WO2010128852A2 - Ear sensor system for noninvasive measurement of quantities - Google Patents
Ear sensor system for noninvasive measurement of quantities Download PDFInfo
- Publication number
- WO2010128852A2 WO2010128852A2 PCT/NL2010/050256 NL2010050256W WO2010128852A2 WO 2010128852 A2 WO2010128852 A2 WO 2010128852A2 NL 2010050256 W NL2010050256 W NL 2010050256W WO 2010128852 A2 WO2010128852 A2 WO 2010128852A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- radiation
- ear
- quantities
- blood
- living
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/6815—Ear
- A61B5/6817—Ear canal
Definitions
- the present invention relates to an ear sensor system.
- Such ear sensor systems are generally known, they are generally used for measuring medical quantities, such as the temperature, for example, in the ear.
- the object of the present invention is to extend the possibilities which the ear, and in particular the ear canal, offers for measuring medical quantities that are relevant for living beings in a reliable, non-invasive manner .
- this system comprises the features defined in claim 1.
- the advantage of the system according to the invention is that by carrying out in vivo absorption measurements or, put differently, transmission measurements, using electromagnetic radiation, on blood which flows to a sufficient extent through an ear crease or ear canal, it is possible to obtain or derive information which is indicative of a number of medical quantities which are vital for living beings.
- Practical examples of such quantities are: heart rhythm, heartbeat, oxygen concentration, glucose content and/or (de) hydration.
- oxygen content, the glucose concentration, the cholesterol concentration and the moisture content in the blood previously needed to be determined in a manner which was objectionable both to humans and to animals, for example by damaging the skin or by drawing and examining blood, in some cases in a laboratory, with the results generally not being available until after some time.
- control unit by means of which the radiation power of the laser (diode) is influenced is designed for continuous operation or for discontinuous (pulsed) operation in an energy-saving manner.
- Control by means of variable laser control currents advantageously makes it possible to have one and the same laser deliver electromagnetic radiation at varying frequencies.
- the sensor means which receive EM radiation that has passed through the blood in the ear crease, data become available, from which, after comparison of the absorption spectra at said varying frequencies, sufficiently reliable medical information can be derived.
- Figure 1 shows a human ear, which is provided around an ear crease with means according to the invention that emit and receive electromagnetic radiation; and
- Figure 2 shows a possible embodiment of an ear sensor system which is provided with a processing unit for processing signals from the means in figure 1.
- Figure 1 shows the ear of a living being, in this case a human being, in which part of an ear sensor system 1 is present, viz. means 2 and 3 emitting and receiving electromagnetic radiation, hereinafter called EM radiation, provided on either side of one or more ear lobes, skin or ear creases, hereinafter generally indicated at 4.
- Said means 2 and 3 may be combined, for example into a clip - a kind of clothes-peg - to be clamped to the ear crease, either above (4-1) or below (4-2) the mouth of the ear canal.
- the transmitting element 2 which comprises one or more lasers or laser diodes (Light Emitting Diodes, LEDs) on one side of the ear crease 4, sends the EM radiation through blood flowing in the ear lobe 4 to the other side, where the receiving (sensor) means 3 is provided.
- Lasers are, by nature, better capable of bundling light emitted by lasers, so that, unlike the situation in which LEDs are used, fewer if any measures are required for converging the EM light rays.
- the emitted radiation is absorbed by the blood and in particular by the components in the blood. It has been determined that said absorptions by the various components, such as moisture, glucose or oxygen, differ to such an extend that it becomes possible to carry out concentration measurements for said components.
- the system 1 to that end comprises a processing unit 5 (schematically shown in figure 2) connected to the aforesaid means.
- the processing unit 5 is designed to determine, advantageously in a non-invasive manner, on the basis of said signals absorption spectra of medical quantities being of relevance to the aforesaid living being.
- the signals received by the receiving means 3 are transmitted to the unit 5, where they will be used for determining, in a manner yet to be explained, the absorption spectra at different frequencies of the EM radiation.
- the system 1 comprises a control unit 6 connected to the EM radiation emitting means 2 for influencing the optical radiation power of said one or more lasers or laser diodes 2.
- the EM radiation may have a wide frequency spectrum, or be temporarily emitted at different, successive frequencies.
- one and the same laser 2 can be used for that purpose for producing radiation having different frequencies by emitting at different current levels or wave modes.
- absolute absorption values tell something about the absorptions effected by the specific substances in the blood, but in most cases the respective absorption at a certain frequency is determined by several substances simultaneously. It is advisable in those cases to compare absorption values at several different frequencies with each other so as to arrive at a reliable measure of the absorption of the relevant medical quantity.
- the processing unit 5 of figure 2 comprises a programmable, processor-controlled CPU 7 connected to the control unit 6, which in this case digitally controls one or more amplifiers for the lasers 2.
