WO2010143827A2 - Oil-gel soft patch for attachment to the skin and method for preparing same - Google Patents

Oil-gel soft patch for attachment to the skin and method for preparing same Download PDF

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Publication number
WO2010143827A2
WO2010143827A2 PCT/KR2010/003283 KR2010003283W WO2010143827A2 WO 2010143827 A2 WO2010143827 A2 WO 2010143827A2 KR 2010003283 W KR2010003283 W KR 2010003283W WO 2010143827 A2 WO2010143827 A2 WO 2010143827A2
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Prior art keywords
ethyl cellulose
oil
castor oil
softener
skin
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PCT/KR2010/003283
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French (fr)
Korean (ko)
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WO2010143827A3 (en
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타카오마루오카
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한웅코텍 주식회사
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Publication of WO2010143827A2 publication Critical patent/WO2010143827A2/en
Publication of WO2010143827A3 publication Critical patent/WO2010143827A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug

Definitions

  • the present invention relates to an oil-gel patch for skin and a method for producing the same for adsorbing an active ingredient such as a drug or a cosmetic ingredient into the body or through the skin by adhering to the skin.
  • a simple lotion or ointment may be used.
  • the base of the patch includes an aqueous, oily, emulsion base, and the like, and the aqueous base is difficult to increase its content when the active ingredient (and the carrier component to assist its movement) is oily, and is also difficult to thin.
  • Oil-based and emulsion-based bases are based on rubber or synthetic resins, which are highly cohesive, and are basically hard gels, which are difficult to increase the content of active ingredients (and carrier components that help them move). The movement is also slow. This is because the active ingredient is not contained by the chemical affinity in the base, but simply because it is physically included.
  • the cohesive oily base is widely used because the patch base must be well-formed, adhere well, and come off cleanly. Therefore, the oily base is an active ingredient (and carrier that helps transport). In most cases, the utilization rate is less than or equal to 1% because the components do not move smoothly.
  • Korean Patent No. 10-0741654 which is a prior application patent of the inventor of the present invention, discloses a skin-applied oil-gel patch based on ethyl cellulose and castor oil as a base component. All of the components have excellent mobility, usability, etc., but improvement is required in terms of adhesion.
  • Skin-applied oil-gel soft patch of the present invention for achieving the above object is characterized in that the base includes ethyl cellulose, castor oil, elastomer and softener.
  • the inventor of the present invention adds an elastomer having loose molecular bonds by softener to ethyl cellulose having loose molecular bonds by castor oil, thereby increasing cohesion of the base without impairing the mobility of the active ingredient within the base, thereby improving adhesion.
  • the assumption is that it will be improved and confirmed through experiments.
  • the elastomer may be used as long as it is mixed with a mixture of ethyl cellulose and castor oil to improve cohesion, that is, adhesion, and may be used, for example, natural rubber, synthetic isoprene rubber, styrene-isoprene-styrene rubber, and polyisoprene rubber.
  • Softeners are added to the mixture of ethylcellulose and castor oil in order to mitigate them because the elastomer is too dense and interferes with the movement of active ingredients.
  • elastomer is too dense and interferes with the movement of active ingredients.
  • mineral oil polyisobutylene, polyacrylic acid ester, polybutene Select and use.
  • the skin oil-gel soft patch The skin oil-gel soft patch,
  • step (3) is prepared through a process comprising applying to the woven fabric, nonwoven fabric or synthetic film a mixture of ethylcellulose and castor oil prepared in step (2), elastomer and softener, drug or cosmetic ingredients,
  • the mixed solution (A) of ethyl cellulose and castor oil and the mixed solution (B) of the elastomer and softener are separately prepared, and then the two mixed solutions (A) and (B) are mixed.
  • cohesion force improves, without compromising the ability of the active ingredient to move in a base material, and adhesive force improves and thickness becomes possible.
  • a comparative sample prepared by applying only the sample according to the present invention and a mixed solution of ethyl cellulose and castor oil (A liquid) was prepared, and adhesion strength was compared.
