetic field having the same polarity from the magnetic field generating end, and controls the driving means in an arrangement that repels each other in the magnetic field application region of the living body. The magnetic induction system of the present invention is configured to have the “homopolar control means”, so that there is little possibility of generating a force to pinch the magnetic field application region (affected part) of the living body, and the magnetic bead induced substance composite can be more safely performed. The body can be guided.

The same-polarity control means is preferable because a part of the body can be prevented from being injured between magnets having different polarities attracted to each other.

(Third aspect)
The magnetic induction system according to the third aspect of the present invention further includes time control means for controlling a site in the living body and the strength of the magnetic field at the site according to the elapsed time after the introduction of the magnetic complex.

The “time control means” has a function capable of controlling the strength of the magnetic field in the magnetic field application region of the living body according to the elapsed time after the introduction of the magnetic bead induced substance complex. For example, when a magnetic bead-inducible substance complex is introduced into a joint, the introduced magnetic bead-inducible substance complex is compared at an early stage in order to spread it uniformly in the jelly-like body fluid of the joint. It is conceivable to apply a relatively weak magnetic field to distribute the complex uniformly by self-diffusion, and then to apply a relatively strong magnetic field to evenly land on a narrow part of the joint where there is a defect. When the magnetic induction system of the present invention is configured to have “time control means”, it is possible to induce the magnetic bead induced substance complex in more various modes.

(Fourth aspect)
A magnetic complex induction system according to a fourth aspect of the present invention includes the magnetic complex and the magnetic induction system according to the present invention, and the complex includes cells and magnetic particles used for treatment, and the magnetic induction system. Has a superconducting bulk magnet and a support means that can continuously adjust the movement, rest, or movement of the superconducting bulk magnet to any narrow position such as the back or side of the knee, and the magnetic field generated by the superconducting bulk magnet Thus, the magnetic complex injected into a site outside the blood vessel in the body can be guided to a diseased part of the patient in the body.

(2. Operation method of magnetic induction system)
In the present invention, a plurality of probe-like magnetic field generating means, a driving means for driving the plurality of magnetic field generating means, an arithmetic means for calculating the position and angle of the magnetic field generating means, and driving of the driving means are controlled. And a drive control means for operating the magnetic induction system, wherein the calculation means calculates the position and angle of the magnetic field generation means so that the combined magnetic field of the plurality of magnetic field generation means acts on a desired part in the living body. And a method of operating the magnetic induction system, wherein the drive control means controls the drive of the drive means so that the plurality of magnetic field generating means have the positions and angles calculated by the computing means.

According to the magnetic induction system of the present invention, a superconducting bulk magnet capable of generating a strong magnetic field as compared with conventional solenoid coil magnets and permanent magnets is used, so that there is no blood vessel (for example, cartilage portion). It is also possible to apply a magnetic force to the deep part of the body. Therefore, the present invention is particularly useful in that the magnetic complex can be guided to the diseased part even when the diseased part is present in a site without a blood vessel or in a deep part of the body.

In addition, since the magnetic induction system of the present invention uses a plurality of magnetic field generating means, it is possible to form a synthetic magnetic field in an arbitrary direction. The magnetic force can be concentrated on. That is, the magnetic complex can be made to act so as to more closely match the site and shape of the diseased part.

Further, according to the present invention, by controlling the position and direction of the plurality of magnetic field generating means, a synthetic magnetic field is initially applied to a relatively wide range around the diseased part, and the magnetic complex is gradually transferred to the diseased part. The magnetic complex can be induced in the local area of the diseased part by narrowing the range to be induced and then applying the synthetic magnetic field. Thus, by concentrating the magnetic complex locally on the diseased part, it becomes possible to cause the magnetic complex to act on the diseased part more effectively.

Furthermore, by using a small and light superconducting bulk magnet, it is possible to provide a small and light magnetic induction system compared to a conventional magnetic induction system using a solenoid coil magnet or a permanent magnet. Thereby, even when the diseased part exists at an arbitrary narrow position such as the back of the knee or the side surface, the magnetic field generating means can be arranged at an arbitrary position.

Further, according to the magnetic induction system of the present invention, even when a part of the patient's living body becomes an obstacle, the magnetic force lines can be appropriately applied to the affected part. Furthermore, the magnetic guidance system of the present invention is easy to move and can be installed in a narrow space as compared with the conventional one, and can exert a magnetic force deeply and widely in any direction.

In addition, the magnetic induction system according to the present invention is a composite in which a magnetic field generator is composed of a small and lightweight superconducting bulk magnet, and cells used for treatment and magnetic particles injected into the body using a syringe are combined. Used to guide the affected area where the body is to be concentrated. Superconducting bulk magnets can generate several tens to hundreds of times stronger magnetic force than permanent magnets of the same size, so cartilage defects that want to concentrate the complex injected with a syringe near the diseased part Can be well guided to the part with high density.

Furthermore, the superconducting bulk magnet according to the present invention generates a main magnetic force in a direction perpendicular to the magnet surface, and this magnetic force is applied to a conventional solenoid coil magnet or a permanent magnet of the same size even in a space away from the magnet surface. Compared with the magnet, the main magnetic force can be generated in the direction perpendicular to the magnet surface, so even if the diseased part where the complex is to be concentrated is located 5 cm away from the magnet, for example, the cartilage defect part Can be guided well and accurately.

As described above, the magnetic induction system according to the present invention generates a main magnetic force in a direction perpendicular to the magnet surface using a superconducting bulk magnet, and a conventional solenoid coil magnet or the same size in a space away from the magnet surface. Compared with a permanent magnet, it is stronger and can generate a main magnetic force in a direction perpendicular to the magnet surface. Therefore, even if the diseased part where the complex is to be concentrated has a cartilage defect surface on a surface having an angle of 45 degrees from the side surface of the knee, for example, the cartilage defect surface and the syringe can be used without moving the patient. The magnet surface can be moved and stationary by the moving support means so that the magnetic force action line connecting the injection sites of the injected complex and the magnetic force line of the magnet match. As a result, the complex can be accurately and accurately guided to the cartilage defect surface.

In addition, the magnetic induction system according to the present invention uses a superconducting bulk magnet, so that even if the cartilage defect surface on which the complex is to be concentrated is on the concave bottom or side surface, the magnet can be moved without moving the patient. Since the position can be adjusted and installed, the complex can be accurately and uniformly guided on the concave surface of the cartilage defect. Specifically, the magnets so that the lines of magnetic force acting between the positions of the concave cartilage defect surfaces on the concave surface and the injection site of the complex injected with a syringe or the like match the magnetic force lines of the magnet. The surface may be continuously controlled while moving in the extracorporeal space near the diseased part.

Other objects, features and advantages of the present invention will become apparent from the following description of embodiments of the present invention with reference to the accompanying drawings.