- the signals received from the receiving means 3 are further processed.
- the means 3 comprise several sensors, if necessary, which are each sensitive to radiation at (a) specific relevant frequency (frequencies) .
- received signals carrying information about oxygen content ⁇ SPO 2 ) / glucose concentration and moisture content (hydration), respectively are supplied to a multiplexer 8-1, so that processing can take place practically simultaneously.
- the signals After being supplied to a sensor amplifier 9-1, the signals are filtered by a filter, a digital filter 10-1 in this case, and made separately available, initially for possible analysis, to the CPU 7.
- the processing unit 5 in this case also has a separate multiplexer 8-2, and connected thereto a sensor amplifier 9-2 and a filter 10-2 for measuring the temperature, in particular the difference temperature, at different depths in the ear canal by means of temperature sensors 2 and transmitting said temperature to the CPU 7.
- a sensor amplifier 9-2 and a filter 10-2 for measuring the temperature, in particular the difference temperature, at different depths in the ear canal by means of temperature sensors 2 and transmitting said temperature to the CPU 7.
- a separate multiplexer 8-2 and connected thereto a sensor amplifier 9-2 and a filter 10-2 for measuring the temperature, in particular the difference temperature, at different depths in the ear canal by means of temperature sensors 2 and transmitting said temperature to the CPU 7.
- a filter 10-2 for measuring the temperature, in particular the difference temperature, at different depths in the ear canal by means of temperature sensors 2 and transmitting said temperature to the CPU 7.
- several infrared sensors are used for carrying out the temperature measurements.
- the heart rhythm and the heartbeat can be recognized in the increase and decrease of the blood volume passing through the crease 4, resulting in an absorption which regularly varies in height. Similarly, the breathing pattern is recognizable.
- the viscosity of the passing blood can be determined by sending the radiation to the passing blood at a certain angle. Based on the Doppler effect, it is possible to derive from the radiation that returns, or is optically broken, or passes through the blood, the current decelerations and accelerations of the blood. From said current information the viscosity of the blood can subsequently be derived.
- the substances glucose and cholesterol in the blood also have their characteristic absorption and transmission properties at certain frequency values. It has been found to be advantageous to have the laser frequency "sweep" through a specific frequency range for determining the concentrations of said substances.
- static averaging techniques can be used for digging up the aforesaid data so as to subsequently be able to correctly interpret said data as reliable parameters for the desired medical quantities to be measured.
- 3500 nm is used for glucose measurements.
- Cortisol, ketone and lactate concentrations are determined at the aforesaid frequencies, so that data regarding stress, overtraining and performance level, respectively, will be continuously available.
- ketone bodies are: beta hydroxybutyrate, L. acetoacetate and L. acetone. Information of this kind is very important to know for sports people, for example, or in the case of prolonged physical exertion. It is furthermore possible to optically determine the average blood pressure value from the extent to which the absorption level jumps back and forth with the blood pressure.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL2002852A NL2002852C2 (en) | 2009-05-07 | 2009-05-07 | EAR SENSOR SYSTEM FOR NON INVASIVE MEASUREMENT OF METHODS. |
NLNL-2002852 | 2009-05-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010128852A2 true WO2010128852A2 (en) | 2010-11-11 |
WO2010128852A3 WO2010128852A3 (en) | 2010-12-29 |
Family
ID=40957897
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL2010/050256 WO2010128852A2 (en) | 2009-05-07 | 2010-05-03 | Ear sensor system for noninvasive measurement of quantities |
Country Status (2)
Country | Link |
---|---|
NL (1) | NL2002852C2 (en) |
WO (1) | WO2010128852A2 (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT14374U1 (en) * | 2014-03-25 | 2015-10-15 | Johannes Dr Krottmaier | Device for the non-invasive determination of lactate values and method therefor |
US10321860B2 (en) | 2015-07-19 | 2019-06-18 | Sanmina Corporation | System and method for glucose monitoring |
US10736580B2 (en) | 2016-09-24 | 2020-08-11 | Sanmina Corporation | System and method of a biosensor for detection of microvascular responses |
US10744261B2 (en) | 2015-09-25 | 2020-08-18 | Sanmina Corporation | System and method of a biosensor for detection of vasodilation |
