WO2011006131A1 - Procédés et appareil pour tamponner des solutions parentérales - Google Patents

Procédés et appareil pour tamponner des solutions parentérales Download PDF

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Publication number
WO2011006131A1
WO2011006131A1 PCT/US2010/041613 US2010041613W WO2011006131A1 WO 2011006131 A1 WO2011006131 A1 WO 2011006131A1 US 2010041613 W US2010041613 W US 2010041613W WO 2011006131 A1 WO2011006131 A1 WO 2011006131A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
buffer
connector
needle
septum
Prior art date
Application number
PCT/US2010/041613
Other languages
English (en)
Inventor
Matthew J. Stepovich
Michael I. Falkel
Original Assignee
Onpharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onpharma Inc. filed Critical Onpharma Inc.
Publication of WO2011006131A1 publication Critical patent/WO2011006131A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2017—Piercing means having three or more piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents

Definitions

  • the present invention relates generally to methods and apparatus for combining parenteral solutions. More particularly, the present invention relates to methods for combining sodium bicarbonate and other buffering solutions with parenteral solutions stored in small cartridges.
  • Solutions containing bicarbonate ions are used in various medical applications such as antidotes, dialysates, artificial cerebrospinal fluid, intraocular irrigating solutions, cardiac perfusates, cardioplegic solutions, peritoneal irrigating solutions, and solutions for organ preservation, etc.
  • bicarbonate solutions are used to buffer the pH dental anesthetic and other parenteral solutions.
  • One of the most commonly used medical bicarbonate solutions consists of sodium bicarbonate (NaHCOa) mixed with water (H 2 O).
  • NaHCOa sodium bicarbonate
  • H 2 O water
  • bicarbonate ions are in equilibrium as represented by the following expression:
  • the pH of sodium bicarbonate solution can be fixed by placing the solution having a known starting pH, in a sealed container under pressure that exceeds the partial pressure of CO 2 in the solution, without a headspace.
  • CO 2 will not evolve out of solution because pressure on the solution is greater than the partial pressure of CO 2 , and therefore the pH will not rise.
  • the pH of the solution will not decrease.
  • CO 2 does not leave or enter solution and, accordingly, the pH does not have the opportunity to either rise or fall.
  • the pH of the solution in this system is therefore, essentially fixed once the system is closed.
  • the headspace can expand to fill the space vacated by the liquid that is leaving the vial, traveling through the hypodermic needle, and entering the barrel of the syringe.
  • the headspace expands more and more, continually lowering the gas pressure in that headspace.
  • the pH of the solution is an important element of its clinical utility, as when the bicarbonate is to be used for buffering the pH of a target solution such as anesthetic, withdrawing bicarbonate from a vial using a syringe may alter the pH to a degree that makes it difficult to predictably buffer any parenteral solution using this method.
  • Another concern when bicarbonate solution is drawn from a vial using a syringe is the effect of the vacuum created in the fluid path that leads from the bicarbonate vial to the syringe.
  • the '271 application discloses a fluid transfer device which utilizes a transfer needle 36 and an exhaust needle 38 positioned in a knob 12 which can removably receive an anesthetic cartridge 28 so that distal ends of both the transfer needle and exhaust needle penetrate a septum on the anesthetic cartridge.
  • a buffer cartridge 16 positioned within a housing 14 is also attached to the knob 12 so that a proximal end 50 of the transfer needle 36 can penetrate a septum 15 of the buffer cartridge when the knob is fully advanced onto the housing.
  • a pusher 20 is provided to drive a plunger 58 on the buffer cartridge to transfer buffer through transfer needle 36 into the anesthetic cartridge 28 and to simultaneously exhaust anesthetic from the anesthetic cartridge back into a reservoir 72 in the housing 14 through the exhaust needle 38.
  • the dosing pen of the '271 application is advantageous in many respects, some improvements can be made such that a similar pen will provide additional benefits .
  • the dosing pen is designed to hold a single buffer cartridge 16, and the design of the pen makes it difficult to replace the buffer cartridge.
  • the pusher 20 is attached to the housing 14 to position an intermediate spring 18 against the plunger of the buffer cartridge, and a mechanism is provided which defines two advancement strokes to allow transfer of two pre-defined volumes of buffer to one or two anesthetic cartridges.
  • the pusher assembly is not easily disassembled, making replacement of the buffer difficult Thus, the entire pen must be disposed of after use.
  • the pusher mechanism desc ⁇ bed above does not allow free selection of a range of transfer volumes prior to use.
  • the pusher mechanism only allows two pre-defined volumes to be transferred by any particular pen construction. It would be desirable to allow a user to select or "dial in” any volume in a given range without being limited to specific preset values.
  • the excess buffer which is exhausted through exhaust needle 38, ends up in the housing 14. While it is theoretically possible to empty the buffer and clean the housing (assuming the device could be disassembled, which is difficult), it would be preferable if the excess buffer were exhausted into another component of the system which could either be more easily cleaned or be disposed of while allowing other components to be reused.
  • removal of the first buffer cartridge from the dosing pen of the '271 application can be done without having removed the transfer needle from the buffer cartridge. Having a needle that can be left in a position where it provides a fluid path open to the ambient air (that is penetrating the septum of the buffer cartridge) could allow carbon dioxide to evolve out of solution, thus potentially affecting the pH of the buffer.
