WO2011031999A3 - Multi-component nanoparticle structure having detectable magnetic resonance properties - Google Patents

Multi-component nanoparticle structure having detectable magnetic resonance properties Download PDF

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Publication number
WO2011031999A3
WO2011031999A3 PCT/US2010/048468 US2010048468W WO2011031999A3 WO 2011031999 A3 WO2011031999 A3 WO 2011031999A3 US 2010048468 W US2010048468 W US 2010048468W WO 2011031999 A3 WO2011031999 A3 WO 2011031999A3
Authority
WO
WIPO (PCT)
Prior art keywords
magnetic resonance
nanoparticle structure
segments
resonance properties
detectable magnetic
Prior art date
Application number
PCT/US2010/048468
Other languages
French (fr)
Other versions
WO2011031999A2 (en
Inventor
Albena Ivanisevic
Hamsa Jaganathan
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of WO2011031999A2 publication Critical patent/WO2011031999A2/en
Publication of WO2011031999A3 publication Critical patent/WO2011031999A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A nanoparticle structure includes a sequence of segments. In particular, the structure includes a first plurality of segments comprising gold-coated DNA, and a second plurality of segments comprising DNA coated with a paramagnetic material. The first plurality of segments are interleaved with the second plurality of segments. The mass ratio of the combined mass of gold and paramagnetic material to a mass of DNA material is less than 5: 1.
PCT/US2010/048468 2009-09-10 2010-09-10 Multi-component nanoparticle structure having detectable magnetic resonance properties WO2011031999A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24121609P 2009-09-10 2009-09-10
US61/241,216 2009-09-10

Publications (2)

Publication Number Publication Date
WO2011031999A2 WO2011031999A2 (en) 2011-03-17
WO2011031999A3 true WO2011031999A3 (en) 2011-08-04

Family

ID=43733112

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/048468 WO2011031999A2 (en) 2009-09-10 2010-09-10 Multi-component nanoparticle structure having detectable magnetic resonance properties

Country Status (1)

Country Link
WO (1) WO2011031999A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020098135A1 (en) * 1997-03-07 2002-07-25 William Marsh Rice University Array of single-wall carbon nanotubes
US20020177143A1 (en) * 2001-05-25 2002-11-28 Mirkin Chad A. Non-alloying core shell nanoparticles
US20060079455A1 (en) * 2003-01-07 2006-04-13 Ramot At Tel Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020098135A1 (en) * 1997-03-07 2002-07-25 William Marsh Rice University Array of single-wall carbon nanotubes
US20020177143A1 (en) * 2001-05-25 2002-11-28 Mirkin Chad A. Non-alloying core shell nanoparticles
US20060079455A1 (en) * 2003-01-07 2006-04-13 Ramot At Tel Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same

Also Published As

Publication number Publication date
WO2011031999A2 (en) 2011-03-17

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