WO2010149947A3 - Antimicrobial agent - Google Patents

Antimicrobial agent Download PDF

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Publication number
WO2010149947A3
WO2010149947A3 PCT/GB2010/001114 GB2010001114W WO2010149947A3 WO 2010149947 A3 WO2010149947 A3 WO 2010149947A3 GB 2010001114 W GB2010001114 W GB 2010001114W WO 2010149947 A3 WO2010149947 A3 WO 2010149947A3
Authority
WO
WIPO (PCT)
Prior art keywords
antimicrobial agent
hydroxyl
amine
optionally substituted
carboxylic acid
Prior art date
Application number
PCT/GB2010/001114
Other languages
French (fr)
Other versions
WO2010149947A2 (en
Inventor
Gareth Griffiths
Zhou Yi
Andrew James Sutherland
Original Assignee
Aston University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aston University filed Critical Aston University
Publication of WO2010149947A2 publication Critical patent/WO2010149947A2/en
Publication of WO2010149947A3 publication Critical patent/WO2010149947A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/597—Unsaturated compounds containing a keto groups being part of a ring of a five-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A compound of the Formula (I) below for use as an antimicrobial agent wherein R1 is H or a C1-C15 hydrocarbyl group that is optionally substituted with a hydroxyl, amine, carboxylic acid and/or ester functional group, and R2 is H or a C1-C15 hydrocarbyl group that is optionally substituted with a hydroxyl, amine, carboxylic acid and/or ester functional group, with the provisos that if R1 is -H, R2 is not H, and if R1 is -CH2CH=CHCH2CH3, R2 is not - (CH2) 7COOH.
PCT/GB2010/001114 2009-06-23 2010-06-08 Antimicrobial agent WO2010149947A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0910856.4A GB0910856D0 (en) 2009-06-23 2009-06-23 Antimicrobial agent
GB0910856.4 2009-06-23

Publications (2)

Publication Number Publication Date
WO2010149947A2 WO2010149947A2 (en) 2010-12-29
WO2010149947A3 true WO2010149947A3 (en) 2011-06-09

Family

ID=40972668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2010/001114 WO2010149947A2 (en) 2009-06-23 2010-06-08 Antimicrobial agent

Country Status (2)

Country Link
GB (1) GB0910856D0 (en)
WO (1) WO2010149947A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976679A (en) * 1970-07-23 1976-08-24 Weinheimer Alfred J Novel compounds from coral
JPS58134073A (en) * 1982-02-05 1983-08-10 Sagami Chem Res Center Cyclopentenone derivative
EP1112742A1 (en) * 1998-08-18 2001-07-04 Takara Shuzo Co, Ltd. Remedies or preventives containing cyclopentenone compounds as the active ingredient
WO2004013077A2 (en) * 2002-08-06 2004-02-12 Charterhouse Therapeutics Ltd Cyclopentanone and cyclopentanone derivatives as potent activators of hsf-1
WO2005080311A1 (en) * 2004-02-25 2005-09-01 Leibniz-Institut Für Pflanzenbiochemie (Ipb) Hygrophorones and derivatives thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976679A (en) * 1970-07-23 1976-08-24 Weinheimer Alfred J Novel compounds from coral
JPS58134073A (en) * 1982-02-05 1983-08-10 Sagami Chem Res Center Cyclopentenone derivative
EP1112742A1 (en) * 1998-08-18 2001-07-04 Takara Shuzo Co, Ltd. Remedies or preventives containing cyclopentenone compounds as the active ingredient
WO2004013077A2 (en) * 2002-08-06 2004-02-12 Charterhouse Therapeutics Ltd Cyclopentanone and cyclopentanone derivatives as potent activators of hsf-1
WO2005080311A1 (en) * 2004-02-25 2005-09-01 Leibniz-Institut Für Pflanzenbiochemie (Ipb) Hygrophorones and derivatives thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 198338, Derwent World Patents Index; AN 1983-767205, XP002618722 *
ITO M ET AL: "Regio- and stereoselective installation of alkyl groups onto cis 4-cyclopentene-1,3-diol monoacetate by using reagents derived from alkylmagnesium halides", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 42, no. 3, 15 January 2001 (2001-01-15), pages 423 - 427, XP004316584, ISSN: 0040-4039, DOI: DOI:10.1016/S0040-4039(00)01983-3 *
MICHIKO ITO, MICHITAKA MATSUUMI, MODACHUR G. MURUGESH, AND YUICHI KOBAYASHI: "Scope and Limitation of Organocuprates, and Copper or Nickel Catalyst-Modified Grignard Reagents for Installation of an Alkyl Group onto cis-4-Cyclopentene-1,3-diol Monoacetate", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 17, 26 July 2001 (2001-07-26), pages 5881 - 5889, XP002618723, DOI: 10.1021/jo010474w *
MILLER J A ET AL: "Synthesis and anti-fungal properties of some simple cyclopentenones and derivatives", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 42, no. 5, 29 January 2001 (2001-01-29), pages 955 - 959, XP004314726, ISSN: 0040-4039, DOI: DOI:10.1016/S0040-4039(00)02110-9 *
WEAVING R ET AL: "A rapid access to chiral alkylidene cyclopentenone prostaglandins involving ring-closing metathesis reaction", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 44, no. 12, 17 March 2003 (2003-03-17), pages 2579 - 2581, XP004412189, ISSN: 0040-4039, DOI: DOI:10.1016/S0040-4039(03)00237-5 *

Also Published As

Publication number Publication date
WO2010149947A2 (en) 2010-12-29
GB0910856D0 (en) 2009-08-05

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