WO2011021218A3 - Process for preparing 4-[3, 5-bis (2-hydroxyphenyl)-lh-l, 2, 4- triazol-i-yl] benzoic acid and its amine salts - Google Patents

Process for preparing 4-[3, 5-bis (2-hydroxyphenyl)-lh-l, 2, 4- triazol-i-yl] benzoic acid and its amine salts Download PDF

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Publication number
WO2011021218A3
WO2011021218A3 PCT/IN2010/000533 IN2010000533W WO2011021218A3 WO 2011021218 A3 WO2011021218 A3 WO 2011021218A3 IN 2010000533 W IN2010000533 W IN 2010000533W WO 2011021218 A3 WO2011021218 A3 WO 2011021218A3
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WO
WIPO (PCT)
Prior art keywords
hydroxyphenyl
bis
preparing
benzoic acid
triazol
Prior art date
Application number
PCT/IN2010/000533
Other languages
French (fr)
Other versions
WO2011021218A2 (en
Inventor
Manne Satyanarayana Reddy
Sajja Eswaraiah
Ghojala Venkat Reddy
Govindan Shanmugam
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2011021218A2 publication Critical patent/WO2011021218A2/en
Publication of WO2011021218A3 publication Critical patent/WO2011021218A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

An improved process for preparing 4-[3, 5-bis (2-hydroxyphenyl)-l, 2, 4-tπazol-l -yl] benzoic acid of formula-1 and a process for its purification are provided The preparation process comprises reacting salicylic acid with salicylamide in the presence of a suitable base, in a suitable solvent and in the presence of thionyl chloride at reflux temperature, then reacting 2-(2-hydroxyphenyl)-benz[e][l,3]oxazin^-one with 4-hydrazinobenzoic acid in a suitable alcoholic solvent at reflux temperature to provide deferasirox.
PCT/IN2010/000533 2009-08-12 2010-08-11 Process for the preparation of 4-[3,5-bis(2-hydroxyphenyl)-1h-1,2,4-triazol-1-yl]-benzoic acid and its amine salts WO2011021218A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1909CH2009 2009-08-12
IN1909/CHE/2009 2009-08-12
IN316/CHE/2010 2010-02-09
IN316CH2010 2010-02-09

Publications (2)

Publication Number Publication Date
WO2011021218A2 WO2011021218A2 (en) 2011-02-24
WO2011021218A3 true WO2011021218A3 (en) 2011-04-28

Family

ID=43607404

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000533 WO2011021218A2 (en) 2009-08-12 2010-08-11 Process for the preparation of 4-[3,5-bis(2-hydroxyphenyl)-1h-1,2,4-triazol-1-yl]-benzoic acid and its amine salts

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WO (1) WO2011021218A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6312718B2 (en) * 2013-03-06 2018-04-18 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ Method for preparing deferasirox
CN104098519B (en) * 2013-04-08 2018-08-21 江苏豪森药业集团有限公司 The process for purification of Deferasirox
CN106554770B (en) * 2015-09-29 2018-10-19 杭州杜易科技有限公司 A kind of triazole derivative metal-ion fluorescent probe and its preparation method and application
US11078167B2 (en) * 2017-07-19 2021-08-03 Aurobindo Pharma Ltd Process for the preparation of Deferasirox
CN108727287B (en) * 2018-05-10 2020-10-27 东南大学 1,2, 4-triazole compound and salt and application thereof
EP4251170A1 (en) 2020-11-25 2023-10-04 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids, and related methods of use
WO2023230587A2 (en) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049395A1 (en) * 1996-06-25 1997-12-31 Novartis-Erfindungen Verwaltungsgesellschaft M.B.H. Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
WO2003053986A1 (en) * 2001-12-21 2003-07-03 Ciba Specialty Chemicals Holding Inc. Use of metal complex compounds as oxidation catalysts
WO2009094956A1 (en) * 2008-01-30 2009-08-06 Farmak, A.S. A method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-benzoic acid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049395A1 (en) * 1996-06-25 1997-12-31 Novartis-Erfindungen Verwaltungsgesellschaft M.B.H. Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
WO2003053986A1 (en) * 2001-12-21 2003-07-03 Ciba Specialty Chemicals Holding Inc. Use of metal complex compounds as oxidation catalysts
WO2009094956A1 (en) * 2008-01-30 2009-08-06 Farmak, A.S. A method for preparing 4-[3,5-bis(2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-benzoic acid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STEINHAUSER, STEFAN ET AL: "Complex Formation of ICL670 and Related Ligands with FeIII and FeII", EUR. J. INORG. CHEM., vol. 21, 2004, pages 4177 - 4192, XP002431758 *

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WO2011021218A2 (en) 2011-02-24

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