WO2011001342A1 - Système d'éclairage de corps pour régulation de l'horloge biologique d'un mammifère par exposition cutanée au rayonnement - Google Patents

Système d'éclairage de corps pour régulation de l'horloge biologique d'un mammifère par exposition cutanée au rayonnement Download PDF

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Publication number
WO2011001342A1
WO2011001342A1 PCT/IB2010/052892 IB2010052892W WO2011001342A1 WO 2011001342 A1 WO2011001342 A1 WO 2011001342A1 IB 2010052892 W IB2010052892 W IB 2010052892W WO 2011001342 A1 WO2011001342 A1 WO 2011001342A1
Authority
WO
WIPO (PCT)
Prior art keywords
illumination system
light
radiation
light sources
body illumination
Prior art date
Application number
PCT/IB2010/052892
Other languages
English (en)
Inventor
Victoria Caroline Patrizia Kolb-Bachofen
Jörg LIEBMANN
Matthias Born
Ulrich Niemann
Original Assignee
Koninklijke Philips Electronics N.V.
Philips Intellectual Property & Standards Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics N.V., Philips Intellectual Property & Standards Gmbh filed Critical Koninklijke Philips Electronics N.V.
Publication of WO2011001342A1 publication Critical patent/WO2011001342A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0618—Psychological treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0636—Irradiating the whole body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light

