WO2011005714A3 - Compositions liposomales de bendamustine - Google Patents
Compositions liposomales de bendamustine Download PDFInfo
- Publication number
- WO2011005714A3 WO2011005714A3 PCT/US2010/040990 US2010040990W WO2011005714A3 WO 2011005714 A3 WO2011005714 A3 WO 2011005714A3 US 2010040990 W US2010040990 W US 2010040990W WO 2011005714 A3 WO2011005714 A3 WO 2011005714A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- bendamustine
- liposomal compositions
- compositions
- treating
- lymphoproliferative disorders
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Abstract
L'invention porte sur des compositions comprenant un liposome couplé à un ligan de siglec comprenant de la bendamustine, et sur leur utilisation dans le traitement de troubles lymphoprolifératifs des lymphocytes B et sur des compositions comprenant des liposomes non ciblés comprenant de la bendamustine, et sur leur utilisation dans le traitement de troubles lymphoprolifératifs des lymphocytes B et de tumeurs solides.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27033009P | 2009-07-07 | 2009-07-07 | |
US61/270,330 | 2009-07-07 | ||
US23890709P | 2009-09-01 | 2009-09-01 | |
US61/238,907 | 2009-09-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011005714A2 WO2011005714A2 (fr) | 2011-01-13 |
WO2011005714A3 true WO2011005714A3 (fr) | 2011-05-26 |
Family
ID=43429800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/040990 WO2011005714A2 (fr) | 2009-07-07 | 2010-07-02 | Compositions liposomales de bendamustine |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2011005714A2 (fr) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1655038A1 (fr) * | 2003-08-01 | 2006-05-10 | National Institute of Advanced Industrial Science and Technology | Liposome dirige sur une cible, enterique et a absorption commandee possedant une chaine de sucre, ainsi que remede contre le cancer contenant ce liposome et diagnostic mettant en oeuvre ce liposome |
US20060193906A1 (en) * | 2002-01-30 | 2006-08-31 | National Institute Of Advanced Industrial Science And Technology | Sugar-modified liposome and products comprising the liposome |
US20070286896A1 (en) * | 2003-08-01 | 2007-12-13 | National Institute Of Advanced Industrial Science And Technology | Therapeutic or Diagnostic Drug for Inflammatory Disease Comprising Targeting Liposome |
US20080193511A1 (en) * | 2004-12-23 | 2008-08-14 | Ulrich Massing | Manufacture of Lipid-Based Nanoparticles Using a Dual Asymmetric Centrifuge |
-
2010
- 2010-07-02 WO PCT/US2010/040990 patent/WO2011005714A2/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060193906A1 (en) * | 2002-01-30 | 2006-08-31 | National Institute Of Advanced Industrial Science And Technology | Sugar-modified liposome and products comprising the liposome |
EP1655038A1 (fr) * | 2003-08-01 | 2006-05-10 | National Institute of Advanced Industrial Science and Technology | Liposome dirige sur une cible, enterique et a absorption commandee possedant une chaine de sucre, ainsi que remede contre le cancer contenant ce liposome et diagnostic mettant en oeuvre ce liposome |
US20070286896A1 (en) * | 2003-08-01 | 2007-12-13 | National Institute Of Advanced Industrial Science And Technology | Therapeutic or Diagnostic Drug for Inflammatory Disease Comprising Targeting Liposome |
US20080193511A1 (en) * | 2004-12-23 | 2008-08-14 | Ulrich Massing | Manufacture of Lipid-Based Nanoparticles Using a Dual Asymmetric Centrifuge |
Also Published As
Publication number | Publication date |
---|---|
WO2011005714A2 (fr) | 2011-01-13 |
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