  • the adhesive strength of the specimen (the present invention) coated by mixing A liquid and B liquid at 3.25: 6.75 was 80 g / 25 mm, and the comparative sample coated with only A liquid 100% more than the adhesive strength of 30g / 25mm.
  • a sample containing vitamin E as an active ingredient was prepared and compared by measuring the amount of vitamin E migration in the base.
  • a liquid single composition (without addition of vitamin E) was coated on the nonwoven fabric at a thickness of 350 g / m 2 .
  • the movement amount of vitamin E measured by HPLC was about 5% of the added amount of the sample of Comparative Example 1 (Compound A composition alone) and 1% of Comparative Sample 2 (composition of B solution alone).
  • the mobility of the SIS / paraffin oil mixed solution (B liquid) alone is significantly lower, the mobility is not lower than that of the ethyl cellulose / castor oil mixed liquid (A liquid) even if it is mixed with the ethyl cellulose / castor oil mixed liquid (A liquid). It means that it does not, it can be seen that by the present invention mixing the liquid A and liquid B has only the advantages of the two compositions, that is, liquid A and liquid B.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to an oil-gel soft patch for attachment to the skin, which is to be attached to the skin of a user to enable the active ingredients of drugs, cosmetic compositions, or the like to be absorbed into the skin or into the body through the skin, and has an aim of improving the adhesiveness of a base material without degrading the flowability of the active ingredients (and carrier ingredients which assist in the flow of the active ingredients) in the base material. The oil-gel soft patch attachment to the skin according to the present invention has a base material containing ethyl cellulose, castor oil, elastomer, and a softener, and is prepared by: (1) a step of mixing the ethyl cellulose and the castor oil to obtain a liquid mixture (A) of the ethyl cellulose and castor oil, and mixing the elastomer and the softener separately from the liquid mixture (A) of the ethyl cellulose and castor oil to obtain a liquid mixture (B) of the elastomer and softener; (2) a step of mixing the liquid mixture (A) of the ethyl cellulose and castor oil, the liquid mixture (B) of the elastomer and softener, and drugs or cosmetic compositions if needed; and (3) a step of applying the liquid mixture of the ethyl cellulose and castor oil, the elastomer and the softener, and the drugs or cosmetic compositions obtained in the step (2), to woven fabric, non-woven fabric, or a synthetic resin film.

Description

피부부착용 오일-겔 소프트 패치 및 그의 제조방법 Oil-gel soft patch for skin adhesion and preparation method thereof
본 발명은 피부에 부착함으로써 약물이나 화장성분 등의 유효성분을 피부로 또는 피부를 통하여 체내로 흡수시키기 위한 피부부착용 오일-겔 패치 및 그의 제조방법에 관한 것이다. The present invention relates to an oil-gel patch for skin and a method for producing the same for adsorbing an active ingredient such as a drug or a cosmetic ingredient into the body or through the skin by adhering to the skin.
어떤 약물이나 화장성분을 피부로 또는 피부를 통하여 체내로 흡수시키고자 하는 경우, 간단한 로션이나 연고 형태가 사용되기도 하지만 피부에 부착하는 패치 형태 또한 많이 사용된다. If you want to absorb certain drugs or cosmetic ingredients into your skin or through your body, a simple lotion or ointment may be used.
패치의 기제로는 수성, 유성, 에멀젼 기제 등이 있는데, 수성 기제는 유효성분 (및 그 이동을 돕는 캐리어 성분)이 유성인 경우 그 함유량을 높이기도 어렵고, 박층화 (薄層化)도 어렵다. The base of the patch includes an aqueous, oily, emulsion base, and the like, and the aqueous base is difficult to increase its content when the active ingredient (and the carrier component to assist its movement) is oily, and is also difficult to thin.