The figure explaining the structure in the superconducting bulk magnet container of the magnetic induction system in one Example of this invention. The magnetic field distribution map of the superconducting bulk magnet surface in one Example of this invention. The magnetic force vector distribution map in the superspace bulk magnet surface upper space in one Example of this invention. The figure which shows the operation | movement procedure of the magnetic guidance system in one Example of this invention. The figure explaining the magnetic guidance system in one Example of this invention. The figure which shows the bone of the femur of a knee, and the cartilage defect location of the bone. The figure which shows a mode that the magnetic composite body was spread and distributed in the jelly-like body fluid of a joint part. The figure which shows the result of the internal magnetic induction of the magnetic composite_body | complex by a prior art. The figure which shows the result of the internal magnetic induction of the magnetic composite_body | complex by the magnetic induction system in one Example of this invention. The figure which shows a mode that a magnetic composite is uniformly landed on the surface of a cartilage defect part by repeating operation of magnetic induction in multiple times. The figure which shows an example of the magnet installation structure in one Example of this invention. The figure which shows the operation | movement procedure of the magnetic guidance system in one Example of this invention. The figure which shows the example using one superconducting bulk magnet in the magnetic induction system of this invention. The figure which shows the example using two superconducting bulk magnets in the magnetic induction system of this invention. The figure which shows the example which adjusts the distance between the magnets of two superconducting bulk magnets and controls the vector of magnetic force in the magnetic induction system of this invention. The figure which shows the other example which controls the vector of magnetic force by adjusting the distance between the magnets of two superconducting bulk magnets in the magnetic induction system of this invention. The figure which shows the patella of the joint part of a pig, and the cartilage defect part of the bone. The figure which shows a mode that white cartilage self-proliferated and reproduced | regenerated to the cartilage defect part.

Hereinafter, specific embodiments of the present invention will be described with reference to the drawings. 1 to 3 show a magnetic induction system according to a first embodiment of the present invention.

As shown in FIG. 1, the superconducting bulk magnet 2 included in the magnetic field generating means 1 is composed of the following components. As the magnetic field generating means 1, for example, a YBCO-based superconducting bulk body and a working gas other than helium gas such as helium or nitrogen is used, and a compressor (not shown) integrated Stirling small refrigerator 3 The structure of directly cooling the superconducting bulk body is shown in FIG. 1, and the outer periphery of the superconducting bulk body is integrated with the ring 4 made of stainless steel or aluminum with an adhesive, etc. Prevents cracking due to magnetic force. The superconducting bulk body and the ring 4 are thermally integrated with a heat transfer flange 5 made of copper or aluminum with an adhesive or the like, and the heat transfer flange 5 and the heat transfer flange 6 include an insulative sheet or grease (not shown). ) Through a bolt (not shown) or the like.

The heat transfer flange 6 is fixedly supported by, for example, a cylindrical body 7 made of epoxy resin steel containing glass fiber (not shown) and a bolt (not shown) having a low thermal conductivity, and the other end of the cylindrical body 7 is For example, the flange 8 made of stainless steel is integrated with an adhesive, and the flange 8 is hermetically fixed by a room temperature flange 9, an O-ring, and a bolt (not shown). A fixed flange 10 of the small refrigerator 3 is metallurgically and integrally integrated with the room temperature flange 9, and a fixed flange 12 of the small refrigerator 3, an O-ring, and a bolt (not shown) through a bellows 11 having vacuum tightness. ) Is airtightly fixed. Since the outer periphery of the superconducting bulk body is vacuum insulated, a vacuum vessel 13 is disposed, and the flange 14 at the end of the vacuum vessel is hermetically fixed to the flanges 8 and 9 by O-rings and bolts (not shown). The cylindrical body 7 is provided with inner and outer vacuum exhaust holes 15.

Due to the operation of the small refrigerator 3, the superconducting bulk body having an extremely low temperature of minus 230 degrees Celsius, the cylinder portion 16 of the refrigerator 3, and the cold stage 7 are exposed to intrusion of radiant heat from components at room temperature. In order to prevent this, the laminated radiant heat insulating material 17, 17 ′, 17 ″ is wound. The space 18 is evacuated by a vacuum pump 19 through a vacuum pipe 20 and a valve 21 to form a vacuum heat insulation space. After being cooled to a very low temperature by the refrigerator, the valve 21 can be closed, and the superconducting bulk magnet 2 and the vacuum pipe 20 can be separated.

The small refrigerator 3 is cooled by being supplied with power from the power supply unit 22 through the power cord 23. The compressor helium gas compression heat generated during the operation of the refrigerator is supplied through the pipe 25 with the refrigerant cooled by the chiller unit 24, and the refrigerant that has absorbed the compression heat is recovered into the chiller unit 24 through the pipe 26. By operating the helium refrigerator 3 while evacuating the space 18, the superconducting bulk material can be operated at a cryogenic temperature of about minus 230 degrees Celsius.

In order to magnetize a superconducting bulk material, a magnetized superconducting magnet capable of generating a predetermined magnetic field to be magnetized, for example, a magnetic field of 10 Tesla, or a normal conducting magnet with a small generated magnetic field is separately prepared (both magnets). Is not shown). Before the superconducting bulk magnet 2 incorporating the superconducting bulk body is cooled, the superconducting bulk magnet 2 is inserted into the magnetic field in the magnetizing magnet that has already generated the magnetic field to be magnetized. Cool body below superconducting temperature. Here, the cylindrical axis direction of the superconducting bulk body and the main magnetic field direction generated by the magnetizing magnet are matched.

Thereafter, when the magnetic field of the magnetizing magnet is demagnetized, the superconducting bulk magnet 2 having a magnetic field equivalent to the magnetizing magnetic field is obtained as long as the magnetic field is trapped in the superconducting bulk that is continuously cooled. In this manner, a high superconducting bulk body that captures a magnetic field of, for example, 5 Tesla to 10 Tesla can be used as the magnetic field generating means 1.

FIG. 2 shows a generated magnetic field distribution diagram on the surface of the superconducting bulk magnet in one embodiment of the present invention. In FIG. 2, I represents the magnetic field strength in the direction perpendicular to the superconducting bulk magnet wavefront, d represents the radial distance from the center of the end surface of the superconducting bulk magnet, and m represents the center of the end surface of the superconducting bulk magnet. Since the magnetic field distribution of the superconducting bulk magnet 2 magnetized as described above is formed by a group of micro magnetic fluxes that are distributed almost uniformly, for example, when the cross-sectional shape of the superconducting bulk body is circular, FIG. As shown in the magnetic field distribution diagram, the magnetic field strength characteristic 27 in the direction perpendicular to the surface within the magnet surface is substantially conical, the magnetic field at the center is strongest, and is almost zero at the outer periphery. Therefore, it has a very large magnetic field gradient in the vertical and radial directions from the center of the superconducting bulk body. Therefore, as shown in FIG. 3, the magnetic force, which is the product of the magnetic field strength and the magnetic field gradient, is a vector in which the magnitude of the magnetic force is represented by a length and the direction in which the magnetic force acts is represented by an arrow indicating the direction. As indicated by a line 28, in the space above the end face of the superconducting bulk body, a very large magnetic force is generated from the vertical direction and the radial direction from the space through which the magnetic field is transmitted toward the center of the end face of the superconducting bulk body.