  • Patent No. 5,984,906 A particular disposable drug cartridge that can find use in the present invention is described in U.S. Patent No. 5,603,695.
  • a device for delivering a buffering agent into an anesthetic cartridge using a transfer needle is described in U.S. Patent No.
  • the present invention provides methods and apparatus for combining medical or parenteral solutions, such as buffe ⁇ ng anesthetics or other medical or parenteral solutions held in a conventional cartridge, particularly those having a penetrable septum and a shdable plunger or plug, such as those generally desc ⁇ bed m US 2009/0292271, the full disclosure of which is incorporated herein by reference
  • Such cartridges are commonly used in dental practice, particularly for delivering anesthetics to a patient p ⁇ or to a procedure
  • Such cartridges are conventionally loaded into a syringe or other delivery device, where the syringe engages the plunger in the cartridge to dispense the anesthetic through a needle which has penetrated the septum
  • it is desirable to buffer conventional dental anesthetics typically hdocame, articame, p ⁇ locaine, or mepivacame, shortly before use It is very important, however, that the buffering solutions themselves have predictable
  • Methods according to the present invention for buffering anesthetic cartridges comprise providing a buffer cartridge having a septum and a plunger and providing an anesthetic cartridge having a septum and a plunger
  • the plunger end of the buffer cartridge is attached to one end of a cartridge connector so that a transfer needle which is part of the cartridge connector penetrates the septum of the buffer cartridge to establish a flow path out of said cartridge
  • a septum end of the anesthetic cartridge is attached to the other end of the cartridge connector so that the transfer needle and an exhaust needle both penetrate the septum of the anesthetic
  • the transfer needle thus provides a transfer flow path from the buffer cartridge to the anesthetic cartridge, while as desc ⁇ bed in more detail below, the exhaust needle provides a flowpath from the anesthetic cartridge to a sealed interior waste chamber in the cartridge connector
  • sealed interior waste chamber it is meant that the waste chamber will receive and hold excess volumes of the anesthetic which are displaced when buffer is transferred into the anesthetic cartridge Usually, the chamber will have
  • the anesthetic cartridge may be removed from the cartridge connector after a desired volume of buffer has been transferred from the buffer cartridge to the anesthetic cartridge.
  • the cartridge connector can be configured so that the transfer needle must be removed from the buffer cartridge before the anesthetic cartridge can be removed from the cartridge connector. In this way, the buffer remains sealed (the septum seals after the transfer needle is removed) within the buffer cartridge and is not exposed to the ambient or atmosphere through the transfer needle when the anesthetic cartridge has been removed and the remote end of the transfer needle is open to the atmosphere.
  • the cartridge connector and other apparatus remain available for attachment to a second anesthetic cartridge for an extended period of time, since the buffer remains sealed within the buffer cartridge.
  • the plunger on the upper cartridge may be further advanced to transfer an additional volume of buffer to the second anesthetic cartridge.
  • the second anesthetic cartridge can then be removed from the cartridge connector with the transfer needle again being withdrawn from the septum of the buffer cartridge to preserve the pH of the buffer and additional anesthetic cartridges inserted until the buffer is used up.
  • the methods of the present invention further allow for different volumes of buffer to be delivered to the different anesthetic cartridges which are sequentially replaced and attached to the cartridge connector.
  • volumes in 0.01 increments in the range from 0.01 ml to 0.60 could be selected and "dialed in” to a device which advances the buffer cartridge plunger to deliver any volume increment in that range, in contrast to the limited number of pre-selected volumes deliverable by the devices of the '271 application discussed above.
  • the amount of buffer remaining in the buffer cartridge will be visible to the user so that the same buffer cartridge can be used multiple times until the buffer cartridge is empty, or until so small a volume remains that it is no longer usable. In such cases, the cartridge connector will have collected a significant volume of anesthetic of other parenteral solution being buffered. It will usually be desirable to dispose of the cartridge connector and to later employ a new, sterile cartridge connector with other components of the system (as described below). [0024] In particular aspects of the methods of the present invention, the cartridge connector is manipulated by removably attaching the connector to a cartridge holder which holds the buffer cartridge.
  • the cartridge connector is thus attached at one end to the cartridge holder and includes a sleeve or receptacle at the other end for removably receiving the anesthetic cartridge.
  • the cartridge holder will have a window which allows visual observation of the contents of the buffer cartridge during use.
  • a separate plunger driver may be attached to an opposite end of the cartridge holder for engaging a plunger on the buffer cartridge to controllably dispense and transfer preselected volumes of the buffer to the anesthetic cartridge.
  • the present invention further provides devices for transferring a volume of solution from a first cartridge having a septum to another solution in a second cartridge having a septum.
  • the device comprises a cartridge holder, a plunger driver, and a cartridge connector.
  • the cartridge holder has a proximal end, a distal end, and a chamber for removably receiving the first cartridge, which is typically a buffer, such as a sodium bicarbonate buffer as described in more detail above.
