WO2011012515A2

WO2011012515A2 - Aqueous barrier solution for protecting skin from non-water-soluble substances

Info

Publication number: WO2011012515A2
Application number: PCT/EP2010/060553
Authority: WO
Inventors: Martin Schmitt
Original assignee: Ursula Rath Gmbh
Priority date: 2009-07-25
Filing date: 2010-07-21
Publication date: 2011-02-03
Also published as: DE102009034771A1; EP2459159A2; DE102009034771B4; WO2011012515A3

Abstract

The invention relates to an aqueous barrier solution for protecting skin from non-water-soluble substances, characterized in that the solution comprises a product of a fatty acid or mixtures or salts thereof and a basic amino acid or salts or mixtures thereof, and additionally at least one emulsifier able to form a film, having an HLB value in the range of 12-25. The solution has a pH of 7.5-9, and is suitable for protecting skin from contamination with oils, fats, paints, lacquers, soot, graphite, rust, fine-particulate metal oxides, other dusty grit, and products containing bitumen.

Description

Aqueous barrier solution to protect the skin against

non-water-soluble substances

The present invention relates to an aqueous barrier solution for protecting the skin against non-water-soluble substances. Practical work with soiled objects causes soiling of the hands and other, possibly exposed parts of the body surface. The term dirt in the context of this patent means primarily so-called "lipo-dirt", ie contamination of the human body surface, in particular the hands with non-water-soluble and / or non-polar substances.These include, for example: engine oil, oil pollution in general, greases, paints and Paints, not being water-based, shoe polish, bituminous products for underbody preservation of cars, but also dusts such as soot, graphite, rust and other metal oxides.

The cleaning of the skin from such soiling is complex and time-consuming. Often this means must be used, which strain and damage the skin to be cleaned. As an example, washing pastes with rubbing agents or technical solvents may be mentioned. It can be said without exaggeration that the removal of such contaminants for unprotected affected skin areas is often a greater burden and may have a greater dermatological damage potential than contact with the dirt itself.

In order to minimize the stress on the skin with "lipo contamination", products of the so-called "personal protective equipment" are used in the professional work process. These include, inter alia, protective gloves and / or hand-skin protection, in the latter preferably cosmetic barrier preparations. The concept of protecting the skin against soiling by means of a barrier-forming preparation has long been the practice in various branches of industry. The hands are rubbed before work eg with soft soap (ie the potassium salt of fatty acid mixtures). This, after drying, forms a film that prevents direct contact between the skin and "lipo dirt." This means that soiling does not build up directly on the skin, but on the fiim, in addition to being able to form a protective barrier, soft soap is amphiphilic and so on When washing hands pretreated with soft soap and contaminated with "lipo dirt", the "lipo dirt" is emulsified by the protective film and can then be rinsed off.

The concept of a barrier against soiling of the skin by means of soft soap was taken up and led to the development of formulations for a wide range of applications. For skin protection products of this purpose, the term "invisible glove" (English, "invisible glove") was coined. Such products are e.g. by Evonik Stockhausen / Krefeld

(www.stoko.de), Greven GmbH (www.petergrevenhautschutz.de) or Ursula Rath GmbH / Senden (www.rath.de) available.

It has long been noted that the presence of sodium silicate often added as a diluent in soaps leads to the formation of particularly effective barriers to "lipo-soiling." This effect is due to the unique action of a PR88 sold by Ursula Rath GmbH, Senden, worldwide The standard of this product has not yet been achieved by any of the many generic drugs on the market: Due to the use of soda water glass, barrier preparations containing water glass have a pH> 11, which has alarmed occupational physicians and dermatologists who use such preparations This assumption is underlined by the fact that barrier preparations as "leave-on ^u Preparation during the work process is applied regularly and over long periods of time.

The assumption of a neutralizing and therefore detrimental effect of alkaline barrier preparations on acid skin hydrolipids is logical, but is apparently based only on chemical-theoretical considerations. It must be emphasized at this point that z. For example, since its market entry nearly five decades ago, the PR 88 has been sold and used worldwide in very large quantities without the product becoming dermatologically conspicuous. Nonetheless, consideration of the skin tolerability of markedly alkaline barrier preparations gave rise to the drafting of directives which set a pH of 9.5 as the upper limit for such preparations (Prevention Guideline on Skin Protection of the Special Committee on Personal Protective Equipment, Hauptverband der gewerblichen Berufsgenossenschaften, March 2008).

