Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
  • A61L27/02—Inorganic materials
  • A61L27/12—Phosphorus-containing materials, e.g. apatite
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
  • A61L27/02—Inorganic materials
  • A61L27/10—Ceramics or glasses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
  • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
  • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
  • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder

Definitions

• the subject of the invention is a preparation for regeneration of postoperative and post-traumatic bone defects and method for implantation of this preparation, employed in many branches of medicine especially in orthopedics, dental surgery, reconstructive surgery, periodenthology and implantology.
• xenogeneic grafts or implants e.g. compositions of horse bone and cattle bone create a risk of transmission of animal diseases, e.g. BSE (Bovine Spongiform Encephalopathy).
• BSE Bovine Spongiform Encephalopathy
• pathogenic micro-organisms There is also a potential risk of transmission of pathogenic micro-organisms.
• the objective of this invention is creating a new therapeutically effective preparation for regeneration bone defects, which will show low biotoxicity and small systematic side effects at surgical application.
• This invention helps to fulfill the above task.
• the preparation components have been marked with letters A, B, C, TCP.
• the essence of this preparation is application of a deproteinized human bone (A), deprived of the smallest molecules of protein, with granulation from 0,3 to 0,5mm, bioglass (B) with granulation from 0,3 to 0,5mm and binder (C) favourably in the form of a patient's own blood in the amount of 20-25% in relation to the quantitative sum of the above components.
• A human bone
• tissue bank in the form of hydroxyapatite, with appropriate granulation, as well as in the form of trochlea.
• the second component of the preparation bioglass (B), in the form of powder with granulation 0,3-0, 5mm, can be obtained with use of zol-gel method in the system CaO-SiCh-PiOs.
• This component can also be used as a high silica component (80% mol. SiOa) or/and as a high calcium component (54% mol. CaO).
• TCP tricalcium phosphate
• This invention enables a faster regeneration of human bone tissue defects arising from intended activities, such as surgical activities, or unintended activities - injuries and disease process.
• Application of the above preparation results in a fast and complete regeneration of anatomic profile and physiological function.
• This invention helps to speed up the process of regeneration of damaged bone, and it contributes to compensation of biodegradation during the process of healing, due to active surfaces of the applied filler.
• an appropriate amount of the preparation is being mixed with binder i.e. the blood from operative wound (the mixture should be homogeneous).
• binder i.e. the blood from operative wound
• the mixture which has consistency of Plasticine
• the obtained mixture which has consistency of Plasticine, is implanted into bone defects.
• Application of a patient's own blood enriches the implanted preparation with organic components, e.g. collagen type 1, proteins, polysaccharides, lipids, necessary for osteogenesis and for preventing the preparation components from moving inside the operative wound.
• the components contained in a regenerating bone amount to 25% of the bone's weight.
• the components enumerated above, especially collagen increase bone's resistance to mechanical destruction caused by tension that occurs during work, and reduce brittleness of bones. More over collagen and protein fibers accelerate crystallization of hydroxyapatite.

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Publications (1)

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Cited By (1)

Citations (5)

• 2009
  • 2009-07-17 WO PCT/PL2009/000075 patent/WO2011008111A1/en active Application Filing

Patent Citations (6)

Non-Patent Citations (2)

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