When the superconducting bulk magnet 2 is placed outside the patient's knee, the magnetic field generated by the superconducting bulk magnet 2 penetrates from the patient's skin to the inside, and the articular cartilage has no blood vessels or nerve tissue and is self-repairing. It is possible to penetrate into a concave damage portion of an articular cartilage damaged portion having no ability.

On the other hand, the magnetic complex used for treatment takes out the patient's own mesenchymal stem cells that change into the patient's bone, cartilage, muscle, etc., and coats the surface of the magnetite fine particles used for contrast media with, for example, peptides. Both are mixed in a liquid for a predetermined time, and stem cells and magnetite fine particles are complexed and produced via a peptide.

FIG. 4 and FIG. 5 show a magnetic induction system and its operation procedure in one embodiment of the present invention. In the magnetic induction system shown in the present embodiment, the superconducting bulk magnet 2 is obtained by using the X-ray imaging apparatus (not shown) and the nuclear magnetic resonance imaging apparatus (not shown) to obtain positional information of the cartilage defect of the patient. Further, the magnetic complex vector distribution information indicating the strength and direction of the magnetic force of the superconducting bulk magnet 2 obtained in advance by calculation or measurement is used, and the magnetic complex previously input as position information in the computing means 100 is used. Calculate the route of the magnetic field lines from the injection position of the body to the cartilage defect, calculate the position and angle of the superconducting bulk magnet necessary for route creation, and use the superconducting bulk magnet 2 as the superconducting bulk. While being held at the tip of the magnet position control device 29, the magnet part at the tip is adjusted and arranged at the calculated predetermined three-dimensional position and the calculated predetermined angle based on the calculation result. Furthermore, the setting is maintained until the magnetic complex is guided to a predetermined site in the body.

FIG. 5 is a diagram showing a magnetic induction system in one embodiment of the present invention. The superconducting bulk magnet position control device 29 is controlled by the calculation means 100 using, for example, a radio signal or a wired cable 101. The superconducting bulk magnet position control device 29 has a predetermined position on a moving platen 32 in the vicinity of a bed 31 on which a patient 30 is placed by a vehicle 34 that is rotated by a drive unit storage box 33 incorporating a motor (not shown). Move up. Furthermore, the superconducting bulk magnet holder 42 is operated by operating the rotary drive unit 36 having a built-in rotary motor (not shown) at the top of the column 35, the arm 37, the rotary joint unit 38, the arm 39, the rotary joint unit 40, and the arm 41. The superconducting bulk magnet 2 is set at a predetermined three-dimensional position and angle calculated by the calculation means 100.

Here, the power supply 22 for the small refrigerator and the chiller unit 24 for the refrigerant shown in FIG. 1 are arranged in the storage box 43, and the power supply line 23 and the refrigerant pipes 25 and 26 are bundled and stored in the protective tube 44. Both of them pass through the support 35 and the upper rotational drive part 36, and then are bundled together and stored in a protective tube 45 made of a flexible bellows-like polymer material and connected to the superconducting bulk magnet 2. Has been. The protective tube 45 is passed through a support ring 46 installed on the arm and held.

As shown in FIGS. 5 to 10 (however, FIG. 8 is based on the prior art), the magnetic induction of the magnetic complex is performed as follows. After the superconducting bulk magnet position control device 29 has arranged the magnet surface of the superconducting bulk magnet 2 at a predetermined position and angle near the predetermined affected area inside the knee of the patient 30, as shown in FIG. When there is a cartilage defect portion 48 which is depressed in a circular concave shape on the left side when viewed from the patient 30 on the bone 47, the magnetic complex 50 is injected into a preset position using a syringe 49 or the like. The injected magnetic complex is distributed while spreading in the jelly-like body fluid of the joint as shown in FIG. Here, when solenoid coil magnets that generate a magnetic field in a conventional ring shape are arranged on the inner side of the knee, as shown in FIG. 8, one of the injected magnetic composite 50 is accumulated in a ring shape according to the magnetic field distribution and injected. However, in the present embodiment using a plurality of magnetic field generating means 1, the magnetic field can be concentrated at a desired position (FIG. 11). As shown in FIG. 9, most of the injected magnetic complex 50 can be concentrated and accumulated only in the cartilage defect 48. In this way, the magnetic force of the superconducting bulk magnet is magnetically induced in the cartilage defect portion of the affected area, and is magnetically guided to the cartilage defect portion of the affected area, for example, by holding the magnetic force for several tens of minutes, Implant on the bone tissue surface of the defect surface. This completes the magnetic induction work.

The implantation state of the magnetic complex can be measured by separately examining the implantation density distribution of the magnetic particles of the magnetic complex in the cartilage defect 48 using a nuclear magnetic resonance imaging apparatus (not shown) or the like. If the part of the body with insufficient implantation density is found, the superconducting bulk magnet position controller 29 again places the magnet surface of the superconducting bulk magnet 2 near the inside of the patient's knee so that it can be guided to that part as shown in FIG. After arranging at a predetermined disease position and angle, the magnetic complex is reinjected into the position where the magnetic complex is reset using a syringe or the like, and the magnetic complex reinjected into the insufficiently implanted site is magnetically induced accurately. By repeating this operation a plurality of times, the magnetic composite can be uniformly deposited on the surface of the cartilage defect portion with a predetermined density and with as little gap as possible.

After being implanted, by resting, the stem cells that are uniformly implanted at a predetermined density on the cartilage defect surface self-proliferate as chondrocytes over a period of several weeks, filling the space of the defect part, It returns to the original cartilage shape in a short time and can be cured early.

Thus, in this embodiment, the magnetic field generating means 1 is composed of a superconducting bulk magnet, so that unlike a solenoid coil magnet, the magnetic composite is placed at a predetermined spot position in a three-dimensional space at a predetermined angle. Since magnetic induction can be performed, a predetermined amount of the magnetic complex can be uniformly deposited on the concave surface of the cartilage defect portion at a predetermined density and with as little gap as possible. Has an effect that can be cured.

In this embodiment, an example in which an electric or gas drive motor is used for moving the superconducting bulk magnet has been described. However, even if the weight balancer is built in and moved manually, the same effect can be obtained. In this case, the position information of the superconducting bulk may be calculated information displayed on the calculation device from the information on the rotation angle of the arm joint, or a superconducting bulk magnet tip position sensor is attached and the information is transmitted wirelessly. The calculation information may be displayed on the calculation device from the information, or the moving operator may adjust it visually.