In anticipation of a general liability of that Directive, a number of barrier preparations have been developed, the formulation of which, although using sodium silicate, has lowered the pH to below the aforementioned limit of pH 9.5 by adding fatty acids (mostly stearic acid) and other ingredients.

It is well known from silicate chemistry that monomeric sodium silicate and smaller oligomers thereof (ie the principal constituents of soda waterglass) are not stable below a pH of 10.5 (see, for example, US2007 / 0161539A1), but yield higher molecular weight Condens species. It can be assumed that this is the reason why all barrier preparations in which water glass has been (partially) neutralized with fatty acids to lower the pH, have a significantly worse efficacy than preparations which have a pH above the stability limit of orthosilicic acid.

The object of the invention is to provide a barrier product for protecting the skin against non-water-soluble contaminants. Another object is the provision of a barrier product for skin protection, the pH in the alkaline range is significantly lower than in known products and allows long-term protection.

Another object is to provide a barrier product that has a consistency that allows use in dosing dispensers.

Another object is to provide a barrier product that does not contain additional preservatives.

It has now surprisingly been found that preparations which contain salts of fatty acids with certain amino acids and film formers have excellent barrier functions against "LJposchmutz".

The invention therefore provides an aqueous barrier solution for protecting the skin against water-insoluble substances, characterized in that the solution comprises a product of a first substance selected from a group consisting of a fatty acid, an alkali salt of a fatty acid, a fatty acid mixture, a mixture of alkali salts of fatty acids and mixtures thereof, and a second substance selected from a group consisting of a basic amino acid, an acid salt of a basic amino acid, a mixture of basic amino acids and a mixture of acid salts of basic amino acids and mixtures thereof, and the solution further comprises at least one film-forming emulsifier having an HLB value in the range of 12-25.

"Protection of the skin against non-water-soluble substances" in the sense of this invention is understood to mean applying a solution according to the invention to the skin of the hands before contact with water-insoluble or non-polar substances (lipo-soiling) and at the same time washing off these substances To facilitate work. "Liposchmutz" in the context of this invention are deposits of water-insoluble or non-polar substances on the skin, in particular oils in general, motor oils, greases, shoe creams, bitumen-containing products, non-water-based paints and varnishes, dusts such as graphite carbon black, rust, other metal oxides.

By "aminose soaps" is meant the products of fatty acids, fatty acid mixtures, alkali salts of fatty acids or fatty acid mixtures with basic amino acids, basic amino acid mixtures, acid salts of basic amino acids or mixtures of amino acids In this context, "product" means an actual chemical reaction product of both

Starting materials or a mixture of Miceüen of amino acid, amino acid and fatty acid, in which no complete reaction has taken place.

Salts of fatty acids with amino acids in washable soap products are known per se and some are commercially available. In WO 00/24375 z. B. Salts of basic amino acids with fatty acids together with fungicidal

Acids and chelating agents described as preservatives for pharmaceutical purposes. DE 3633453 A1 describes the use of lysine or arginine salts of fatty acids as z. Emollient, emulsifier or antioxidant for cosmetic, dermatological or food purposes. In contrast, the aqueous solution according to the invention as a single-phase formulation is a product which contains no fatty phase and therefore none

Emulsion on the skin remains (leave-on product) and a comprehensive barrier effect against "Liposchmutz" shows Further advantages are described below.The starting material for the preparation of barrier-forming solutions according to the invention are fatty acids, monounsaturated or polyunsaturated, individually or The fatty acid or the fatty acid mixture should preferably give a clearly water-soluble fatty acid soap, fatty acids or fatty acid mixtures having a melting point of 15 to 40 ^° C., in particular from 20 to 35 ^° C. are therefore particularly suitable. Saturated fatty acids should have an average chain length, eg from C6 to C14, in particular from C8 to C12. Fatty acid mixtures are particularly preferred; coconut fatty acids, paimo fatty acids or palm kernel fatty acids, in each case also in hardened form, may be mentioned by way of example.

