WO2010141680A3 - Hedgehog pathway antagonists and methods of use - Google Patents

Hedgehog pathway antagonists and methods of use Download PDF

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Publication number
WO2010141680A3
WO2010141680A3 PCT/US2010/037200 US2010037200W WO2010141680A3 WO 2010141680 A3 WO2010141680 A3 WO 2010141680A3 US 2010037200 W US2010037200 W US 2010037200W WO 2010141680 A3 WO2010141680 A3 WO 2010141680A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
hedgehog pathway
pathway antagonists
pathway
antagonists
Prior art date
Application number
PCT/US2010/037200
Other languages
French (fr)
Other versions
WO2010141680A2 (en
Inventor
James K. Chen
Joel M. Hyman
Cory A. Ocasio
Original Assignee
The Board Of Trustees The Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees The Leland Stanford Junior University filed Critical The Board Of Trustees The Leland Stanford Junior University
Publication of WO2010141680A2 publication Critical patent/WO2010141680A2/en
Publication of WO2010141680A3 publication Critical patent/WO2010141680A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present disclosure provides for a compound, pharmaceutical preparations, kits and methods for the inhibition of the Hh pathway and the alleviation of cancer and developmental disorders associated with the Hh pathway.
PCT/US2010/037200 2009-06-03 2010-06-03 Hedgehog pathway antagonists and methods of use WO2010141680A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18358709P 2009-06-03 2009-06-03
US61/183,587 2009-06-03

Publications (2)

Publication Number Publication Date
WO2010141680A2 WO2010141680A2 (en) 2010-12-09
WO2010141680A3 true WO2010141680A3 (en) 2011-03-31

Family

ID=43298500

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/037200 WO2010141680A2 (en) 2009-06-03 2010-06-03 Hedgehog pathway antagonists and methods of use

Country Status (1)

Country Link
WO (1) WO2010141680A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102329277B (en) * 2011-10-24 2013-08-07 海南霞迪药业有限公司 Method for preparing Parecoxib

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060132615A (en) * 2003-12-15 2006-12-21 니뽄 다바코 산교 가부시키가이샤 Cyclopropane compounds and pharmaceutical use thereof
WO2008124524A2 (en) * 2007-04-03 2008-10-16 Janssen Pharmaceutica N.V. Aryl sulfonamide compounds as modulators of the cck2 receptor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060132615A (en) * 2003-12-15 2006-12-21 니뽄 다바코 산교 가부시키가이샤 Cyclopropane compounds and pharmaceutical use thereof
WO2008124524A2 (en) * 2007-04-03 2008-10-16 Janssen Pharmaceutica N.V. Aryl sulfonamide compounds as modulators of the cck2 receptor

Also Published As

Publication number Publication date
WO2010141680A2 (en) 2010-12-09

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