Definitions

  • Body illumination system for controlling the biological clock of a mammal by radiation exposure of the skin
  • the invention relates to a body illumination system for controlling the biological rhythm of a mammal, such as a human. More specifically, the invention relates to a body illumination system for controlling the biological rhythm of a mammal using extra- ocular radiation.
  • a disadvantage of the administering of radiation through the eye of a person in order to affect the biological rhythm is that it requires the person to be awake. Furthermore, visual exposure of persons to blue light that, as typically applied, may cause so-called "blue light hazard".
  • GB 2 378 656 discloses a means for modulating circadian rhythm where the output wavelength of the applied light source is concentrated around a wavelength of 440- 480 nm.
  • the light is directed extra-ocularly, especially to blood vessels in or subjacent to the skin.
  • the light energy in the selected wavebands is in the range of 2OxIO 12 - 100x10 12 photons per square centimeter per second.
  • a body illumination system configured for controlling a biological rhythm of a mammal.
  • the illumination system comprises one or more light sources configured for emitting light in a wavelength range of 400-480 nm.
  • the body illumination system is configured for exposing a surface area greater than 0.5 m 2 of the body to the emitted light.
  • the body illumination system is configured such that the power density of the emitted light on the surface area of the body is greater than 125 mW/cm 2 .
  • a method for controlling the biological rhythm of a mammal involves exposing a part of a body greater than 0,5 m 2 to a body illumination system emitting light in a wavelength range of 400-480 nm such that the power density of the emitted light on the surface area of the body is greater than 10 mW/cm 2 .
  • UVB irradiation targeting superficial layers of skin namely keratinocytes
  • the UVB irradiation used comprises a wavelength range of 280-320 nm and the power density of the emitted light was 0.35 mW per cm 2 .
  • the experimental system of Kawara et al is not practically applicable for controlling biological rhythms, since the applied wavelength of the radiation is toxic for mammals and the power density is too small to obtain a noticeable effect within a reasonable time period. While the wavelength range of the radiation as disclosed in GB 2 378 656 substantially avoids toxic radiation effects, the document prescribes that very low power densities, i.e. smaller than 40 microwatts per square centimeter, should be used.
  • the light sources of GB 2 378 656 may be mounted on a human body, e.g. using a head- worn device.
  • the applicant of the present invention has found that it is possible to use an illumination system capable of exposing a larger part of a body to radiation in a non-toxic dominant wavelength regime with a much greater power density in order to obtain effective control of a human biological rhythm within a reasonable period of time.
  • the exposure of the skin of the mammal allows for the administering of the radiation without exposing the eyes of the person to the radiation, e.g. during sleep.
  • the embodiment as defined in claim 3 provides for a highly effective type of light source to accomplish a body illumination system with the required parameters defined in claim 1.
  • other light sources such as high intensity discharge lamps, may be applied, more heat is generated by such light sources towards the body.
  • light sources generate light at other visible wavelengths which is experienced as annoying by users.
  • the high power blue light sources may e.g. be Luxeon ® Rebel LED's.
  • the LED's may have an optical power in the range of 175-740 mW and an operating current between
  • the embodiment as defined in claim 4 has the advantage of efficient placement and control of the light sources.
  • claims 5 and 12 define a relatively short exposure time of the mammal to the specified radiation to control the biological rhythm. This short exposure time is possible as a result of the high power density and large surface area that is radiated by the body illumination system.
  • claims 6-8, 13 and 14 define suitable means for incorporating at least a part of the body illumination system. Both resting means and clothing can be used as a result of the illumination of the skin of the mammal as opposed to the eye, i.e. extra-ocular application of the radiation. These can be conveniently applied during sleep.
  • FIGS. IA- 1C show schematic illustrations of a body illumination system according to various embodiments of the invention.
  • FIG. 2 shows a further illustration of a body illumination system incorporated in clothing of a human being
  • FIGS. 3A-3F provide results of in vitro experiments using 453 nm radiation on human skin cell cultures; DETAILED DESCRIPTION OF THE DRAWINGS
  • FIGS. IA- 1C provide schematic illustrations of a body illumination system 1 for controlling a biological rhythm of a person 2.
  • a person 2 lies on a bed 3 to be illuminated by the body illumination system 1.
  • the body illumination system 1 comprises a plurality of light sources 4 configured for emitting light L to the person 2 in a sun-bed like arrangement.
  • FIG. IB two panels, oriented at an angle of 45° with respect to the bed 3, are provided that comprise light sources 4.
  • the light sources 4 are not necessarily provided over the entire body of the person 2.
  • the body illumination system 1 may e.g. be comprised in a room R, the light sources 4 being accommodated in the walls of the room R, or being integrated in a standing system, as shown in FIG. 1C.
  • the body illumination system 1 is arranged for exposing a surface area greater than 0.5 m 2 of the person 2 to the emitted light, or greater than 0.75 or 1 m 2 of the skin of the person 2.
  • the light sources 4 are preferably high power light-emitting diodes (LED's).
  • These LED's 4 may be Luxeon ® Rebel ® LED's of Lumileds.
  • the LED's have an optical power in the range of 175-740 mW and an operating current between 350-700 mA.
  • the number of LED's may vary between 10 and 1000, dependent on the application.
  • the LED's 4 may be provided in modules 5 (see e.g. FIG. IA).
  • the body illumination system 1 comprises a control unit 6 containing a controller 7 and a timer 8. It is noted that the control unit 6 may also be provided for the body illumination systems 1 of FIGS. IB and 1C.
  • the light sources 4 of the body illumination system 1 are specifically configured for emitting light in a wavelength range of 400-480 nm.
  • the controller 5 is programmed such that the power density is greater than 10 mW/cm 2 , particularly greater than 50, 75, 100, 120, 125 or even 200 mW/cm 2 of the body of the person 2. These settings effectively expose the person 2 to the radiation in order to control a biological rhythm, such as the circadian clock, of the person 2 within a reasonable period of time.
  • the control unit 6 may comprise further modules, including e.g. a memory module for data storage, including storage of the settings of the power density.
  • the control unit 6 is configured for controlling the light sources 4 by means of the controller 7 and the timer 8.
  • the controller 7 may be triggered to activate the light sources 4 (and, possibly, to set operating parameters of the light sources) by the timer 8.
  • the timer 8 may be programmed to allow exposure to the radiation of the light sources 4 for only a limited period of time, e.g. 1 hour or 40 minutes, during a particular time period, e.g. a day.
  • FIG. 2 schematically depicts a plurality of light sources 4 of a body
  • illumination system 1 incorporated in a shirt 10.
  • other types of clothing such as trousers, jackets or other garment, may be used as well.
  • FIGS. 3A-3F provide results of in vitro experiments using 453 nm radiation on human skin cell cultures using different energy densities of 33, 66 and 100 J/cm 2 delivered three times during three consecutive days. The radiation was applied to the human skin cell cultures at a power density of about 125 mW/cm 2 .
  • FIGS. 3 A and 3B illustrate the relative proliferation of endothelial cells and keratinocytes, respectively, for various energy densities. Clearly, cell proliferation is inhibited with increasing energy density. For the keratinocytes, the decrease of the cell proliferation results from an increased cell differentiation, as shown in FIG. 3C. The differentiation measurement was performed using Involucrin as a differentiation marker.
  • FIG. 3D shows the analysis of cleavage of poly(ADP-ribose) polymerase (PARP), which is a marker for programmed cell death (apoptosis).
  • PARP poly(ADP-ribose) polymerase
  • FIG. 3D shows the analysis of cleavage of poly(ADP-ribose) polymerase (PARP), which is a marker for programmed cell death (apoptosis).
  • PARP poly(ADP-ribose) polymerase
  • FIG. 3E shows a real-time polymerase chain reaction (PCR) analysis of the expression of circadian clock cycle genes Cry-1 and Cry-2 in human keratinocytes after exposure to 453 nm radiation at a energy density of 100 J/cm 2 .
  • PCR polymerase chain reaction
  • inflammation i.e. no increase of cytokine production, occurs in response to the radiation and that also the normal state of homeostasis is not affected, i.e. the cytokine production does not decrease below base level.
  • wavelength ranges of 400-480 nm may be used. While in the lower part of this range toxic effects have been observed for the in vitro cell cultures, it is believed that practical in vivo application on humans may not show these toxic effects as a result of absorption and scattering of part of the radiation.