Overall, preference is given to saturated C8-C12 fatty acids and monounsaturated C8-C18 fatty acids and mixtures thereof, it also being possible for small proportions of polyunsaturated fatty acids, such as linoleic acid, to be present in fatty acid mixtures. Particularly preferred is the fatty acid mixture obtained from paimkern oil. It is commercially available at low cost. Another advantage is that, when reacted with arginine or lysine, each gives a fatty acid soap which becomes plastic at body temperature on the skin and therefore both a pleasant

Skin sensation is mediated as well as the mechanical properties of the barrier are favorably influenced

Mixtures of palm oil fatty acids contain oleic acid, palmitic acid, linoleic acid, stearic acid and myristic acid in varying concentrations, with oleic acid and palmitic acid being the main components.

Mixtures of palm kernel oil fatty acids include lauric acid, palmitic acid, stearic acid, capric acid, caprylic acid, myristic acid and linoleic acid, with lauric acid, myristic acid and oleic acid being the main components.

Coconut fatty acids include oleic acid, linoleic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid and stearic acid, with caprylic acid, lauric acid and myristic acid being the main components. "Main ingredient" means that this acid is most contained by percentage. The second products of the invention include the basic amino acids arginine, lysine and histidine, with arginine and lysine being preferred, especially arginine.

The pK values of these amino acids are in the range of 7.5-12.5 at an isoelectric point above 7.

Further preferred are acid salts of these amino acids such as the hydrochlorides, eg. As L-arginine hydrochloride or L-lysine hydrochloride.

The formation of the salts of the fatty acids according to the invention, referred to below as aminosurfactants, is carried out by reacting the fatty acid (s) with the amino acid in a molar ratio of 1: 2 to 2: 1, preferably 1: 5: 1 to 1: 1, 5 and in particular in approximately stoichiometric amounts. It is possible to form the aminose in situ in the preparation of the barrier solution, i. Add amino acid and fatty acid as a single substance. In addition, it is possible to use an alkali salt of the fatty acid or fatty acid mixture, e.g. a sodium salt, with a hydrochloride of the amino acid. In this case, in addition to the fatty acid salt, the barrier solution also contains the alkali salt of the acid, e.g. NaCl. The barrier solutions thus prepared are more viscous at the same concentration of aminose soap.

Furthermore, it should be pointed out that complete conversion of fatty acid (s) and amino acid (s) need not necessarily have taken place in the barrier solutions according to the invention: It is conceivable that mixed micelles of amino acid and fatty acid are also present in the solution. For the sake of simplicity, however, in the context of the present invention, only salt or aminose should be mentioned. The formulations according to the invention are distinguished in particular by their good skin tolerance. They have a pH of about 7.8-9.5, in particular of 8.0-9.0, which is a special feature of the invention because of the above-mentioned prevention guideline "skin protection" The Ami ^'noseifen employed in this invention have a significantly mikrobi- ziden character, so this containing skin protection products do not have to be preserved, as ensured by a comparative preservation stress test. The particularly high activity of the barrier solution according to the invention results from the combination of the amino acid with other skin-compatible substances which are capable of film formation and are preferably provided with emulsifying properties. These are film formers which also have emulsifying properties which have an HLB value which is suitable for emulsion formation with "lipo dirt." Typically, this HLB value is in the range from 12 to 25, preferably from 12 to 24, especially 12 to 18, especially 12 to 15th

The use of poloxamers has proved to be particularly advantageous. Poloxamers are block copolymers of ethylene oxide and propylene oxide and are commercially available. Mixtures of aminose soaps with poloxamers have synergistic effects on their barrier properties. Especially at mixing ratios of amino acid fatty acid salt: poloxamer in the range of 1: 5 to 5: 1, the barrier effect is significantly better compared with barrier preparations containing only one of the two components. Examples of poloxamer are those having molecular weights in the range from 7,000 to 20,000, preferably in the range from 9,000 to 15,000. The proportion of ethylene oxide may preferably be 70 to 85% by weight, preferably 70 to 75% by weight.

Furthermore, it has proved to be advantageous to combine the inventive barrier formulation prepared from aminose soap with other water-soluble polar, capable of film-forming solids. A combination with polyvinylpyrrolidone (PVP) has proven particularly advantageous, as a result of which the protective film gains mechanical strength. Furthermore, PVP does because of his hygroscopic character the use of skin-moisturizing formulation components such. As glycerol, propylene glycol, 1,2-pentanediol, polydiol, etc. superfluous. Low molecular weight PVP such as. As Luviskol®K17 or Luviskol®K30 are preferred. Preference is further given to the use of other nonionic emulsifiers both because of their contribution to the protective film on the skin and their skin compatibility and in terms of their property as emulsifiers in the final washing process, for. B. the hand wash. These other nonionic emulsifiers should have an HLB value in the range of 12 to 20. For example, copolymers of higher fatty alcohols, such as stearyl and cetyl alcohol, with ethylene glycol, called ceteareth-n, are suitable. Here, n is the number of ethylene glycol groups in the polyoxyethylene chain. Are suitable

Ceteareth-15 to Ceteareth-30, especially preferred is Ceteareth-25.

