WO2011024049A3 - Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations - Google Patents

Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations Download PDF

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Publication number
WO2011024049A3
WO2011024049A3 PCT/IB2010/002060 IB2010002060W WO2011024049A3 WO 2011024049 A3 WO2011024049 A3 WO 2011024049A3 IB 2010002060 W IB2010002060 W IB 2010002060W WO 2011024049 A3 WO2011024049 A3 WO 2011024049A3
Authority
WO
WIPO (PCT)
Prior art keywords
proanthocyanidin polymer
producing
pharmaceutical formulations
polymer compositions
processes
Prior art date
Application number
PCT/IB2010/002060
Other languages
French (fr)
Other versions
WO2011024049A9 (en
WO2011024049A2 (en
Inventor
John Chow
Nitin Pradhan
Suresh Mahadev Kadam
Yingzhong Chen
Jonathan Tsang
Mubeen Ahmed Khan
Vipin Kumar Pandey
Original Assignee
Glenmark Pharmaceuticals Ltd
Napo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Ltd, Napo Pharmaceuticals Inc filed Critical Glenmark Pharmaceuticals Ltd
Priority to EA201290098A priority Critical patent/EA023814B1/en
Publication of WO2011024049A2 publication Critical patent/WO2011024049A2/en
Publication of WO2011024049A3 publication Critical patent/WO2011024049A3/en
Priority to ZA2012/02160A priority patent/ZA201202160B/en
Publication of WO2011024049A9 publication Critical patent/WO2011024049A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Processes for producing pharmaceutical compositions containing a proanthocyanidin polymer useful for the treatment and prevention of various conditions are provided. The invention specifically relates to processes for producing pharmaceutical formulations of a proanthocyanidin polymer composition which has been isolated from a Croton spp. or a Calophyllum spp. In particular, the invention relates to a process for producing proanthocyanidin polymer compositions which achieve concentrations and purities useful for addition to pharmaceutically effective formulations.
PCT/IB2010/002060 2009-08-26 2010-08-24 Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations WO2011024049A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EA201290098A EA023814B1 (en) 2009-08-26 2010-08-24 Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations
ZA2012/02160A ZA201202160B (en) 2009-08-26 2012-03-23 Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1962MU2009 2009-08-26
IN1962/MUM/2009 2009-08-26

Publications (3)

Publication Number Publication Date
WO2011024049A2 WO2011024049A2 (en) 2011-03-03
WO2011024049A3 true WO2011024049A3 (en) 2011-05-19
WO2011024049A9 WO2011024049A9 (en) 2013-04-25

Family

ID=43337818

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/002060 WO2011024049A2 (en) 2009-08-26 2010-08-24 Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations

Country Status (3)

Country Link
EA (1) EA023814B1 (en)
WO (1) WO2011024049A2 (en)
ZA (1) ZA201202160B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2816416C (en) 2010-10-31 2020-02-11 Salix Pharmaceuticals, Ltd. Methods and compositions for treating hiv-associated diarrhea
BR112013018688B1 (en) * 2011-01-27 2021-08-24 Napo Pharmaceuticals, Inc METHOD OF PRODUCTION OF A POLYMER COMPOSITION OF PROANTHOCYANIDINE
CN102210538A (en) * 2011-05-04 2011-10-12 惠州市欧野科技有限公司 Eaglewood powder and latex mixed pillow and manufacturing method thereof
WO2013093655A1 (en) * 2011-12-22 2013-06-27 Glenmark Pharmaceuticals Limited Non-enteric pharmaceutical composition comprising crofelemer
CA2913489C (en) * 2013-06-07 2019-04-30 Remi Shrivastava Composition for topical application comprising glycerol and tannins
US20170095442A1 (en) * 2014-05-29 2017-04-06 Jaguar Animal Health, Inc. Methods of Treating Salmonella-Induced Diarrhea in Non-Human Animals
US20170119834A1 (en) * 2014-05-29 2017-05-04 Jaguar Animal Health, Inc. Methods of Treating Diarrhea in Adult Non-Human Animals
CN105294636B (en) * 2015-11-16 2018-11-27 大兴安岭林格贝寒带生物科技股份有限公司 A method of preparing glucosidase procyanidins
RU2639291C2 (en) * 2016-03-29 2017-12-20 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Method and composition of producing dry forms of blue anthocyanins
US20220088102A1 (en) * 2020-09-22 2022-03-24 Alphyn Biologics, Llc Croton lechleri compositions and their use in the treatment of cystic fibrosis
US20220110992A1 (en) * 2020-09-22 2022-04-14 Alphyn Biologics, Llc Topical croton lechleri compositions and their use in the treatment of a bacterial colonization or primary or secondary bacterial infection of an underlying skin disorder
JP2024508454A (en) 2021-02-25 2024-02-27 アルフィン バイオロジックス、エルエルシー Composition for topical skin bacterial skin disease treatment

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006695A1 (en) * 1990-10-12 1992-04-30 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
WO1998016111A1 (en) * 1996-10-16 1998-04-23 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
WO2000047062A2 (en) * 1999-02-01 2000-08-17 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same
WO2007130893A2 (en) * 2006-05-01 2007-11-15 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006695A1 (en) * 1990-10-12 1992-04-30 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
WO1998016111A1 (en) * 1996-10-16 1998-04-23 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
WO2000047062A2 (en) * 1999-02-01 2000-08-17 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same
WO2007130893A2 (en) * 2006-05-01 2007-11-15 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GUPTA ET AL: "Dragon's blood: Botany, chemistry and therapeutic uses", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER SCIENTIFIC PUBLISHERS LTD, IE, vol. 115, no. 3, 22 October 2007 (2007-10-22), pages 361 - 380, XP022401667, ISSN: 0378-8741 *

Also Published As

Publication number Publication date
ZA201202160B (en) 2013-08-28
WO2011024049A9 (en) 2013-04-25
WO2011024049A2 (en) 2011-03-03
EA201290098A1 (en) 2013-01-30
EA023814B1 (en) 2016-07-29

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