유성 및 에멀젼 기제는 기제의 주성분으로 고무계나 합성수지계가 사용되는데 이들은 응집력이 강하고, 기본적으로 하드 겔(hard gel)이어서 역시 유효성분 (및 그 이동을 돕는 캐리어 성분)의 함유량을 높이기 어렵고, 내부에서의 이동도 완만하다. 이는 유효성분이 기제 중에 화학적 친화력에 의해 함유되는 것이 아니라 단순히 물리적으로 포함되기 때문이라 판단된다.Oil-based and emulsion-based bases are based on rubber or synthetic resins, which are highly cohesive, and are basically hard gels, which are difficult to increase the content of active ingredients (and carrier components that help them move). The movement is also slow. This is because the active ingredient is not contained by the chemical affinity in the base, but simply because it is physically included.
어떻든 패치의 기제는 형태가 잘 유지되어야 하고, 잘 붙고 깨끗하게 떨어져야 하는 등 특유의 기능이 요구되기 때문에 응집력이 강한 유성 기제가 많이 사용되는데, 유성 기제는 기제에 함유된 유효성분 (및 이동을 돕는 캐리어 성분)의 이동이 원활하게 이루어지지 않기 때문에 대부분의 경우 그 이용율이 1% 이하에 그친다.In any case, the cohesive oily base is widely used because the patch base must be well-formed, adhere well, and come off cleanly. Therefore, the oily base is an active ingredient (and carrier that helps transport). In most cases, the utilization rate is less than or equal to 1% because the components do not move smoothly.
그리하여 보다 정교한 다층구조의 약물전달 시스템(drug delivery system)이 개발되기도 하였으나 비용과는 상관없이 유효성분을 의도한대로 효과적으로 전달시키는 것만이 전부는 아니므로 다시 말하면, 비용 대비 효과가 좋은 단층구조의 패치도 요구되기 때문에 실용적으로 큰 차이가 나지 않는 범위 내에서 형태유지성 및 점착력을 약간 희생시키는 대신 유효성분의 이동능 (이용율), 점착성과 박리성, 사용감 등이 우수한 오일 겔 패치가 개발되었다.Thus, a more sophisticated multi-layer drug delivery system has been developed, but it is not only cost effective delivery of the active ingredient as intended regardless of cost. Instead of sacrificing formability and adhesive strength slightly within the practically insignificant difference, oil gel patches having excellent mobility (availability), adhesiveness and peelability, and usability have been developed.
오일 겔 패치에 관한 발명으로, 본 발명의 발명자의 선출원특허인 대한민국 등록특허 10-0741654에는 에틸셀룰로즈와 피마자유를 기제의 기본 성분으로 하는 피부적용 오일-겔 패치가 개시되어 있는데 이는 형태유지성, 유효성분의 이동능, 사용감 등 모두 우수하지만 점착력 측면에서는 개선이 요구된다.As an invention relating to an oil gel patch, Korean Patent No. 10-0741654, which is a prior application patent of the inventor of the present invention, discloses a skin-applied oil-gel patch based on ethyl cellulose and castor oil as a base component. All of the components have excellent mobility, usability, etc., but improvement is required in terms of adhesion.
[문헌1] 대한민국 등록특허 10-0741654[Document 1] Republic of Korea Patent Registration 10-0741654
본 발명은 기제 내에서의 유효성분 (및 이동을 돕는 캐리어 성분)의 이동능은 손상시키지 않으면서 기제의 점착력이 향상된 피부부착용 오일-겔 소프트 패치 및 그의 제조방법을 제공하는 것이 목적이다.It is an object of the present invention to provide an oil-gel soft patch for skin adhesion with improved adhesion of a base without impairing the mobility of the active ingredient (and carrier component which assists movement) in the base and a method for producing the same.
상기 목적을 달성하기 위한 본 발명의 피부적용 오일-겔 소프트 패치는 그 기제가 에틸셀룰로즈, 피마자유, 탄성체와 연화제를 포함하는 것을 특징으로 한다.Skin-applied oil-gel soft patch of the present invention for achieving the above object is characterized in that the base includes ethyl cellulose, castor oil, elastomer and softener.
