WO2010131114A3 - Carbohydrate binding module and use thereof - Google Patents

Carbohydrate binding module and use thereof Download PDF

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Publication number
WO2010131114A3
WO2010131114A3 PCT/IB2010/001302 IB2010001302W WO2010131114A3 WO 2010131114 A3 WO2010131114 A3 WO 2010131114A3 IB 2010001302 W IB2010001302 W IB 2010001302W WO 2010131114 A3 WO2010131114 A3 WO 2010131114A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding module
carbohydrate binding
provides
present
subject
Prior art date
Application number
PCT/IB2010/001302
Other languages
French (fr)
Other versions
WO2010131114A2 (en
Inventor
Margaret Dah-Tsyr Chang
Yuan-Chuan Lee
Rong-Yuan Huang
Shu-Chuan Lin
Wei-I Chou
Shi-Hwei Liu
Original Assignee
National Tsing Hua University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Tsing Hua University filed Critical National Tsing Hua University
Priority to EP10774609.1A priority Critical patent/EP2430045B1/en
Priority to CN201080021113.XA priority patent/CN103097411B/en
Priority to JP2012510383A priority patent/JP5746149B2/en
Publication of WO2010131114A2 publication Critical patent/WO2010131114A2/en
Publication of WO2010131114A3 publication Critical patent/WO2010131114A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Abstract

The present invention provides a method of inhibiting HIV infection of a subject, comprising administering to the subject an effective amount of an antibody mimetic of carbohydrate binding module (CBM) which specifically binds to an epitope on HIV glycoprotein. The present invention also provides a pharmaceutical composition comprising a therapeutically or prophylactically effective amount of an antibody mimetic of carbohydrate binding module and a pharmaceutically acceptable carrier. The present invention also provides a method of detecting HIV of a sample.
PCT/IB2010/001302 2009-05-12 2010-05-12 Carbohydrate binding module and use thereof WO2010131114A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP10774609.1A EP2430045B1 (en) 2009-05-12 2010-05-12 Carbohydrate binding module and use thereof
CN201080021113.XA CN103097411B (en) 2009-05-12 2010-05-12 Carbohydrate Binding Module and application thereof
JP2012510383A JP5746149B2 (en) 2009-05-12 2010-05-12 Antiviral carbohydrate binding module compositions and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/464,788 US20100291540A1 (en) 2009-05-12 2009-05-12 Carbohydrate binding module and use thereof
US12/464,788 2009-05-12

Publications (2)

Publication Number Publication Date
WO2010131114A2 WO2010131114A2 (en) 2010-11-18
WO2010131114A3 true WO2010131114A3 (en) 2011-11-24

Family

ID=43068807

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/001302 WO2010131114A2 (en) 2009-05-12 2010-05-12 Carbohydrate binding module and use thereof

Country Status (6)

Country Link
US (2) US20100291540A1 (en)
EP (1) EP2430045B1 (en)
JP (1) JP5746149B2 (en)
CN (1) CN103097411B (en)
TW (1) TWI391491B (en)
WO (1) WO2010131114A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107073093A (en) * 2014-08-22 2017-08-18 纳大进公司 Rabphilin Rab and application thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105219753B (en) * 2015-11-03 2018-11-02 绍兴加华生物科技有限公司 A kind of organophosphorus pesticide degradation enzymes of immobilization and the preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050090643A1 (en) * 2002-02-25 2005-04-28 Government Of The United Stateso Of America, Repre -Resented By The Secretary, Department Of Health Obligate domain-swapped dimer of cyanovirin with enhanced anti-viral activity
US20070116651A1 (en) * 2005-03-03 2007-05-24 Chang Margaret D Recombinant protein comprising starch binding domain and use thereof
US20090297516A1 (en) * 2008-06-02 2009-12-03 California Institute Of Technology Engineered lectins for viral inactivation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003267356A1 (en) * 2002-10-01 2004-04-23 Unilever Plc Proteins having polysaccharidase activity
EP1934605B1 (en) * 2005-09-22 2014-03-26 Prosci Incorporated Glycosylated polypeptides produced in yeast mutants and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050090643A1 (en) * 2002-02-25 2005-04-28 Government Of The United Stateso Of America, Repre -Resented By The Secretary, Department Of Health Obligate domain-swapped dimer of cyanovirin with enhanced anti-viral activity
US20070116651A1 (en) * 2005-03-03 2007-05-24 Chang Margaret D Recombinant protein comprising starch binding domain and use thereof
US20090297516A1 (en) * 2008-06-02 2009-12-03 California Institute Of Technology Engineered lectins for viral inactivation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOTOS ET AL.: "Proteins that bind high-mannose sugars of the HIV envelope.", PROG BIOPHYS MOL BIOL, vol. 88, no. 2, June 2005 (2005-06-01), pages 233 - 282, XP027691178 *
CALARESE ET AL.: "Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV- 1 antibody 2G12.", PROC NAT ACAD SCI, vol. 102, no. 38, 20 September 2005 (2005-09-20), pages 13372 - 13377, XP002595010 *
CHRISTIANSEN ET AL.: "The carbohydrate-binding module family 20-diversity, structure, and function.", FEBS J, vol. 276, no. 18, September 2009 (2009-09-01), pages 5006 - 5029, XP002669193 *
MACHOVIC ET AL.: "A new clan of CBM families based on bioinformatics of starch-binding domains from families CBM20 and CBM21.", FEBS J, vol. 272, no. 21, November 2005 (2005-11-01), pages 5497 - 5513, XP002374813 *
See also references of EP2430045A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107073093A (en) * 2014-08-22 2017-08-18 纳大进公司 Rabphilin Rab and application thereof

Also Published As

Publication number Publication date
US8293465B2 (en) 2012-10-23
TWI391491B (en) 2013-04-01
WO2010131114A2 (en) 2010-11-18
US20100291601A1 (en) 2010-11-18
TW201040280A (en) 2010-11-16
JP2012529426A (en) 2012-11-22
CN103097411A (en) 2013-05-08
CN103097411B (en) 2016-09-28
JP5746149B2 (en) 2015-07-08
US20100291540A1 (en) 2010-11-18
EP2430045A2 (en) 2012-03-21
EP2430045A4 (en) 2013-02-13
EP2430045B1 (en) 2015-07-08

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