The proportion of active substances in the barrier solution is in the following ranges fatty acid-amino acid salt 6 to 18 wt .-%, in particular 8 - 16 wt .-%

Film former {poloxamer) 2 to 9 wt.%, In particular 3 to 7 wt.%

Film Form ner (PVP) 3 to 11 wt .-%, in particular 3 - 8 wt .-%

nonionic emulsifiers 1 to 8 wt .-%, in particular 1, 5 - 6 wt .-%. The cosmetic preparation in the form of the barrier solution according to the invention may further contain other customary additives in order to give it desired properties. These include z. As fragrances, defoamers, dyes, solids such as SiO ₂ or other particulate inorganic oxides or organic solids to improve the grip strength or to modify the consistency of the preparation, skin-care additives (such as allantoin, bisaboloi, panthenol, tocopherol, tocopheryl acetate, retinol , Retinol derivatives such as retinyl acetate, palmitate, propionate, etc.), antioxidants, preservatives, bodying agents, perfume oils, buffers for pH stabilization, foam stabilizers, thickeners, oily active ingredients or auxiliaries up to a concentration of 1%, and others. These are in themselves are known and used in the usual amounts, either

Foam stabilizers are used (foams) or defoamers (clear solutions).

The addition of fine particulate matter to the solution is particularly suitable for the formulation of gelatinous products, and z. B. increase the grip of the barrier solution.

The formulation according to the invention was developed as a barrier preparation against "lipo-stain" ("invisible glove") Because of the aforementioned microbicidal action of medium-chain fatty acids and their soaps, the preparation also has a germ-reducing effect on the hands of the users is advantageous.

It is a further benefit of the formulation that it can also be used as a liquid soap to remove this contamination in contamination of unprotected skin with "lipo-soiling." The invention also relates to the use of a preparation containing an amino acid or amino acid salt and a fatty acid or fatty acid salt Aqueous barrier solution for protecting the skin against non-water-soluble lipo-soil The aqueous barrier solution is protected against contamination with lipo-soiling on the to-be-protected fatty acid mixture and at least one emulsifier capable of film-forming After the contamination, the contaminated surfaces are moistened, and the moistened surfaces are rubbed to emulsify lipo-soiling and protective preparation, for example washing strokes of the hands, and the emulsions formed thereby n is then washed off with water. To clean unprotected skin, the aqueous barrier solution itself can be used, in which case it is rinsed with clean water. Typically, the formulations of the present invention are provided as a single phase solution of the amino acid (s) in water. The inventive

Barrier solution but has the potential, when using suitable excipients in another cosmetic agent, such as a lotion, milk, cream, ointment, foam u. ä. forms to be transferred. The formulation or preparation of other forms of skin protection agents is carried out in a manner known per se.

It is advantageous that the barrier solutions according to the invention with the amino soaps contain an active ingredient which is well compatible with most common ingredients in cosmetic products and therefore allows great freedom in formulation. It should be noted that the barrier solution of the invention has the well-known from the prior art very good protection in the same or almost the same extent, without Alkaüsilikate are included and thus without having the high pH, bring the Aikalisilikate with it or require.

Another advantage of the barrier solution according to the invention is its consistency, which allows use in dosing dispensers. On the other hand, known products with high pH values have a partially foamed or gelatinous consistency, which is impractical for dosing dispensers. Another advantage of the invention is the long-term protection by the product according to the invention, d. H. a lasting over several hours protection without significant loss of barrier effect.

The invention will be explained with reference to the following examples, but without being limited to the specifically described embodiments. Unless otherwise stated or necessarily different from the context, percentages are based on weight, in two cases on the total weight of the mixture. The invention also relates to all combinations of preferred embodiments, as far as these are not mutually exclusive. The information "about" or "approx." in conjunction with a numerical indication, means that at least 10% higher or lower values or 5% higher or lower values and in any case 1% higher or lower values are included.