본 발명의 발명자는 피마자유에 의해 분자결합이 느슨해진 에틸셀룰로즈에 연화제에 의해 분자결합이 느슨해진 탄성체를 추가하면 기제 내부에서의 유효성분의 이동능을 손상시키지 않으면서 기제의 응집력을 높여 점착력이 향상될 것이라는 가정을 하고 실험을 통하여 확인한 것이다. The inventor of the present invention adds an elastomer having loose molecular bonds by softener to ethyl cellulose having loose molecular bonds by castor oil, thereby increasing cohesion of the base without impairing the mobility of the active ingredient within the base, thereby improving adhesion. The assumption is that it will be improved and confirmed through experiments.
탄성체는 에틸셀룰로즈와 피마자유의 혼합물에 혼화되어 응집력 즉, 점착력을 향상시킬 수 있는 물질이면 사용이 가능한데 이를테면, 천연고무, 합성 이소프렌고무, 스티렌-이소프렌-스티렌고무, 폴리이소프렌고무에서 선택하여 사용한다.The elastomer may be used as long as it is mixed with a mixture of ethyl cellulose and castor oil to improve cohesion, that is, adhesion, and may be used, for example, natural rubber, synthetic isoprene rubber, styrene-isoprene-styrene rubber, and polyisoprene rubber.
연화제는 에틸셀룰로즈와 피마자유의 혼합물에 탄성체만 추가하면 탄성체가 지나치게 치밀하여 유효성분의 이동을 방해하기 때문에 이를 완화하기 위하여 추가하는 것인데 이를테면, 미네랄오일, 폴리이소부틸렌, 폴리아크릴산 에스테르, 폴리부텐에서 선택하여 사용한다.Softeners are added to the mixture of ethylcellulose and castor oil in order to mitigate them because the elastomer is too dense and interferes with the movement of active ingredients. For example, in mineral oil, polyisobutylene, polyacrylic acid ester, polybutene Select and use.
상기 피부부착용 오일-겔 소프트 패치는,  The skin oil-gel soft patch,
(1) 에틸셀룰로즈와 피마자유를 혼화하여 에틸셀룰로즈와 피마자유의 혼화액(A)을 만들고, 에틸셀룰로즈와 피마자유의 혼화액(A)과는 별도로 탄성체와 연화제를 혼화하여 탄성체와 연화제의 혼화액(B)을 만드는 단계; (1) Mixing ethyl cellulose and castor oil to form a mixed solution of ethyl cellulose and castor oil (A), and mixing an elastic body and a softener separately from the mixed solution (A) of ethyl cellulose and castor oil, B) making;
(2) (1) 단계에서 제조된 에틸셀룰로즈와 피마자유의 혼화액(A)과, 탄성체와 연화제의 혼화액(B)과, 필요에 따라 약물 또는 화장성분을 혼합하는 단계; 및  (2) mixing a mixed solution (A) of ethyl cellulose and castor oil prepared in step (1), a mixed solution (B) of an elastic body and a softener, and a drug or cosmetic component as necessary; And
(3) (2)단계에서 제조된 에틸셀룰로즈와 피마자유, 탄성체와 연화제, 약물 또는 화장성분의 혼화액을 직포, 부직포 또는 합성수지필름에 도포하는 단계를 포함하는 공정을 통하여 제조하는데, (3) is prepared through a process comprising applying to the woven fabric, nonwoven fabric or synthetic film a mixture of ethylcellulose and castor oil prepared in step (2), elastomer and softener, drug or cosmetic ingredients,
에틸셀룰로즈와 피마자유의 혼화액(A)과, 탄성체와 연화제의 혼화액(B)을 따로따로 제조한 후, 두 혼화액 (A)와 (B)를 혼합하는 것이 특징이다.  The mixed solution (A) of ethyl cellulose and castor oil and the mixed solution (B) of the elastomer and softener are separately prepared, and then the two mixed solutions (A) and (B) are mixed.