Further, in this example, the linear distance between the position of the magnet and the affected part was kept constant, but when the magnetic complex 50 is injected into a preset position using the syringe 49 or the like, at an initial stage, In order to spread the injected magnetic complex uniformly in the jelly-like body fluid of the joint part, leave the linear distance, weaken the magnetic force and distribute uniformly by self-diffusion, and then the linear distance May be placed close to each other to apply a strong magnetic force to uniformly land on a wide surface of the cartilage defect site 48 that is depressed in a circular concave shape.

FIG. 11 shows an embodiment of the present invention. In this figure, when the affected part 52 in the patient's knee 51 has an opening of a cartilage defect in the longitudinal direction of the bone, the patient's body obstructs the superconducting bulk magnet 2 on the back side of the bottom of the defect. 2 shows a magnet installation structure when two superconducting bulk magnet position control devices 29 are used, and the superconducting bulk magnet 2 supported by each superconducting bulk magnet position control device 29 is attached to the knee 51. Both superconducting bulk magnets 2 are arranged so that the resultant force vector 53 of the magnetic force in the magnetic field acts on the opening surface of the affected part 52. According to the present embodiment, if a magnetic complex is injected into the position upstream of the resultant magnetic force vector 53 using a syringe or the like, it can be accumulated in the affected area 52 along the line of action of the magnetic force.

FIG. 12 shows the operation procedure of the magnetic induction system in another embodiment of the present invention. The plurality of magnetic field generating means 1 generate a magnetic field by the superconducting bulk magnet 2. The drive control unit includes a calculation unit 100. The calculation unit 100 is position information of a cartilage defect portion of a patient obtained in advance from an X-ray imaging apparatus (not shown) or a nuclear magnetic resonance imaging apparatus (not shown). In addition, using the vector distribution information of the magnetic force indicating the strength and direction of the plurality of superconducting bulk magnets 2 obtained in advance by calculation or measurement, the body of the magnetic complex previously input as position information The route of the magnetic field lines from the injection position to the cartilage defect is calculated. The calculation means 100 further calculates the positions and angles of a plurality of superconducting bulk magnets necessary for route creation, and holds the superconducting bulk magnet 2 at the tip of the superconducting bulk magnet position control device 29. Based on the calculation result, the tip magnet portion is adjusted and arranged at the calculated predetermined three-dimensional position and the calculated predetermined angle.

FIG. 13A shows an example in which one superconducting bulk magnet is used in the magnetic induction system of the present invention. In FIG. 13A, f represents the magnetic force vector, Bz represents the magnetic field strength, g represents the magnetic gradient, and L1 represents the distance from the magnet surface. When a system with a surface magnetic field of 5T is used with one superconducting bulk magnet, the magnetic field strength Bz is 0.8 Tesla (T) and the magnetic gradient g = dBz / dz = 1 (T / at the center position of L1 = 5 cm from the magnet surface. cm). At this time, the magnetic force vector f is directed in the direction of the superconducting bulk magnet, and this force can induce the magnetic bead induced substance complex in the direction of the bulk magnet. The magnitude of the magnetic force vector f was recorded as 0.8 (T ² / cm).

FIG. 13B shows an example in which two superconducting bulk magnets are used in the magnetic induction system of the present invention. 13B to 13C below, f represents a magnetic force vector, Bz represents a magnetic field strength, g represents a magnetic gradient, L1 represents a distance from the magnet surface of the first superconducting bulk magnet, and L2 Indicates the center-to-center distance between the first superconducting bulk magnet and the second superconducting bulk magnet. Using a system of two superconducting bulk magnets with the same excitation as in FIG. 13A, the distance L2 between the centers of the two magnets is 5.8 cm, and the magnetic field axis is L1 = 5 cm away from the center. When the magnetic field strength Bz at this position was measured with the axis facing and the same polarity of the two magnets facing, 1.4 Tesla (T) and magnetic gradient g = dBz / dz = 1.81 (T / cm). These magnetic fields and magnetic gradients have a vector f that faces the center of the two magnets. The magnitude of the magnetic force vector f was recorded as 2.5 (T ² / cm).

As described above, by using two superconducting bulk magnets, a larger magnetic field strength and magnetic gradient, and thus a larger magnetic force can be applied than in the case of one.

Further, FIG. 13C shows an example in which the magnetic force vector is controlled by adjusting the distance between two superconducting bulk magnets in the magnetic induction system of the present invention. By adjusting the distance between the two superconducting bulk magnets, it is possible to control the magnetic force and the direction in which the magnetic force acts. Using a system of two superconducting bulk magnets with the same excitation, the center distance L2 between the two magnets is 4 cm, and the axis of the magnetic field is L1 = 5 cm away from the center. Furthermore, when the magnetic field strength Bz at this position was measured with the same polarity of the two magnets, 1.8 Tesla (T) and magnetic gradient g = dBz / dz = 2.3 (T / cm) were recorded. did. These magnetic fields and magnetic gradients have a vector f that faces the center of the two magnets. The magnitude of the magnetic force vector f was recorded as 4.1 (T ² / cm).

As described above, by adjusting the distance between the superconducting magnets, it is possible to control the magnetic force at the position intended for cartilage regeneration. Furthermore, control of the direction vector of the magnetic force is also required by controlling the magnet arrangement.

FIG. 13D shows another example of adjusting the magnetic force vector by adjusting the distance between two superconducting bulk magnets in the magnetic induction system of the present invention. In FIG. 13D, L3 indicates the distance from the first superconducting bulk magnet 2 to the central axis, and L4 indicates the distance from the second superconducting bulk magnet 2 to the central axis. f represents the magnetic force vector, Bz represents the magnetic field strength, g represents the magnetic gradient, L1 represents the distance from the magnet surface of the first superconducting bulk magnet, and L2 represents the first superconducting bulk magnet and The center distance of the 2nd superconducting bulk magnet is shown. Using a system of two superconducting bulk magnets with the same excitation as in FIG. 13C, the magnet 2 is abolished at a distance L3 = 2.9 cm from the center, and the magnet 2 is abolished at a distance L4 = 2 cm from the center. The magnetic field strength Bz at this position is such that the axis of each magnetic field is oriented at a position L1 = 5 cm away from the center position between the magnets, and the same polarity of the two magnets is oriented. Was measured. At this time, the maximum magnetic field strength Bz was 1.6 Tesla (T), but the vector was shifted in the direction of the magnet closer to this position as shown in the figure. The highest magnetic gradient g = dBz / dz = 2.04 (T / m) was recorded, but the vector f was also shifted in the same direction as shown in the figure. The magnitude of the magnetic force f was recorded as 3.3 (T ² / cm). In this way, by changing the relative position of the magnets, it is possible to control the vector on which the force acts as well as the strength of the magnetic force.

