WO2011045807A3 - A novel process to manufacture (2r,3s)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol - Google Patents

A novel process to manufacture (2r,3s)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol Download PDF

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Publication number
WO2011045807A3
WO2011045807A3 PCT/IN2009/000752 IN2009000752W WO2011045807A3 WO 2011045807 A3 WO2011045807 A3 WO 2011045807A3 IN 2009000752 W IN2009000752 W IN 2009000752W WO 2011045807 A3 WO2011045807 A3 WO 2011045807A3
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WIPO (PCT)
Prior art keywords
fluoropyrimidin
butan
difluorophenyl
triazol
manufacture
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Application number
PCT/IN2009/000752
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French (fr)
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WO2011045807A2 (en
Inventor
Arul Ramakrishnan
Gobind Singh Kapkoti
Sanjay Kumar Dehury
Original Assignee
Neuland Laboratories Ltd.
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Publication date
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Publication of WO2011045807A2 publication Critical patent/WO2011045807A2/en
Publication of WO2011045807A3 publication Critical patent/WO2011045807A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a novel industrially viable, cost effective process to manufacture substantially pure form of (2R,3S)-2-(2,4-difluorophenyl)-3-(5- fluoropyrimidin-4-yl)-l-(lH-l,2,4-triazol-l-yl)butan-2-ol (Voriconazole) with a chiral purity level of greater than 99.9 % and impurity level of less than 0.1 %.
PCT/IN2009/000752 2009-10-14 2009-12-30 A novel process to manufacture (2r,3s)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol WO2011045807A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2490CH2009 2009-10-14
IN2490/CHE/2009 2009-10-14

Publications (2)

Publication Number Publication Date
WO2011045807A2 WO2011045807A2 (en) 2011-04-21
WO2011045807A3 true WO2011045807A3 (en) 2013-02-07

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PCT/IN2009/000752 WO2011045807A2 (en) 2009-10-14 2009-12-30 A novel process to manufacture (2r,3s)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2619928C2 (en) * 2012-10-15 2017-05-22 Пфайзер Айеленд Фармацойтикалз Method for preparing voriconazole and its analogues
CN111675659B (en) * 2020-06-16 2022-03-11 阿里生物新材料（常州）有限公司 Synthesis method of (5-fluoropyrimidine-4-yl) methanol

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009020323A2 (en) * 2007-08-06 2009-02-12 Hanmi Pharm. Co., Ltd. Process for preparing voriconazole
WO2009084029A2 (en) * 2007-12-03 2009-07-09 Neuland Laboratories Ltd Improved process for the preparation of (2r,3s)-2-(2,4- difluqrophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009020323A2 (en) * 2007-08-06 2009-02-12 Hanmi Pharm. Co., Ltd. Process for preparing voriconazole
WO2009084029A2 (en) * 2007-12-03 2009-07-09 Neuland Laboratories Ltd Improved process for the preparation of (2r,3s)-2-(2,4- difluqrophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol

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Publication number Publication date
WO2011045807A2 (en) 2011-04-21

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