WO2011021216A3 - Improved process for preparing 4-(l, l-dimethylethyl)-n-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2' -bipyrimid in]-4-yl]benzene sulfonamide - Google Patents

Improved process for preparing 4-(l, l-dimethylethyl)-n-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2,2' -bipyrimid in]-4-yl]benzene sulfonamide Download PDF

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Publication number
WO2011021216A3
WO2011021216A3 PCT/IN2010/000525 IN2010000525W WO2011021216A3 WO 2011021216 A3 WO2011021216 A3 WO 2011021216A3 IN 2010000525 W IN2010000525 W IN 2010000525W WO 2011021216 A3 WO2011021216 A3 WO 2011021216A3
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WO
WIPO (PCT)
Prior art keywords
methoxyphenoxy
dimethylethyl
hydroxyethoxy
preparing
improved process
Prior art date
Application number
PCT/IN2010/000525
Other languages
French (fr)
Other versions
WO2011021216A2 (en
Inventor
Manne Satyanarayana Reddy
Sajja Eswaraiah
Ghojala Venkat Reddy
Original Assignee
Msn Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Msn Laboratories Limited filed Critical Msn Laboratories Limited
Publication of WO2011021216A2 publication Critical patent/WO2011021216A2/en
Publication of WO2011021216A3 publication Critical patent/WO2011021216A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

An improved process for preparing 4-(l, l-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-[2, 2'-bipyπmidin]-4-yl] benzene sulfonamide monohydrate compound of formula-1 is disclosed
PCT/IN2010/000525 2009-08-10 2010-08-09 Improved process for the preparation of 4-(1,1-dimethylethyl)-n-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide WO2011021216A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1889CH2009 2009-08-10
IN1889/CHE/2009 2009-08-10
IN2112CH2010 2010-07-26
IN2112/CHE/2010 2010-07-26

Publications (2)

Publication Number Publication Date
WO2011021216A2 WO2011021216A2 (en) 2011-02-24
WO2011021216A3 true WO2011021216A3 (en) 2011-04-28

Family

ID=43607403

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000525 WO2011021216A2 (en) 2009-08-10 2010-08-09 Improved process for the preparation of 4-(1,1-dimethylethyl)-n-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide

Country Status (1)

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WO (1) WO2011021216A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015521594A (en) * 2012-06-12 2015-07-30 カディラ ファーマシューティカルズ リミテッド Method for producing bosentan
PL402305A1 (en) * 2012-12-30 2014-07-07 Instytut Farmaceutyczny A method of producing bosentan in the form of monohydrate of pharmaceutical grade
CN114907275A (en) * 2022-04-29 2022-08-16 武汉工程大学 Preparation method of bosentan

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136971A (en) * 1998-07-17 2000-10-24 Roche Colorado Corporation Preparation of sulfonamides
WO2009095933A2 (en) * 2008-01-10 2009-08-06 Msn Laboratories Limited Improved and novel process for the preparation of bosentan

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136971A (en) * 1998-07-17 2000-10-24 Roche Colorado Corporation Preparation of sulfonamides
WO2009095933A2 (en) * 2008-01-10 2009-08-06 Msn Laboratories Limited Improved and novel process for the preparation of bosentan

Also Published As

Publication number Publication date
WO2011021216A2 (en) 2011-02-24

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