Also, by changing both magnets, the direction and magnitude of the resultant magnetic force vector can be changed to magnetically induce the magnetic composite in any direction. Therefore, according to the present embodiment, even if the patient's body is obstructed by one superconducting bulk magnet and accurate magnetic induction cannot be performed, the magnetic composite can be accurately integrated in the affected area 52. is there.

In this embodiment, both superconducting magnets have the same polarity, and both magnets are repelled depending on the installation status of both magnets. Thereby, the attractive force of both magnets acts and it has the effect of pinching the patient's knee and preventing the patient from being injured. That is, in one embodiment, the magnetic poles of the magnetic field generation ends of each of the plurality of magnetic field generation means 1 are the same, and the drive control means determines that the magnetic field generated from the plurality of magnetic field generation means 1 is a desired position of the living body. The position and angle of the magnetic field generating means 1 may be set so as to repel each other.

Furthermore, in an embodiment, the drive control means may adjust the strength of the magnetic field at a desired position in the living body according to the elapsed time after the introduction of the magnetic complex. In particular, immediately after the introduction of the magnetic complex, the magnetic field generating means 1 is installed at a position slightly away from the diseased part of the living body so that the magnetic complex diffuses over a wide range, and then a relatively weak magnetic field is applied. Depending on the elapsed time after the introduction, the magnetic field generating means 1 may be brought closer to the diseased part of the living body to apply a relatively strong magnetic field. Thereby, a magnetic composite can be integrated | stacked on the diseased part which has a three-dimensional shape.

(Production example of superconducting bulk magnet)
In order to realize the apparatus of the present invention, a superconducting bulk magnet that has excellent directivity and generates a strong magnetic field at a high temperature is required. In order to realize this system, a bulk superconductor having a high critical temperature, excellent critical current at high temperature and high magnetic field, excellent mechanical properties and thermal stability is required. In the following, an example of manufacturing a superconducting bulk body applied to the present system is shown. Table 1 shows an outline of each production example of the superconducting bulk material.

(Production Example 1)
(Nd, Eu, Gd) Ba ₂ Cu ₃ O _y (where 6.8 ≦ y ≦ 7.0) and (Nd, Eu, Gd) 2BaCuO ₅ powders with a 1: 1: 1 mixing ratio of Nd, Eu and Gd Are prepared and weighed so that the ratio of these compounds is 4: 1, and after adding 0.5 wt% of Pt, mix well (step 1001). Thereafter, it is molded into a pellet having a diameter of 42 mm and a thickness of 15 mm under a hydrostatic pressure of 2000 MPa (step 1002). The pellet is heated in air at 900 ° C. for 1 hour to perform pre-sintering (step 1003). Next, along the circumference of 20 mm from the center of the sintered body, six artificial holes with a diameter of 2 mm are processed with a carbide drill at equal intervals (step 1004). Next, on top of a 50 mm diameter Al ₂ O ₃ crucible, first put Nd ₂ O ₃ powder in a 45 mm diameter 2 mm pellet shape, and then add BaCuO ₂ powder to a 45 mm diameter. A 10 mm pellet is molded (step 1005). In addition, a (Nd, Eu, Gd) -Ba-Cu-O sintered body having six artificial holes is installed (step 1006).

After that, place the Al ₂ O ₃ crucible in an electric furnace adjusted to an atmosphere of 1% O ₂ + 99% Ar and place a 2 mm square in the center of the (Nd, Eu, Gd) -Ba-Cu-O sintered body. A NdBa ₂ Cu ₃ O _y single crystal having a thickness of 1 mm is placed as a seed (step 1007). After that, the electric furnace was heated to 1100 ° C at a rate of 50 ° C / h and held for 1 hour, then cooled to 1050 ° C for 1 hour, and then gradually cooled to 950 ° C at a rate of 0.2 ° C / h. Furnace cooling was performed (step 1008). The sample taken out of the furnace was finally subjected to oxygen annealing treatment at 300 ° C. for 100 hours in a 100% oxygen stream (step 1009). In this state, the superconducting critical temperature is measured and a value of 95K is obtained.

Next, six aluminum rods with a diameter of 1.8 mm and a length of 20 mm are inserted into the artificial hole (step 1010), and then the Pb—Bi—Sn alloy is heated to 200 ° C. and then deaerated with a vacuum pump. Was impregnated (step 1011). In addition, after arranging a ring made of Fe-Mn-Si shape memory alloy with an inner diameter of 19 mm, a thickness of 3 mm, and a height of 20 mm around the bulk body, the Pb-Bi-Sn alloy was heated to 300 ° C, By performing deaeration with a vacuum pump, pre-compression with a shape memory alloy and vacuum impregnation were simultaneously performed (step 1012).

As a result, the (Nd, Eu, Gd) -Ba-Cu-O superconducting bulk magnet composited with an aluminum rod and pre-compressed with a Fe-Mn-Si shape memory alloy ring captured 4T on the surface. A magnetic field was obtained.

(Production Example 2)
The same processing as in (Step 1001) to (Step 1010) of Production Example 1 is performed to produce a (Nd, Eu, Gd) -Ba-Cu-O superconducting bulk body. Also in Production Example 2, six aluminum rods having a diameter of 1.8 mm and a length of 20 mm are inserted into the artificial hole. The difference from Production Example 1 is that the Pb—Bi—Sn alloy is heated to 200 ° C. and then impregnated by degassing with a vacuum pump (Step 1011), and made of Fe—Mn—Si shape memory alloy. A step of performing pre-compression and vacuum impregnation with a shape memory alloy at the same time by placing the ring around the bulk body and heating the Pb—Bi—Sn alloy to 300 ° C. and then degassing with a vacuum pump (step 1012). ) Is not performed.

In the (Nd, Eu, Gd) -Ba-Cu-O superconducting bulk magnet made based on the production example 2 and composited with an aluminum rod, a trapping magnetic field of 3.5 T was obtained on the surface.

(Production Example 3)
The same processing as in (Step 1001) to (Step 1009) of Production Example 1 is performed to produce a (Nd, Eu, Gd) -Ba-Cu-O superconducting bulk body. The difference from Production Example 1 is that a step of inserting six aluminum rods having a diameter of 1.8 mm and a length of 20 mm into the artificial hole (step 1010), and then heating the Pb-Bi-Sn alloy to 200 ° C, A step of impregnation by degassing with a vacuum pump (Step 1011) and a Fe-Mn-Si shape memory alloy ring placed around the bulk body, and then heating the Pb-Bi-Sn alloy to 300 ° C Thereafter, by performing deaeration with a vacuum pump, the step (step 1012) of simultaneously performing pre-compression with a shape memory alloy and vacuum impregnation is not performed. Therefore, in Production Example 3, the aluminum rod is not inserted into the artificial hole.

