WO2010132758A3 - Ospc-based diagnostic test for lyme disease - Google Patents

Ospc-based diagnostic test for lyme disease Download PDF

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Publication number
WO2010132758A3
WO2010132758A3 PCT/US2010/034885 US2010034885W WO2010132758A3 WO 2010132758 A3 WO2010132758 A3 WO 2010132758A3 US 2010034885 W US2010034885 W US 2010034885W WO 2010132758 A3 WO2010132758 A3 WO 2010132758A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
borrelia
lyme disease
ospc
infection
Prior art date
Application number
PCT/US2010/034885
Other languages
French (fr)
Other versions
WO2010132758A2 (en
Inventor
Maria J. Gomes-Solecki
Raymond J. Dattwyler
Original Assignee
Gomes-Solecki Maria J
Dattwyler Raymond J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gomes-Solecki Maria J, Dattwyler Raymond J filed Critical Gomes-Solecki Maria J
Publication of WO2010132758A2 publication Critical patent/WO2010132758A2/en
Publication of WO2010132758A3 publication Critical patent/WO2010132758A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/20—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates, e.g., to a composition comprising OspC polypeptides from Lyme Disease-causing Borrelia species, wherein the composition comprises one or more isolated polypeptides from OspC families as follows: (a) at least one of each of K, B, and J; or (b) at least one of each of K and E; or (c) at least one of each of K and F. These polypeptides bind specifically to antibodies induced by a causative agent of Lyme disease (a pathogenic Borrelia), e.g. in a sample from a subject having Lyme disease, and exhibit a high degree of cross-reactivity with OscC polypeptides from other families. Therefore, the noted combinations of polypeptides can be used to diagnose infection from broad cross-section of Borrelia. Also disclosed are diagnostic reagents and kits comprising compositions of the invention, methods for diagnosing infection by Borrelia, and vaccines against Borrelia infection.
PCT/US2010/034885 2009-05-14 2010-05-14 Ospc-based diagnostic test for lyme disease WO2010132758A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17826109P 2009-05-14 2009-05-14
US61/178,261 2009-05-14

Publications (2)

Publication Number Publication Date
WO2010132758A2 WO2010132758A2 (en) 2010-11-18
WO2010132758A3 true WO2010132758A3 (en) 2011-04-07

Family

ID=43085593

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/034885 WO2010132758A2 (en) 2009-05-14 2010-05-14 Ospc-based diagnostic test for lyme disease

Country Status (1)

Country Link
WO (1) WO2010132758A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103175963A (en) * 2011-12-26 2013-06-26 苏州新波生物技术有限公司 Treponema (TP) antibody detection method and detection kit thereof
UY34745A (en) * 2012-04-18 2013-11-29 Zoetis Llc VACCINES AND PROCEDURES TO TREAT LYME'S DISEASE IN DOGS
US9562079B2 (en) 2012-04-18 2017-02-07 Zoetis Services Llc Vaccines and methods to treat lyme disease in dogs
EP4088115A1 (en) * 2020-01-10 2022-11-16 Quidel Corporation Test strip with structured substrate for multiplex lateral flow assay for disease diagnostics

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059894A1 (en) * 1997-06-30 2003-03-27 Philipp Mario T. Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease
US20030138866A1 (en) * 1996-05-02 2003-07-24 Statens Serum Institut Novel Osp-C derived peptide fragments
US7060281B1 (en) * 1999-06-18 2006-06-13 Research Foundation Of The State University Of New York Groups of barrelia burgdorferi and borrelia afzelii that cause lyme disease in humans
WO2007065098A2 (en) * 2005-11-29 2007-06-07 Virginia Commonwealth University Polyvalent chimeric ospc vaccinogen and diagnostic antigen

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138866A1 (en) * 1996-05-02 2003-07-24 Statens Serum Institut Novel Osp-C derived peptide fragments
US20030059894A1 (en) * 1997-06-30 2003-03-27 Philipp Mario T. Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease
US7060281B1 (en) * 1999-06-18 2006-06-13 Research Foundation Of The State University Of New York Groups of barrelia burgdorferi and borrelia afzelii that cause lyme disease in humans
WO2007065098A2 (en) * 2005-11-29 2007-06-07 Virginia Commonwealth University Polyvalent chimeric ospc vaccinogen and diagnostic antigen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHRISTOPHER, G. ET AL.: "Development of an OspC-based tetravalent, recombinan t, chimeric vaccinogen that elicits bactericidal antibody against diverse Ly me disease spirochete strains", VACCINE, vol. 25, 2007, pages 466 - 480, XP005798900, DOI: doi:10.1016/j.vaccine.2006.07.052 *

Also Published As

Publication number Publication date
WO2010132758A2 (en) 2010-11-18

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