US10744262B2 (en) | 2015-07-19 | 2020-08-18 | Sanmina Corporation | System and method for health monitoring by an ear piece |
US10750981B2 (en) | 2015-09-25 | 2020-08-25 | Sanmina Corporation | System and method for health monitoring including a remote device |
US10888280B2 (en) | 2016-09-24 | 2021-01-12 | Sanmina Corporation | System and method for obtaining health data using a neural network |
US10932727B2 (en) | 2015-09-25 | 2021-03-02 | Sanmina Corporation | System and method for health monitoring including a user device and biosensor |
US10945676B2 (en) | 2015-09-25 | 2021-03-16 | Sanmina Corporation | System and method for blood typing using PPG technology |
US10952682B2 (en) | 2015-07-19 | 2021-03-23 | Sanmina Corporation | System and method of a biosensor for detection of health parameters |
US10973470B2 (en) | 2015-07-19 | 2021-04-13 | Sanmina Corporation | System and method for screening and prediction of severity of infection |
US11375961B2 (en) | 2015-09-25 | 2022-07-05 | Trilinear Bioventures, Llc | Vehicular health monitoring system and method |
US11675434B2 (en) | 2018-03-15 | 2023-06-13 | Trilinear Bioventures, Llc | System and method for motion detection using a PPG sensor |
US11737690B2 (en) | 2015-09-25 | 2023-08-29 | Trilinear Bioventures, Llc | System and method for monitoring nitric oxide levels using a non-invasive, multi-band biosensor |
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US5213099A (en) * | 1991-09-30 | 1993-05-25 | The United States Of America As Represented By The Secretary Of The Air Force | Ear canal pulse/oxygen saturation measuring device |
US5673692A (en) * | 1995-02-03 | 1997-10-07 | Biosignals Ltd. Co. | Single site, multi-variable patient monitor |
JP2003310561A (en) * | 2002-04-26 | 2003-11-05 | Itc:Kk | Biological data transmission system |
US20050209516A1 (en) * | 2004-03-22 | 2005-09-22 | Jacob Fraden | Vital signs probe |
US7658716B2 (en) * | 2004-12-07 | 2010-02-09 | Triage Wireless, Inc. | Vital signs monitor using an optical ear-based module |
-
2009
- 2009-05-07 NL NL2002852A patent/NL2002852C2/en active
-
2010
- 2010-05-03 WO PCT/NL2010/050256 patent/WO2010128852A2/en active Application Filing
Non-Patent Citations (1)
Title |
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Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT14374U1 (en) * | 2014-03-25 | 2015-10-15 | Johannes Dr Krottmaier | Device for the non-invasive determination of lactate values and method therefor |
US11666703B2 (en) | 2015-07-19 | 2023-06-06 | Trilinear Bioventures, Llc | System and method for health monitoring by an ear piece |
US10973470B2 (en) | 2015-07-19 | 2021-04-13 | Sanmina Corporation | System and method for screening and prediction of severity of infection |
US11744487B2 (en) | 2015-07-19 | 2023-09-05 | Trilinear Bioventures, Llc | System and method for glucose monitoring |
US10744262B2 (en) | 2015-07-19 | 2020-08-18 | Sanmina Corporation | System and method for health monitoring by an ear piece |
US10952682B2 (en) | 2015-07-19 | 2021-03-23 | Sanmina Corporation | System and method of a biosensor for detection of health parameters |
US10321860B2 (en) | 2015-07-19 | 2019-06-18 | Sanmina Corporation | System and method for glucose monitoring |
US10932727B2 (en) | 2015-09-25 | 2021-03-02 | Sanmina Corporation | System and method for health monitoring including a user device and biosensor |
US10945676B2 (en) | 2015-09-25 | 2021-03-16 | Sanmina Corporation | System and method for blood typing using PPG technology |
US10750981B2 (en) | 2015-09-25 | 2020-08-25 | Sanmina Corporation | System and method for health monitoring including a remote device |
US11375961B2 (en) | 2015-09-25 | 2022-07-05 | Trilinear Bioventures, Llc | Vehicular health monitoring system and method |
US11737690B2 (en) | 2015-09-25 | 2023-08-29 | Trilinear Bioventures, Llc | System and method for monitoring nitric oxide levels using a non-invasive, multi-band biosensor |
US10744261B2 (en) | 2015-09-25 | 2020-08-18 | Sanmina Corporation | System and method of a biosensor for detection of vasodilation |
US11980741B2 (en) | 2015-09-25 | 2024-05-14 | Trilinear Bioventures, Llc | System and method of a biosensor for detection of vasodilation |
US10736580B2 (en) | 2016-09-24 | 2020-08-11 | Sanmina Corporation | System and method of a biosensor for detection of microvascular responses |
US10888280B2 (en) | 2016-09-24 | 2021-01-12 | Sanmina Corporation | System and method for obtaining health data using a neural network |
US11675434B2 (en) | 2018-03-15 | 2023-06-13 | Trilinear Bioventures, Llc | System and method for motion detection using a PPG sensor |
Also Published As
Publication number | Publication date |
---|---|
NL2002852C2 (en) | 2010-11-09 |
WO2010128852A3 (en) | 2010-12-29 |
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