According to Production Example 3, a (Nd, Eu, Gd) -Ba-Cu-O superconducting bulk material produced without an artificial hole was also produced, and these samples were applied with a magnetic field with a 5T superconducting magnet. Cool with liquid nitrogen (77K) for 20 minutes, then reduce the external magnetic field at a rate of 0.1 T / min, hold it for 5 minutes, and then measure the captured magnetic field with a two-dimensional scanning magnetic field distribution analyzer did.

In the (Nd, Eu, Gd) -Ba-Cu-O superconducting bulk magnet produced based on Production Example 3 and not complexed with a metal, a trapping magnetic field of 2 T was obtained on the surface.

In the above production examples 1 to 3, when the same measurement was repeated, the (Nd, Eu, Gd) -Ba-Cu-O superconducting bulk magnet composited with an aluminum rod had an Fe-Mn-Si shape memory. A similar trapping field was recorded with and without the alloy ring. In the (Nd, Eu, Gd) -Ba-Cu-O superconducting bulk magnet that was not complexed with metal, a trapped magnetic field of 1.7 T was obtained on the surface.

(Production Example 4)
GdBa ₂ Cu ₃ O _y and Gd ₂ BaCuO ₅ powders are prepared, weighed so that the ratio of these compounds is 10: 3, 0.5% by weight of Pt is added, and then mixed well (step 4001). Thereafter, it is molded into a pellet having a diameter of 42 mm and a thickness of 15 mm under a hydrostatic pressure of 2000 MPa (step 4002). The pellet is heated in air at 900 ° C. for 1 hour to perform pre-sintering (step 4003). Next, along the circumference of 20 mm from the center of the sintered body, six artificial holes with a diameter of 2 mm are processed with a carbide drill at equal intervals (step 4004). Next, on top of an Al ₂ O ₃ crucible with a diameter of 50 mm, first put Gd ₂ O ₃ powder into a 2 mm pellet shape with a diameter of 45 mm, and then add BaCuO ₂ powder with a diameter of 45 mm. The one molded into a 10 mm pellet is placed (step 4005). On top of that, a Gd—Ba—Cu—O sintered body having six artificial holes is installed (step 4006).

After that, an Al ₂ O ₃ crucible was installed in an electric furnace adjusted to an atmosphere of 1% O ₂ + 99% Ar, and 2 mm square and 1 mm thick NdBa in the center of the Gd-Ba-Cu-O sintered body _{A 2} Cu ₃ O _y single crystal is set as a seed (step 4007). Thereafter, the electric furnace was heated to 1100 ° C. at a rate of 50 ° C./h and held for 1 hour, then cooled to 1055 ° C. in 1 hour, and then gradually cooled to 950 ° C. at a rate of 0.2 ° C./h. Furnace cooling was performed (step 4008). The sample taken out from the furnace was finally subjected to oxygen annealing treatment at 300 ° C. for 100 hours in a 100% oxygen stream (step 4009). In this state, the superconducting critical temperature was measured, and a value of 94K was obtained.

Next, six aluminum rods with a diameter of 1.8 mm and a length of 20 mm are inserted into the artificial hole (step 4010), and then the Pb—Bi—Sn alloy is heated to 200 ° C. and then deaerated with a vacuum pump. (Step 4011). In addition, after arranging a ring made of Fe-Mn-Si shape memory alloy with an inner diameter of 19 mm, a thickness of 3 mm, and a height of 20 mm around the bulk body, the Pb-Bi-Sn alloy was heated to 300 ° C, By performing deaeration with a vacuum pump, pre-compression with a shape memory alloy and vacuum impregnation were simultaneously performed (step 4012).

As a result, in the Gd-Ba-Cu-O superconducting bulk magnet composited with an aluminum rod and pre-compressed with an Fe-Mn-Si shape memory alloy ring, a 3T trapping magnetic field was obtained on the surface.

(Production Example 5)
The same processing as in (Step 4001) to (Step 4010) of Production Example 4 is performed to fabricate a Gd—Ba—Cu—O superconducting bulk material. Also in Production Example 4, six aluminum rods having a diameter of 1.8 mm and a length of 20 mm are inserted into the artificial hole. The difference from Production Example 4 is that the Pb—Bi—Sn alloy is heated to 200 ° C. and then impregnated by degassing with a vacuum pump (Step 4011), and made of Fe—Mn—Si shape memory alloy. A step of performing pre-compression and vacuum impregnation with a shape memory alloy simultaneously by placing the ring around the bulk body and heating the Pb-Bi-Sn alloy to 300 ° C. and then degassing with a vacuum pump (step 4012). ) Is not performed.

In the Gd—Ba—Cu—O superconducting bulk magnet that was fabricated based on fabrication example 5 and combined with an aluminum rod, a 2.5 T trapping magnetic field was obtained on the surface.

(Production Example 6)
The same process as in (Step 4001) to (Step 4009) of Production Example 4 is performed to fabricate a Gd—Ba—Cu—O superconducting bulk material. The difference from Production Example 4 is that a step (step 4010) of inserting six aluminum rods having a diameter of 1.8 mm and a length of 20 mm into the artificial hole, and then heating the Pb—Bi—Sn alloy to 200 ° C., A step of impregnation by degassing with a vacuum pump (step 4011) and a ring made of Fe-Mn-Si shape memory alloy are arranged around the bulk body, and then the Pb-Bi-Sn alloy is heated to 300 ° C. Thereafter, by performing deaeration with a vacuum pump, the step (step 4012) of simultaneously performing pre-compression with a shape memory alloy and vacuum impregnation is not performed. Therefore, in Production Example 6, no aluminum rod is inserted into the artificial hole.

According to Production Example 6, a Gd—Ba—Cu—O superconducting bulk material produced without an artificial hole was also produced. These samples were cooled with liquid nitrogen (77K) for 20 minutes while applying a magnetic field with a 5T superconducting magnet, and then the external magnetic field was reduced at a rate of 0.1 T / min. Then, the captured magnetic field was measured with a two-dimensional scanning magnetic field distribution measuring device.

In the Gd—Ba—Cu—O superconducting bulk magnet produced based on Production Example 6 and not complexed with metal, a trapping magnetic field of 1.2 T was obtained on the surface.

In the above production examples 4 to 6, when the same measurement was repeated, the Gd—Ba—Cu—O superconducting bulk magnet combined with the aluminum rod had no Fe—Mn—Si shape memory alloy ring. Despite this, a similar trapping field was recorded, but a 1.2 T trapping field was obtained at the surface of the Gd-Ba-Cu-O superconducting bulk magnet that was not complexed with metal.

