WO2011036326A3 - Novel recombinant proteinic polymers and method for bioactivating surfaces with said polymers - Google Patents

Novel recombinant proteinic polymers and method for bioactivating surfaces with said polymers Download PDF

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Publication number
WO2011036326A3
WO2011036326A3 PCT/ES2010/070617 ES2010070617W WO2011036326A3 WO 2011036326 A3 WO2011036326 A3 WO 2011036326A3 ES 2010070617 W ES2010070617 W ES 2010070617W WO 2011036326 A3 WO2011036326 A3 WO 2011036326A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymers
proteinic
bioactivating
novel recombinant
domains
Prior art date
Application number
PCT/ES2010/070617
Other languages
Spanish (es)
French (fr)
Other versions
WO2011036326A2 (en
Inventor
Conrado José APARICIO BÁDENAS
Josep Anton Planell Estany
Emiliano Salvagni
Michael Werner
Francisco Javier Gil Mur
José Carlos RODRÍGUEZ CABELLO
Matilde Alonso Rodrigo
Francisco Javier Arias Vallejo
Alessandra Girotti
Artur Ribeiro
Original Assignee
Universitat Politècnica De Catalunya
Universidad De Valladolid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitat Politècnica De Catalunya, Universidad De Valladolid filed Critical Universitat Politècnica De Catalunya
Publication of WO2011036326A2 publication Critical patent/WO2011036326A2/en
Publication of WO2011036326A3 publication Critical patent/WO2011036326A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend

Abstract

The invention relates to proteinic polymers or mixtures thereof comprising domains that can promote the nucleation/growth and/or adhesion of calcium phosphates of biological interest, and domains that can promote cellular adhesion by means of peptides of the proteins of the extracellular matrix. The invention also relates to methods for activating materials for osseous implants using said proteinic polymers and to the implants that can be obtained by said methods.
PCT/ES2010/070617 2009-09-24 2010-09-23 Novel recombinant proteinic polymers and method for bioactivating surfaces with said polymers WO2011036326A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200901903A ES2387115B1 (en) 2009-09-24 2009-09-24 NEW RECOMBINANT PROTEIN POLYMERS AND SURFACE BIOACTIVATION METHOD WITH SUCH POLYMERS
ESP200901903 2009-09-24

Publications (2)

Publication Number Publication Date
WO2011036326A2 WO2011036326A2 (en) 2011-03-31
WO2011036326A3 true WO2011036326A3 (en) 2011-07-14

Family

ID=43796297

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2010/070617 WO2011036326A2 (en) 2009-09-24 2010-09-23 Novel recombinant proteinic polymers and method for bioactivating surfaces with said polymers

Country Status (2)

Country Link
ES (1) ES2387115B1 (en)
WO (1) WO2011036326A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2595208T3 (en) * 2011-06-09 2016-12-28 Universidad De Valladolid Thermosensitive and bioactive biopolymer and associated cell collection method
ES2443815B1 (en) * 2012-06-15 2014-12-04 Universitat Politècnica De Catalunya Method for obtaining tantalum foams for replacement of hard tissues

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068289A1 (en) * 2002-02-15 2003-08-21 Cv Therapeutics, Inc. Polymer coating for medical devices
US20040136926A1 (en) * 2002-11-08 2004-07-15 Periathamby Antony Raj Intra-oral drug delivery system
WO2005072223A2 (en) * 2004-01-23 2005-08-11 California Institute Of Technology Engineered proteins, and methods of making and using

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068289A1 (en) * 2002-02-15 2003-08-21 Cv Therapeutics, Inc. Polymer coating for medical devices
US20040136926A1 (en) * 2002-11-08 2004-07-15 Periathamby Antony Raj Intra-oral drug delivery system
WO2005072223A2 (en) * 2004-01-23 2005-08-11 California Institute Of Technology Engineered proteins, and methods of making and using

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BARBOSA, J.S. ET AL.: "Multi-layered films containing a biomimetic stimuli-responsive recombinant protein", NANOSCALE RES. LETT., vol. 4, no. 10, 1 October 2009 (2009-10-01), pages 1247 - 1253, Retrieved from the Internet <URL:http://www.springerlink.com/content/80j1153284224r80/fulltext.pdf><DOI:10.1007/s11671-009-9388-5> [retrieved on 20090716] *
CROSS, K.J. ET AL.: "The role of multiphosphorylated peptides in mineralized tissue regeneration", INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS., vol. 13, no. 4, 1 December 2007 (2007-12-01), pages 479 - 495 *
GILBERT, M. ET AL.: "Biomimetic peptides that engage specific integrin-dependent signaling pathways and bind to calcium phosphate surfaces", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART A, vol. 67, no. 1, 1 October 2003 (2003-10-01), pages 69 - 77 *
KAUFMANN, D. ET AL.: "Chemical conjugation of linear and cyclic RGD moieties to a recombinant elastin-mimetic polypeptide. A versatile approach towards bioactive protein hydrogels", MACROMOLECULAR BIOSCIENCE., vol. 8, no. 6, 11 June 2008 (2008-06-11), pages 577 - 588 *
RODRIGEZ-CABELLO, J.C. ET AL.: "Nanobitechnological approach to ingineered biomaterial design: the example of elastin-like polymers", FUTURE MEDICINE. NANOMEDICINE., vol. 1, no. 3, 1 October 2006 (2006-10-01), pages 267 - 280 *
SEGVICH, S.J. ET AL.: "The adsorption of preferential binding peptides to apatite-based materials", BIOMATERIALS, vol. 30, no. 7, 1 March 2009 (2009-03-01), pages 1287 - 1298 *

Also Published As

Publication number Publication date
WO2011036326A2 (en) 2011-03-31
ES2387115B1 (en) 2013-07-03
ES2387115A1 (en) 2012-09-14

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