Abstract

La présente invention concerne une méthode et un système d'éclairage de corps conçu pour réguler un rythme biologique d'un mammifère. Ledit système d'éclairage comprend une ou plusieurs sources lumineuses conçues pour émettre de la lumière dans une plage de longueur d'ondes de 400 à 480 nm. Ledit système d'éclairage de corps est conçu pour exposer une zone de surface supérieure à 0,5 m2 du corps à la lumière émise. Le système d'éclairage de corps est conçu de telle sorte que la densité de puissance de la lumière émise sur la zone de surface du corps est supérieure à 125 mW/cm2. Ladite méthode et ledit système procurent un système d'éclairage capable d'exposer une plus grande partie d'un corps à un rayonnement dans un régime de longueur d'ondes dominant non toxique, avec une densité de puissance nettement supérieure, afin d'obtenir une régulation efficace d'un rythme biologique humain dans une période de temps raisonnable. L'exposition de la peau du mammifère permet l'administration du rayonnement sans exposer les yeux de la personne au rayonnement, par exemple durant le sommeil.
PCT/IB2010/052892 2009-06-30 2010-06-24 Système d'éclairage de corps pour régulation de l'horloge biologique d'un mammifère par exposition cutanée au rayonnement WO2011001342A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09164096.1 2009-06-30
EP09164096 2009-06-30

Publications (1)

Publication Number Publication Date
WO2011001342A1 true WO2011001342A1 (fr) 2011-01-06

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Family Applications (1)

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PCT/IB2010/052892 WO2011001342A1 (fr) 2009-06-30 2010-06-24 Système d'éclairage de corps pour régulation de l'horloge biologique d'un mammifère par exposition cutanée au rayonnement

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WO (1) WO2011001342A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2288410A1 (fr) * 2008-04-10 2011-03-02 Koninklijke Philips Electronics N.V. Système d'éclairage de corps à l'aide d'une lumière bleue
GB2529278A (en) * 2014-08-03 2016-02-17 Josef Wolfgang Tainsh Retinal sleep lamp V2

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2360461A (en) * 2000-03-23 2001-09-26 Photo Therapeutics Ltd Therapeutic light source and metho
WO2003005883A2 (fr) * 2001-07-09 2003-01-23 Perricone Nicholas V Traitement de la peau a base de lumiere bleue et violette
GB2378656A (en) 2001-08-14 2003-02-19 Stephen Bryce Hayes Means for modulation of circadian rhythms
US20030187486A1 (en) * 2002-03-29 2003-10-02 Savage Henry C. Portable light delivery apparatus and methods
DE10224705A1 (de) * 2002-06-04 2003-12-18 Uwe Rathsack Geräte zur positiven Beeinflussung lebender Organismen mittels Licht
US6669627B1 (en) * 1999-07-09 2003-12-30 Cornell Research Foundation Inc. REM sleep augmentation with extra-ocular light
US20050002178A1 (en) * 2003-07-02 2005-01-06 Jenny Wu Apparatus for adjusting biological clock of a traveler
US20090105791A1 (en) * 2007-10-23 2009-04-23 Mcginnis William J Light emitting medical garment device, kit and method of using

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6669627B1 (en) * 1999-07-09 2003-12-30 Cornell Research Foundation Inc. REM sleep augmentation with extra-ocular light
GB2360461A (en) * 2000-03-23 2001-09-26 Photo Therapeutics Ltd Therapeutic light source and metho
WO2003005883A2 (fr) * 2001-07-09 2003-01-23 Perricone Nicholas V Traitement de la peau a base de lumiere bleue et violette
GB2378656A (en) 2001-08-14 2003-02-19 Stephen Bryce Hayes Means for modulation of circadian rhythms
US20030187486A1 (en) * 2002-03-29 2003-10-02 Savage Henry C. Portable light delivery apparatus and methods
DE10224705A1 (de) * 2002-06-04 2003-12-18 Uwe Rathsack Geräte zur positiven Beeinflussung lebender Organismen mittels Licht
US20050002178A1 (en) * 2003-07-02 2005-01-06 Jenny Wu Apparatus for adjusting biological clock of a traveler
US20090105791A1 (en) * 2007-10-23 2009-04-23 Mcginnis William J Light emitting medical garment device, kit and method of using

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KAWARA ET AL., J. INVEST. DERMATOL., vol. 119, 2002, pages 1220 - 1223

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2288410A1 (fr) * 2008-04-10 2011-03-02 Koninklijke Philips Electronics N.V. Système d'éclairage de corps à l'aide d'une lumière bleue
GB2529278A (en) * 2014-08-03 2016-02-17 Josef Wolfgang Tainsh Retinal sleep lamp V2

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