  • the plunger driver is attachable to the proximal end of the cartridge holder and has a piston rod which engages a plunger on the first cartridge, where the piston rod is controllable to axially advance the plunger to deliver pre-selected "dialed-in" volumes of the content of the first cartridge.
  • Such plunger drivers are commercially available from suppliers such as Haselmeier GmbH, St. Gallen, Switzerland.
  • such plunger drivers will have a mechanism which allows a variable volume to be selected and delivered, typically by rotating a knob which displays the volume in a window, and further includes a button which may be depressed for advancing the piston rod to cause the piston rod to travel a distance which will dispense the desired volume of liquid from the first cartridge.
  • the cartridge connector of the present invention has a proximal end which is attachable to the distal end of the cartridge holder and a distal end which is adapted to engage a septum end of the second cartridge.
  • the cartridge connector will further have a sealed interior waste chamber and includes a transfer needle and an exhaust needle.
  • the transfer needle extends from one end of the cartridge connector to the other so that it will penetrate through a septum of the first (e.g. buffer) cartridge at one end and through a septum of the second (e.g. anesthetic) cartridge at the other end.
  • the exhaust needle extends from the second cartridge and terminates within the interior waste chamber.
  • the cartridge holder has a body, typically cylindrical, with a window to allow visual observation of the contents of the cartridge in the cartridge holder. In this way, the user can see when the first cartridge is running low and needs to be replaced.
  • a distal region of the cylindrical body is typically enlarged to removably receive the cartridge connector, and the cartridge connector will typically be interlocked so that the transfer needle can penetrate the first cartridge (held within the cartridge holder) only when the second cartridge is placed over the other end of the transfer needle.
  • the cartridge connector will usually also comprise a cylindrical body, and the cylindrical body will typically be removably received within the enlarged end of the distal region of the cartridge holder.
  • the sealed interior waste chamber of the cartridge connector is defined between spaced-apart walls in the cylindrical body of the cartridge connector, and usually a first end of the cylindrical body will form a cylindrical sleeve which surrounds the exposed ends of the exhaust needle and the transfer needle, where the sleeve is adapted to removably receive the septum end of the second cartridge.
  • the present invention still further provides a cartridge connector for providing or establishing fluid transfer paths between a first cartridge having a septum and a second cartridge having a septum.
  • the cartridge connector comprises a body having a first end, a second end, and a sealed interior waste chamber.
  • a transfer needle has a first end exposed at a first end of the body and a second end exposed at a second end of the body. Both the first and second ends of the transfer needle are capable of penetrating a cartridge septum.
  • An exhaust needle is provided on the body and has a first end exposed at the first end of the body and a second end terminating in the sealed interior waste chamber. At least the first end of the exhaust needle is capable of penetrating a cartridge septum.
  • the first end of the cartridge connector will typically include a cylindrical sleeve or similar structure surrounding the exposed ends of the transfer needle and the exhaust needle.
  • the cylindrical sleeve will be adapted to removably receive the septum of a cartridge, typically an anesthetic cartridge.
  • the first end of the transfer needle is axially spaced-apart from the first end of the exhaust needle so that the material being exhausted will be segregated from the material being transferred in through the transfer needle.
  • the transfer needle will be axially or otherwise disposed through the sealed interior waste chamber, and the second end of the transfer needle will be free from surrounding structure.
  • the cartridge connector will be provided as a separate sterile component of the devices and systems described herein and will be provided with a separate removable cap for placing over the exposed second end of the transfer needle for safety.
  • Fig. 1 is a side view of a dosing pen system constructed in accordance with the principles of the present invention and having a buffer cartridge and an anesthetic cartridge attached.
  • Fig. 2 is a perspective view of the dosing pen system of Fig. 1.
  • Fig. 3 is an exploded view of the dosing pen system of Figs. 1 and 2 illustrating each of the components separately.
  • FIG. 4 illustrates the cartridge connector of the dosing pen system of Figs. 1-3, including a safety cap for protecting an exposed end of a transfer needle.
  • FIG. 5 is an axial cross-sectional view of the cartridge connector of the dosing pen of the present invention illustrating the relative positions of the transfer needle, the exhaust needle, and a sealed interior waste chamber thereof.
  • Figs. 6 and 7 illustrate the attachment of a first (buffer) cartridge and a second (anesthetic) cartridge to the cartridge connector of Fig. 5.
  • Fig. 8 illustrates the manual actuation of the dosing pen system of the present invention.
  • Fig. 9 illustrates the fluid transfer flow between a first (buffer) cartridge, second (anesthetic) cartridge, and sealed interior waste chamber caused by the manual actuation of the dosing pen system.
  • a dosing pen system 10 includes a cartridge holder 12, a plunger driver 14, and a cartridge connector 16.
  • the cartridge connector 16 is removably received in an enlarged distal end 18 of the cartridge holder 12, and the plunger driver 14 includes a piston rod 20 which drives a plunger 22 on a first (buffer) cartridge 24 (best seen in Fig. 3) which is observable through a window 26 through a wall of the cartridge holder 12.