(Production Example 7)
YBa ₂ Cu ₃ O _y (where 6.8 ≦ y ≦ 7.0) and Y ₂ BaCuO ₅ powders were prepared, weighed so that the ratio of these compounds was 10: 3, and 0.5 wt% Pt was added. Then, mix well (step 7001). Thereafter, it is molded into a pellet having a diameter of 42 mm and a thickness of 15 mm under a hydrostatic pressure of 2000 MPa (step 7002). The pellet is heated in air at 900 ° C. for 1 hour to perform pre-sintering (step 7003). Next, six artificial holes with a diameter of 2 mm are machined by a carbide drill at equal intervals along a circumference of 20 mm from the center of the sintered body (step 7004). Next, on the bottom of an Al ₂ O ₃ crucible with a diameter of 50 mm, a Y ₂ O ₃ powder first molded into a 2 mm pellet shape with a diameter of 45 mm and a BaCuO ₂ powder with a diameter of 45 mm is placed. The one molded into a 10 mm pellet is placed (step 7005). On top of that, a Y-Ba-Cu-O sintered body having six artificial holes is installed (step 7006).

After that, the Al ₂ O ₃ crucible was installed in an electric furnace in the atmosphere, and a 2 mm square and 1 mm thick NdBa ₂ Cu ₃ O _y single crystal was used as a seed at the center of the Y-Ba-Cu-O sintered body. Install (step 7007). After that, the electric furnace was heated to 1100 ° C at a rate of 50 ° C / h and held for 1 hour, then cooled to 1050 ° C for 1 hour, and then gradually cooled to 950 ° C at a rate of 0.2 ° C / h. Furnace cooling was performed (step 7008). The sample taken out from the furnace was finally subjected to oxygen annealing treatment at 300 ° C. for 100 hours in a 100% oxygen stream (step 7009). In this state, the superconducting critical temperature was measured, and a value of 90K was obtained.

Next, six aluminum rods with a diameter of 1.8 mm and a length of 20 mm are inserted into the artificial hole (step 7010). After that, the Pb—Bi—Sn—Cd alloy is heated to 300 ° C. and then deaerated with a vacuum pump. Thus, impregnation was performed (step 7011). In addition, an Fe-Mn-Si shape memory alloy ring with an inner diameter of 19 mm, a thickness of 3 mm, and a height of 20 mm was placed around the bulk body, and then the Pb-Bi-Sn-Cd alloy was heated to 300 ° C. Thereafter, by performing deaeration with a vacuum pump, pre-compression with a shape memory alloy and vacuum impregnation were simultaneously performed (step 7012).

As a result, in the Y-Ba-Cu-O superconducting bulk magnet composited with an aluminum rod and pre-compressed with a Fe-Mn-Si shape memory alloy ring, a trapped magnetic field of 1.1 T was obtained on the surface. .

(Production Example 8)
The same process as in (Step 7001) to (Step 7010) of Production Example 7 is performed to produce a Y—Ba—Cu—O superconducting bulk material. In Production Example 8, six aluminum rods having a diameter of 1.8 mm and a length of 20 mm are inserted into the artificial hole. The difference from Production Example 7 is that the Pb—Bi—Sn alloy is heated to 200 ° C. and then impregnated by degassing with a vacuum pump (Step 7011), and made of Fe—Mn—Si shape memory alloy. A step of performing pre-compression and vacuum impregnation with a shape memory alloy at the same time by placing the ring around the bulk body and heating the Pb—Bi—Sn alloy to 300 ° C. and then degassing with a vacuum pump (step 7012). ) Is not performed.

That is, the superconducting bulk material according to Production Example 8 is produced as follows. YBa ₂ Cu ₃ O _y (where 6.8 ≦ y ≦ 7.0) and Y ₂ BaCuO ₅ powders were prepared, weighed so that the ratio of these compounds was 10: 3, and 0.5 wt% Pt was added. Then mix well. Then, it is molded into pellets with a diameter of 42mm and a thickness of 15mm under hydrostatic pressure of 2000MPa. The pellets are heated in air at 900 ° C. for 1 hour to perform preliminary sintering. Next, along the circumference of 20 mm from the center of the sintered body, six artificial holes with a diameter of 2 mm are machined with a carbide drill at equal intervals. Next, on the bottom of an Al ₂ O ₃ crucible with a diameter of 50 mm, a Y ₂ O ₃ powder formed into a 2 mm pellet shape with a diameter of 45 mm is placed, and then a BaCuO ₂ powder with a diameter of 45 mm is added. Place what was molded into a 10mm pellet. On top of that, a Y-Ba-Cu-O sintered body with six artificial holes is installed. After that, the Al ₂ O ₃ crucible was installed in an electric furnace in the atmosphere, and a 2 mm square and 1 mm thick NdBa ₂ Cu ₃ O _y single crystal was used as a seed at the center of the Y-Ba-Cu-O sintered body. Install. After that, the electric furnace was heated to 1100 ° C at a rate of 50 ° C / h and held for 1 hour, then cooled to 1050 ° C for 1 hour, and then gradually cooled to 950 ° C at a rate of 0.2 ° C / h. Furnace cooling was performed. The sample taken out from the furnace was finally subjected to oxygen annealing treatment at 300 ° C. for 100 hours in a 100% oxygen stream. In this state, the superconducting critical temperature was measured, and a value of 90K was obtained. Next, six aluminum rods with a diameter of 1.8 mm and a length of 20 mm are inserted into the artificial hole.

In the Y-Ba-Cu-O superconducting bulk magnet made based on the production example 8 and combined with the aluminum rod, a trapping magnetic field of 1.0 T was obtained on the surface.

(Production Example 9)
The same process as in (Step 7001) to (Step 7009) of Production Example 7 is performed to fabricate a Y-Ba-Cu-O superconducting bulk material. The difference from Production Example 7 is that a step of inserting six aluminum rods having a diameter of 1.8 mm and a length of 20 mm into the artificial hole (step 7010), and then heating the Pb—Bi—Sn alloy to 200 ° C., A step of impregnation by degassing with a vacuum pump (Step 7011) and a Fe-Mn-Si shape memory alloy ring placed around the bulk body, and then heating the Pb-Bi-Sn alloy to 300 ° C Thereafter, by performing deaeration with a vacuum pump, the step (step 7012) of simultaneously performing pre-compression with a shape memory alloy and vacuum impregnation is not performed. Therefore, in Production Example 9, the aluminum rod is not inserted into the artificial hole.

According to Production Example 9, a Y-Ba-Cu-O superconducting bulk material produced without providing artificial holes was also produced. These samples were cooled with liquid nitrogen (77K) for 20 minutes while applying a magnetic field with a 5T superconducting magnet. After that, the external magnetic field was reduced at a rate of 0.1 T / min. Then, the captured magnetic field was measured with a two-dimensional scanning magnetic field distribution measuring device.

In the Y-Ba-Cu-O superconducting bulk magnet produced based on Production Example 9 and not complexed with metal, a trapping magnetic field of 0.5 T was obtained on the surface.

In the above Preparation Examples 7 to 9, when the same measurement was further repeated, no significant change was observed in the captured magnetic field characteristics in any of the samples.