Example 1: Barrier Solution for Dispensers From the Following Constituents

1. Aqua (demin.) 77.7

2. Palm Kernel Acid 6,43

3. Arginine 4,53

4. PVP (Luviskol® K30) 4.5

5. Poloxamer 407 (HLB 18-23) 3.6

6. Ceteareth-25 2.7

7. Bisabolol 0.27

8. Panthenol 0.27, a solution is prepared as follows. Position 1 is presented, positions 4 to 8 are successively merged, then position 3 is entered and after that

Dissolve position 2 and stir until a clear solution is obtained. The solution obtained has a pH of 8.2-8.6 and can be well dosed by means of conventional dispensers.

Example 2: Foam

The following ingredients were mixed as in Example 1

1. Aqua (demin.) 81.0

2. Palm Kernel Acid 5.45

3. Arginine 3,84

4. PVP 3.85

5. Poloxamer 407 3.08 6. Cetear6th-25 2,3

7. Bisaboloi 0.24

8. Panthenol 0.24 A clear solution is obtained, which can be well dosed with conventional foam dispensing devices and gives a stable, cosmetically elegant foam. The pH is 8.2 - 8.6.

Example 3: Microbiological Stability

With solutions prepared analogously to the above examples, a microbial load test according to Ph.Eur. (European Pharmacopoeia) performed. On the one hand, an unpreserved sample of the skin protection composition according to the invention and, for comparison, a second sample containing a broadband preservative based on silver chloride and a third sample to which a mixture of methylisothiazolinone and phenylethanol had been added were tested. After inoculation with the usual test germs, sterility could be achieved in all three samples within two days. Since the unpreserved sample also became germ-free again, the skin protection agent according to the invention can be termed self-preserving.

Example 4: Effect Test (Comparative Experiment)

The formulations given in the following table were evaluated for their barrier effect by 15 persons on a scale from 1 (very good) to 5 (poor), the results (in each case averaged) are also given.

The various barrier solutions according to Example 4 (see table) and the comparison product PR 88 are applied in an amount of 2 g each with washing movements on the entire palms evenly within 1 minute. After a further drying time of 2 minutes, the lipo-soil to be tested is applied. The paint is sprayed red acrylic paint on an area of about 4 x 4 cm of the back of the hand; Drying time 5 - 7 minutes until the paint is no longer wipeable.

Graphite dust is powdered on approx. 4 x 6 cm palms and back of the hand including the fingers, rubbed lightly and the loose components are blown off with compressed air.

From soot oil as used motor oil, a few drops are rubbed on the entire palm of the hand including the fingers for 1 min, an excess is blotted with crepe paper.

Shoe cream is pressed in a quantity of 0.5 cm from a conventional cream tube with a round opening and applied to an area of 4 x 4 cm each of the palm and back of the hand and spread for 20 sec with a paper towel.

The hands of the subjects contaminated with lipo-dirt are moistened slightly with water (water spray bottle or a few ml from the water pipe), and washing movements of the hands are achieved for 20 seconds, reaching the backs of the hands and the inside of the hands equally. The "emulsified" lipo-soiling is then washed off under running water with further washing movements of the hands over a period of 30 seconds.

The evaluation of the barrier effect on the scale of 1 to 5 is: 1 complete removal of lipo contamination

2 good (hardly any residues of lipo contamination)

3 satisfactory (recognizable residual constituents of lipo contamination)

4 deficient (considerable residual components)

5 bad (insufficient removal of lipo dirt)

The comparative product PR 88 was set as "1". table

The table shows that the anime soap with the film former Poloxamer shows a slightly worse but still good to very good barrier effect compared to the tested soil substances and in comparison to the standard. Completely equivalent to the standard is a barrier solution with amino acid and three different film formers (Example 1), which shows a synergistic effect.

Example 5: Barrier solution II

The solution contains the following ingredients

Aqua ad 100

Coconut Acid 7,4

Lysine 5.1

Poloxamer 188 3.9

Propylene glycol 2,2

Tocopheryl acetate 0.8

After dissolution of all components at ambient temperature (15-25 ° C) with about 100 - 300 U / min gives a clear solution that can be used directly as a barrier solution. Example 6: Barrier Solution III

Aqua ad 100

Hydrogenated Palm OiI 9.0

Arg ine 6,2

Poloxamer 338 4.4

Ceteareth-18 3.8

Bisabolol 0.3

Retinyl palmitate 0.5

The processing succeeds as in example 5. Example 7: Barrier Solution IV

A solution is prepared as in Example 1 using instead of palm kernel acid their sodium salts and instead of arginine the L-arginine hydrochloride.