  • the plunger driver 14 may be obtained as a pre-assembled unit from commercial vendors. In particular, Haselmeier GmbH, article number 435300, is suitable for use in the present invention.
  • an anesthetic cartridge 30 is inserted through a distal end 32 of the cartridge connector 16, as will be described in greater detail below with respect to Figs. 5-7.
  • the cartridge connector 16 in turn, is inserted in through distal end 34 of the cartridge holder 12 so that it is received in the enlarged distal end 18.
  • the buffer cartridge 24 is inserted in through a proximal end 36 of the cartridge holder 12 so that it is visible through the window 26 and a septum end penetrates needles of the cartridge connector 16, as described in more detail with respect to Figs. 6 and 7 below.
  • the plunger driver 14 is attached to the proximal end 36 of the cartridge holder 12, typically using a threaded or similar connector 38 at a distal end of the plunger driver. With all the connections just described, the dosing pen 10 is in the configuration illustrated in Figs. 1 and 2.
  • the cartridge connector 16 will typically be provided with a removable cover or cap 40 which protects an exposed end 42 of transfer needle 44, as seen in Figs. 5-7.
  • the cap 40 is provided to protect personnel handling the connector.
  • the cartridge connector 16 will be provided as a sterile component with the cap 40 attached over the exposed end 42 of needle 44, usually in a sterile pack, such as a pouch.
  • the remaining components of the dosing pen, and in particular the cartridge holder 12 and the plunger driver 14 will typically be reusable and will not need to be maintained in or returned to a sterile condition.
  • cleaning with conventional cleaning agents is sufficient between successive uses.
  • the cartridge connector 16 comprises a cylindrical body 50, typically formed from a molded plastic such as ABS, and includes at least one interior chamber 52 (which may be divided into more chambers and/or may include vents, membranes, absorptive materials or other features).
  • the cylindrical body 50 will also usually include an open region or sleeve segment 54 which is adapted to receive the septum end of the anesthetic cartridge 30.
  • the transfer needle 44 extends from proximal end 56 of the cylindrical body 50 to a position within the interior of the open region 54.
  • An exhaust needle 60 has one end within the open region 54 and another end terminating within the sealed chamber 52. Sealed chamber 52 will receive anesthetic or other solution which is being exhausted from the first cartridge 30 as buffer or other solutions are transferred into the first cartridge.
  • the sealed chamber 52 will typically be liquid tight but may have gaseous exhaust paths so that the liquid may fill the chamber while exhausting air or other gases initially present within the chamber. Such exhaust paths can be provided by having capillary exhaust paths formed in the chamber which allow gas to vent while preventing liquid passage. [0044] As shown in Figs.
  • the buffer cartridge 24 is attached to the exposed end 42 of transfer needle 44 by advancing the sharpened end of the needle through the septum end 64 of the first cartridge, as shown in Fig. 7.
  • the septum end 66 of the second cartridge 30 is advanced over the ends of the transfer needle 44 and exhaust needle 60, as shown in Fig. 7.
  • attachment of the second (anesthetic) cartridge 30 to the transfer needle 44 and exhaust needle 60 can be interlocked with the presence of the exposed end 42 of the transfer needle in the first (buffer) cartridge 44.
  • a user can transfer buffer or other parenteral solution to an anesthetic or other parenteral solution by connecting the cartridges 24 and 30 to the cartridge connector 16 as generally shown in Figs. 1-3, 6, and 7.
  • the user then turns knob 70 on the plunger driver 14 to choose the desired transfer volume, as shown in window 72.
  • the user can press the knob 40 using thumb T in order to advance the piston rod 20 a distance determined by the knob rotation which corresponds to the desired volume.
  • the cartridge 30 may be removed and replaced with another cartridge to which the buffer or other solution is to be transferred.
  • the desired transfer volume can then be dialed in and the knob depressed to transfer the buffer to the second cartridge. This process can be continued with further cartridges until the volume of buffer or other solution in cartridge 24 is depleted, as can be seen through window 24 when plunger 22 reaches the far left of the window 26, as shown in Fig. 1.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L’invention concerne un système pour transférer des solutions depuis une première cartouche dans une seconde cartouche, qui comprend un porte-cartouche, un entraîneur de piston et un connecteur de cartouche. Le connecteur de cartouche porte une aiguille de transfert et une aiguille d’évacuation. Le porte-cartouche positionne la première cartouche contre le connecteur de cartouche de manière à ce que l’aiguille de transfert pénètre dans le septum de la première cartouche. La seconde cartouche est insérée de manière amovible dans une autre extrémité du connecteur de cartouche de manière à ce qu’à la fois l’aiguille de transfert et l’aiguille d’évacuation pénètrent dans le septum de la seconde cartouche. L’entraîneur de piston est disposé de manière à faire avancer un piston dans la première cartouche pour transférer une solution depuis la première cartouche dans la seconde cartouche, déplaçant ainsi une solution depuis la seconde cartouche dans l’aiguille d’évacuation. Le connecteur de cartouche comprend une chambre à déchets intérieure scellée destinée à recevoir la solution issue de la seconde cartouche.
PCT/US2010/041613 2009-07-09 2010-07-09 Procédés et appareil pour tamponner des solutions parentérales WO2011006131A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27057209P 2009-07-09 2009-07-09
US61/270,572 2009-07-09