Next, in Preparation Examples 7 to 9, when the trapped magnetic field characteristics were measured by cooling to 50K using a refrigerator instead of liquid nitrogen, it was combined with an aluminum rod and made of an Fe-Mn-Si shape memory alloy ring. In the Y-Ba-Cu-O superconducting bulk magnet with pre-compressed load applied at 5.0, a trapped magnetic field of 5.0T was obtained on the surface. In the Y-Ba-Cu-O superconducting bulk magnet combined with an aluminum rod, a trapping magnetic field of 4.5T was obtained on the surface. In the Y-Ba-Cu-O superconducting bulk magnet that was not complexed with metal, a trapped magnetic field of 3.5T was obtained on the surface.

In the above production examples 7 to 9, when the same measurement was further repeated, there was no Fe-Mn-Si shape memory alloy ring in the Y-Ba-Cu-O superconducting bulk magnet combined with the aluminum rod. Regardless of the Y-Ba-Cu-O superconducting bulk magnet, which recorded a similar trapping field but was not complexed with metal, a trapping field of 3.5T was obtained on the surface.

(Experiment using Superconducting Bulk Magnet Production Example 8)
FIG. 14 shows the patella of the joint part of a pig and the cartilage defect part of the bone obtained as a result of an animal experiment using the above-described Superconducting Bulk Magnet Production Example 8. As shown in the photograph of FIG. 14, a magnetic composite comprising a pig spinal cord stem cell and a magnetic bead combined with a circular concave cartilage defect 55 physically and intentionally provided on the patella 54 of the pig joint. Using the magnetic force of the superconducting bulk magnet placed outside the body, the magnetic complex injected with the syringe is magnetically induced in the body and is then implanted in the cartilage defect 55, and then the magnetic field is removed for 3 months. A photograph of the cartilage defect 55 after a lapse of time is shown in FIG. As shown in FIG. 15, white cartilage self-propagates and regenerates in the cartilage defect portion 55, and it can be seen that the magnetic induction of the cartilage defect portion 55 of the magnetic composite is effective for cartilage regeneration.

This effect is obtained when the magnetic flux density of the magnetic field at the location of the cartilage defect 55 generated by the superconducting bulk magnet is 0.8 Tesla (T) or more, or when the magnetic flux density and the magnetic gradient are 1 (T2 / m). ), It was found that the cartilage can be uniformly regenerated in the cartilage defect portion. Further, in the above embodiment, the case where the magnetic composite is magnetically guided to the bone defect of the joint has been described. However, the magnetic composite is applied to the defect such as a fracture of the head, arm, or leg bone. The same effect occurs when magnetic induction is performed.

Here, for the superconducting bulk material, if the following materials are produced and applied in order to further increase the magnetic field strength, the magnetic force after magnetization is further increased, and the composite magnetic material is more satisfactorily grounded, From the end face of the conductive bulk magnet 2, a large magnetic force is applied to a deeper part of the body, and the magnetic complex can be satisfactorily guided to the affected part located in the deep part.
While the above description has been made with reference to exemplary embodiments, it will be apparent to those skilled in the art that the invention is not limited thereto and that various changes and modifications can be made within the spirit of the invention and the scope of the appended claims.

DESCRIPTION OF SYMBOLS 1 Magnetic field generation means 2 Superconducting bulk magnet 3 Small refrigerator 13 Vacuum container 19 Vacuum pump 22 Power supply unit 24 Chiller unit 29 Superconducting bulk magnet position control device 30 Patient 31 Bed 33 Drive part storage box 36 Rotation drive part 38, 40 rotation Indirect portion 42 Superconducting bulk magnet holder 43 Storage box 48 Cartilage defect 50 Magnetic complex 100 Arithmetic controller

Claims (13)

1. A plurality of probe-like magnetic field generating means;
   Calculating means for calculating the position and angle of the magnetic field generating means so that the combined magnetic field generated by the plurality of magnetic field generating means acts on a desired site in the living body;
   Drive control means for controlling the drive means so that the plurality of magnetic field generating means have the position and angle calculated by the calculation means;
   Having a magnetic induction system.
2. The magnetic induction system according to claim 1, wherein the magnetic field generating means includes a superconducting bulk magnet device.
3. The magnetic induction system according to claim 2, wherein the superconducting bulk magnet has a composition capable of obtaining a required critical current density at a liquid nitrogen temperature of 77K.
4. The magnetic induction system according to claim 2 or 3, wherein the composition of the superconducting bulk magnet is RE-Ba-Cu-O (RE: rare earth element).
5. The magnetic induction according to claim 4, wherein the composition of the superconducting bulk magnet is (Nd, Eu, Gd) -Ba-Cu-O, Gd-Ba-Cu-O, or Y-Ba-Cu-O. system.
6. The magnetic guidance system according to any one of claims 1 to 5, wherein the calculation unit calculates a position and an angle of the magnetic field generation unit so that the synthetic magnetic field guides the magnetic complex to a desired site in a living body. .
7. The magnetic induction system according to claim 6, wherein the magnetic complex is a magnetic bead induced substance complex consisting of a magnetic bead made of a magnetic material and an induced substance.
8. The magnetic induction system according to any one of claims 1 to 7, wherein the desired part is an articular cartilage part in the living body.
9. The magnetic poles of the magnetic field generation ends of the plurality of magnetic field generation means are the same polarity,
   9. The homopolar control unit capable of controlling the driving unit in an arrangement in which the magnetic poles of the plurality of magnetic field generating units repel each other at a desired part of the living body. A magnetic induction system according to claim 1.
10. The magnetic induction system according to any one of claims 6 to 9, further comprising time control means for controlling a site in the living body and a magnetic field strength at the site according to an elapsed time after the introduction of the magnetic complex. .
11. A plurality of probe-like magnetic field generating means, a driving means for driving the plurality of magnetic field generating means, an arithmetic means for calculating the position and angle of the magnetic field generating means, and a drive control for controlling the driving of the driving means A method of operating a magnetic induction system comprising:
    Calculating the position and angle of the magnetic field generating means so that the arithmetic means acts on a desired magnetic field in the living body with the combined magnetic field of the plurality of magnetic field generating means;
    The drive control means controlling the drive of the drive means so that the plurality of magnetic field generating means are at the position and angle calculated by the computing means;
    A method of operating the magnetic guidance system comprising:
12. The magnetic guidance system further comprises homopolar control means;
    The magnetic poles of the magnetic field generation ends of the plurality of magnetic field generation means are the same polarity,
    12. The magnetic induction system according to claim 11, further comprising a step of controlling the drive unit in an arrangement in which the magnetic poles of the plurality of magnetic field generation units repel each other at a desired part of the living body. How it works.
13. The magnetic guidance system further comprises time control means;
    The operation of the magnetic induction system according to claim 11, wherein the time control unit further includes a step of controlling a site in the living body and a magnetic field strength at the site according to an elapsed time after the introduction of the magnetic complex. Method.

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