에틸셀룰로즈, 피마자유, 탄성체 및 연화제의 4가지 성분을 한꺼번에 혼합하여 기제로 사용하면 점착력과 유효성분의 이동능이 떨어지는데 이는 피마자유가 에틸셀룰로즈의 분자결합을 느슨하게 하고, 연화제가 탄성체의 분자결합을 느슨하게 할 것이라는 가정과 일치한다. 부연하여 설명하면, 피마자유와 연화제가 희석되어 제 역할을 충분히 하지 못하게 되는 것이다. When four ingredients of ethyl cellulose, castor oil, elastomer and softener are mixed at the same time, adhesive force and effective ingredient mobility are reduced. Castor oil loosens the molecular bond of ethyl cellulose and softener loosens the molecular bond of elastomer. It is consistent with the assumption that In other words, castor oil and softeners are diluted so that they do not fully function.
본 발명에 의하면 기제 내에서의 유효성분의 이동능은 손상시키지 않으면서 응집력이 향상되어 점착력의 개선되고 박층화가 가능해진다.ADVANTAGE OF THE INVENTION According to this invention, cohesion force improves, without compromising the ability of the active ingredient to move in a base material, and adhesive force improves and thickness becomes possible.
본 발명의 구성은 후술하는 실시예를 통하여 더욱 명확해질 것이나 본 발명의 권리범위가 이에 한정되는 것은 아니다.The configuration of the present invention will be clearer through the following examples, but the scope of the present invention is not limited thereto.
<실시예 1 및 비교예><Example 1 and Comparative Example>
본 발명에 의한 검체와 에틸셀룰로즈와 피마자유의 혼합액(A액)만 도포한 비교검체를 제작하여 점착력을 비교하였다.A comparative sample prepared by applying only the sample according to the present invention and a mixed solution of ethyl cellulose and castor oil (A liquid) was prepared, and adhesion strength was compared.
1. 검체의 제작1. Preparation of Specimen
a) 본 발명에 의한 검체a) specimen according to the present invention
에틸셀룰로즈 : 피마자유 = 1 : 5로 혼합하여 에틸셀룰로즈/피마자유 혼합액 (A액)을 만들고, SIS(스티렌-이소프렌-스티렌고무) : 파라핀오일(미네랄오일)= 1 : 2로 혼합하여 SIS/파라핀오일 혼합액 (B액)을 만든 다음, A액과 B액을 3.25 : 6.75로 혼합하여 부직포에 350g/m2의 두께로 코팅하였다.Ethyl cellulose: Castor oil = 1: 5 mixed to make an ethyl cellulose / castor oil mixed solution (A liquid), SIS (styrene-isoprene-styrene rubber): paraffin oil (mineral oil) = 1: 2 mixed with SIS / Paraffin oil mixture solution (B solution) was prepared, and then A solution and B solution were mixed at 3.25: 6.75 and coated on a nonwoven fabric having a thickness of 350 g / m 2 .
b) 비교 검체b) comparative sample
부직포에 A액만 350g/m2의 두께로 코팅하였다. Only non-woven fabric A was coated with a thickness of 350 g / m 2 .
2. 점착력의 비교2. Comparison of adhesive force
두 검체의 점착력을 JIS Z 0237의 방법에 따라 측정한 결과, A액과 B액을 3.25 : 6.75로 혼합하여 코팅한 검체(본 발명)의 점착력은 80g/25mm로, A액만을 코팅한 비교 검체의 점착력 30g/25mm보다 100% 이상 증가하였다.As a result of measuring the adhesive strength of the two specimens according to the method of JIS Z 0237, the adhesive strength of the specimen (the present invention) coated by mixing A liquid and B liquid at 3.25: 6.75 was 80 g / 25 mm, and the comparative sample coated with only A liquid 100% more than the adhesive strength of 30g / 25mm.