Publications (1)

Publication Number Publication Date
WO2011006131A1 true WO2011006131A1 (fr) 2011-01-13

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013188703A1 (fr) * 2012-06-13 2013-12-19 Py Daniel C Dispositif avec septum pénétrable et aiguille à fermeture
US9931274B2 (en) 2015-09-15 2018-04-03 Dr. Py Institute Llc Septum that decontaminates by interaction with penetrating element
USD829896S1 (en) 2015-09-15 2018-10-02 Dr. Py Institute Llc Septum
US10202214B2 (en) 2013-03-15 2019-02-12 Dr. Py Institute Llc Controlled non-classified filling device and method
WO2024073405A1 (fr) * 2022-09-27 2024-04-04 Onpharma Company Procédé et appareil de mise en tampon d'anesthésiques

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143084A (en) * 1990-05-24 1992-09-01 Spacelabs, Inc. Disposable cartridge for sampling and analyzing body fluids
US5603695A (en) * 1995-06-07 1997-02-18 Erickson; Kim Device for alkalizing local anesthetic injection medication
US20080045925A1 (en) * 2006-06-19 2008-02-21 Stepovich Matthew J Drug delivery system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143084A (en) * 1990-05-24 1992-09-01 Spacelabs, Inc. Disposable cartridge for sampling and analyzing body fluids
US5603695A (en) * 1995-06-07 1997-02-18 Erickson; Kim Device for alkalizing local anesthetic injection medication
US20080045925A1 (en) * 2006-06-19 2008-02-21 Stepovich Matthew J Drug delivery system

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013188703A1 (fr) * 2012-06-13 2013-12-19 Py Daniel C Dispositif avec septum pénétrable et aiguille à fermeture
US10202214B2 (en) 2013-03-15 2019-02-12 Dr. Py Institute Llc Controlled non-classified filling device and method
US9931274B2 (en) 2015-09-15 2018-04-03 Dr. Py Institute Llc Septum that decontaminates by interaction with penetrating element
USD829896S1 (en) 2015-09-15 2018-10-02 Dr. Py Institute Llc Septum
US10688020B2 (en) 2015-09-15 2020-06-23 Dr. Py Institute Llc Septum that decontaminates by interaction with penetrating element
WO2024073405A1 (fr) * 2022-09-27 2024-04-04 Onpharma Company Procédé et appareil de mise en tampon d'anesthésiques

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