A clear solution of slightly higher viscosity than that of Example 1 is also obtained

Example 8: Hautgei

The gel contains the following ingredients

Water ad 100

Glycerol 2

Barrier solution according to Ex. 1 65

Dehydroxanthan Gum 1

SiO ₂ 0.7

Triethanolamine 1

Tocopheryl Acetate 0.8

Perfumes 0.8

The ingredients are sequentially with stirring at ambient temperature (15 - 25 ⁰ C) was added.

Claims

claims

An aqueous barrier solution for protecting the skin against non-water soluble substances, wherein the solution comprises a product of a first

Substance selected from a group consisting of one

Fatty acid, an alkali salt of a fatty acid, a fatty acid mixture, a mixture of alkali salts of fatty acids and mixtures thereof, and a second substance selected from a group consisting of a basic amino acid, an acid salt of a basic

Amino acid, a mixture of basic amino acids and a mixture of acid salts of basic amino acids and mixtures thereof, and the solution further comprises at least one suitable for film formation nonionic emulsifier having an HLB value in the range of 12-25.

2. A barrier solution according to claim 1, wherein the fatty acid is selected from the group consisting of a saturated fatty acid having a chain length of C ₈ to C ₁₂ , mono- or polyunsaturated fatty acids having a

Chain length of C ₈ to Ci ₈ and mixtures thereof.

3. A barrier solution according to claim 1 or 2, wherein the fatty acid is a fatty acid mixture selected from the group consisting of palm oil fatty acids, Paimkernölfettsäuren or coconut oil fatty acids, and the mixture is uncured or wholly or partially cured.

4. A barrier solution according to claim 3, wherein the fatty acid mixture is a palm kernel oil-fatty acid mixture comprising as main components lauric acid, myristic acid and oleic acid.

A barrier solution according to any one of claims 1 to 4, wherein the basic amino acid is arginine, lysine or histidine.

A barrier solution according to any one of claims 1 to 5, wherein the acid salt of the basic amino acid is the hydrochloride.

7, barrier solution according to one of claims 1 to 6, characterized in that it has a pH in the range of 7.5 to 9.5, in particular 8.0 to 9.0.

8. A barrier solution according to any one of claims 1 to 7, wherein the emulsifier suitable for film formation is a poloxamer having a molecular weight in the

Range from 7000 to 20,000.

9. barrier solution according to any one of claims 1 to 8, wherein the solution

comprises at least one further water-soluble film former.

10. barrier solution according to any one of claims 1 to 9, wherein the further

Film former is polyvinylpyrrolidone or a copolymer of a fatty alcohol with ethylene glycol or a mixture of PVP and copolymer.

11. A barrier solution according to any one of claims 1 to 10, wherein the amino acid is arginine.

A barrier solution according to any one of claims 1 to 11, wherein the fatty acid is a hardened palm kernel oil fatty acid.

The barrier solution according to any one of claims 1 to 12, wherein the ratio of fatty acid: amino acid is in the range of 1: 5 to 5: 1, based on the

Weight of the substances.

14. A barrier solution according to any one of claims 1 to 13, wherein the solution contains no additional preservatives

15. Use of a preparation containing an amino acid or amino acid salt and a fatty acid or fatty acid salt or fatty acid mixture and a for Film formation capable of having an emulsifier with an HLB value in the range of 12 - 25 comprises as an aqueous barrier solution for the protection of the skin against non-water-soluble lipo-soiling.

16. Skin protection formulation against water-insoluble Liposchmutz, characterized in that the formulation comprises a product of a first

A substance selected from the group consisting of a fatty acid, an alkali salt of a fatty acid, a fatty acid mixture, a mixture of alkali salts of fatty acids and mixtures thereof, and a second substance selected from a group consisting of a basic amino acid, an acid salt of a basic

Amino acid, a mixture of basic amino acids and a mixture of acid salts of basic amino acids and mixtures thereof; at least one emulsifier capable of film formation having an HLB value in the range of 12-25 and cosmetic additives of the group water, dyes, fragrances, antioxidants, radish scavengers, pH stabilization buffers, thickeners, humectants, particulate solids,

Main care substances, foam stabilizers, defoaming agents.