<실시예 2 및 비교예><Example 2 and Comparative Example>
유효성분으로 비타민 E를 함유시킨 검체를 제작하여 기제 내에서의 비타민 E의 이동량을 측정하여 비교하였다.A sample containing vitamin E as an active ingredient was prepared and compared by measuring the amount of vitamin E migration in the base.
1. 검체의 제작1. Preparation of Specimen
a) 본 발명에 의한 검체a) specimen according to the present invention
실시예 1에서 제작한 본 발명에 의한 검체와 동일한 조성에 비타민 E를 1% 첨가하고, 부직포에 350g/m2의 두께로 코팅하였다.1% of vitamin E was added to the same composition as the sample according to the present invention prepared in Example 1, and the nonwoven fabric was coated with a thickness of 350 g / m 2 .
b) 비교검체 1과 비교검체 2b) Comparative Sample 1 and Comparative Sample 2
에틸셀룰로즈 : 피마자유 = 1 : 5로 혼합한 에틸셀룰로즈/피마자유 혼합액 (A액) 단독조성에 비타민 E를 1% 첨가하고 부직포에 350g/m2의 두께로 코팅하여 비교검체 1로 하고, SIS(스티렌-이소프렌-스티렌고무) : 파라핀오일= 1 : 2로 혼합한 SIS/파라핀오일 혼합액 (B액) 단독조성에 비타민 E를 1% 첨가하고 부직포에 350g/m2의 두께로 코팅하여 비교검체 2로 하였다.Ethyl cellulose: Castor oil = 1: 5 Ethyl cellulose / castor oil mixed solution (liquid A) 1% vitamin E was added to the single composition, and the nonwoven fabric was coated with a thickness of 350 g / m 2 to make Comparative Sample 1. (Styrene-isoprene-styrene rubber): SIS / paraffin oil mixed solution (paraffin oil) mixed with paraffin oil = 1: 2 (B liquid) 1% of vitamin E is added to the single composition and coated on a non-woven fabric with a thickness of 350g / m 2 . It was set to two.
c) 리셉터 시트 (receipter sheet)c) receptor sheet
(비타민 E를 첨가하지 않고) A액 단독조성을 부직포에 350g/m2의 두께로 코팅하였다. A liquid single composition (without addition of vitamin E) was coated on the nonwoven fabric at a thickness of 350 g / m 2 .
2. 실험방법2. Experimental method
비타민 E를 1%씩 첨가한 본 발명의 검체, 비교검체 1, 비교검체 2를 리셉터 시트에 중층시켜 37℃에서 24시간 방치한 후, 리셉터 시트로 이동한 비타민 E의 양을 HPLC를 이용하여 측정하였다.The sample, Comparative sample 1, and Comparative sample 2 of the present invention, each containing 1% of vitamin E, were laminated on the receptor sheet and left at 37 ° C. for 24 hours, and then the amount of vitamin E transferred to the receptor sheet was measured by HPLC. It was.
3. 결과3. Results
HPLC로 측정한 비타민 E의 이동량은 본 발명의 검체, 비교검체 1(A액 단독조성)은 첨가량의 5% 전후였고, 비교검체 2(B액 단독조성)는 1% 전후였다. The movement amount of vitamin E measured by HPLC was about 5% of the added amount of the sample of Comparative Example 1 (Compound A composition alone) and 1% of Comparative Sample 2 (composition of B solution alone).
이는 SIS/파라핀오일 혼합액 (B액) 단독조성으로는 이동능이 현저히 낮지만 이를 에틸셀룰로즈/피마자유 혼합액 (A액)에 혼합해도 에틸셀룰로즈/피마자유 혼합액 (A액) 단독조성보다 이동능이 저하되지 않는다는 것을 의미하며, A액과 B액을 혼합하는 본 발명에 의해 두 조성물 즉, A액과 B액의 장점만 가지게 된다는 것을 알 수 있다.Although the mobility of the SIS / paraffin oil mixed solution (B liquid) alone is significantly lower, the mobility is not lower than that of the ethyl cellulose / castor oil mixed liquid (A liquid) even if it is mixed with the ethyl cellulose / castor oil mixed liquid (A liquid). It means that it does not, it can be seen that by the present invention mixing the liquid A and liquid B has only the advantages of the two compositions, that is, liquid A and liquid B.

Claims (4)

  1. 에틸셀룰로즈, 피마자유, 탄성체와 연화제를 포함하는 기제로 형성되는 것을 특징으로 하는 피부적용 오일-겔 소프트 패치.Skin-applied oil-gel soft patch, characterized in that formed of a base comprising ethyl cellulose, castor oil, elastomer and softener.
  2. 제1항에 있어서, 탄성체가 천연고무, 합성 이소프렌고무, 스티렌-이소프렌-스티렌고무, 폴리이소프렌고무에서 선택되는 것을 특징으로 하는 피부적용 오일-겔 소프트 패치.The skin-based oil-gel soft patch of claim 1, wherein the elastic body is selected from natural rubber, synthetic isoprene rubber, styrene-isoprene-styrene rubber, and polyisoprene rubber.
  3. 제1항에 있어서, 연화제가 미네랄오일, 폴리이소부틸렌, 폴리아크릴산 에스테르, 폴리부텐에서 선택되는 것을 특징으로 하는 피부적용 오일-겔 소프트 패치. The skin-based oil-gel soft patch of claim 1, wherein the softener is selected from mineral oil, polyisobutylene, polyacrylic acid ester, and polybutene.
  4. (1) 에틸셀룰로즈와 피마자유를 혼화하여 에틸셀룰로즈와 피마자유의 혼화액(A)을 만들고, 별도로 탄성체와 연화제를 혼화하여 탄성체와 연화제의 혼화액(B)을 만드는 단계; (1) mixing ethyl cellulose and castor oil to form a mixed solution (A) of ethyl cellulose and castor oil, and separately mixing an elastic body and a softener to form a mixed solution (B) of the elastic body and a softener;
    (2) (1) 단계에서 제조된 에틸셀룰로즈와 피마자유의 혼화액(A)과, 탄성체와 연화제의 혼화액(B)과, 필요에 따라 약물 또는 화장성분을 혼합하는 단계; 및  (2) mixing a mixed solution (A) of ethyl cellulose and castor oil prepared in step (1), a mixed solution (B) of an elastic body and a softener, and a drug or cosmetic component as necessary; And
    (3) (2)단계에서 제조된 에틸셀룰로즈와 피마자유, 탄성체와 연화제, 약물 또는 화장성분의 혼화액을 직포, 부직포 또는 합성수지필름에 도포하는 단계를 포함하는 피부부착용 오일-겔 소프트 패치의 제조방법. (3) Preparation of oil-gel soft patch for skin adhesion comprising applying a mixed solution of ethyl cellulose and castor oil prepared in step (2), an elastomer and a softener, a drug or a cosmetic ingredient to a woven fabric, a nonwoven fabric or a synthetic resin film. Way.
PCT/KR2010/003283 2009-06-09 2010-05-25 Oil-gel soft patch for attachment to the skin and method for preparing same WO2010143827A2 (en)

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WO2002022182A1 (en) * 2000-09-14 2002-03-21 Ssp Co., Ltd. Preparations for coating wound
KR100325122B1 (en) * 1998-09-24 2002-10-19 한국화학연구원 Method of manufacturing skin disease treatment and protective transdermal drug system
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US20070196453A1 (en) * 2004-06-07 2007-08-23 Jie Zhang Two or more non-volatile solvent-containing compositions and methods for dermal delivery of drugs

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KR100325122B1 (en) * 1998-09-24 2002-10-19 한국화학연구원 Method of manufacturing skin disease treatment and protective transdermal drug system
KR20010109042A (en) * 2000-06-01 2001-12-08 이영길 A cataplasma containing an aloe concentrate which shows an anti-inflammatory effect
WO2002022182A1 (en) * 2000-09-14 2002-03-21 Ssp Co., Ltd. Preparations for coating wound
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